# STOCKHOLM 1.0
#=GF ID   CEP1-DNA_bind
#=GF AC   PF09287.5
#=GF DE   CEP-1, DNA binding
#=GF AU   Sammut SJ
#=GF SE   pdb_1t4w
#=GF GA   17.80 17.80;
#=GF TC   18.30 17.80;
#=GF NC   17.60 17.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   15242600
#=GF RT   Structural differences in the DNA binding domains of human p53
#=GF RT   and its C. elegans ortholog Cep-1. 
#=GF RA   Huyen Y, Jeffrey PD, Derry WB, Rothman JH, Pavletich NP,
#=GF RA   Stavridi ES, Halazonetis TD; 
#=GF RL   Structure. 2004;12:1237-1243.
#=GF DR   INTERPRO; IPR015367;
#=GF DR   SCOP; 1t4w; fa;
#=GF CC   Members of this family of DNA-binding domains are found the
#=GF CC   transcription factor CEP-1. They adopt a beta sandwich
#=GF CC   structure, with nine strands in two beta-sheets, in a Greek-key
#=GF CC   topology [1].
#=GF SQ   2
#=GS CEP1_CAEEL/223-418  AC Q20646.2
#=GS CEP1_CAEEL/223-418  DR PDB; 1T4W A; 223-418;
#=GS CEP1_CAEBR/238-432  AC A8WW61.2
CEP1_CAEEL/223-418             EKWMEIDVLKQKVAKSSDMAFAISSEHEKYLWTKMGCLVPIQVKWKLDKRHFNSNLSLRIRFVKYDKKENVEYAIRNPRSDVMKCRSHTEREQHFPFDSFFYIRNSEHEFS..YSAEKGSTFTLIMYPGAVQANFDIIFMCQEKCLDLDDRRKTMCLAVFLDDENGNEILHAYIKQVRIVAYPRRDWKNFCEREDAKQ
#=GR CEP1_CAEEL/223-418  SS    --EEEEEE-HHHHTT-SSEEEEE-TT--EEEEE-TT--EEEEEEEE--TTTTT---EEEEEEEEE-SSS-HHHHTT-TT-B----HHHHHT--SSSTT-SEEEES-SSEEE..EE-TTSSEEEEE--TT--EEEEEEEESS-GGGS-HHHHTSEEEEEEEEE-TTS-EEEEEEEEEEEE-S-HHHHHHHHHHHHHH--
CEP1_CAEBR/238-432             EEWLTFEVKKERASKVSDFEFETVVNDGIYLWAKMKCNIPFIVKWNVSSCH..KQLFLKVRLVNYMASDNIENSIRVP.SNLAKCHNHRMTEEKTPRESFFYVVKSGEHWTPQINSKKDQCFVAKLAPGTTQVLFDLIFKCQRSCLDLAERRKRMCLAVFLEDENGNELLHDVIKQLLIVGYPRRDWKNFCEKRGDFK
#=GC SS_cons                   --EEEEEE-HHHHTT-SSEEEEE-TT--EEEEE-TT--EEEEEEEE--TTTTT---EEEEEEEEE-SSS-HHHHTT-TT-B----HHHHHT--SSSTT-SEEEES-SSEEE..EE-TTSSEEEEE--TT--EEEEEEEESS-GGGS-HHHHTSEEEEEEEEE-TTS-EEEEEEEEEEEE-S-HHHHHHHHHHHHHH--
#=GC seq_cons                  EcWhph-VhKp+suKsSDhtFthsspcthYLWsKMtC.lPh.VKWplsppH..ppL.L+lRhVpY.tp-NlE.uIRsP.SslhKC+sHp.pEp+hPh-SFFYlhpStccao..hsucKspsFshhhhPGssQs.FDlIFhCQcpCLDLs-RRKpMCLAVFL-DENGNElLHshIKQlhIVuYPRRDWKNFCE+csshp
//