# STOCKHOLM 1.0 #=GF ID HNH_4 #=GF AC PF13395.1 #=GF DE HNH endonuclease #=GF AU Bateman A #=GF SE Jackhmmer:Q7P7J1 #=GF GA 21.50 21.50; #=GF TC 21.50 21.50; #=GF NC 21.40 21.40; #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq #=GF TP Domain #=GF DR INTERPRO; IPR025978; #=GF CC This HNH nuclease domain is found in CRISPR-related proteins. #=GF SQ 93 #=GS Q7MRD3_WOLSU/573-627 AC Q7MRD3.1 #=GS A3ZPG1_9PLAN/558-612 AC A3ZPG1.1 #=GS A1WH93_VEREI/615-668 AC A1WH93.1 #=GS D3NT09_AZOS1/659-712 AC D3NT09.1 #=GS A5EIM8_BRASB/580-633 AC A5EIM8.1 #=GS Q1QGC9_NITHX/661-714 AC Q1QGC9.1 #=GS A8LN05_DINSH/600-653 AC A8LN05.1 #=GS A3VED0_9RHOB/517-570 AC A3VED0.1 #=GS D1AUW6_STRM9/623-676 AC D1AUW6.1 #=GS B5ZLK9_GLUDA/564-619 AC B5ZLK9.1 #=GS Q13CC2_RHOPS/560-615 AC Q13CC2.1 #=GS C7VV80_ENTFL/580-633 AC C7VV80.1 #=GS B1BZW1_9FIRM/549-604 AC B1BZW1.1 #=GS A8REH9_9FIRM/541-596 AC A8REH9.1 #=GS Q6KIQ7_MYCMO/662-717 AC Q6KIQ7.1 #=GS C0WRP7_LACBU/705-756 AC C0WRP7.1 #=GS D7V2X1_9LACO/855-906 AC D7V2X1.1 #=GS C2KFJ4_9LACO/12-64 AC C2KFJ4.1 #=GS D6S374_9LACO/860-911 AC D6S374.1 #=GS D2EJF1_PEDAC/837-888 AC D2EJF1.1 #=GS E7FPD8_9LACO/847-902 AC E7FPD8.1 #=GS C0WXA2_LACFE/855-907 AC C0WXA2.1 #=GS C4VKS7_9LACO/860-912 AC C4VKS7.1 #=GS Q1WVK1_LACS1/821-874 AC Q1WVK1.1 #=GS C8JX96_LISMN/824-875 AC C8JX96.1 #=GS C2H9N2_ENTFC/833-884 AC C2H9N2.1 #=GS B5XLC1_STRPZ/821-872 AC B5XLC1.1 #=GS B4U3U9_STREM/820-871 AC B4U3U9.1 #=GS C6SPS8_STRMN/821-872 AC C6SPS8.1 #=GS F2MQN1_ENTFO/832-883 AC F2MQN1.1 #=GS B3W9S6_LACCB/839-890 AC B3W9S6.1 #=GS C0BCW4_9FIRM/160-213 AC C0BCW4.1 #=GS C0WE68_9FIRM/835-889 AC C0WE68.1 #=GS C2CKI6_9FIRM/849-903 AC C2CKI6.1 #=GS A6BJV4_9FIRM/831-885 AC A6BJV4.1 #=GS C5NZ04_9BACL/848-902 AC C5NZ04.1 #=GS B0RZQ7_FINM2/844-900 AC B0RZQ7.1 #=GS C2KY78_9FIRM/135-191 AC C2KY78.1 #=GS C7XMU0_9FUSO/849-905 AC C7XMU0.1 #=GS D1YP75_9FIRM/874-927 AC D1YP75.1 #=GS A7HP89_PARL1/579-633 AC A7HP89.1 #=GS C8PNV2_9SPIO/430-486 AC C8PNV2.1 #=GS C9LGP5_9BACT/680-736 AC C9LGP5.1 #=GS D1VXP4_9BACT/666-722 AC D1VXP4.1 #=GS C9PX91_9BACT/665-721 AC C9PX91.1 #=GS D2EGB9_9EURY/499-546 AC D2EGB9.1 #=GS B2KB46_ELUMP/642-695 AC B2KB46.1 #=GS B1GZ57_UNCTG/486-539 AC B1GZ57.1 #=GS B2UP49_AKKM8/631-682 AC B2UP49.1 #=GS B1ZMJ1_OPITP/127-175 AC B1ZMJ1.1 #=GS C0QF30_DESAH/22-70 AC C0QF30.1 #=GS A6VF81_METM7/225-273 AC A6VF81.1 #=GS C6BT14_DESAD/351-398 AC C6BT14.1 #=GS B6BL56_9PROT/256-305 AC B6BL56.1 #=GS Q15ND6_PSEA6/467-514 AC Q15ND6.1 #=GS B0P0H4_9CLOT/100-148 AC B0P0H4.1 #=GS B5W8V8_SPIMA/251-299 AC B5W8V8.1 #=GS D1PFN2_9BACT/3-51 AC D1PFN2.1 #=GS A6EGE9_9SPHI/232-280 AC A6EGE9.1 #=GS A7NHK9_ROSCS/251-299 AC A7NHK9.1 #=GS C4LF28_TOLAT/241-289 AC C4LF28.1 #=GS Q01TQ5_SOLUE/211-274 AC Q01TQ5.1 #=GS A6GZR9_FLAPJ/723-776 AC A6GZR9.1 #=GS C7M7G9_CAPOD/791-844 AC C7M7G9.1 #=GS A9DTN2_9FLAO/743-796 AC A9DTN2.1 #=GS C7X9T0_9PORP/777-830 AC C7X9T0.1 #=GS D1JW17_9BACE/793-846 AC D1JW17.1 #=GS C2G539_9SPHI/793-847 AC C2G539.1 #=GS Q1VXN8_9FLAO/428-481 AC Q1VXN8.1 #=GS C9MPM6_9BACT/841-894 AC C9MPM6.1 #=GS D1W1M7_9BACT/844-897 AC D1W1M7.1 #=GS B6W3J8_9BACE/839-892 AC B6W3J8.1 #=GS C2M5N8_CAPGI/824-879 AC C2M5N8.1 #=GS D7VKD0_9SPHI/827-880 AC D7VKD0.1 #=GS D3FJ35_MYCGF/647-702 AC D3FJ35.1 #=GS Q4A5I2_MYCS5/699-751 AC Q4A5I2.2 #=GS Q5M542_STRT2/576-631 AC Q5M542.1 #=GS D3HEG7_STRG3/576-631 AC D3HEG7.1 #=GS A8AY02_STRGC/575-630 AC A8AY02.1 #=GS D4IZM9_BUTFI/576-631 AC D4IZM9.1 #=GS A5Z395_9FIRM/569-624 AC A5Z395.1 #=GS C4ZA16_EUBR3/583-638 AC C4ZA16.1 #=GS D3UFL8_HELM1/576-630 AC D3UFL8.1 #=GS C5F1G9_9HELI/237-291 AC C5F1G9.1 #=GS B8I085_CLOCE/550-604 AC B8I085.1 #=GS A5KEK9_CAMJU/537-591 AC A5KEK9.1 #=GS C5ZYI3_9HELI/554-608 AC C5ZYI3.1 #=GS B9M9X8_ACIET/599-654 AC B9M9X8.1 #=GS C6SH44_NEIME/566-620 AC C6SH44.1 #=GS B1UZL4_CLOPF/560-614 AC B1UZL4.1 #=GS C2UN05_BACCE/559-613 AC C2UN05.1 #=GS C0FXH5_9FIRM/605-658 AC C0FXH5.1 #=GS B1GZM3_UNCTG/557-611 AC B1GZM3.1 Q7MRD3_WOLSU/573-627 CAYTGDVIELERLFD.EGYCEIDHILPRSR.SAD........DS.FANKVLCLARANQQ...KTDR.TPY A3ZPG1_9PLAN/558-612 CIYTGKVISQAQLFD.SGEVDVDHILPRWR.SLD........DS.MANKVIAHRSANNE...KGDR.TPW A1WH93_VEREI/615-668 CPYSGERISATMLLS..EAVEIEHILPFSR.TLD........DS.LNNRTVAMRRANRI...KGDR.TPW D3NT09_AZOS1/659-712 CPYSGETISMRMLLS..EQVDIDHILPFS.VSLD........DS.AANKVVCLREANRI...KRNR.SPW A5EIM8_BRASB/580-633 CPYTGEAIGLERLVS..DDVDIDHLIPFS.ISWD........DS.AANKVVCMRYANRE...KGNR.TPF Q1QGC9_NITHX/661-714 CVYTGEQISIERLLS..DEVDIDHILPVA.MTLD........DS.PANKIICMRYANRH...KRKQ.TPS A8LN05_DINSH/600-653 CPYTGTRISAAMIFD..GSCDVDHILPYSR.TLD........DS.FPNRTLCLREANRQ...KRNQ.TPW A3VED0_9RHOB/517-570 CPYTGKPISVTMLFD..GACDVDHILPYSR.TLD........DS.FANRTICLREANRQ...KGDR.TPW D1AUW6_STRM9/623-676 CMYSGRTIEKYQLTS..AEVQIDHILPYSK.SFD........NS.YSNKVLVFSNENQD...KKER.TPY B5ZLK9_GLUDA/564-619 CLYTGKAIHIRQIAATDNSVQVDHILPWSRF.GD........DS.FNNKTLCLASANQQ...KKRS.TPY Q13CC2_RHOPS/560-615 CIYSGDPIDPAGISANDTRYQVDHILPWSRF.GD........DS.YVNKTLCTARSNQN...KRGR.TPF C7VV80_ENTFL/580-633 CAYTGLSISPELLVS..DSTEIDHIIPIS.ISLD........DS.INNKVLVLSKANQV...KGQQ.TPY B1BZW1_9FIRM/549-604 SAYTLQDINLKELIEDEKAYEIDHIIPIS.ISLD........DS.FNNKVLTTHDENQE...KGNL.TPI A8REH9_9FIRM/541-596 TAYSLEPIDLKLLIDDPNAYEVDHIIPIS.ISLD........DS.ITNKVLVTHRENQE...KGNL.TPI Q6KIQ7_MYCMO/662-717 DAYSLRKIEANDVINKPWNYDIDHIVPRS.ISFD........DS.FSNLVIVNKLDNAK...KSND.LSA C0WRP7_LACBU/705-756 DMYTGKEINFDELVN....YQIDHILPQA.FIKD........DS.LDNRVLVSAPINNA...KSDN.VPV D7V2X1_9LACO/855-906 DAYTGEPINIDDL....GQYDIDHILPQS.FIKD........DS.LENRVLVKKAVNNG...KSDN.VPV C2KFJ4_9LACO/12-64 DAYTGKPINIDEVS...QYYDIDHILPQS.FIKD........DS.LNNRVLVAKPINNG...KSDG.VPL D6S374_9LACO/860-911 DAYSGEKLSLDNL....QDYDIDHIYPQS.FIKD........DS.FDNRVLVQRAYNNG...KSDN.VPV D2EJF1_PEDAC/837-888 DVYTGDTISLDKL....NDYDVDHILPQS.FIKD........DS.LDNRVLTIRAVNNG...KSDN.VPA E7FPD8_9LACO/847-902 DMYSGHPLDFDKVIS.GQEYDIDHILPQA.VIKD........DS.LDNRVLTTKALNND..VKSKG.VPC C0WXA2_LACFE/855-907 DMYTGDPINFDEIST...KYDIDHILPQS.FVKD........DS.LDNRVLVSRAENNK...KSDR.VPA C4VKS7_9LACO/860-912 DAYTGDKLSLDQL....QNYDIDHIFPRS.FIKD........DS.LDNRVLTQKPINAK...KSDYGIPA Q1WVK1_LACS1/821-874 DMYTGEKMNIDELH...QKYDIDHILPQS.FIKD........DS.LNNRVLTSKSVNIK..EKSDK.TAA C8JX96_LISMN/824-875 DMYTGQELDIHNLSN....YDIDHIVPQS.FITD........NS.VDNLVLTSSAGNRE...KGDN.VPP C2H9N2_ENTFC/833-884 DMYTGAPLDIHRLSD....YDIDHIIPRS.FTTD........NS.IDNKVLVSSKENRL...KKDD.VPS B5XLC1_STRPZ/821-872 DMYVDQELDINRLSD....YDVDHIVPQS.FLKD........DS.IDNKVLTRSDKNRG...KSDN.VPS B4U3U9_STREM/820-871 DMYTGDDLDIDYLSS....YDIDHIIPQS.FIKN........NS.IDNKVLTSQGANRG...KLDN.VPS C6SPS8_STRMN/821-872 DMYTGEELDIDYLSQ....YDIDHIIPQA.FIKD........NS.IDNRVLTSSKENRG...KSDD.VPS F2MQN1_ENTFO/832-883 DMYTGDELSLHRLS....HYDIDHIIPQS.FMKD........DS.LDNLVLVGSTENRG...KSDD.VPS B3W9S6_LACCB/839-890 DIYTGTPLNIDQLSS....YDIDHILPQS.LIKD........NS.LDNRVLVHAIINRE...KNAT.FAS C0BCW4_9FIRM/160-213 CLYTGKPIDITRIAS..NDYYVDHVVPLA.YRKD........ES.LDNKVLVYAEASRY...KSET.LLV C0WE68_9FIRM/835-889 DMYTGDPIKLEHI.KDQSFYNIDHIYPQS.MVKD........DS.LDNKVLVQSEINGE...KSSR.YPL C2CKI6_9FIRM/849-903 CMYSLDPIDLEELSN.KNLYDQDHIYPKSK.IYD........DS.IENRVLVKKQLNLD...KSNE.YPI A6BJV4_9FIRM/831-885 CMYSGEVIELKDLWD.NTKYDIDHIYPQSK.TMD........DS.LNNRVLVKKKYNAT...KSDK.YPL C5NZ04_9BACL/848-902 CMYSEEPINISELFD.NNKYDIDHIYPQSK.IKD........DS.FTNTVLVKRESNAA...KTDR.YPL B0RZQ7_FINM2/844-900 DMYTGEKIDLDKLFD.STHYDKDHIIPQS.MKKD........DSIINNLVLVNKNANQT..TKGNI.YPV C2KY78_9FIRM/135-191 DMYTGEEIDLGRLYD.DNLYDIDHIYPRH.YVKD........DSIMNNLVLVNRRANQD..IKKDL.YPI C7XMU0_9FUSO/849-905 CMYTGREIDLDRLLQNNDTYDIDHIYPRSKVIKD........DS.FDNLVLVLKNENAE...KSNE.YPV D1YP75_9FIRM/874-927 CAYTGEIIELSLLNT..DNYDIDHIYPRS.LTKD........DS.FDNLVLCKRTANAQ...KSDA.YPI A7HP89_PARL1/579-633 CPYTGDQIGFNALFR.EGRYEVEHIWPRSR.SFD........NS.PRNKTLCRKDVNIE...KGNR.MPF C8PNV2_9SPIO/430-486 CPYTGKHISFTDLFGPIPKFDFEHTIPRS.LSYD........DS.LENLTLCDSEFNRN..IKKQR.LPS C9LGP5_9BACT/680-736 CLYTGKKIGIADFLGANPKFDIEHTIPRSR.GGD........ST.QENLTLCESKFNRD..IKRDK.LPT D1VXP4_9BACT/666-722 CLYTGEQIGITDFIGSNPKFDIEHTIPQS.VGGD........ST.QMNLTLCDNRFNRE..VKKAK.LPT C9PX91_9BACT/665-721 CLYTGTQIGICDFLGDNPKFDIEHTVPRS.VGGD........ST.QMNLTLCDATFNRQ..VKGAQ.LPS D2EGB9_9EURY/499-546 DIYTGEKLKKD........FEIEHIFPRAR.MGP........SI.RENEVASNLETNKE...KADR.TPW B2KB46_ELUMP/642-695 CPFCGGQISPNDIIN..NQADIEHLFPIAE.SED........NG.RNNLVISHSACNAD...KAKR.SPW B1GZ57_UNCTG/486-539 CPFCSEKITPDDIIN..SKVDVEHIFPIEE.SED........IT.KNNLVIAHNECNAD...KGKK.SPF B2UP49_AKKM8/631-682 CPFTGATYGDHEL....ENLELEHIVPHS.FRQS........NA.LSSLVLTWPGVNRM...KGQR.TGY B1ZMJ1_OPITP/127-175 CQYTGEFVGKNG.......GNLDHVVPRDR.GGR........DS.FENLVWSKKEINSL...KANR.LPH C0QF30_DESAH/22-70 CFYTGRPIKREEMV.......IDHLHPVSK.GGE........DS.FHNYVLTFQDFNLG...KSNK.TDS A6VF81_METM7/225-273 CFYSGKELNDED.......CTIDHVIPWS.FMYS........DD.IWNLVYCDKSENSR...KSNR.IPD C6BT14_DESAD/351-398 CIYSGKPLPKK........YDMDHLLPYA.IFFN........ND.LWNLVPSLPTVNNK...KSNK.IIT B6BL56_9PROT/256-305 CVWSGKELSGTN.......YDVDHVLPFS.VWFN........ND.LWNMLPTDRDLNQR..RKKNK.IPS Q15ND6_PSEA6/467-514 CVWSAKTLK........RKYDIDHSMPFSR.WPN........ND.LWNLVPSDSKVNNN...KRDK.LPS B0P0H4_9CLOT/100-148 DVFTGQPVKKKK.......YDIDHFIPWS.FVMN........DE.LWNLMPMDASLNSS...KSNR.LPK B5W8V8_SPIMA/251-299 CIYSGTILTPNNIS.......LDHYLPWS.YVAH........DR.LWNLVPTLPEINSS...KSNK.LPN D1PFN2_9BACT/3-51 CIYTGQEIHIGD.......YAVDHFLPWS.FVAH........DQ.LWNLIPADNSINSS...KSDK.LPP A6EGE9_9SPHI/232-280 CIYTNRQLTIGD.......YAVEHFVPYA.FVSH........DL.LWNLIPADKSFNSS...KSDK.LPS A7NHK9_ROSCS/251-299 CIYSGSKLKRGQ.......FTLDHFIPWS.FVTH........DA.LWNIVPASRSANSS...KSDN.LPK C4LF28_TOLAT/241-289 CIYSDEQLNPGE.......YDLDHFIPWS.YIGH........DQ.HWNLIPASALANGQ...KSNS.LPH Q01TQ5_SOLUE/211-274 CFYCFADISVENAS..TRLADVDHFLPRM.LG.QVDRSSLRLDG.VWNLVLACRDCNRGVEGKSSR.LPH A6GZR9_FLAPJ/723-776 SLYTGNPIKASDLFS..KNYDIEHIIPKSR.LFD........DS.FSNKTLCERQLNID...KSNK.TAY C7M7G9_CAPOD/791-844 ELYTNAPIARDMLFS..KNIEIEHIVPKAR.VFD........DS.FSNKTLTFHRINSD...KGEY.TAF A9DTN2_9FLAO/743-796 TLFTNKYIPKEQLFS..KDVDIEHIIPKA.ILFD........DS.FSNKTLAYRNVNLA...KADA.TAF C7X9T0_9PORP/777-830 TLYSNQYIPKEKIFS..KEIDIEHIIPQSR.LFD........DS.LSNKTLEYKAINIE...KGNK.TAY D1JW17_9BACE/793-846 TLYSNTYISREKLFS..KEFDIEHIIPQAR.LFD........DS.FSNKTLEARSVNIE...KGNK.TAY C2G539_9SPHI/793-847 SPYTGQPISLSELFN.RERYDVDHIIPQSR.YFD........DS.LSNKVICEKSINNE...KGNR.TSM Q1VXN8_9FLAO/428-481 SPYTGKIIPLTKLFT..HEYQIEHIIPQSR.YYD........NS.LGNKIICESEVNED...KDNK.TAY C9MPM6_9BACT/841-894 SPYTGKSISLTKLFT..SAYQIEHVIPQSR.YFD........DS.FSNKVICESEVNSL...KDNM.LGY D1W1M7_9BACT/844-897 SPYTGKAISLSKLFT..TAYEIEHIIPQSR.YFD........NS.FNNKVICEAEVNKA...KGNM.LGY B6W3J8_9BACE/839-892 SPYTGEVIPLGKLFT..PAYEIEHVIPQS.YYFD........DS.FSNKVICEAEVNKL...KSNL.LGH C2M5N8_CAPGI/824-879 SPYTGQIISPENLFT..DNYEIEHIIPQSRF.FD........DS.LSNKVVCESIVNKAP.YKDRQ.LGL D7VKD0_9SPHI/827-880 SPYTGQIIPLNKLFT..PEYEIEHIIPQSR.YFD........DS.FTNKIICESAVNKL...KDNY.IGL D3FJ35_MYCGF/647-702 DPYSLKEIAFDDIFTKTEKFEIDHIIPYS.ISFD........DS.SSNKLLVLAESNQA...KSNQ.TPY Q4A5I2_MYCS5/699-751 DPYTQLDIKINEI...EDETEIDHVIPYSK.SAD........DS.WFNKLLVKKSTNQL...KKNK.TVW Q5M542_STRT2/576-631 CLYTGKTISIHDLINNPNQFEVDHILPLS.ITFD........DS.LANKVLVYATANQE...KGQR.TPY D3HEG7_STRG3/576-631 CLYSGKPIPIQELVHNSNNFEIDHILPLS.LSFD........DS.LANKVLVYAWTNQE...KGQK.TPY A8AY02_STRGC/575-630 CLYTGKNIPISDLIHNQYKYEIDHILPLS.LSFD........DS.LSNKVLVLATANQE...KGQR.TPF D4IZM9_BUTFI/576-631 CPYSGKSIKIDDLLDNPNLFEVDHIIPLS.ISFD........DS.RNNKVLVYSSENQD...KGNR.TPL A5Z395_9FIRM/569-624 CLYSGKKIAIEDLLNHPEFFEIDHIIPKS.ISLD........DS.RSNKVLVYKTENSI...KEND.TPY C4ZA16_EUBR3/583-638 CLYSGKTIDPNDIINNPQLFEIDHIIPRS.ISFD........DA.RSNKVLVYRSENQK...KGNQ.TPY D3UFL8_HELM1/576-630 CLYSGEKITIDHL.KDQRALQIDHAFPLSR.SLD........DS.QSNKVLCLTSSNQE...KSNK.TPY C5F1G9_9HELI/237-291 CVYSGRKITLANLK.EQGALEIDHILPYSR.SSD........DS.YMNKVLVFTNENQN...KGNK.TPY B8I085_CLOCE/550-604 CAYSGKPIPVCDLLN.DSLTQIDHIYPYSR.SMD........DS.YMNKVLVLTDENQN...KRSY.TPY A5KEK9_CAMJU/537-591 CAYSGEKIKISDL.QDEKMLEIDHIYPYSR.SFD........DS.YMNKVLVFTKQNQE...KLNQ.TPF C5ZYI3_9HELI/554-608 CAYSGKKITIDDLK.EDKALEVDHIYPYSR.SYD........DS.YNNKVLVFIKENQL...KLNQ.TPY B9M9X8_ACIET/599-654 CAYSQQPLDIQRVLDDHNYAQVDHALPYSR.SYD........DS.KNNKVLVLTHENQN...KGNR.TAF C6SH44_NEIME/566-620 CLYSGKEINLGRLNE.KGYVEIDHALPFSR.TWD........DS.FNNKVLVLGSENQN...KGNQ.TPY B1UZL4_CLOPF/560-614 CAYTQSQIPLERLFS.PGYCEIDHIIPFSR.SFD........DS.LSNKILVLGSENQR...KGNR.TPY C2UN05_BACCE/559-613 CLYTGRQMELSSLFK.PGYSIVNHIIPYNR.SFD........DT.YHNRVLTLTETKYE...KGNK.IPF C0FXH5_9FIRM/605-658 CLYSGKKIPLEELFD..GGYDIDHILPYS.ITFD........DS.YRNKVLVTAQENRQ...KGNR.TPY B1GZM3_UNCTG/557-611 CVYSGRKISFEDLLD.TGFLDIDHIIPYSK.SMD........DS.FNNKVLCLAEENRN...KKND.IPF #=GC seq_cons shYoGctIslscLhs..tta-IDHIlPhS.hhhD........DS.hsN+VLstpphNpp...Kusc.sPh //