Summary: Abi-like protein
Abi-like protein Provide feedback
This family, found in various bacterial species, contains sequences that are similar to the Abi group of proteins, which are involved in bacteriophage resistance mediated by abortive infection in Lactococcus species [1,2]. The proteins are thought to have helix-turn-helix motifs, found in many DNA-binding proteins, allowing them to perform their function .
Garvey P, Fitzgerald GF, Hill C; , Appl Environ Microbiol 1995;61:4321-4328.: Cloning and DNA sequence analysis of two abortive infection phage resistance determinants from the lactococcal plasmid pNP40. PUBMED:8534099 EPMC:8534099
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR011664Bacteria have numerous mechanisms to resist bacteriophage infection. While most are based on preventing infection in the first place, the abortive infection (Abi) systems provide protection by the abortion of an existing phage infection [PUBMED:20348932]. Typically, these Abi systems target a crucial step of phage multiplication such as replication, transcription or translation, and lead to the death of the infected cell. These protein sequences, found in various bacterial species, are similar to those of the AbiD and AbiF proteins from Lactococcus species [PUBMED:8534099, PUBMED:7601848]. The proteins are thought to have helix-turn-helix motifs, found in many DNA-binding proteins, allowing them to perform their function [PUBMED:7601849].
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Curation and family details
|Seed source:||Pfam-B_8740 (release 14.0)|
|Number in seed:||111|
|Number in full:||1544|
|Average length of the domain:||178.60 aa|
|Average identity of full alignment:||18 %|
|Average coverage of the sequence by the domain:||63.71 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||6|
|Download:||download the raw HMM for this family|
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