# STOCKHOLM 1.0
#=GF ID   YycH
#=GF AC   PF07435.6
#=GF DE   YycH protein
#=GF AU   Vella Briffa B, Szurmant H, Mistry J
#=GF SE   Pfam-B_21457 (release 10.0)
#=GF GA   20.60 20.60;
#=GF TC   20.80 21.70;
#=GF NC   20.50 20.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   9829949
#=GF RT   A two-component signal transduction system essential for growth
#=GF RT   of Bacillus subtilis: implications for anti-infective therapy. 
#=GF RA   Fabret C, Hoch JA; 
#=GF RL   J Bacteriol 1998;180:6375-6383.
#=GF RN   [2]
#=GF RM   16030236
#=GF RT   YycH regulates the activity of the essential YycFG two-component
#=GF RT   system in Bacillus subtilis. 
#=GF RA   Szurmant H, Nelson K, Kim EJ, Perego M, Hoch JA; 
#=GF RL   J Bacteriol 2005;187:5419-5426.
#=GF RN   [3]
#=GF RM   16600972
#=GF RT   The crystal structure of YycH involved in the regulation of the
#=GF RT   essential YycFG two-component system in Bacillus subtilis
#=GF RT   reveals a novel tertiary structure. 
#=GF RA   Szurmant H, Zhao H, Mohan MA, Hoch JA, Varughese KI; 
#=GF RL   Protein Sci. 2006;15:929-934.
#=GF DR   INTERPRO; IPR009996;
#=GF DR   SCOP; 1fgt; fa;
#=GF CC   This family contains the bacterial protein YycH which is
#=GF CC   approximately 450 residues long. YycH plays a role in signal
#=GF CC   transduction and is found immediately downstream of the
#=GF CC   essential histidine kinase YycG.  YycG forms a two component
#=GF CC   system together with its cognate response regulator YycF. PhoA
#=GF CC   fusion studies have shown that YycH is transported across the
#=GF CC   cytoplasmic protein. It is postulated that YycH functions as an
#=GF CC   antagonist to YycG [2]. The molecule is made up of three
#=GF CC   domains, and has a novel three-dimensional structure. The
#=GF CC   N-terminal domain features a calcium binding site and the
#=GF CC   central domain contains two conserved loop regions [3].
#=GF SQ   6
#=GS Q8EKY2_OCEIH/4-433  AC Q8EKY2.1
#=GS Q9K5R3_BACHD/4-439  AC Q9K5R3.1
#=GS YYCH_BACSU/4-455    AC Q794W0.1
#=GS YYCH_BACSU/4-455    DR PDB; 2FGT A; 50-447;
#=GS Q8YA70_LISMO/5-440  AC Q8YA70.1
#=GS Q8NYX5_STAAW/5-444  AC Q8NYX5.1
#=GS Q8CU86_STAES/8-448  AC Q8CU86.1
Q8EKY2_OCEIH/4-433             ETAKSLLLVVLIGTSMILTFGMWNYQADYDP.....LSERSVEGA......LNGVEKSVDDIVMPSEIIF..KQEGNYYTHATPNLKEQFYNSLQELRITEMERLPAEEERT.....PSNYEI.......EVIFPQEVPFLLF.DRILQLEDEAAPFPTFSIDRFYITFEPNSKSLQLEFISIDGREKVVAEVTSTARYEEVWDEMNRLQSEDYQRMTLIEGT.....ENDFYIPREVPAMQPISIFFTQMNKSVLQEMLFENTSGI...R..GSATPGNGYLYATDVRQLTIERNVMEY.......IYLEQPEAISDLNLIENSIQNINGHSGFTED..FRLMNI..DNNTITYQMYYDGHPVFQGSSSDI...STIKQTHSNQHLLEYKRPAIYLDTTDIIRKTKKEMRSGEEILEELV.DNEIDMDSVNDLKVGYKIQVETDDNGD....YVSMEPEWFMKINNNWSAVP..YYQPGAAAKGGD
Q9K5R3_BACHD/4-439             ENIKTVLLTGLVIMSWVLTWQLWTFQLDYAV.....LDNENNYEE....LIRLEEERSMNEVIVPESMIVHGGDEEYYIVRPDLEQHKDFLATMSETTFID.DDMRVQHPFA.....SAPTGI.......QLIYPTSIPSELF.VHLFDVEDEDFLLPLTSINRIYFYVEPDEGVVAQLLSLFDEQVVTIKTDMSPSDLEALMEDTDDYMAATSIVMGMH........QQSQYVPVDHTHLPTLSYTATMLSSMQFSQALFTDPSAVSMYH..QSNGKDDSYTDGNRIISEQGGGNFMEY.....TNPVFSETTERSGRHIIQASFDFINSHGGWTDQYILDDWQSFGTRDLVSYRLRVNGFPVMSFQGEDLMKLDLVRRGSGNQPT.EYRRPLFDID.NQPIDGGKKELPSGEEVLDALKEREDFNPRSLEKMVIGYEMVKPS.........YVIAEPFWFVKYDGRWEKID..LTAKEEATDGLE
YYCH_BACSU/4-455               ENIKTILLTVLVVISLVFTWGIWTFQPNFSEGSSSTESTVRVKHK......IEKTTQKLSETVRPRDMFI..HDDGAHYKVDDNALYEEIWSDLPHWDVKGIKDISDQYDKA..GFKSWFYGIGGSEAKLDLQFSDTIPIDIF.QTLFKWSNQS..FEYSSFDHILIPFNETKA.NKKIYLVSYSKQLILEVTVESANYRNIMNDLKNRQSNMPAFSLFSIGS.....KKEFLLPNKPLTMDKKEFVTESIKTNTFKQALFSDPSIV...REDSNYNNRNVLTDGISRLDVNLSQRQVQF....QQ.RNLVQSTSYQTGELIKKSQKYLEDTGSWTDH..YQFFNI.NDSQQLSFYIFMDQIPVINSTAKPFGATSAITVQWANDDILSYKRPNYSLG.TNPIKTSETELMGGSEVKMLLSKQTAYDTDKIDQIFLAYQLVSTS.TNDDP...LVELEPVWAMKVNGKIVPITKDLLRKEGANSGVE
#=GR YYCH_BACSU/4-455    SS    XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--......--S----HHHHS--SEEEE..EETTEEEE---HHHHHHHHHHGGGSEEEEEEE-GGG--HH..HHHHHHTT-TTS--EEEEEEEEEEEHHHH.HHHHT----S..STT-EEEEEEEES---SS.SEEEEEEETTTTEEEEEEEE-SSHHHHHHHHHHHGGGS-BEEEEEETT.....TEEEEEESS-EEEE----------HHHHHHHHSS-GGG-...B-XXXXXXX-EEE-SS-EEEEETTTTEEEE....E-.XX----SS--HHHHHHHHHHHHHHTT--SS-..EEEEEE.-TT--EEEEEEETTEEEEE-SSS--SS--EEEEEE-SSSEEEEEEES----.--XXXX-EEEE--SHHHHHHHHT--SS-GGGEEEEEEEEEEXXXX.XXXXX...XXX-EEEEEEEETTEEEEESTT-XXXXXXXXXXX
Q8YA70_LISMO/5-440             TGFRSFILTILVVLSIVLSYFIWKGQPDYEA.....INVKEVEKT......TIDKTMTTSQVFKPYKLAVNANENNYQSL..DADLLNELMAQGKAFSFSEVVLASKKSSEDYEKLIHKNGTI.......EIIFPNNIPFSIF.AQIFQVEGEG..LESAFFNRIVFDINKTDTGLHSVYFTNDDQENIYQSSLQNKDIDKIEKIVKKNESKLTQNDKLISN......KRNLFLSSEKTKLNRKKYIIDSLEINLFTSALFQDSGTV........KSEGNTYTDGSSVIEMDTDNKVLEYVNPSQERTNPEDLSSVKRAGLIQDSFNFVNDHAGWTGDGAYYFTGYAAESATTNFSLFIDNLQVYNENGM.....ADISVTEGLEAVYKYMRPFFRLDTDVPGEKKEVTLPSSYSVYSALAQNPNVKAEEIEDIVPGYHMTRSESSGMNR...LVTLEPTWLYKYHDKW......FIFQPDAEKAGE
Q8NYX5_STAAW/5-444             EHIKSVILALLVLMSVVLTYMVWNFSPDIAN.....VDNTDSKKSE.TKPLTTPMTAKMDTTITPFQIIH.SKNDHPEGTIATVSNVNKLTKPLKNKEVKSVEHVRRDHNLM..IPDLSSDFT.......LFDFTYDLPLSTYLGQVLNMNAKV..PNHFNFNRLVIDYDADDNIV..LYAISKDRHDYVKLTTTTKN.DHFLDALAAVKKDMQPYTDIITNKDTIDRTTHVFAPSKPEKLKTYRMVFNTISVEKMNAILFDDSTIV...R..SSKSGVTTYNNNTGVANYNDKNEKYHY....KN.LSEDEASSSKMEETIPGTFDFINGHGGFLNED.FRLFSTNNQSGELTYQRFLNGYPTFNKEGS.....NQIQVTWGEKGVFDYRRSLLRTD.VVLNSEDNKTLPKLESVRSSLANNSDINFEKVTNIAIGYEMQDNSDHNHIEVQINSELVPRWYVEYDGEW......YVYNDG...RLE
Q8CU86_STAES/8-448             EHTKSIILVLLVLMSIVLTYMVWNFSPDLSN.....IDNTDNSKSDKPKPLTKPMTAEMEGTITPFQIVH.SRDDKSQGTVASGAVLDKMIQPLKNQEVKSVSHLKREHNLV..IPELSNNFI.......VLDFTYDLPLSTYLSQVLDIDAKV..PNNFNFDRLLIDQDHNNHVV..LFAISKDRHEVVKLKTTMKG.NNVDKAFKSIEPDMQPYTEIITNKDTIDKATHVFAPSKPKDLKTYRMVFNTISVERMNSILFDDSTIV...R..SSQSGTTTYNNNTGVANYNDKDEMYHY....KN.LSEDAKSSSNMQETIPGTYEFINSHGGFLNED.YRLFKTDNRTGKLTYQRFLNGYPTFNKQNF.....NEIQVTWGDKGVYDYQRSLLKTD.VTLNSEESKSVPTVESVRSALANHPDIDFEKVTNIAIGYDMDDKANNEDIEVQRNCELIPRWFVEYDGNW......YAYKDG...RLE
#=GC SS_cons                   XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--......--S----HHHHS--SEEEE..EETTEEEE---HHHHHHHHHHGGGSEEEEEEE-GGG--HH..HHHHHHTT-TTS--EEEEEEEEEEEHHHH.HHHHT----S..STT-EEEEEEEES---SS.SEEEEEEETTTTEEEEEEEE-SSHHHHHHHHHHHGGGS-BEEEEEETT.....TEEEEEESS-EEEE----------HHHHHHHHSS-GGG-...B-XXXXXXX-EEE-SS-EEEEETTTTEEEE....E-.XX----SS--HHHHHHHHHHHHHHTT--SS-..EEEEEE.-TT--EEEEEEETTEEEEE-SSS--SS--EEEEEE-SSSEEEEEEES----.--XXXX-EEEE--SHHHHHHHHT--SS-GGGEEEEEEEEEEXXXX.XXXXX...XXX-EEEEEEEETTEEEEESTT-XXXXXXXXXXX
#=GC seq_cons                  EshKSllLslLVlhSlVLTahlWsFQPDaus.....lsspcsc+s......ppshTtphspslpPhpllh.u+--psphshsssslhcchhssLpphclpslcclpccashs..h...usstI.......pl.FspslPhslF.splhpl-scs..hsphsFsRllIsh-tscsslt.lahlsc-+cpllchssospsh-plhcshcshpuchp.hsplIpsp.....ppchalPscspcLpshchlhsolsspphsphLFsDoohV...R..uSposssoYssuouVhshsscschhcY....pp.hs.-psoShpttclIpsSacFINuHGGaTs-..achash.scosploYphFlsGaPVaNppup.....spIpVTaGscslh-Y+RPhhclD.ss.hccscKpLPouEpVhsuLupps-lch-clssIslGYcMscsossst.....hVpLEPpWahKYcGcW......ahhp-uAtpulE
//