# STOCKHOLM 1.0
#=GF ID   Lact-deh-memb
#=GF AC   PF09330.6
#=GF DE   D-lactate dehydrogenase, membrane binding
#=GF AU   Sammut SJ
#=GF SE   pdb_1f0x
#=GF GA   25.00 25.00;
#=GF TC   70.10 61.00;
#=GF NC   20.70 20.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   Lactate_dehydrogenase
#=GF RN   [1]
#=GF RM   10944213
#=GF RT   The crystal structure of D-lactate dehydrogenase, a peripheral
#=GF RT   membrane respiratory enzyme. 
#=GF RA   Dym O, Pratt EA, Ho C, Eisenberg D; 
#=GF RL   Proc Natl Acad Sci U S A. 2000;97:9413-9418.
#=GF DR   INTERPRO; IPR015409;
#=GF DR   SCOP; 1f0x; fa;
#=GF CC   Members of this family are predominantly found in prokaryotic
#=GF CC   D-lactate dehydrogenase, forming the cap-membrane-binding
#=GF CC   domain, which consists of a large seven-stranded antiparallel
#=GF CC   beta-sheet flanked on both sides by alpha-helices. They allow
#=GF CC   for membrane association [1].
#=GF SQ   19
#=GS Q5NQX4_ZYMMO/284-573  AC Q5NQX4.1
#=GS Q6FFS0_ACIAD/279-567  AC Q6FFS0.1
#=GS Q6WB82_ALCFA/276-564  AC Q6WB82.1
#=GS Q1NHT9_9SPHN/271-556  AC Q1NHT9.1
#=GS Q7VS08_BORPE/283-572  AC Q7VS08.1
#=GS Q66D31_YERPS/279-568  AC Q66D31.1
#=GS DLD_ECOLI/278-567     AC P06149.3
#=GS DLD_ECOLI/278-567     DR PDB; 1F0X A; 278-567;
#=GS DLD_ECOLI/278-567     DR PDB; 1F0X B; 1278-1567;
#=GS Q6D2B5_ERWCT/284-573  AC Q6D2B5.1
#=GS Q7N371_PHOLL/278-567  AC Q7N371.1
#=GS Q7V9S2_PROMA/275-565  AC Q7V9S2.1
#=GS A5WED9_PSYWF/295-585  AC A5WED9.1
#=GS Q2BK95_9GAMM/272-562  AC Q2BK95.1
#=GS Q1VBS3_VIBAL/273-563  AC Q1VBS3.1
#=GS Q1YWQ9_PHOPR/273-563  AC Q1YWQ9.1
#=GS Q5FRI2_GLUOX/282-571  AC Q5FRI2.1
#=GS Q8NRY8_CORGL/279-570  AC Q8NRY8.1
#=GS LDHD_HAEIN/272-562    AC P45295.1
#=GS Q5F898_NEIG1/272-561  AC Q5F898.1
#=GS Q2VHK1_9LACT/268-556  AC Q2VHK1.1
Q5NQX4_ZYMMO/284-573             VFYIGTNDPDELTELRRQVLKSFKYLPISGEYMHRHAYDIAAKYGKDTFLAIEYLGTDRLPQLFAMKGWFDGLNNRVSFLPRYLSDRVMQFASTLFPHHLPKRMDDFRDRYEHHLILKVSEEGTEEARSFLKDFFEKAS..GGYFECSDEEGKKAFLHRFAAAGAAIRYRDVHQDEVEDIVALDIALPRNNRAWEEHLPSEITDKISHILYYGHFFCQVFHQDYIVKKGGNCADIEHAMWKILDSRHAEYPAEHNVGHLYYAKDSLKTHYHELDPTNSFNPGIGHTSKAAYW
Q6FFS0_ACIAD/279-567             VFYVGSNDADDLTAIRRYLLTSLPSLPIAGEYIHRDAYQIGEKYGKDTFLFIEKFGTANVPKAFAMKDKIDGVLEKLKI..KGLTDHLLQALTFCLPSHLPKRMTEFRDLYQHHLILRIEKNSKALTEQFLTEYFALHS.TGAYFLCDQDEGRKAFLHRFAIAGAAIRYRDTHRNEVEDIVALDIALRRNDRQWVEQLPEEMEKKILHKLYYGHFFCHVFHQDYIIQKGVNPLEMEHEMWKLLDARRAEYPAEHNVGHLYIAKPALANFYQRLDPTNRFNVGIGHTSKLKYW
Q6WB82_ALCFA/276-564             VFYIGTNEPDELTAVRRHLLTQLPRLPIAGEYIHRTAYDIGEQYGKDTFLLIDRFGTAKVPSAFAMKSRIDGFFERFGW..RGVTDRVIQAVMNRLPSHLPARMRQWRDRFEHHLLLRVSNDTAQATRDYLQQQFGDST.QGAYFECDAEEGRKAFLHRFAIAGAAIRYRESHPNSVEDIVALDIALRRNDREWVEQLPDDMEKDIVHKLYYGHFLCHVFHQDYIIKKGVAPLEMEHRMWKLLDERQAEYPAEHNVGHLYVAKPALAGFYRELDPTNTFNPGIGHTSRRKWW
Q1NHT9_9SPHN/271-556             TFYVGTNDPARLTRLRRTILRDFSALPIAGEYMHRDAFDIADRYGKDMFVAIERMGTARLPRLFAAKSWVD....NLPCIRPGWSDRMMQRFGRLLPDHLPPEMRRFRDRFAHHLLLKMPARAAAEARELLAADFDGGE..ADHFECTPALAAKAFLHRFVAAGAAVRYRAVHRQAVADIVALDIALPRNATAWQEILPADLAAQSIHSLYYGHFFCHVFHQDYIVRRGVDPLAFEHRIWALLDERGAEYPAEHNVGHLYRAKPTLERFYRSLDPRNQCNPGLGQTTRQRYW
Q7VS08_BORPE/283-572             VFYIGTNDPGELTAIRRHMLTRLPALPIAGEYLHRDAFDIADVYGKDTFLAIRQLGTARLPRLFAIKARIDSFCERVPLLPKYLSDRVLQFASRLFPDHLPRRLREYRDAYAHHLMIKVPGKIGDQTRRFLQAYFDDAT..GASFECTPEEGKAAFLLRFAAAGAAVRYRAVHAGQVEDIVALDIALKRNDRDWLEQLPPDVEAPILMKLYYGHFFCHVFHQDYIVKKGEDCLALEHRMWKLLDERGAEYPAEHNVGHLYDAKPELKAFYRGLDPCNQFNPGIGRTSKLQGW
Q66D31_YERPS/279-568             VFYIGTNQTQVLTELRRIILRDFKHLPIAGEYLHRDIFDIAETYGKDTFVMINSMGTNNMPRFFTLKGKIDARLNKIPHLVDHLTDRVMQGFSQILPNHLPKRLKTYRNQYEHHLLLKMSGDGITEAQQHLRAFFATAE..GNFIACTADEGKKAFLHRFAAAGAAVRYHAVHADQVEDILALDIALRRNEKQWFETLPPEIEKCLIAKLYYGHFLCHVFHQDYIVKKGVDVKALKEKMLSLLNDKGAEYPAEHNVGHLYLAKPALKDFYQQIDPTNSFNPGIGKTSKRKRW
DLD_ECOLI/278-567                VFYIGTNQPEVLTEIRRHILANFENLPVAGEYMHRDIYDIAEKYGKDTFLMIDKLGTDKMPFFFNLKGRTDAMLEKVKFFRPHFTDRAMQKFGHLFPSHLPPRMKNWRDKYEHHLLLKMAGDGVGEAKSWLVDYFKQAE..GDFFVCTPEEGSKAFLHRFAAAGAAIRYQAVHSDEVEDILALDIALRRNDTEWYEHLPPEIDSQLVHKLYYGHFMCYVFHQDYIVKKGVDVHALKEQMLELLQQRGAQYPAEHNVGHLYKAPETLQKFYRENDPTNSMNPGIGKTSKRKNW
#=GR DLD_ECOLI/278-567     SS    EEEEEES-HHHHHHHHHHHHHH-SS--SEEEEEEHHHHHHH-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--HHHHHHHHH-SEEEEEEE-TTHHHHHHHHHHHHCCCSS..-EEEE--HHHHHHHHHHHTTHHHHHHHHHHHTCCCEECEEEEEEE-BTT-S--S----HHHHTTEEEEEEEEECCCTEEEEEEEEETTS-HHHHHHHHHHHHHHCT-BSSSSS--TTTS---HHHHHHHHHH-TT--BSTTTTT---SS--
Q6D2B5_ERWCT/284-573             VFYIGTNQPQVLTELRRHMLADFKNLPVAGEYMHRDIFDIAETYGKDTFMMIDKLGTDKLPLFFNLKGQVDTIFSKVPFLPSHLVDRTMQFLGRLLPSHLPARMKTYRDRFEHHLMVKMAGDGIDEAHRWLEEYFHDAD..GEFFVCTPEEGAKAFLHRFAAAGAAIRYHAVHSNDVENILALDIALRRNDREWFEHLPADISDMLVHRLYYGHFMCHVFHQDYIVKKGVDVHELKERMLALLDQRGAEYPAEHNVGHLYQAKPQLKAFYQKSDPTNSLNPGIGKTTKLKNW
Q7N371_PHOLL/278-567             VFYIGTNQTGVLTELRRHILANFHNLPMAGEYMHRDIFDIAEIYGKDAFIMIDKLGTDKMPTYFTLKGRMDAIFNRVPFLPVNLIDRIMQGLSRLLPSHLPKRLKEYRNRFEHHLILKMSGDGVEEARSWLEDYFSRVE..GDFFACTPEEGAKAFLHRFSAGGSAIRYQAVHSNEVGNILSLDIALRRNDREWFEQLPPEFDDVLVHKLYCGHFMCYVFHQDYIVKKGVDVQALKARMIELLDKRGAEYPAEHNVGHLYQAKPQLKAFYRMSDPTNTLNPGIGKTSKLKNW
Q7V9S2_PROMA/275-565             VFFVGTNNAEHLTHLREKILTNMNSLPDMGEYMHFSYFDGSAKYCKDTFLFLKYFGTKYLPKLLEAKRYIDQLTGQVTFLPENISDRLMQFIADILPNHLPIRLLSFRKKFNYYMLLLASNNSIEEMKLLLDIETEKSE.DFEYIECTESEGKDALLHRYVAGAAPARYKILNPDLAGDLLPLDIAFPRNFKDWDQLLPQDILNEMSDSFEMAHFLCMVFHLDFVVKKGVDSKLLKEKILKFLDSINAKYPAEHNVGHLYKAEKSLEVFYRELDPTNTFNSGIGKMSKRKNY
A5WED9_PSYWF/295-585             TFYIGSNSIGELAQLRRQILLGFTNIPEVGEYMHRDIFDVSTKYGKDTFLSIKHLGTDTLPRLFSIKGAIDAKLNKWSWMPKHFTDKVMQFIANIFPNHLPKRMTQYRNKYEHHLILKMSDAGIIEAQVFLEKFFADST.TGDYFECSDEESESAFLHRFAAAGAALRYEVIHQEEVGDILALDIAIPRNELAWFEALPEEINQHLEKKLYYGHFFCYVFHQDYILKKGSDAQQVKHFMLELLNTRGAKYPAEHNVGHLYEAEPDLQNFYQRLDPTNSFNPGIGKMSKTKRN
Q2BK95_9GAMM/272-562             VYYIGTNDPQELTDIRRHILQHFENLPEVAEYMHKDIYDIAEKYGKDTFMMINYFGTDPLPKLFAIKGKIAAYLNKISFLPKDIPDRVMQFACKLWPNIIPKRMRDFREKYDHYLVLKMSDGGIKEADKFLKQFFAASD.KGDYFECDADEAKKAYLHRFAAAGAAIRYQIIHQNEVEDILALDIALRRNDPDWVENLPEEISQHIVHSLYYGHFMCHVFHQDYILKKGADGKAVKKMMLDLLKEKGAKYPAEHNVGHLYEAEEGLQNFYFDLDPTNSFNPGIGKTQKTRCG
Q1VBS3_VIBAL/273-563             VFYLGTNDPAKLTKLRKDFLSTFDNLPEMGEYLHRDIFNMAEKYGKDVFLSIDLLGTDKLPKMFALKAKVENFLERIPFVSKYLPDTILYYASKLFPQHLPERMLDFRDKYEHHLVLKMSDGGIAEAQKYLKEVWAVED.DCDFFECTPEEGKKAYLHRFAAAGAAIRYETIHRKDVEDIVALDIALRRNDEEWLETLPEEVSKNLVQALYYGHFMCYVFHQDYIFKKGTDTKLMKKLMLEHLNSRGAKYPAEHNVGHLYEAENSLQKFYHELDPTNTFNPGIGKMDKYKRN
Q1YWQ9_PHOPR/273-563             VFYIGTDDAEKLTQLRRDILSKFDNLPEMGEYMHRDIFNLSEKYGKDVFLSINHLGTESLPKFFALKAKVENFLGRIPYVNKYLPDTILYYVSKLFPQHLPKRMLDFRNKYQHHLILKMSDEGIEEAKAYLENNWGEGS.GGSYFACTADEGKKALLHRFAAAGAAIRYETIHRNEVEEIVALDIALRRNDREWVEKLSEEITKNMVTSLYYGHFMCHVFHQDYIFKKGTDTKKMKKLMLELLEQKGAKYPAEHNVGHLYEAENTLQEFYHKLDPTNTFNPGIGKMSKYKRN
Q5FRI2_GLUOX/282-571             VFYIGTNNTSDLEDLRRHVLTHFDELPIAGEYLHRDAFNIAEKYGKDTFAVIRYFGTKYLPMFFSMKSRFDVFAQRLPFLSDHFSDLAMQFLSRFLPKQLPQRMCDYRDRFEHHLMLKVSAHMTAPVRAYLEQWASSTG..GAFFECTPDEGTRAFLHRFAAAGAAVRYRAVHTKTAEDIVALDVALRRNDREWFEVLPKEIEDRIIVKLYYGHFFCHVMHQDYVIKKGYNAMKVEHDMLPGLDARGARYPAEHNVGHLYKAPEEMVEHYRSLDPCNCFNPGIGLATKKRNW
Q8NRY8_CORGL/279-570             VFYIGTNNTHELEEIRRLFLEADMPLPISGEYMGRSAFDLAEKYGKDTFVFLKFMSPALQTRMFSFKTWANGLFSKIPGIGPTFADTVSQAMFSVLPNQLPKRMMEYRNRFEHHLLLTVSESQKAASEKMLKEFFAEPEHTGEFFICTSDEEKSASLNRFGAASAATRYAALKRRHIAGLIPIDVALRRDDWNWLEVLPEEIDDQLEVKAYYGHFFCHVMHQDYVAKQGVDLEALHDRIQHLLEERGAKLPAEHNYGRIYKLPESMEEHFKELDPTNTFNAGIGGTSPHKDW
LDHD_HAEIN/272-562               VFYIGTNQTSVLSDIRRHMLVNFEVLPISGEYIHRDAFDIAAKYGKDTFWVIKKFGTHWLPKLFSLKSNVDRIGKKFFFLPQHLSDKFMQTVSKFIPEHLPQSLWDYRNKYEHHLIIKMGGKGIQEAREYLESYIADGS.KGGYFECNAIETQAAMLHRFAVASAAIRYRAIHEKEVEEIVALDVALRRNDQDWFEVLPPEIDNRIISKLYYGHFMCHVFHQDYIVKKGYDYEELEYEMLKLLDKRGAQYPAEHNVGHLYEAKPTLRKFYKELDPTNSFNPGIGKTTRKKYW
Q5F898_NEIG1/272-561             VFYIGTNDINELTDIRRAALGEFESLPVSGEYIHRHAFDIADVYGKDTFYVIKKFGTHQLPKLFDLKARVDRFGKKVSFLPKHFSDKAMQFVSKFLPDHLPKSMRDYRDKYEHHLILKMGGKGVDEARAFLKEYFSHHG..GAFFECNAEETQAAMLHRFAVASAAIRYRSVHDDEVEDLVALDIALRRDDRDWFEKLPPEIDNKIIHKLYYGHFMCHVFHQDYIIKKGNGCMALEHEMLHLLDQRGAQYPAEHNVGHLYEAKPALKQFYRKLDPTNSFNPGIGKTSKKKNW
Q2VHK1_9LACT/268-556             MFYIGTNNPDELEDIRRHIMTTFKELPVSGEYMHKNAYKLAKKYGKDSLIVIEKIGTGHLPQMFALKAWGERFLKHIPFFKPYFPDRLLQTLSNLFPNQMPKRLDDYYEKYDHYLQLKMAGNGIEEAREYLKSYFDKAS..GDYFEADANETSNAATHRYVTAGVAIRYQELKQDSI.DILPLDIALASNDYKWFEHLPKEIEDKIEHKIYYGHLLDHVMHQDYILKPGVDAHELKKEMLKILDERHAVYPAEHNVGHLYLAAPALIKHYKKNDPTNSFNPGVGKQTMSKYW
#=GC SS_cons                     EEEEEES-HHHHHHHHHHHHHH-SS--SEEEEEEHHHHHHH-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--HHHHHHHHH-SEEEEEEE-TTHHHHHHHHHHHHCCCSS..-EEEE--HHHHHHHHHHHTTHHHHHHHHHHHTCCCEECEEEEEEE-BTT-S--S----HHHHTTEEEEEEEEECCCTEEEEEEEEETTS-HHHHHHHHHHHHHHCT-BSSSSS--TTTS---HHHHHHHHHH-TT--BSTTTTT---SS--
#=GC seq_cons                    VFYIGTNssscLTclRRclLssFcsLPluGEYhHRDhFDIA-KYGKDTFlhIcphGTcpLP+hFulKuplDshhp+lsalscaloD+lMQhhuclhPsHLPcRMp-aR-+YEHHLlLKMuscGlpEA+paLcpaFucus..GsaFECos-EGp+AaLHRFAAAGAAIRYcslHpscVEDIlALDIALRRNDc-WhEpLPtEIsspllcKLYYGHFhCHVFHQDYIlKKGsDsptlc+cMLcLLDpRGAcYPAEHNVGHLYcAcssLppFY+cLDPTNoFNPGIGKTSKpKpW
//