# STOCKHOLM 1.0 #=GF ID ATG_C #=GF AC PF09333.6 #=GF DE ATG C terminal domain #=GF AU Mistry J, Wood V #=GF SE Pfam-B_61662 (release 20.0) #=GF GA 21.20 21.20; #=GF TC 21.20 21.20; #=GF NC 21.10 21.10; #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq #=GF TP Family #=GF RN [1] #=GF RM 11382760 #=GF RT Apg2 is a novel protein required for the cytoplasm to vacuole #=GF RT targeting, autophagy, and pexophagy pathways. #=GF RA Wang CW, Kim J, Huang WP, Abeliovich H, Stromhaug PE, Dunn WA #=GF RA Jr, Klionsky DJ; #=GF RL J Biol Chem. 2001;276:30442-30451. #=GF DR INTERPRO; IPR015412; #=GF CC ATG2 (also known as Apg2) is a peripheral membrane protein. It #=GF CC functions in both cytoplasm to vacuole targeting and autophagy #=GF CC [1]. #=GF SQ 36 #=GS ATG2_YARLI/1425-1522 AC Q6C6M0.2 #=GS ATG2_PICPA/1764-1861 AC Q9HFR4.1 #=GS ATG2_PICAN/1661-1758 AC A7KAI1.1 #=GS ATG2_MAGO7/1992-2089 AC Q51ZN8.2 #=GS ATG2_NEUCR/1952-2049 AC Q871L5.2 #=GS ATG2_CHAGB/1944-2041 AC Q2GYD8.1 #=GS ATG2_COCIM/1999-2096 AC Q1E702.1 #=GS ATG2_AJECN/2006-2103 AC A6R6E3.1 #=GS ATG2_PENCW/1999-2096 AC A7KAL3.1 #=GS ATG2_SCLS1/2060-2157 AC A7E6F5.1 #=GS ATG2_USTMA/1970-2076 AC Q4PFE7.1 #=GS ATG2_CRYNJ/1838-1935 AC P0CM30.1 #=GS Q8MMZ9_DICDI/2528-2625 AC Q8MMZ9.1 #=GS ATG2_SCHPO/1546-1643 AC O94649.4 #=GS Q16FD9_AEDAE/1615-1707 AC Q16FD9.1 #=GS Q54T12_DICDI/1619-1713 AC Q54T12.1 #=GS A3BAI7_ORYSJ/1805-1889 AC A3BAI7.1 #=GS A5ALG6_VITVI/1449-1547 AC A5ALG6.1 #=GS Q9LJK9_ARATH/220-318 AC Q9LJK9.1 #=GS A8XC81_CAEBR/2197-2295 AC A8XC81.1 #=GS Q5BRC7_SCHJA/15-116 AC Q5BRC7.2 #=GS Q95TX2_DROME/718-815 AC Q95TX2.1 #=GS Q17EJ4_AEDAE/794-891 AC Q17EJ4.1 #=GS A7SRE0_NEMVE/793-890 AC A7SRE0.1 #=GS ATG2B_MOUSE/1974-2071 AC Q80XK6.3 #=GS ATG2A_MOUSE/1811-1908 AC Q6P4T0.2 #=GS Q4RPB4_TETNG/1683-1810 AC Q4RPB4.1 #=GS A5DUF2_LODEL/1964-2061 AC A5DUF2.1 #=GS ATG2_CANAL/1758-1855 AC Q59X11.1 #=GS ATG2_DEBHA/1784-1881 AC Q6BTX0.2 #=GS ATG2_PICST/1740-1837 AC A3LT28.2 #=GS ATG2_ASHGO/1417-1514 AC Q75E74.2 #=GS ATG2_KLULA/1397-1494 AC Q6CQ43.1 #=GS ATG2_VANPO/1458-1555 AC A7TM79.1 #=GS ATG2_YEAST/1487-1586 AC P53855.1 #=GS ATG2_CANGA/1484-1583 AC Q6FP05.1 ATG2_YARLI/1425-1522 KLISLYANQ...PLGVYAGLQDAYSSFGK..............................HMNVAKTAIHNLSEDI..SE....ADTAGAA..........AYAVVKAAPVALIRPIIGTTEAVSKTLFGVANEMDPSGRELARDKYK ATG2_PICPA/1764-1861 KTISLYANQ...PTTMKEGLQLAYQSFGR..............................NIDSAKRAISKASSKV..SE....DNRTSNI..........AYEVMKATPVVVLRPIIGTTEAVSKALLGGLNQFDPDNRSKSEDKYK ATG2_PICAN/1661-1758 KIVSLYSNQ...PENLNEGLQTAYTSLGR..............................NLDTAREAIVSASTRA..AR....SGSAQTA..........AREFAKATPIMVIRPIIGTTEAISRTLQGGINILDPEEKRRSEEKYK ATG2_MAGO7/1992-2089 HQISLYANQ...PTGVIQGLRHGYRSLSR..............................DISIARQAIIAVPGEV..RE....SSSATGA..........AKAVLEKAPIFIFRPAIGATKAIGQTLLGATNSLDPQNLRRMDNKYK ATG2_NEUCR/1952-2049 KAISLYADQ...PLGIMQGMRGAYASLSR..............................DIAIARDAIIAVPTEV..ME....SSSAQGA..........AKAVLMQAPTILFRPAIGVSKAIGQTLLGATNALDPNHRKRIEAKYK ATG2_CHAGB/1944-2041 RKFSLYADQ...PLGIVQGVRGAYASLAR..............................DLSVARDAIIAVPAEI..ME....SEGAQGA..........AAAVLKKAPTIILRPAIGATKAIGQTLLGATNSLDPMHRKRVDAKYK ATG2_COCIM/1999-2096 PRISLYADQ...PLGVAQGLRGAYSSLER..............................DILMTRDAIVAMPSEV..LE....SGSATEA..........ARRLLGRTPTVVLRPAIGASKAVSQTLLGVSNALDPKNRRKIDDKYK ATG2_AJECN/2006-2103 KQFSPYADQ...PVGVVQGLRGAYASLER..............................DLLIARNAIVAVPGEV..IE....SGSAQGA..........ARALLKRAPTVILRPAIGASKALGQTLLGAGNSLDPTNRRRVEDKYK ATG2_PENCW/1999-2096 KKISLYADQ...PVGVVQGLRGAFSGLER..............................DLLLARDAVVAVPGEV..VE....SGSAKAA..........AKAVWKRAPTVILRPAIGVSKAVGQTLLGAGNTLDPSNRRKMEDKYK ATG2_SCLS1/2060-2157 KQISLYANQ...PVGVFQGLKGGYAGLQR..............................DLVMARDAIIAVPGEV..ME....GGSAKGV..........LRAVRKHAPTVILRPAIGVAKGAGQVLMGATNSLDKRNLERADAKYK ATG2_USTMA/1970-2076 GSVSRYAQQ...PLDMRDALAQAYSGLTD..............................HLTSAAQTILAIPMDV..FD....ASDLAGAPTTRSSEHTRSRPVVKAVPIAILRGAQGASHAIAKTMQGVQVALGDRQNVD.EQKYK ATG2_CRYNJ/1838-1935 EAISRYADQ...PESMKEGVQAAYKSLSK..............................NVNAAAQTILAVPMEV..YE....RSGDDGP..........LKAVIRAVPIAVLKPMIGTTEAVSKTLLGMRNSLDPSARRELDDKYK Q8MMZ9_DICDI/2528-2625 HGISKFSDQ...PNDTKEGIQHAYESVSR..............................ELKSAAHTIIAIPMKE..YH....QKGTKGY..........VKSIVQAVPIAIIRPMIGITEGVSKTLLGVRNQIDPNKKLEMDNKYK ATG2_SCHPO/1546-1643 RARSYYAEQ...PETIEQGLRQGYSGLKQ..............................GLLGAKSTLMGLPRET..RS....HKSLGGV..........AQTVGRKVPLIVLQPMIGATEAVSKTLLGLSNSLQPQRRQDMREKYK Q16FD9_AEDAE/1615-1707 RTDALRRRR...PQGMTEGFTQGLTGLGI..............................SILGAVGGLAHHPLQ.........ARSPMDV..........VTGVGKGIVGAFTKPISGAAELVALTGQGMLHSVGYNTMP..TPKYF Q54T12_DICDI/1619-1713 HNQSIWTSQ...PENLTEGAKKGMSKIFG..............................GFYNGVKGVIDPFSQ.........STGPINF..........LNNMFWAVPGLLVNPILGISDGITFFSLGLRNSLDYTKIEMERKKFK A3BAI7_ORYSJ/1805-1889 TKDNVRANQ...PESAQEGLKKAYESLTD..............................GFGRTASALIGNPIKV..YN...RGAGAGSA..........LATAICGAPGAAVAPLSASFRAAHYTLLGIRN..............R A5ALG6_VITVI/1449-1547 LKANIRTNQ...PKDAQQGIQQAYESLSD..............................GLGRSASALVQTPLKK..YQ...RGAGAGSA..........LATAVQAAPAAAIAPASGLARAVHCALLGVRNSLDPEHKKESMEKYL Q9LJK9_ARATH/220-318 TKTNVRHNQ...PRNAKQGMLKACESIGD..............................GIGKTASALVRTPLKK..YQ...RGDGAGSA..........FATVVQGVPTAAIAPASACARAVHSALVGIRNSLDPEHKKESMEKYL A8XC81_CAEBR/2197-2295 RSRRYNRNHGTNPTDVRHSLQLAYGILYD..............................GYQQTRDDLELAAQED........RASGNSV..........VRSAFRYAVPTFLGPIVMATQVTYQLLGGLRNQLRPDTYQDERRKWG Q5BRC7_SCHJA/15-116 RSRRLYLRQ...PADLREGFGNAVNVMTR..............................GFQMVAEDLCGATALP..SEVEIGYKGPVGM..........VGDVLRQIPPTMVTPIVAGCEVTANILGGLRNQLRPEAKAEDEQKWK Q95TX2_DROME/718-815 QGKRRRQGR...PKDLREGVANAYTIVRE..............................GINESANTLIEAAITE..HD....QKGYSGA..........VGAVVRQIPQLVVCPAVLATQATTNILGGAKSSLIPEAKLEARDKWK Q17EJ4_AEDAE/794-891 KGKRKRLHP...PQDIREGMSNAIQIVRE..............................GISETAHNLVELTALE..HD....QKGYTGA..........VGAVMRQIPPIVVQPIVLATQATSNVLGGVKNQLVPDARAEAREKYK A7SRE0_NEMVE/793-890 RGRHRLARQ...PADLREGVANAYNVVTK..............................GLNRTASNIAKVARDE..HE....EKGMTGA..........VGGVLRQVPATMVQPLILATEATSNVIGGVRNQILPDARREAVEKWR ATG2B_MOUSE/1974-2071 FPHHRLAHQ...PVDLREGVAKAYSVVKE..............................GITDTAQTIYETAARE..HE....SRGVTGA..........VGEVLRQIPPAVVRPLIVATEATSNVLGGMRNQIRPDVRQDESQKWR ATG2A_MOUSE/1811-1908 SRKLRRGQQ...PADLREGMAKAYDAVRE..............................GILDTAQTICDVASRG..HE....QKGLTGA..........VGGVIRQLPPTVVKPIIVATEATSNVLGGMRNQILPDAHKDHALKWR Q4RPB4_TETNG/1683-1810 SSRPRRAAQ...PADLREGVAKAYDTVREVTFSLLDRDTHIISWTLVTDCAFVFLSFIQGVIDTAQTLCDVASRG..HE....QKGLPGA..........VGGVLRQIPPTVVRPLIVASEATSNLLGGMRNQIKPDARKEDFLKWR A5DUF2_LODEL/1964-2061 KMISLYSNQ...PETMQQGFKSAYKSLGT..............................NFKVTQKQLKKLKRDL..EG....KETVQDT..........LLTVLKSSPIILIRPVIGTTEAIAKTLMGIGNVIDSKHIVENKDKYR ATG2_CANAL/1758-1855 KLVSLYSNQ...PETIEQGLKSAYKSLGT..............................NFKLTKKQLLKLRREL..AE....TDTIQDS..........MVTVLKNSPIILMRPLIGSTEAVSKLLMGVGNQIDGKKLVEKKDKYP ATG2_DEBHA/1784-1881 KLVSLYSNQ...PENTQQGLKLAYKSLGE..............................NFEITKKAVNNLRKEL..NA....SSNVQES..........LKSMVKSSPILIIRPMIGTTEALSKALMGISNEIDSNHIIESKDKYR ATG2_PICST/1740-1837 KLISLYSNQ...PENIQEGMKLAYKSFGN..............................NLKITKRQLINLKNEL..NE....SENIQDS..........LKSILKSSPIIFIRPIIGSTEALSKALMGLGNEIDSKRIVESRDKYR ATG2_ASHGO/1417-1514 KAISLYADQ...PQNAQKGVKEAYGSLGK..............................NLTIAYGAVRRAQRDA..RH....SISAQDA..........ATAFARATPIAFIRPMIGATEAVSKTLQGISNQMDRDQLVHMRDKYK ATG2_KLULA/1397-1494 KVLSLYADQ...PKDFNSGLQDAYESMER..............................NLYLTFDSMKKAKKEL..KT....AKGAQEA..........VSTVAKAAPFVLIRPLIGVTEALSKTLQGLNNQYDEDRIAQIEEKYK ATG2_VANPO/1458-1555 KIVSLYADQ...PLDVREGLEEAYHSLER..............................HLFIAYNSIKNRSTNM..DV....LESPTMT..........VLSMAKAAPIAIIRPLIGATEALSKALQGISNQLDKNQIENNKDKYK ATG2_YEAST/1487-1586 TIVSLYADQ...PLDLPTGLKEAYSSLEK..............................HMHIAYDAVWRAKGQMKDDK....RGGPSAA..........AVYVARAAPVAIIRPLIGATEAVSKTLQGIANQVDKTHNEQINDKYK ATG2_CANGA/1484-1583 KVVSLYSEQ...PLDLHKGLEEAYHALEK..............................HIQIAYNTIWQTNQELRGEE....SRSAKAA..........AVTIAKAAPVAVIRPMIGATEAIAKTLQGIYNQLDKSNIEEINDKYK #=GC seq_cons +thSlYusQ...PtslppGlppAYpoLpc..............................slthstpslhpsstch..hc....spuspuA..........stsVl+tsPssllRPhIGuT-AlupsLhGlpNplDPppppc.c-KYK //