# STOCKHOLM 1.0
#=GF ID   HGTP_anticodon2
#=GF AC   PF12745.2
#=GF DE   Anticodon binding domain of tRNAs
#=GF AU   Wood V, Coggill P
#=GF SE   Pfam-B_20896 (release 24.0)
#=GF GA   21.00 21.00;
#=GF TC   21.10 21.10;
#=GF NC   20.80 20.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF DR   INTERPRO; IPR024435;
#=GF CC   This is an HGTP_anticodon binding domain, found largely on Gcn2
#=GF CC   proteins which bind tRNA to down regulate translation in certain
#=GF CC   stress situations.
#=GF SQ   30
#=GS A6ZYN2_YEAS7/1387-1658  AC A6ZYN2.1
#=GS Q6FSE4_CANGA/1377-1647  AC Q6FSE4.1
#=GS C5E0Y7_ZYGRC/1387-1656  AC C5E0Y7.1
#=GS A7TGA0_VANPO/1397-1666  AC A7TGA0.1
#=GS C4R5R6_PICPG/1424-1692  AC C4R5R6.1
#=GS Q6CEK5_YARLI/1380-1640  AC Q6CEK5.2
#=GS GCN2_SCHPO/1326-1576    AC Q9HGN1.2
#=GS B6JXM9_SCHJY/1324-1574  AC B6JXM9.1
#=GS B6QG71_PENMQ/1331-1582  AC B6QG71.1
#=GS B6HND6_PENCW/1330-1577  AC B6HND6.1
#=GS Q2U916_ASPOR/1345-1593  AC Q2U916.1
#=GS Q5BB34_EMENI/1298-1547  AC Q5BB34.1
#=GS C1GPN0_PARBA/1276-1530  AC C1GPN0.1
#=GS C5FVW9_ARTOC/1335-1588  AC C5FVW9.1
#=GS B2VUI6_PYRTR/1224-1477  AC B2VUI6.1
#=GS Q0UGA3_PHANO/1143-1398  AC Q0UGA3.2
#=GS A7E5P7_SCLS1/1343-1585  AC A7E5P7.1
#=GS Q2GWD3_CHAGB/1350-1553  AC Q2GWD3.1
#=GS B2B7B1_PODAN/1374-1619  AC B2B7B1.1
#=GS O74297_NEUCS/1372-1645  AC O74297.1
#=GS A5E786_LODEL/1546-1804  AC A5E786.1
#=GS C5MFL8_CANTT/1436-1709  AC C5MFL8.1
#=GS C4YTJ1_CANAW/1463-1762  AC C4YTJ1.1
#=GS B5RUH6_DEBHA/1464-1741  AC B5RUH6.1
#=GS A5DLN9_PICGU/1351-1611  AC A5DLN9.2
#=GS A3LWI3_PICST/1404-1670  AC A3LWI3.2
#=GS C4YBZ4_CLAL4/1388-1652  AC C4YBZ4.1
#=GS Q6CTQ8_KLULA/1399-1671  AC Q6CTQ8.1
#=GS C5DM71_LACTC/1436-1709  AC C5DM71.1
#=GS Q75F11_ASHGO/1426-1697  AC Q75F11.1
A6ZYN2_YEAS7/1387-1658             WKPSRCDVLISSFSNSLLDTIGVTILNTLWKQNIKADM.LRDCSSVDDVVTGAQQDGIDWILLIKQQA...........................YPLTNHKRKYKPLKIKKLSTNV..DIDLD.LDEFLTLYQQET.....GN.KSLINDSLTLGDKA...DEFKRWDENSS........AGSSQEGDIDDVVAGSTNNQKVIYVPNMATRSK.KANKREKW.VYEDAARNSSNMILHNLS.....NAPIITVDALRDETLEIISITSLA.QKEEWLRKVFGSGNNSTPRSFATSIYNNLS..KEAHKGNR...........WAILYCHKTGKSSVIDLQ
Q6FSE4_CANGA/1377-1647             WKPSRCDVLVSSFSNSIFDTIGVNILNQLWKNGIKADF.LRNCYTVDDVVSGAQQDGVDWIVLIKQQS...........................YTVNSQKRKYKPLKVKHLGSDI..DVDVT.LEEFLVLYRQET.....TR.KLGVENQLLASEKY...EETKRWDDGSS........AGSSQEDDNDEPLNGNA.NRKITYVPNMATRSK.KASKREKW.VYEDGARHASQAIINDLS.....NAPIIAVDALRDEAMDIIAITSLA.QKDEWLRKVFGSGNNSTPRSFATSIYNNLS..KEASKGHK...........WAILYCHKNNKSCVVDLQ
C5E0Y7_ZYGRC/1387-1656             WRPSRCDVLVSCFSNSILNTTGVNILNTLWKNGISTDF.LRHCYTVDDVVSGAQKDGVDWIILIKQQT...........................YTLPNHKRKYKPLRVKNLQTAL..DIDLD.LDEFLHLYHQER.....QP.KHLNDKMLGPVDAV...EDSKKVDDGSS........AGSSRESDEDAVPSST..NQKVVFVPNPATRSK.KLSKREKW.VYEDGARAASNSIVNSLV.....SAPVVTVDALRDETLEMISITSLG.QKDEWLKRVFGSGNNSVPRSFATGIYNTLS..KEASKGNK...........WAILYCHRTGKSCVIDLQ
A7TGA0_VANPO/1397-1666             WKPRRCDVLISSFSNPLLNTIGVNILNQLWKKGINADM.LRNCNSIEDVVSGAQRDGVDWIILVKQQS...........................YAVTGHNRKFKPLKVKRLTTNT..DIDMD.LDEFFTIYQHDT.....EG.IPFVKDKLSSIEL....DDSKHWDDISS........ASSSQGGDLDEGLNYLS.RQKIVYVPNQATRSK.KSNKRDKW.VYEEGARAASQNIVNSMM.....SAPIIAVDTLREETLQIISITSLA.QKDEWLRKVFGSSNNSAPRSFATSIYNNLS..KEASKGHR...........WAILYSNKTNQSCVVDLQ
C4R5R6_PICPG/1424-1692             WSASRVDVLVCSFTSSLLRSIGIDLLQQLWSCEIRADL.LKNCLTTDDVINRAQLDGATWVILIKQQQQEPNQ......................YGTINTKKRYKPLRLKNFEKQT..DTDLD.FEEVIPYIKNEM.....RE.RNEVEETTIAPATLPLRSLSEESQLRDL........STAENDSG..........QQKVILVPNDATRANRKSNRKDRW.AMEDASRNAAIQVTNEIS.....NCPIFPIDA.RDEVLDMLSITSLD.QPEEWKRKVGGA.SNATPRSYVVNLYNALS..KESAKGTR...........WAIVHSTKTGKICICDLQ
Q6CEK5_YARLI/1380-1640             WYPSRCDALVTSFNSNTLRTVCLDVLKDLWGAGIRADL.CRDCSSSEELVARAQSEGINWIIIVKQHS............................GYSSAAAAYKPLRVKNVARND..DTDID.RDGIVGHMMTEL.....NE.RGGSYSNTNALAPPSLSVPHDPSPPASI........VDTSDIYA..........TNKVSVITNEWNKSK.SSKRTNQWNDEEERALRHTRSLVHDIQ.....EAPIFTIDV.KEDILDAISVTSLA.SFDEWRRKVIGI.QPS.HKPYLAKIYNQLVKLKETRS..............TALLYSPKADKLILYNLR
GCN2_SCHPO/1326-1576               WAPRRVDVLVTSIGKDSI.LEKCSLLQELWALNIQADIVLRGASSLEEIVTHYRSEGINWVLVVRQKN.................................TQMEHSVKARNILKNE..DDEIR.FDEVGMWLLGEI.....NE.R...KRNESMLQSKRILDSAQQDVAKFV..........................DTSQSNLDVQLISLKDVNDRKYKW.KHKQNAMNKVYDLVQSAIRESSEDAIALAVDC.DSEAMEKLRSTTTL.DEESW.KRLIES.CPASQREYMQRLQKKLV..TLAEQDKK...........RVWICSFRTNEIYLYGLK
B6JXM9_SCHJY/1324-1574             WIPRRLDVIVASIGKDSL.TEKCAVLRILWALNIKADVLHKGATSLEEVVTRFRNDGINWVLVVRQKN.................................TAMQNSIKVRNISKGE..DYEIR.TEEIGLWMLSEI.....NE.R...KRLKNTKQTTELSRTSSQEAFSQM..........................EGQDLNLDVQLVSLKDVNDRKYKW.KHKMNAMNKVYDLVKNAISDCSTDAVALAVDC.STEVMHNLRSTTLQ.NEESW.KRFIDS.SPASQRQYLEQLHQKLL..AFKEEGKQ...........RVWVASFRTNELCLYELN
B6QG71_PENMQ/1331-1582             WRSRRCDVLVASFDPTVLRTVGVRIVQDLWAHDIIAELAVDAS.SFEELISHYKEDNHSWVVLVKA...................................DSNERGLKIRSLVKKE..EIDVR.ASDLVPWLRAEI.....RA.QH..HREILVDNPKVLRNPSQPDTGGPS........................GERGNDVRILVAQHRSK.KTNRRNII.ES...ALLRSRELVDKAL.....NGPIAAVDT.RDDLLDAIRDTRLC.DPDSW.RAVIQN.APLTERKYLGQVHELLRDLASEYA.PG...GGKEHESNNAFIYNLRTGTCIYYDLG
B6HND6_PENCW/1330-1577             WATRRCDVLVASFDPTVLRTTGVKLIEELWSNNISAELAVDAS.SLEELLAKYKDSNHRCIVIAKQ...................................DSKERGFKVRNLMRKE..EFDIR.TAELVMWLRSEV.....QA.R...HREGTVD.PRQSRQMSQQEALGFH.........................ERANDVRILIPQHRSK.KTNRRNIV.ES...ALLSSREVAENAR.....NGPVAAIDT.RDEVLDAIRGTRLS.DTESW.RSVIQN.APLTERKYLSQVHELLMDLAVENR.TS...DNTESYT.NAFIYNYRTGSCVYYDLG
Q2U916_ASPOR/1345-1593             WKTRRCDVLVASFDSKILRKKGIEVVQDLWANDISAELAVDAS.SLEELLTKYKDHNHSWIVIVKQ...................................DSQERGFKVRCLVPKE..EFDLR.SSELIPWLRNEI.....RA.RN..QREGAVD.FRQSRLPSQPDPGIDG.........................ERSSDVRILVPQHRSK.KTNRRNIV.EN...ALFRSREVIEDAL.....NGPIAAIDT.RDDLLEAIRDTRLS.DPESW.RTVIQS.APLTERKYLSQVHELLVDLAHENH.VN...DGADNFS.NAFIYNYRTGSCVYYDLG
Q5BB34_EMENI/1298-1547             WKTRRCDVLVASFDPTILREMGVQLTQDLWSNSISAELAVDAS.SLEELLTKYKEHNHSWIVIAKQ...................................DSKERGFKVRCLVPKE..ELDIR.GSELIPWLRSEI.....RA.RN..QREGAPENPRFARLPSQSEVNTPA........................NDRSNDVRILVSQHRSK.KTNRRNIV.EQ...ALTRAREVVENAL.....NGPIAAIDT.RDDLLEAIRDTRLS.DPDSW.RAVIQN.APLTERKYLQQVYDLLAEFASESH..G...DSADYPG.NAFIYNFRTGSCLYYDLG
C1GPN0_PARBA/1276-1530             WRSRRCDVLVASFDATVLRTVGVGVIQELWAHGISAELSVDTS.SLEEILSRYRNDSHSWVVIVKQ...................................DSMERGLKVKNISTKE..EFEVR.SSELAGWLRGEI.....GA.RN..QREHQTGTGKPLKHLNHQECSFST........................REKDPDVRILTALHRNK.KTNRRNII.ETVFLAIRESRNVMDRAL.....EGPIAAIDT.RDEVLEVLRHTRLS.DADSW.RAVIQN.GPLTERKYMAQLHELLNDLANERRDPQ...DGKENYR.NAFIYNYRTGSCIYYDLS
C5FVW9_ARTOC/1335-1588             WRRNKCDVLVASFDPSVLRTVGVGIVSTLWANDISAELAADTTPSLEDLLTRYVDDNYSWVVIVKQ...................................DSIERGLRVKSVQRKE..DFDVR.SSDLVPWLRNEM.....RA.RKKFKHDRPPESPKLIKHPSQSEAILSS........................KERDPEVRILTPLHKNK.KTNRRNIV.EF...ALRRSREVLDKGL.....DGPIAAIDI.RDDVLESIRDTRLS.DPDSW.RNAIQS.APLVERKYLGNIHELLMDLASESV.AQ...DGTVKYS.NAFVYNYRTGNCIYYDLK
B2VUI6_PYRTR/1224-1477             WMPRRCDCLVASFDPSVLRSTGVKMVADLISHGYTAELAVDAR.NTEELLRHYRDDRHSWVIVIKQGV...............................GPDKPE..LKVKSISKKE..DTDMR.SAELLNYLRNEF.....RD.RE..EREETAA..RLIKAITQPTNTANT..........................PKSSVDVLIAQHRSK.KSNKWSIV.EA...AQSRSAELLSAFQ.....SAPIAAIES.KEEVMTLIKETRLS.DQESW.RSFIQR.MPLAERKYLQELHDLLLGYRSKWLESKGLEGGGEGAVGKAFVYNFRTGGCLLYDLE
Q0UGA3_PHANO/1143-1398             WMPRRCDCLVASFDSNVLRSAGVKLVAELIAHGYTAELAVDAH.SVEDILRHYRDDRHSWVIVIKHGL...............................APDKPE..LKVKSIGKKE..DTDLR.TGDLLNYLRNEL.....RD.RE..AREGSAAQRLTKAVPTASSSAPAS..........................AKNNVDVLMAQHRSK.KSNKWSIV.EA...AQTRSSELLSSFN.....SAPIAAIET.KEEVMNLIRETRLS.DPDSW.RQAIQK.MPIAERKYLQELHDLLLGYRARWNEMKNEEGRGSGEGGKAFVYNFRTGGCLLYDLE
A7E5P7_SCLS1/1343-1585             WSTKRCDVLVASHDAAILRSTGVELVSNLWSHDISAELARDSR.SPEDLLSKYRDDSYSWIVIIKQ...................................DSV...VRCKTTGRKDIPDSDIP.STQLVSWLRGEM.....RE.RD..QREGTYNRAKLPRHHSQPDTGPSE..........................HEQDVRVLFAGTKSK.KSNRRSIV.DQ...AQGRAATLVQSFL.....DGPIAAIET.TDHVMDLIRETKLS.DPDSW.RKVTHS.VPTTERRYIGEIHDLMSTLAFQNKDIT..........RNAFVYNFRTGTCIYYDLG
Q2GWD3_CHAGB/1350-1553             FSAKR.................VSLTTSLPS.......................NHG............................................DNQ...LKIKTMGRKDASDADIS.AKELLNWLKSEI.....RD.RD..SRSGTRLRTTGLPHSDSGGALPTT.....................ATAEHGPQEVHVLVAQTKSK.KFNRHAVV.EQ...AHASASRLVQTFL.....DGPVAAIET.SDAVVDLIRGTSLS.DPESW.RRVEHG.VGTAEKKYVRELHDMLLQWRWAWEARK......EGSAPNAFVYNFRTGKCVYYDLG
B2B7B1_PODAN/1374-1619             FSMKRCDVLIASFDPSVLRSSGIELLQMLWAHNISAELARDTR.SPEDLLSSYREESYSWIVIIKQ...................................DNM...VKVKSMGRKDASDADIS.ATDLLNWLKSEI.....RE.RD..SRVLAKTRSMPTAAHVDSANAIEG.........................DREQEVHILVAQTKSK.KFNRHAVV.EQ...AQTSASRLVKGFL.....EGPIAAIET.SDTVMDMIKSTNIA.DAESW.RKVEQN.VGTAEKKYVREIHEMLKGWRWEWETKK........GPGHAFVYNFRTGKCIYYDLG
O74297_NEUCS/1372-1645             FNIKRCDVLVASFDPEVLRSSGIELVQTLWAHSISAELARDAR.SPEDLLSKYRDESYLWVVIIKQ...................................DNM...LKIKSMARKDAPDADIP.AKELLNWLKAEM.....RENRDALMRGTGSGSISSGAAIKFRGGGGSGGGGGLSSFGTNNSELNSGLFLGADGEREQEVHVLVAQTKSK.KFNRRQVV.EQ...AQMSAAKLLQSFL.....DGPIAAIET.SDSVMDMIRRTSLS.DAESW.RRVEHN.VGTSEKKYVKEIHDMLKGWRWEWEAKK........GSEHAFVYNFRTGRCIYYDLS
A5E786_LODEL/1546-1804             AGGSRCDVIIASTDLENISKIGYELAGRLWTRKFSVDI.LPKAAPQDELIHQALDAGAQLIVLIRAGEI..........................HKKSKKGSSYKPLRVKNLCTGK..ETNWDNYDDVVQHLHEEI........HGDQFDEESSVNKQD.....................DDFDDVGNLPEDQVTIDINQKVIVVNNEAPRGR.K.NKRDKW.EVEGKGRSAGTKTVQSLA.....NGPVLVFDI.RDETLDMIGITSIN.QQEEWIRKVVYS.TNNLPKSFALNIYNTLV..KEAAKGSR...........WCILVASRTQHSTIVDLQ
C5MFL8_CANTT/1436-1709             WKGSRCKVVIGSTQQQFLSQCGYSLLASLWNRNISADI.NLGSKSQDEIYHNATTDGATWVVIIRQLPSNVGG......................RKVRKSGSIFKPLKAKNIINGK..EIDLE.FDELVTYLVGEL.GESE.Q.EDDQDEAN......PVPSSAANNINGNT........TNNSEQTELSGPVSTVDIDQKIIVVNNDAPRGR.K.NKRDKW.ESENDAKLCGQSAIKELS.....LGPVIVIDA.RDEILDMISITSIH.QQDEWIRKVVFT.TNNFPKSFAINIQNTLI..KEYNKGHK...........WCILVSSRTQHTTIVDLR
C4YTJ1_CANAW/1463-1762             WKGNRCKVLISSTQQQFLSQVGYQLVSKFWNKNISADITSVAAKTQDEIFQNGNSEGAIWIVIIRSLPTTIGNSFSSLNGGSGGSSSTTTTSTSIRRSKKSGSGFKPLKLRNIITGK..DIDLD.YDEVIDYLVTELLEDSEHE.ENDQDNGTMTNSTTLLTSSSL.....SS........KTNQEEELLNGPIDSVEIDQKIIVVKNDAPRGR.K.NKRDKW.ESENDAKLAGQQCIKNLS.....GGPVVVIDA.RDEILDMISITSIH.QQDEWIRKVVYT.TNNFPKSFAMNIYNTLI..KEFNKGSI...........WCILVSSRTQHTTIVDLR
B5RUH6_DEBHA/1464-1741             WKKSRCDVLVTSLNESYIRLSGYEIVKSLWAHDISSDI..FTSTSLEDIAHKTDIDGANWVVLIKQPNSLQK.......................SKQKRSTGKFKPLRVKNVITNK..VSDIE.YEELVQFLQSEI...EERN.NDDEFDNLAGSGSTESTREGLKSDHNED........SESDKLSIRSGPIFTVDIDQKVVVVPNAAPRGR.KNNKKEKW.EIENDSKLASASLIKNVA.....NSPIITIDA.RDEVLDMISITSLN.QPDEWIRKVIFS.NNNLPKSFATNIYNTLK..KEASKGTR...........WVILHSSKTDKTCIIDLQ
A5DLN9_PICGU/1351-1611             WRGTRCDVLITSTNKSLVRLAGFEIAQSLWKNRISCDF..AYSASQTDIMDQAAQDGCGWIVFIKQTNSSSR.......................VKSRRGPSNFKPLRVRSVQSEK..DTDLE.YEELVPFLAEEI........NGSNEDESERHDMNY.....................TDSSLDSMPTGPLFSTDINNRVIVVPNDAPRGR.KNNKREKW.ELENDSKMASANFIKTLS.....NAPVIDLDV.QDEVLDMISITPLR.QQDEWVRKIVYF.SNNFPKSFGVNIYNTLK..KEANKGTQ...........WAMLHSSKTDKTCVIDLQ
A3LWI3_PICST/1404-1670             WRGVRCDVIITSPSAAYMDQSIYEIAKELWAHNINCDT..FVFSSQEELSHKVQTDGANWIVVTKQPNTL............................QKRNRNFKPLRVKTLHPNK..EVDLG.YDELVDYLESEI........EERNTEFEVECGDNSNDHGKAPEDNNNH........MESDTSHHELNPLFSVDIEQKAIVVPNEAPRGR.KNNKREKW.ELENDSKIASAQALKDLA.....TSPVITVDA.RDEVLDMIAITSIS.QQEEWLRKVIFS...NLPRSYAINIHNSLS..KEASKGHR...........WAVIYSPKTQKTNIVDLQ
C4YBZ4_CLAL4/1388-1652             WRKSRCDVLVTSSQESIIKDSGFKVLNELWAHGISSDW..FFAKSNEELNNRAIEDGCDWIVQLKQKNTG.........................SGRRSKKSSFKPIRVKSIEANK..DTDLD.YDELLHFLLNEI........EERNAEANEGSSYIDRKEDL................SQTNDDSRIGEPLFNLDIDQRVIVVSNSAPRGR.KNNKKEKW.ELENDSKLAGADLMKSLA.....KAPIVTVDS.NDSTLDMISSMSLNTSQEEWHKKLFFT.DNKLPRSYAAAIYETLN..KEAARGVR...........WALLHSPKTDKTTIVDLQ
Q6CTQ8_KLULA/1399-1671             WKPKRCEVLVSSFSNSILNTVGIEVVSKLWKAGISADI.VRGCFSVEDVITSAQKDGVDWIVLIKQQS...........................YSIANTKRKYKPLKIKNLSTNF..DADMD.IDEFLSLYEDSF......N.REANNDLPMKDDFFSEHDDRNKWDDNSS........QERSQDGESDTISAAG..PQKVIFIPNPATRAKGKPSKKDKW.VFEESARNASRQLIHSLS.....SVPIFAVDAIHDETLEIISITSLS.QKDEWLRKVFGSAANSAPRSFATNIYNNLS..KEAAKGGR...........WAIVHCNKTGKSCVVDLQ
C5DM71_LACTC/1436-1709             WKPMRCEVLVSSFSKTILNTIGVETLNQLWKAGISADF.VHSCYTVDDVVSAAQRDGVNWIILIKQQK...........................YSAPSNKRKYKPLKVKKLGSEL..DVDLD.FDEFLAIYQQEA.....ES.KFISSDFPQILESNPVSPDDKRWEDFTS........TEESQDGASDTSAIGKT.AQKVVYIPNMATRAK.KSNKKDKW.VYEDSARNASRAIISSLS.....TAPIFAVDAVRDETLEIISVTSLA.QKDEWLRKIFGVGNNSAPRSFATSIYNNLA..KEASKGGK...........WAIVHCDKTGKSCVVDLQ
Q75F11_ASHGO/1426-1697             WKPKRCDILVASFSDAILNSLGVRIVNKLWKLGISVDL.VRNCYSVEDVISAAQIDGCDWIILIKQQN...........................FSASSHKRKYKPLRIRKLDSEI..DVDMD.LDEFIQLYQQET......G.IRSTAEILPSSENSQIEEGTSKWEEFSS........ADGSQDGGSGIAPIG...QQKVVHIPNNSARAKAKQNKKDKW.VFEESARNASKAIVHSLS.....SAPVFSVDAIRDEVLEIISITSLA.QKDEWLRKVFGSGANSAPRSFATSIYNSLS..KEAAKGTK...........WAILHCHKTGSSCVVDLQ
#=GC seq_cons                      W+spRCDVLVuSFssslLcosGlcllppLWupsISADl.hcss.ShE-llsphppDGhsWIVllKQ.................................t.csp.+sLKVKslsppc..DsDlc.h-EllsaLcsEl.....pt.+p..pcptssspsp.hppsspptsshss..........................pppslhl.sstsRuK.KsN++spW.Ehc.tAptuoppllcshh.....suPIhAlDs.RDElL-hIphToLu.pt-pW.R+Vhts.ssss.RpYsspIastLt..+pts+up+...........hAhlYshRTGcsslhDLp
//