# STOCKHOLM 1.0 #=GF ID Na_H_antiport_2 #=GF AC PF13726.1 #=GF DE Na+-H+ antiporter family #=GF AU Coggill P #=GF SE Jackhmmer:C5B988 #=GF GA 23.60 23.60; #=GF TC 23.60 23.60; #=GF NC 23.50 23.50; #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq #=GF TP Family #=GF RN [1] #=GF RM 9190799 #=GF RT Role of the nhaC-encoded Na+/H+ antiporter of alkaliphilic #=GF RT Bacillus firmus OF4. #=GF RA Ito M, Guffanti AA, Zemsky J, Ivey DM, Krulwich TA; #=GF RL J Bacteriol 1997;179:3851-3857. #=GF DR TC; 2.A.35; #=GF CC This family includes integral membrane proteins, some of which #=GF CC are NA+-H+ antiporters [1]. #=GF SQ 42 #=GS C4L1E0_EXISA/2-89 AC C4L1E0.1 #=GS B1YEV1_EXIS2/3-90 AC B1YEV1.1 #=GS Q5WDV8_BACSK/2-89 AC Q5WDV8.1 #=GS A3IGC2_9BACI/8-95 AC A3IGC2.1 #=GS Q2B2R2_9BACI/2-89 AC Q2B2R2.1 #=GS B7GKU7_ANOFW/4-91 AC B7GKU7.1 #=GS C3F6D3_BACTU/2-89 AC C3F6D3.1 #=GS A7Z8B4_BACA2/2-89 AC A7Z8B4.1 #=GS Q9K7K2_BACHD/2-89 AC Q9K7K2.1 #=GS E6U2C3_BACCJ/2-89 AC E6U2C3.1 #=GS D6XUM8_BACIE/2-89 AC D6XUM8.1 #=GS Q65UQ2_MANSM/4-91 AC Q65UQ2.1 #=GS C5BE39_EDWI9/2-89 AC C5BE39.1 #=GS A4Y5U0_SHEPC/2-89 AC A4Y5U0.1 #=GS Q084K9_SHEFN/4-91 AC Q084K9.1 #=GS A6FIU9_9GAMM/2-89 AC A6FIU9.1 #=GS A4SNQ6_AERS4/2-89 AC A4SNQ6.1 #=GS D1B1X3_SULD5/2-89 AC D1B1X3.1 #=GS D0YVL6_LISDA/2-89 AC D0YVL6.1 #=GS Q1ZN28_PHOAS/2-89 AC Q1ZN28.1 #=GS A1F5K2_VIBCL/2-89 AC A1F5K2.1 #=GS B5FCM4_VIBFM/2-89 AC B5FCM4.1 #=GS C8A2Z4_STAAU/3-90 AC C8A2Z4.1 #=GS B9EAL6_MACCJ/2-89 AC B9EAL6.1 #=GS A4SIT2_AERS4/144-241 AC A4SIT2.1 #=GS Q73KL4_TREDE/3-90 AC Q73KL4.1 #=GS Q9ZL85_HELPJ/10-97 AC Q9ZL85.1 #=GS A3YN61_CAMJU/6-93 AC A3YN61.1 #=GS D0BZZ4_9GAMM/2-89 AC D0BZZ4.1 #=GS C0VHK3_9GAMM/2-89 AC C0VHK3.1 #=GS Q1QX04_CHRSD/2-89 AC Q1QX04.1 #=GS Q2BHM1_9GAMM/2-89 AC Q2BHM1.1 #=GS Q02NE5_PSEAB/2-89 AC Q02NE5.1 #=GS A1TWP4_MARAV/2-89 AC A1TWP4.1 #=GS A4XTU4_PSEMY/2-89 AC A4XTU4.1 #=GS C0W230_9ACTO/19-106 AC C0W230.1 #=GS D0WS18_9ACTO/27-114 AC D0WS18.1 #=GS C0WF19_9CORY/2-89 AC C0WF19.1 #=GS C0E4G0_9CORY/2-89 AC C0E4G0.1 #=GS Q1Q9H8_PSYCK/4-91 AC Q1Q9H8.1 #=GS D1DEI3_NEIGO/2-101 AC D1DEI3.1 #=GS D4DM42_NEIEG/10-109 AC D4DM42.1 C4L1E0_EXISA/2-89 NAVLLAVIVLFALAISR..VHIVLSLILAALVGGLVGGLGFNDT............LTAFS.DGLGGGASIALSYALLGAFAVGLSKTGLPDVL.....AEKLIAMSG B1YEV1_EXIS2/3-90 NAVIIAVALLFILAIFR..VHIVLAMVLSAVAGGLIGGLGINKT............IATFA.EGLGAGAEIALSYALLGAFAVALSKTGLPDAL.....AHALIKRSK Q5WDV8_BACSK/2-89 NAVVVAVGLMLLLSLLR..VHVVLALAISAIVGGLVGGLSFNTT............IEVFT.AGLGGNAEIAFSYALLGGFAIALAKTGLPDFL.....ISKLQQWME A3IGC2_9BACI/8-95 NAVIVAVAVMLILSLLR..INVVLSLVLGAFVGGLTSGMSIEAT............VESFT.EGLGAGATIALSYGLLGAFAIAIAKTGIPELM.....ITGMLKILN Q2B2R2_9BACI/2-89 NAVIAAVLVMLALSLLR..VNVVFALIAGALVGGLTGGLSVDKV............IEVFT.NGLGGSAEVALSYALLGGFAVAISKTGLPNLM.....VDWVLGVVG B7GKU7_ANOFW/4-91 NAVIISVLVMLILSLMR..MNVVFSLLIASLVGGWFGNLGLSKT............VESFS.EGLGNSAEVALSYALLGGFAIAISKTGLPNAI.....VHVIIKIVG C3F6D3_BACTU/2-89 NAVLVAVAVMLLLSLLR..VQVIVAIIVGALTGGMIGGLGISET............INTFT.TGLGNSAPIALSYAMLGGFAISLSKTGLPDAM.....IQTALKWIG A7Z8B4_BACA2/2-89 NAVVVAVLLMLVLSLLR..VNIIIALMIGALAGGLTGGLGLGET............VKAFT.DGLGGNATVAVSYALLGAFAAALTKTGLPDAM.....VEASVKLIG Q9K7K2_BACHD/2-89 NAVLLAVIVMLVLSLLR..VHVVLALSIGAIVGGVVGGLGFLET............IEVFS.EGLGGNATVALSYALLGAFAVAISKTGLPDVM.....VNVVLRLVG E6U2C3_BACCJ/2-89 NAVLIAVFVMILLSLLR..VHVVVAMVTGAIVGGIVAGIPFTET............LDVFA.SGLGSGARIALSYAMLGAFAVAISYTGIPNLL.....VKLALMIVG D6XUM8_BACIE/2-89 NAVIVAVLIMIVLSLSR..VHVVLALAAGAIAGGLTAGMSITET............VDIFT.AGLETNVSIALSYGLLGAFAISLNFTGLPDLM.....VKMAIKLVG Q65UQ2_MANSM/4-91 NEVVISILVLLILSLLR..INVVIALVISALTAGLVGGLGITKT............IETFT.GGLGGGAEVAMNYAILGAFAVAISKSGITDLL.....AYKVIKRLG C5BE39_EDWI9/2-89 NAVVIAVVVMLLLSLLR..INVVIALIVAALVAGLSGGLTLDTT............ITTFS.SGLGGGAEIALSYAMLGTFAVAISRSGITDVL.....AHGVIRRMG A4Y5U0_SHEPC/2-89 NAVVIAVCLMLALSLFR..VNVVIALTVSALVAGLIGGMDLHQT............IDAFN.TGLGGGAQIALSYALLGAFAVALSHSGLTALI.....SKSIISSLG Q084K9_SHEFN/4-91 NAVVIAVCLMLFLSFIR..INVVVSLTISAVVAGLVGGLDIHQT............IAAFN.DGLGGGAQIALSYALLGAFAAALSHSGLTTLI.....SHSIIKKLG A6FIU9_9GAMM/2-89 NPVVIAVLAMLILSFMR..INVVVALTISAFLGGLIGGLPLEEV............ISAFN.SGLGGGASIALNYAMLGAFAVAISKSGITDLL.....AKKIVSRLG A4SNQ6_AERS4/2-89 NPVVVAVSLMLVLSLLR..INVVVSLSISAIVGGLLGGLSLADT............LSTFS.GGLGGGAEIALSYAMLGAFAVAISRSGITDLL.....ARKVINQLG D1B1X3_SULD5/2-89 NPVVVAVFLMLALSLLR..VNVVIALTLSALIGGLIAGMPLSDT............IEAFN.KGLGGGATIALSYAMLGAFAVAISHSGITDIL.....ARYVIKKMG D0YVL6_LISDA/2-89 NPVVIAVCVMLVLALLR..VNVVVALTFSAIVGGLIGGLSLTDA............VTAFQ.NGLGGGATTALSYAMLGTFAVAISHSGITDVL.....AQKVIKRIS Q1ZN28_PHOAS/2-89 NPVIISVCIMLLLSLMR..LNVVVALTFSAIVGGIVGGLSIHDT............ISAFE.GGLGGGATIALSYAMLGTFAVAISRSGITDVL.....AQTVVKKLQ A1F5K2_VIBCL/2-89 NPVVISVCVMLLLALMR..VNVVVALTFSAVVGGLVAGMSLNET............VAAFE.SGLGGGATIALSYAMLGTFAVAISKSGITDLL.....AQSVIRRIH B5FCM4_VIBFM/2-89 NPIILSVSVMLILALLR..VNVVVALTFSALIGGLVGGLSLSET............ISAFE.GGLGGGATIALSYAMLGAFAVAISKSGVTDLL.....AHSVIKRIN C8A2Z4_STAAU/3-90 NAVVIAVILMIVLCLCR..LNVVISLFISALVGGLISGMSIEKV............INVFG.KNIVDGAEVALSYALLGGFAALISYSGITDYL.....VGKIINAIH B9EAL6_MACCJ/2-89 NAVLIAVLVMVILSLCR..LNVVLSLFIGALAGGLVSGLGIDKT............IVTFT.GGIVDGSEVALSYALLGGFAAILSYSGITDYF.....VEKIINMLK A4SIT2_AERS4/144-241 GAAISAPLVAILLLALRPLAGIVVDPLIALPLGGLVGALMMGKFSK..........VNQFAVSGLARMAPVAIMLLGTGTLAGIIANSGLKDVLISGLTASGLPSYLL Q73KL4_TREDE/3-90 NPVVIAVIVMMVLCLLK..INILIAIMISGIVGGIIGGLGLQNT............ISILI.SGMGGNAETALSYILLGTLAAAITSTSIVELL.....AVKLQKWLK Q9ZL85_HELPJ/10-97 NPAFVAIICMCVLSLLR..LNVMLSMISATLIAGLMGGLGITES............FNMMI.DGMKGNLNIALSYILLGALAVAIAKSNLIKVA.....LNKLIGLMD A3YN61_CAMJU/6-93 NPIIISVVLMTLLCLFR..FNVLLSLLISALVAGVFSHLELVDT............MNILI.SGMKENLKTALSYILLGAIAAAISKTNLTAYL.....IKIVSHFIS D0BZZ4_9GAMM/2-89 NAVVVAIAVMFLLSLAR..VSVVLILVVSAIVGGLVAGLSLSQT............VEAFN.AGLGDGAEVALAYAVLGAFALALSKSGLPDLL.....AHKLIGLLG C0VHK3_9GAMM/2-89 FAIIAAVAVMFGLSLGR..VPVVFALVIGALTGGLLAGLGLQGT............LDAFN.NGLGGGAKIALAYGVLGAFALALARSGLPDLL.....AYKLVKSLK Q1QX04_CHRSD/2-89 NAVILAVLVMVGLALAR..VSVVFALIVGALVGGLVGGLGLEDT............LAAFN.DGVGGGAKVALAYATLGAFAVAISRSGLPDLL.....AQRLIRLLG Q2BHM1_9GAMM/2-89 NAVILAVLTMLVLSLFR..THVVIALLIGALVGGLTGGLGIQAT............IDAFN.SGIGGGASVALSYALLGGFAVAIAQSGLPHAL.....ANRIVILLG Q02NE5_PSEAB/2-89 NAVVLAVALMLVLSLCR..VHVVLALIIGAVVGGLFGGLGLEGT............LKAFN.GGLGGGATVALSYAMLGAFAVAIARSGVAHAL.....ADKVLVLLG A1TWP4_MARAV/2-89 NAVVAAVLIMLVLSLCR..IHVVVALIIGAISGGLVAGMSLEDT............INAFN.TGLGGGATVALSYATLGAFAVAIGKSGLAHAL.....ADKALAMVG A4XTU4_PSEMY/2-89 NAVIAAVGIMLVLSLCR..VHVVVALIVGALAGGLLGGLGVEGT............LKAFN.QGLGGGATVALSYALLGAFAVAIAKSGLAHAL.....ADRALALVG C0W230_9ACTO/19-106 NAVLVAVILMLLLALAR..VHVVLALFIGALVGGLLGGLGFDGT............MLAFQ.DGLAGGAKIALSYALLGAFAMAVAESGVPNLL.....AGTLIRRMG D0WS18_9ACTO/27-114 NSVLIAVVVMLALSLVR..VHVVVALFIGAIVGGLLGGLGLDGT............LVAFQ.EGLSGGAKIALSYALLGAFAMAVANSGLPKLL.....ADALISRIG C0WF19_9CORY/2-89 NAVLIAVIVMLALALLR..VHVVVALFIGAIVGGLLSGMGLDAT............MVAFQ.DGLGGGAKIALSYALLGAFAMGVASAGLPQIS.....ANFLIAKLG C0E4G0_9CORY/2-89 NAVLIAVLVMLILSVAR..VHVVISLFIGALVGGLISGIGLGPT............MVAFQ.DGLAGGAKIALSYALLGAFAMAVASSGLPTLL.....ARWIMSKIG Q1Q9H8_PSYCK/4-91 NAVLLAVVIMLGLSLAR..VHVVLSLLIGALAGGLIAGLGMTDT............LNAFQ.EGIKNGAQIALSYALLGAFAVAIAHSGLPQSL.....AGAVIKRID D1DEI3_NEIGO/2-101 NAVVVAVIVMLVLSLSR..VHVVLSLTVGAFVGGAVAGMPLQNIADAAGQVSQAGIIPVFN.KGLEGGAKIALSYAMLGAFAMAITHSGLPQQL.....AGAVVRKLN D4DM42_NEIEG/10-109 NAVVIAVIVMLALSLSR..IHVVLSLAIGAFVGGLVAGMPLANVTDVSGEVAQTGIISAFN.EGLKGGAQIALSYAMLGAFAMAITHSGLPQQL.....AGSIVRRLN #=GC seq_cons NAVllAVhlMLlLSLhR..lpVVlALhluAlVGGLlGGLulspT............lssFs.sGLGGGAplALSYAlLGAFAlAIo+SGLsclL.....Aptllphlu //