Summary: Autophagy protein 16 (ATG16)
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Autophagy protein 16 (ATG16) Provide feedback
Autophagy is a ubiquitous intracellular degradation system for eukaryotic cells. During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. ATG16 (also known as Apg16) has been shown to be bind to Apg5 and is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway .
Matsushita M, Suzuki NN, Fujioka Y, Ohsumi Y, Inagaki F; , Acta Crystallograph Sect F Struct Biol Cryst Commun. 2006;62:1021-1023.: Expression, purification and crystallization of the Atg5-Atg16 complex essential for autophagy. PUBMED:17012802 EPMC:17012802
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This tab holds annotation information from the InterPro database.
InterPro entry IPR013923Macroautophagy is a bulk degradation process induced by starvation in eukaryotic cells. In yeast, 15 Apg proteins coordinate the formation of autophagosomes. The pre-autophagosomal structure contains at least five Apg proteins: Apg1p, Apg2p, Apg5p, Aut7p/Apg8p and Apg16p. It is found in the vacuole [PUBMED:11689437]. The C-terminal glycine of Apg12p is conjugated to a lysine residue of Apg5p via an isopeptide bond. During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. Auotphagy protein 16 (Apg16) has been shown to be bind to Apg5 and is required for the function of the Apg12p-Apg5p conjugate [PUBMED:10406794]. Autophagy protein 5 (Apg5) is directly required for the import of aminopeptidase I via the cytoplasm-to-vacuole targeting pathway [PUBMED:10712513].
This entry represents auotphagy protein 16 (Apg16), which is required for the function of the Apg12p-Apg5p conjugate.
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Curation and family details
|Author:||Mistry J, Wood V|
|Number in seed:||16|
|Number in full:||330|
|Average length of the domain:||170.80 aa|
|Average identity of full alignment:||25 %|
|Average coverage of the sequence by the domain:||44.66 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||6|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the ATG16 domain has been found. There are 8 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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