Summary: F420H2 dehydrogenase subunit FpoO
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F420H2 dehydrogenase subunit FpoO Provide feedback
This is the FpoO subunit of F420H2 dehydrogenase, an enzyme which oxidises reduced coenzyme F420. Reduced coenzyme F420 is a universal electron carrier in methanogens.
Friedrich T, Scheide D; , FEBS Lett. 2000;479:1-5.: The respiratory complex I of bacteria, archaea and eukarya and its module common with membrane-bound multisubunit hydrogenases. PUBMED:10940377 EPMC:10940377
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This tab holds annotation information from the InterPro database.
InterPro entry IPR018288
This entry represents the FpoO subunit of membrane-bound multi-subunit F420H2 dehydrogenase, which oxidises the reduced coenzyme F420H2 to coenzyme F420 and feeds the electrons via an FeS cluster into an energy-conserving electron transport chain [PUBMED:9933933, PUBMED:15168610]. This enzyme plays a role in the methanogenic pathway in methanogenic archaea. Reduced coenzyme F420H2 is the major cytoplasmic electron carrier of methanogens and a reversible hydride donor, much like NADH [PUBMED:10940377].
Where CoB-S-S-CoM (the heterosulphide of 2-mercaptoethanesulphonate and 7-mercaptoheptanoylthreonine phosphate) is the terminal electron acceptor of the methanogenic pathway, and is reduced with the concomitant generation of a transmembrane proton potential and ATP synthesis.
The FpoO subunit of F420H2 dehydrogenase probably participates in the reduction of methanophenazine, where it acts as a special mechanism for the reduction of the methanogenic cofactor [PUBMED:10751389].
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|Seed source:||FIG062058 (Release 2.0)|
|Author:||FIGfam, Mistry J, Coggill P|
|Number in seed:||3|
|Number in full:||11|
|Average length of the domain:||103.40 aa|
|Average identity of full alignment:||43 %|
|Average coverage of the sequence by the domain:||94.51 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||4|
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