# STOCKHOLM 1.0 #=GF ID DUF4138 #=GF AC PF13595.1 #=GF DE Domain of unknown function (DUF4138) #=GF AU Ellrott K, Bakolitsa C #=GF SE Bacteroides thetaiotaomicron: BT_4780 #=GF GA 25.50 25.50; #=GF TC 25.60 25.80; #=GF NC 23.60 25.40; #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq #=GF TP Family #=GF WK Domain_of_unknown_function #=GF RN [1] #=GF RM 15790854 #=GF RT Glycan foraging in vivo by an intestine-adapted bacterial #=GF RT symbiont. #=GF RA Sonnenburg JL, Xu J, Leip DD, Chen CH et al #=GF RL Science 2005 Mar 25;307(5717):1955-9. #=GF RN [2] #=GF RM 16735464 #=GF RT A hybrid two-component system protein of a prominent human gut #=GF RT symbiont couples glycan sensing in vivo to carbohydrate #=GF RT metabolism. #=GF RA Sonnenburg ED, Sonnenburg JL, Manchester JK, Hansen EE et al. #=GF RL Proc Natl Acad Sci U S A 2006 Jun 6;103(23):8834-9. #=GF DR INTERPRO; IPR022298; #=GF CC Based on Bacteroides thetaiotaomicron gene BT_4780, a putative #=GF CC uncharacterized protein. As seen in gene expression experiments #=GF CC (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231), it #=GF CC appears to be upregulated in the presence of host or vs when in #=GF CC culture [1,2]. #=GF SQ 30 #=GS C3JCP8_9PORP/58-311 AC C3JCP8.1 #=GS A7LRN0_BACOV/45-299 AC A7LRN0.1 #=GS B2RIB8_PORG3/51-305 AC B2RIB8.1 #=GS A7UXR2_BACUN/74-328 AC A7UXR2.1 #=GS B3CCF8_9BACE/42-296 AC B3CCF8.1 #=GS A5FFK8_FLAJ1/37-283 AC A5FFK8.1 #=GS D7W816_9FLAO/42-291 AC D7W816.1 #=GS D7W0S7_9FLAO/35-285 AC D7W0S7.1 #=GS D7W2Y6_9FLAO/56-307 AC D7W2Y6.1 #=GS D4IQ23_9BACT/36-301 AC D4IQ23.1 #=GS C6W392_DYAFD/33-272 AC C6W392.1 #=GS A5FBQ7_FLAJ1/37-279 AC A5FBQ7.1 #=GS A5FE19_FLAJ1/37-279 AC A5FE19.1 #=GS D2QV39_SPILD/106-372 AC D2QV39.1 #=GS C2FTS9_9SPHI/35-282 AC C2FTS9.1 #=GS D7W8Z5_9FLAO/31-288 AC D7W8Z5.1 #=GS D7W5G2_9FLAO/34-296 AC D7W5G2.1 #=GS Q64ME3_BACFR/37-274 AC Q64ME3.1 #=GS D2ET34_9BACE/31-273 AC D2ET34.1 #=GS A6L5P3_BACV8/24-272 AC A6L5P3.1 #=GS C6Z2D1_9BACE/24-273 AC C6Z2D1.1 #=GS B6VZ84_9BACE/24-273 AC B6VZ84.1 #=GS D1QR60_9BACT/55-296 AC D1QR60.1 #=GS D1Q0K6_9BACT/56-296 AC D1Q0K6.1 #=GS B7ADV6_9BACE/121-362 AC B7ADV6.1 #=GS C6IUJ3_9BACE/118-365 AC C6IUJ3.1 #=GS C7X7W6_9PORP/41-291 AC C7X7W6.1 #=GS C3R003_9BACE/41-293 AC C3R003.1 #=GS Q89YF2_BACTN/39-293 AC Q89YF2.1 #=GS D4IKG7_9BACT/40-294 AC D4IKG7.1 C3JCP8_9PORP/58-311 GLDVTFDKTVHLIFPAPIRYVDLGSQNIIAGKAEDAENVLRVKA...................AVKDFETETNMSVICEDGSFY..AFNVKYADEPEKLSVEM...........KDFL.SPVDGRLPSNRADIYFKELGNESPVLVKLMMQTIYQNNRRTVKHIGAQQFG.....MKFLLRGLYAHNGLLYFHTRMENGTNMPYSVDFITFKVVDKKMAKRTAIQEQVLQPLRAWHQVM.QVKGKDSEHSVFVLEQFALSEDKQLEVTLYERN.GGRTLTFYVGQEDLLLAKKI A7LRN0_BACOV/45-299 GLEITYDKTVHVIFPSPIKYVDLGSTNLIAGKADAAENVIRVKA...................AKKHFRDETNMSVITEDGNFY..TFNVRYADEPLLLNVEM...........CDFIHDGETVNRPNNAMEIYLQELGNESPRLVRLIMKSVHRQDKRRVRHIGCKRFG.....VQFLLRGLYTHNDLLYFHTQLRNETNVPFDVDFVTFKIVDKKIVKRTAMQEQVIYPLRACNYVT.RVDGKSSERTVFALPKFTIPEDKKLVVEMYEKQ.GGRHQMFEVDNEDLVRAEPV B2RIB8_PORG3/51-305 ALEVTFSKTVHIIFPAAIRYVDLGSADLLAAKADGAENVLRVKA...................ALRDFSRESNLAVITEDGAYY..TFNVKYADEPVKLSIEM...........ADFIRDGEAVNRPNNAMDIYLKELGNESPLLVRLIMQSIHQNNRREIKHIGSKRFG.....IQFTLKGIYTHNGLLYFHTQLKNASHVPFDVDYITFKIIDKKVVKRTAVQEQVIAPLRAYNHLM.CAGGKRTERTVFTLPKFTIPDDKHLVVELHEKD.GGRHQSFTVENTDLVRARVI A7UXR2_BACUN/74-328 GLEVTFSKTVHLIFPAAIRYVDLGSADIIAGKADGSENVLRVKA...................ALRDFSRETNLAVITEDGSYY..TFNVKYADEPTKLNIEM...........KDFIHDGEAVNRPNNSMEVYLKELGSESPLLVRLIMKSIHANNDRLVKHIGCKRFG.....IQYTLKGIYTHNGLLYFHTELKNSSNVPFHVDYITFKVVDRKIAKRTAIQEQVIVPLRAYNYVT.VVNGKSRERTVFTLPKFTLPDDKELVVEMNEQA.GGRHQKFVIGNAELIRARVI B3CCF8_9BACE/42-296 GVQVTFAKTVHIIFPSAVKYVDLGSNYIIAGKADGAENVVRVKA...................TTEGFPGETNFSVICEDGSFY..SFNAKYAHEPEMLNIEM...........KDFLENEDTTDFSHTRMNIYFRELGNESPLLVKLIMQSIYKNNDREIKHLGCKRFG.....VQFLVKGIYSHNGLFYIHTQTKNNSNVPFDTDFIRFKIVDKKVAKRTAIQETVIDPVRSYNEIL.VIDGKSTVRTVYTVPQFTIPDDKILVIELVEKN.GGRHQTIRVENSDIVAAKVI A5FFK8_FLAJ1/37-283 RLGITYDKTSHLIFPSEIRYADLGSGLLMAAKAEDANNVLRVKA...................AVRDFEQQTNLSVITTDGRFY..SFDVHYDPNPKILGYNI...................GANGNAGSQSTLFEELGESSPSTAESVMKRIYDNDKRVIRHIRTRNAG.....AEFRLNGIYVHDGKYYFHIALYNSTNVPYRIDFLNFKIADRNKARRTAVQQKAISPLRVYRPAG.EIKAGGSERCVYVLDLFTLTDGKLLLIEIYEKN.GGRQQTLKIKNSDLLKACLP D7W816_9FLAO/42-291 RINVTYNKTSHLIFPSSIRYVDLGSDLLVANKAEPIGNVLRVKS...................AVRDFEEETNFSVITEDGKFY..SFDASYSSYPEILSYDL................VKLQRGMERQYADVLFEDLKGSSTSFTWLIMENLYRKSNRIIKHIVSKSYG.....IEFSVRALHVNDSKFYFTLQVKNQSNVGYAIEWVNFKIVDKKNLKRTVVQDKILEKVRTYFPER.IIADHSDSKGIYMLDQFTLLKDQVLEIEILEKN.GGRHLKVQLENEDIVHARLI D7W0S7_9FLAO/35-285 RLEVTYNKTCHLIFPVAIRYTDLGSNYLIAEKAEDAQNVLRIKA...................AIKDFAEETNFSVITEDGQFY..SFNVIYNADPYTLSYDL...............KKMKTDVEREEGRNVQFEELGFNPPSLTEIVLKTIYQQNKRYVRHIAARSYG.....IQSILKGIYVHNGKFYFHLEVKNRSNVPFVVDFCTYKIVDKQIAKRTVSQEKQLVPVRQYPGLE.VISDNSIAGNVILLDQFTITDEQVLRIEIFERN.GARNQVLEIENSDLVAAKPV D7W2Y6_9FLAO/56-307 KMEVTYDKTSHLIFPTAIRYVDLGSEYLIAGKAEDAENVLRVKA...................AVRSFETETNFSVITNDGRYY..SFDVYYSSYPDALSYDL...............LTMQKAVDKANGNDVLFEELGNNSPSLAGLLLETIYKKDKRIVKHIGAKSFG.....IQFILKGIYIHNGKYYFHTELRNKSNVPFDIDFINFKVVDKKVAKRTVVQERALTPLRTYKPLEDGINGKSTEQNVFLLDKFTIADDKVLLIEIFEKN.GGRHQTLQVENSDLINARVI D4IQ23_9BACT/36-301 RIEAGFTKTVHILFPSPVTYIDIGSMDIIAGKADGAENVVRVKA...................AVRNFAAETNLTVITEDGGFF..TFDVHYAENPAVSTLNLTVQEPQPESMKKPAAVGYPQPTAPASEGRVLLREVGREKPATIKRMLSDIYRQNRTDVKGIRTKKYG.....IEVEVLGIYVFNDVIYIHSCISNDTNISFEVDARHFIVADRKLTKRTAQQQSTLEVLRVCNDPA.VVRGHQRQRTVFALPKLTISDDKVLLLEIIEKN.GARHQTVEIPAEELLEAKLL C6W392_DYAFD/33-272 PLEITTSKTTHLVFPYNIKTVDRGNGGILAQTAAGFDNILQVKA...................AIASF.DTTNLTVITGDGTLY..SFLASYCPNPVSINIRI........................GKSINVGATSVAEPNEAEIEEALIQASQNDSSNV.SIKDQSSQ.....AKLELSGIYICGDILLCKLTLTNNSHIIYDIETLRFSVRDKKRPKRTAIQETFITPFRVLSDTT.SVGPNAEHTFIYAIPKMTIPDKKLLSIALHEKN.GGRHLNLKVRNRHILKSLPL A5FBQ7_FLAJ1/37-279 NLKIGFSKTTSIIFPYTIKSIDKGSAEVLVQKAKGVENILLVKA...................AKQHF.FQTNLTVVTSDGKLY..VFVLNYDDSCPDLNFKA.....................ENAVAASRDVLFSLENENQKRIEQCALAAYSKK.KKISGLKKSKYQ.....IRLEVNGIFIQQDVLYLRIVFENKSKINYDIDQLRFFIRDQKKSKRTASQEIELQPLYVTSSSS.VIPYKSEIIKVYALEKFTIPENKYLTLQMIEKN.GGRHLEVDINNNLTDKVIPI A5FE19_FLAJ1/37-279 NLNIGYSKTTSLVFPYAIKSIDKGSPDIIMQKAKGVENILLLKA...................NRQNF.AQTNLTIITADSRLY..VFVLNYNDDCPDLNVNA.....................DNLAVVNDDILFSKENENQKKIEQFAALALAKK.KKITGIQRSKFD.....IKLSVSGIFIHEDVMYFRLVIDNNSKINYELDQLRFFIRDKKKAKRTASQEIEIIPLYDSNSRN.VIAAKSEWTAVYAMPKVIIPEKKYLTIQLIEKN.GERQLEVDINNNLTKKISAI D2QV39_SPILD/106-372 YVDLAYNKTVSIIFPTAVRSVDLGSRSIMADKAADVENVLKVKA...................SQIGF.NETNFSVMTTDGKFY..SFVVNYNETPAVLALNL....AGSGNTNLGSQGSQINLNDRTQSVNGLDGQEGNIQFAGVKATQSDIVYASDRILHNRSRGKRGTEANKMEAHLRGLYVKDNVLYYRLAIENESNLNYDIDYVRYFIVDGKTAKLTSRQEIELRPIYVHNEAITTVRGHQRVERVYAFQRFTIPGNKQLLIVIGEQN.GGRELAFQVQNKDIMKARPL C2FTS9_9SPHI/35-282 ELSLHRGHTVHILSPEPIQYVDIASHHVSGDLP..LENVLRIKL................HEDTTQTEHLDFELGTITIVGDNFVAQYRLTAPLWMNDTGIPA...................MLEIKPEHTRPLEISEIGLSRSQMKNLALGLLTKN.AHRPVRSTRDYG.....VGIALNSISTLGDYIFLDVSFTNTSNLSYNVDELRFFIEDKKITKATNVQTVEIKTLWQYQPLT...EFKKRHRNVFVLKKATFPGSKVLRVTLTEKQISGRTVNLKIKYGDILKADTF D7W8Z5_9FLAO/31-288 EIEITEGVNLHIISPEPIQYVDLSTEKLTGDLP..TTNIARIKI......TDSQTSEEKDKKKKTSIFFNGNQVGIITVVGQSFIAQYKAVYRHSENLNTITN....................IHIQPEAMQPIEFDKMVFSNLELRKFAMGIIQKKSEGNPIREEKNLK.....LSFQLNNVYVISDYIFLDMTFKNNSNLSYDIEALKFSIEDKKIHKATNSQSIEMTPLFQLNPQK...HFKKNFRNIFVFKKFTYPNSKVMMIRLIEEQLSGRTIEMKVNYSDILKADTF D7W5G2_9FLAO/34-296 EIYITGNVNLHFRSPQPIQFVDLSTKHLIGDLP..TENVVRIKIQQFEEESHSATDSIRIKEETPIYYYDNQELGIVTIVGQSFMAQYKLIYKVDSSATIMTN....................IEILPEDMQALEYPDYQMSSAELRKYSVEIIRKK.EANKIRRNRDLG.....IESQLNNVYAFGDYVFLDISFKNNTNLIYDIDKLKFSIDDKKVYKATNVQSIEIEPVFRLYDLK...TFKKSYRNIFVFKKFTYPNNKVLNIRLIENQISGRTINLEIKYSDILQADTF Q64ME3_BACFR/37-274 VIYVNKDVSTHFIAMEDIKYVDISISDIVGDIP..VDNSLRVKP........................IKEGASGVITITTERFLVQYLLVYTSDLSKACSRF.....................NIPYSDVVSYMNPETNMTKAEMYDYAYRMFISK.NKFFDVSTKGNL.....MKIILNNIYTMDKYFFIDISMINKSNIRYDIDQIRFKIEDKKQTKATNFQSIEIMPLMQVNNAT...FFKKKYRNIFVFEKFTFPDEKVLTIEISEKQISGRTITLRIDYADVLHADSF D2ET34_9BACE/31-273 QLTVNEQVTTVITASEPIRFVDISTDKVVGDQP..INNTIRLKP...................KETGYEDGEVLAIVTIVTERYRTQYALLYTTRMQEAVTDK.....................EIELRERNAYNNPAVSMPLADMTRFARRIWNSP.AKYRNVTSRSHR.....MTMKLNNIYAVGDYFFIDFSIENRTNIRFDIDEIRVKLADKKVAKATNAQIIELTPALVLEQAK...SFRHGYRNVIVIKKMTFPNDKVLTIEMTEKQISGRNISLNIDYEDVLSADSF A6L5P3_BACV8/24-272 KIYVNCEVTTHIVMPENIKLVDISTTKIMGNQC..ADNMVRIKP............YLEQDSIKAS.FDENELLGTITLVGERHIAQYEVVYTHYPSMAASIF.....................EVAYSDTQSYINPEVSMPKAEMVRYAWAVYGSK.RKYNQVVSNAHG.....MKAIVNNIYTIGDYFFIDYSLQNKTKIAYDIEELRVKLTDKKETKATNSQTIELTPVYSLNPVK...KFKKNYRNVLVIEKLTFPDEKVLRLEISENQISGRVITLTIEYEDILNADGF C6Z2D1_9BACE/24-273 KIYVNREVTTHIVMSENIKLVDISTTKIIGNQC..ADNIVRIKP............FMESDSIETSGYQNDELLGTVTLIGERHIAQYDIIYTGSAQYAASIY.....................HVSYQHAESYINPEVSMPVSEMARYAWAVYGSN.RKYNQVVSRMHG.....MKAVVNNIYSIGDYFFIDYSLENRTKIAYDIEELRIKLTDKKEAKATNSQTIELTPVYTLNLAK...KFKKHYRNVLVLPKLTFPDEKVLRLEISENQISGRLITLTIEYEDILHADGF B6VZ84_9BACE/24-273 KIYINREVTTHIVMPENIKMVDISTTKIIGNQC..TDNIVRIKP............YLENDSISSEGYSENELLGTLTIIGERHIAQYDILYTESPKYASTIY.....................NVSYNETQSYINPEVSMPMAEIARYAWAVYGSR.RKFNQIVSDKNG.....IRAYINNIYSIGDYFFLDYTLKNRTRIAYDIEEIRVKLTDKKETKATNSQTIELTPVFSMNNTS...KFRKDYRNVLVIPKLTFPEEKVLRLEISENQISGRVVVLTIEYEDILNADGF D1QR60_9BACT/55-296 TVYVNEQITTHIIMPENIKLVDISTNNIIGNQC..ADNIVRIKP....................AGRMYDHELAGTMTVIGERHIAQFNVVYVKGPARANSIF.....................NIDIKDTKRYNNPEVLMPEADMARFAWAIYSMP.AKFHNIHYKKYG.....IKAVINNIYAIDDYFFVDFSLYNHTNIKFDIDEIRVKLTDKKESKATNTQTIELTPTYMLNKTN...TFKKGYRNVLVLNKLTFPDEKILNLEISENQISGRVIYIPIEYSDILYADGF D1Q0K6_9BACT/56-296 VVFVNEEVTTHLLMPENIKLVDISTNKIVGNQC..TDNIVRIKP....................SRRMYDNELVGTVTVIGERHIVQLNVVYTAGPAKANSIY.....................RIKTRDMGRYENPDVTMPRKEMAAYAWAIFASKPQK..HIRSHEYG.....IRARVNNIFSIGDYFFIDYSLYNATKIKYDISEVRIKLTDKKELKATNSQTIELTPVYSLNSAK...SFKKAYRNVLVLDKLTFPEEKVLKLEISEEQISGRVVTLNIDYKDILHADGI B7ADV6_9BACE/121-362 ILPVGRDKQLFLIFPSAVSYVDYGSTNVEVEKAEGVDNILAVKA....................MRAYTEDTNISVVVESGKFY..TFDLRYVPAPERFSFVI......................DKEDTQKVAILDEKERSSEQKERIREAIGKRLPLDL.GLKDKNAG.....MEFEIGNIFIDADILLLRMTLTNRTQIGYTTDFMRFYIQDAKIRKKTAVQQLEQNILFTFDYPE.EIPAHESRTFTVAMNKFTIPDKKRLVIEIQEKN.GGRHFLYKLKNKSLLDAEEV C6IUJ3_9BACE/118-365 TIYLNEVSQTHLIAPEKVIYIDYGDTCIQVSKAENTENIVRMIA................ATGKVEEFPRQTNVSLATEGGKFY..TFNVDYRQQPEAFVYEI....................GEKRPEKKANVILTDNIIPAGERDQVMSRVYNAK.RGIFNKGIVRNK.....IVFSVNNLHIYDNLLLFTFEIENKSKLPYDIDYIRYYIIDKKTAKLTASQEVDQQALFSENYSP.RIEGNGRMKYVIAFDKFTIPDEKVFRIEINEKN.GGRHVLFDLENSDIVNVEDI C7X7W6_9PORP/41-291 RIGVPFSKTVHILFPSEVRYVDLGSTDIIAGKADGVENVVRVKA...................AVRDFPGETNFSVITGDGSFY..SFLVSYEEEPEALNIDM...........DRWF....PAESSAGRSAVRLTELCEEDPSVIASLMYTVHRLDRRDLKHIGCRQFG.....MQALLKGIYVHKDLLFLHISLANSSHVPFDIDFVRFKVVDKKVAKRTAQQETYLEPVRTLNDLR.RIEGKSKGRVVYAFQKVVIPDDKLIEVEIYEKG.GGRHQRFHIENSDLVDARVV C3R003_9BACE/41-293 KIEVTFGKTVHILFPSEVRYVDLGSNNIIAGKADGVENVVRVKA...................AVKEFPGETNFSVITGDGSFF..SFNVVYKEEPSTLNINM...........DQWM..NPDEGEKKGGSSIRVTELGEEDPTVIASVMYTIHRLDRRDVKHIGCRQFG.....MQALLKGIYVHKDLIFFHVSLTNNSNVPFDVDFVRFKIVDKKIAKRTAQQETYIEPVRTLNALT.RIEGKSTGRIVYAFPKIVIPDDKLLEVEIYEKG.GGRHQRFYIENSDLVDARIV Q89YF2_BACTN/39-293 KIEVTFQKTVHILFPSEVKYVDLGSFDIIADKATGAENVVRIKA...................AVKGFEGETNFSVITADGCFY..SFNVVYKDEPAQLSIEM...........EDWLRDNPEGGIAGDRMFVKLKELGGETPLVVNRIMYTLYKKNKRDIRHIGCKKYG.....IQTLLKGLYINNDLLYLHTSLRNSSDISFDIDYIRFKVVDKKVAKRTAMQENFIEPVRTYNRLI.TVDGKATVRGIFVLPKLTLPDDKLLVVEVYEKG.GARHQSFRIENTDLVAAKPI D4IKG7_9BACT/40-294 DIEVTYNKTVHVLFPAAVQYVDLGSNDIIAGRASGAENVVRIKS...................AVAGFPGETNFSVITADGCFY..TFNVTYADEPGQLSVEM...........DDWLRKNPTAEYANDRLFVRLSELGGETPVLVNRIMYSIYKKNAADIKSVGSKQFG.....IQTLLKGVYIHKDLMYFHIAVRNMSNVSYDIDFIRFKVVDKKVAKRTAVQETYVNPVRVFSQQN.TVDGKATVRNVFVFPKMTLPDDKVLTVEIFEKG.GGRHQSFNIANGELIGAKLI #=GC seq_cons plpVshsKTsHllFPpsI+YVDlGSspIlusKApss-NllRlKA...................sspsF.s-TNhoVITtDGphY..sFslhYsspPsthshph.....................phtssstpshhpphss.sssthpphhhslapps.+cl+plss+paG.....lphhLpuIYspsDhhah+hslcNpSNlsYDIDhlRFKlsDKKhsK+TssQphtlpPlhshNthp..lpsKpshRsVaslsKhTlPD-KlLplElhEKs.GGRphslpIcNsDllcAcsl //