# STOCKHOLM 1.0 #=GF ID ACC_epsilon #=GF AC PF13822.1 #=GF DE Acyl-CoA carboxylase epsilon subunit #=GF AU Eberhardt R #=GF SE Jackhmmer:D0L8S8 #=GF GA 25.00 25.00; #=GF TC 25.20 25.70; #=GF NC 24.50 24.80; #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq #=GF TP Family #=GF RN [1] #=GF RM 12048195 #=GF RT Kinetic and structural analysis of a new group of Acyl-CoA #=GF RT carboxylases found in Streptomyces coelicolor A3(2). #=GF RA Diacovich L, Peiru S, Kurth D, Rodriguez E, Podesta F, Khosla C, #=GF RA Gramajo H; #=GF RL J Biol Chem. 2002;277:31228-31236. #=GF CC This family includes the epsilon subunits of propionyl-CoA #=GF CC carboxylase, EC:6.4.1.3, and acetyl-CoA carboxylase, EC:6.4.1.2. #=GF CC These enzymes are involved in the biosynthesis of long-chain #=GF CC fatty acids. The epsilon subunit is necessary for an efficient #=GF CC interaction between the alpha and beta subunits of these enzymes #=GF CC [1]. #=GF SQ 83 #=GS Q83X24_STRRO/9-64 AC Q83X24.1 #=GS A6WF64_KINRD/21-83 AC A6WF64.1 #=GS B8Y4E9_STRAU/7-68 AC B8Y4E9.1 #=GS B5I2J3_9ACTO/19-76 AC B5I2J3.1 #=GS Q84CI6_9ACTO/29-93 AC Q84CI6.1 #=GS B5HM65_9ACTO/3-62 AC B5HM65.1 #=GS B5HGJ7_STRPR/9-69 AC B5HGJ7.1 #=GS E8W8M0_STRFA/7-65 AC E8W8M0.1 #=GS B4V580_9ACTO/6-65 AC B4V580.1 #=GS Q9AMI3_STRAT/13-74 AC Q9AMI3.1 #=GS Q82KR8_STRAW/3-58 AC Q82KR8.1 #=GS Q47LT3_THEFY/11-74 AC Q47LT3.1 #=GS D7B6Q2_NOCDD/7-69 AC D7B6Q2.1 #=GS D2B8V0_STRRD/4-61 AC D2B8V0.1 #=GS D9TAU9_MICAI/5-63 AC D9TAU9.1 #=GS D2NP01_ROTMD/64-126 AC D2NP01.1 #=GS B8HFH5_ARTCA/15-73 AC B8HFH5.1 #=GS A9WU03_RENSM/17-78 AC A9WU03.1 #=GS A0JUF4_ARTS2/24-82 AC A0JUF4.1 #=GS A1R4M9_ARTAT/14-72 AC A1R4M9.1 #=GS B2GL76_KOCRD/49-109 AC B2GL76.1 #=GS Q8KSY4_9ACTO/49-110 AC Q8KSY4.1 #=GS A5CPN8_CLAM3/12-72 AC A5CPN8.1 #=GS A4AI77_9ACTN/10-72 AC A4AI77.1 #=GS Q6AGN0_LEIXX/7-70 AC Q6AGN0.1 #=GS B5H6R8_STRPR/1-61 AC B5H6R8.1 #=GS B4VAK5_9ACTO/1-50 AC B4VAK5.1 #=GS B9VRF6_9ACTO/1-62 AC B9VRF6.1 #=GS E8VYZ5_STRFA/1-61 AC E8VYZ5.1 #=GS Q82I26_STRAW/1-62 AC Q82I26.1 #=GS Q9EWV8_STRCO/1-62 AC Q9EWV8.1 #=GS B5HUZ9_9ACTO/1-62 AC B5HUZ9.1 #=GS D2PKM7_KRIFD/12-71 AC D2PKM7.1 #=GS D2SG53_GEOOG/4-62 AC D2SG53.1 #=GS D1C5B7_SPHTD/7-68 AC D1C5B7.1 #=GS A1SMG1_NOCSJ/20-77 AC A1SMG1.1 #=GS D3MJS3_PROAA/2-64 AC D3MJS3.1 #=GS C7PY61_CATAD/3-66 AC C7PY61.1 #=GS C7NFF2_KYTSD/14-71 AC C7NFF2.1 #=GS C7MUU6_SACVD/18-78 AC C7MUU6.1 #=GS C3VLZ9_9ACTO/21-78 AC C3VLZ9.1 #=GS D1BK41_SANKS/13-70 AC D1BK41.1 #=GS A3TQM8_9MICO/8-67 AC A3TQM8.1 #=GS Q0RXM2_RHOSR/35-94 AC Q0RXM2.1 #=GS D3Q7Z7_STANL/1-52 AC D3Q7Z7.1 #=GS C7QAE8_CATAD/7-67 AC C7QAE8.1 #=GS B1MFA0_MYCA9/20-74 AC B1MFA0.1 #=GS A4FF49_SACEN/8-75 AC A4FF49.1 #=GS D1BYX5_XYLCX/2-60 AC D1BYX5.1 #=GS D5UKX6_CELFN/14-80 AC D5UKX6.1 #=GS C5C107_BEUC1/28-88 AC C5C107.1 #=GS D5UV85_TSUPD/21-79 AC D5UV85.1 #=GS C4LKA4_CORK4/30-89 AC C4LKA4.1 #=GS C0VQN7_9CORY/25-87 AC C0VQN7.1 #=GS D7WAF7_9CORY/9-68 AC D7WAF7.1 #=GS C0XV08_9CORY/1-59 AC C0XV08.1 #=GS Q4JTL7_CORJK/1-56 AC Q4JTL7.1 #=GS C6R6U9_9CORY/3-63 AC C6R6U9.1 #=GS C0WIY2_9CORY/3-63 AC C0WIY2.1 #=GS C3PEA4_CORA7/3-58 AC C3PEA4.1 #=GS C2CQH7_CORST/3-68 AC C2CQH7.1 #=GS E0DD15_9CORY/5-65 AC E0DD15.1 #=GS Q6NIV9_CORDI/20-80 AC Q6NIV9.1 #=GS Q8FRM4_COREF/12-73 AC Q8FRM4.1 #=GS Q8NSG9_CORGL/14-76 AC Q8NSG9.1 #=GS D0L8S8_GORB4/15-72 AC D0L8S8.1 #=GS A0QKF4_MYCA1/20-76 AC A0QKF4.1 #=GS Q49671_MYCLE/18-74 AC Q49671.1 #=GS P96886_MYCTU/111-167 AC P96886.1 #=GS A0PRJ2_MYCUA/40-96 AC A0PRJ2.1 #=GS Q1BCH9_MYCSS/25-82 AC Q1BCH9.1 #=GS A4TF30_MYCGI/25-83 AC A4TF30.1 #=GS A0QTE6_MYCS2/27-84 AC A0QTE6.1 #=GS Q5Z153_NOCFA/60-119 AC Q5Z153.1 #=GS C1B1A7_RHOOB/58-118 AC C1B1A7.1 #=GS C0ZWV3_RHOE4/46-105 AC C0ZWV3.1 #=GS E3J1Z9_FRASU/11-70 AC E3J1Z9.1 #=GS D3D5U4_9ACTO/11-68 AC D3D5U4.1 #=GS A8L9X1_FRASN/11-68 AC A8L9X1.1 #=GS Q0RRE7_FRAAA/11-68 AC Q0RRE7.1 #=GS Q2JF59_FRASC/11-68 AC Q2JF59.1 #=GS C6WKE1_ACTMD/4-66 AC C6WKE1.1 #=GS D1A206_THECD/6-66 AC D1A206.1 Q83X24_STRRO/9-64 RAVLRVERGQATSEELAAVTVTLLSR..LADLAGRRSARRSERPGTAPRSGW.................DTGRVY A6WF64_KINRD/21-83 LTALRIERGHPEPEELAALTVVLTTR..LAQAPEPEAAAV.PAP....RSRWADPRR....SL.GLPPAPGRGSW B8Y4E9_STRAU/7-68 DHLIRVVKGRPDAAELAALTAVVLAR..AAAHEGRHGGTAGSGP...ALAGWQRPER........LRGFLGPRTW B5I2J3_9ACTO/19-76 AMSFRVLRGEPSAEELAAITTVLTLR..LTAQDEPTPQRPAT.......ARWTRPER........LRAYNCPRAW Q84CI6_9ACTO/29-93 RELLRVERGNPDPEELAALAALFFAH..FSAIEARREAARVLIPRQRRSASWRRTER........APGFDGPRTW B5HM65_9ACTO/3-62 TPDIRVEKGHAEPEEVAAITAILLAR..AAARPSET.PAH.RGR...PKAGWRRLER........EGGFRAPHSW B5HGJ7_STRPR/9-69 SSLLRVEKGQADPEELAAITAVLLAR..ASARSTDATPAH.RGR...TTAGWRRLER........QRGFQPSHSW E8W8M0_STRFA/7-65 DSVLRVEKGQAGPEELAAITAVLLAR..AAAQPDA..PAH.RGR...STAGWRRLER........TPGFRAPHSW B4V580_9ACTO/6-65 DTLLKVEKGNAAPEELAAITAILLAR..AAATPTAA.PVH.RIG...SQAGWRRLER........TPGFRAPHSW Q9AMI3_STRAT/13-74 TDAIRVESGHLEPEELAALTVVLLAR..IRGAAPDRAAGDGGSL...VAATWRRLER........ANGFQSPSSW Q82KR8_STRAW/3-58 TPCIRIEKGAATDEELAALTVLFLTR..APRPEPDTAPPSPGS.....TTAWRPDPF............HAPHSW Q47LT3_THEFY/11-74 APFLRVVRGSPTPEETAALVAVLTARARAIQAARSRAAGAAPR......SGWRDRAR.....LLGVPPRPSPDAW D7B6Q2_NOCDD/7-69 PPHLAVVRGEPTAEELAALTAVLSAR..ARAARAAEEPAPERP......SGWRDRSR....LVRGAPPRPGPGAW D2B8V0_STRRD/4-61 GPLLRVVRGNPTPEELAALIAVVLAR..ASSAAAAEAVP..........SAWADRSR.....SMRQPPVPGRRAV D9TAU9_MICAI/5-63 EPLFRIVRGVPTAEELAALVGAIVVR..TRPAQAAAPA...PV......SQWARSAR....PA.LAGPVAGPGAW D2NP01_ROTMD/64-126 EPLLKVVKGSPTPEEIAALTAVVAMM..QASAAKQEQNLLVGAA....SRILNRGQR......LGVSLRPGPGSW B8HFH5_ARTCA/15-73 APLLSVVKGQPNAEELAALTAVVLSL..GGPEAAKPAAPTA........RHWVRRQR......LGLAPTPGPGAW A9WU03_RENSM/17-78 LPLFQVTKENPNAEDLAALTAVVLAL..ASAESGAEAADSVEH.....GRAWIRRER......LRLAPTPGPGAW A0JUF4_ARTS2/24-82 EPLFSVVKGKPTDVELVALTAVVLSL..GSAEPEGEAKPSV........RHWVRRQQ......LRLAPAPGPGAW A1R4M9_ARTAT/14-72 EAMFSVVKGEPTAEELAALAAVVLSL..GAPQEVAASKPNV........RHWVRRQQ......LRLDPTPGPGAW B2GL76_KOCRD/49-109 EPLFTVTRGNPGPEELAALTAVLTAL..PAPQEERPARPTRAP......RPQSRRLR......LGLRLRPGRGAW Q8KSY4_9ACTO/49-110 RPAWRISGGSPTAEETAALAAVLAVV..LGRAAGGGRDAADAPGS..TGTGWHRPPR.........VRAPSPGTW A5CPN8_CLAM3/12-72 LGGFRVLGGSPTEEELAAATAVIAAL..AAQPAAEQPVRRAP.......DAWQRSQR.....SVRGTLVPGPGRW A4AI77_9ACTN/10-72 PVDIRIVSPHVTPEEVAAVTAVVRAA..LVESAELAGEDDAAQ.....ISTWSRNQR.....PIRQPLQPGPGAW Q6AGN0_LEIXX/7-70 PSQLRFVTRRVTAEEIAAVTAVLTAA..VAEQAAAARGSRLAAG....ADGWQRSQR.....PLRTLLIPGLGQW B5H6R8_STRPR/1-61 M..IKVVRGNPTPEELAAALAVVQAR..AAATSTTHEAPDRL.......NQWAARERN...VPRGRLPLPGPGMW B4VAK5_9ACTO/1-50 M.VIKVVKGNPTPEELAAALAVVQAR..AAALASAPSGAPPVA......DEWR................RRPAWP B9VRF6_9ACTO/1-62 M.VIKVVKGNPTPEELAAALAVVRAR..AAALASAPSDAPRAA......DAWSAPDR....VARRTLPHPGPGAW E8VYZ5_STRFA/1-61 M..IKVVRGNPTPEELAAALAVVQAR..AAAVAAVPSGAPLPP......EQWSDPGR....IARRGALRPGPRSW Q82I26_STRAW/1-62 M.TIKVIRGNPTPEELAAALAVVRAR..AAAAASVPSGAPGPR......DSWADPAR....IAADRLPQPGPTTW Q9EWV8_STRCO/1-62 M.TIKVVRGNPTPEELAAALTVVRAR..AVTAAAEPSTTDRPH......DAWSDPSR....IATHHMPHPGPTAW B5HUZ9_9ACTO/1-62 M.NIKVVRGNPTPEELAAALAVVRAR..AAAATDTPSGAEETR......AAWSDPSR....IAGRRLPQPGPTAW D2PKM7_KRIFD/12-71 TAILRVVKGDPSAEELAALVAVVSAR..AAAPPASADPDRA........SDWATYWR.....TRQRPLHPGPGRW D2SG53_GEOOG/4-62 TPLLRVVRGEPSAEELAALTVVVAAL..SRRRTRRRPT...PV......GAWASFGD....AH.RRPLHPGPGGW D1C5B7_SPHTD/7-68 SLGRVEVRPQPSPEELAAIGAVLRAR..KARQDEAGPAPM.........PAWVEAGRR..EAMRAREVGPTPGGW A1SMG1_NOCSJ/20-77 RPLLRVVRGDATPEEVAAVVAVFAAL..RTTQPPARRPA..........PAWSAHHR.....RVRRALPHGPGGW D3MJS3_PROAA/2-64 NDAITVTKGNLTDEELGALVTVLAEL..TRPSPNAYVPDDRPI.....AFGWKSYWR.....TIREPFMPGQAAW C7PY61_CATAD/3-66 GGHFTVLRGNPTPEELAAAVTVLLSL..AATARTVVRPVSRTT.....RPHWHSRRR....ITHARGRHLPAAAW C7NFF2_KYTSD/14-71 GEAAFAVRGAATPEELAALTVVLSAL..GGGEATTPAPV..........GGWGGAGT.....GVRRTPASGPGAW C7MUU6_SACVD/18-78 NVLLRVVRGAPDDAELAALTAVVAGL..TATTRNASTPSPRR.......SRWADPAS.....RLRLPARPARDGW C3VLZ9_9ACTO/21-78 EHLVRVVRGAPGEMELAALLAVLSAL..TGTREQVVASSAARQR...RKSGWGEIRY............TPPGAW D1BK41_SANKS/13-70 AAQMRVVRGAPDEVEVAALVASLAAV..ASRATSTVADEPPVR......SEWARPLR.........TATPSPRAA A3TQM8_9MICO/8-67 AAQRIEVIGDATPEQVAALVAVLSAA..SGGAVEVAAPRHT........SQWSAPAR.....QHRKPLTPGTRAA Q0RXM2_RHOSR/35-94 AAPAVTFTGNPSDTDIAAVLAVFAAI..ASSGSAAEAPASDN.......DSWGTPAL......ILRRQVAAAAVL D3Q7Z7_STANL/1-52 ME.ITVTAGNPDEAEIAALVLALRAR..PAAATAVPRRI..........SAWRDPAR..........RLGADRDW C7QAE8_CATAD/7-67 ESAVRVLSGYPTEEEVAALIAVLAVV..GQAARAAPGPE..........AAGARPGRI..PAAAFAAGYQSPTSW B1MFA0_MYCA9/20-74 AADIQVLSGNPTDEEIAALVAALSAL..ASKAEAAELKPR.........NLWAEPID.........MLRYSPHSW A4FF49_SACEN/8-75 RPVLRIVRGEPDDVELAALTAALAAV..SAAAAAAQTEPEPTG.....WSLWADRSAALRHPAGRRPLRPGPAAW D1BYX5_XYLCX/2-60 TPAVRIVRGEPDEVEVAALVAGLAAV..AAAGGLPDDEAPI........EEWTNRAR......SVRANVAGATAT D5UKX6_CELFN/14-80 DPHVQVVRGTPDEDELAALVAGLVAA..AASRAPQEETPDEHARA..ARARWVAPGR....LRGTSLPTRGPDAW C5C107_BEUC1/28-88 QPVVHVVRGAPDDVELAALVAGLAAA..RAALAAEADDDAAPS......SAWVAASR......VRRLPGTGAGAA D5UV85_TSUPD/21-79 RAAIRFERGNPSAADVAAIVTVLAAA..SGSAPRSSAELK.........SLWGDTRE.....RLRPQYFNGPNAF C4LKA4_CORK4/30-89 PVFLKVIKGNPTAPQVAALTALFAGM..SANAGDDGEPETP........NNWGRFDE.....KFTNTHTSNAGNF C0VQN7_9CORY/25-87 KPLFHVVGGNPTEEELGALTAVLSTL..EAEAQKAATDERYKP.....VNNWGNLGD.....RLDRPQTYNPNAF D7WAF7_9CORY/9-68 QPQFTVVKGNPTEAELAALTQVLSDLQQEAKSRTAGGHR..........NLWGRPSN.....RVHGPVVFNPSAF C0XV08_9CORY/1-59 MD.ITLIKGNPTDDELTALTMVLADL..QAKATNAQD...PGE.....RNLWGSHVTP..LH...PRPLFNPGAF Q4JTL7_CORJK/1-56 MTDFQVIKGNPDEVETQALQLIVDDL..AKEAEALRNAKPDTR......GHYGRELR...........HSSPGAF C6R6U9_9CORY/3-63 TPEIKVVKGNPTEDELAALRTVLAQM..SAKHSGATGER..........NEWGNPAER..FERFGTQRVYNPSAF C0WIY2_9CORY/3-63 EPEIKVLKGNPTEEECAALSTVLKQM..QKDHSGAFGDR..........NHWGRPGER..FDHYGAQRVFNPSAF C3PEA4_CORA7/3-58 ASLFTVLKGNPTDAEVAALTTVLSQL..DSEARAKAADTRSER......DLWGQPGD...........VFNPSAF C2CQH7_CORST/3-68 APTFRVLKGNPSDDEVAALTAVLAQL..SADARAKQAGSDAGE.....RNLWGRLDER..FDAYGAQDVFNPSAF E0DD15_9CORY/5-65 KPFLRIIKGNPSDVEVATLTALFATM..ANNAASAAAPERER.......NLWGNVSE.....RLHRPMIYNPSAF Q6NIV9_CORDI/20-80 KPILRVVKGNPDPTQVATLTALFASM..ADNAAQQSKQERER.......NLWGNVEE.....RLQRPTTYNPTAF Q8FRM4_COREF/12-73 KPVLQVLSGNPDDSQVAALTVLFAGL..ASAAAASADTVERDR......NRWGSLEE.....RLQRPATYNPSAF Q8NSG9_CORGL/14-76 KPFLQIVSGNPTDQEVAALTVVFAGL..AKAAAAQQMVSASKD.....RNNWGNLDE.....RLSRPNTFNPSAF D0L8S8_GORB4/15-72 RPFLQIIRGNPSDEEIAVLTALIAGA..AAGSGNTSPEPR.........NEWGRAID......RLRPQWGSPSSF A0QKF4_MYCA1/20-76 EPHIQILKGEPTVEEVAALVTVLGCV..GGAPEPEQPEK..........TRWGLPVD......RLRFAMSNYQRL Q49671_MYCLE/18-74 NPHIQITKGQPTDQELAALIVVLSSI..GGASQVKQPEP..........TRWGLPVD......KLRYPVFSWQRI P96886_MYCTU/111-167 EPHIEILRGQPTDQELAALIAVLGSI..SGSTPPAQPEP..........TRWGLPVD......QLRYPVFSWQRI A0PRJ2_MYCUA/40-96 EPHIHVLKGAPTEQELAALVAVLGSL..RSAAPAAAPEP..........SRWGLSVD......RLRYPVFSWQRI Q1BCH9_MYCSS/25-82 DPHIHVLKGQPSDEEIAALAAVLAGA..GGGHSEPGPQEF.........NPWGHPAD......KLRYDVTSWQRV A4TF30_MYCGI/25-83 DPHFQVVKGDPSPEEIAALVTVLASA..GGGAAADPGPQEL........NLWGHPVD......KLRYDTTSWQRT A0QTE6_MYCS2/27-84 EAHIKVLRGEPTPEEMAALMAVLASA..GGGPAEPVKKER.........NMWGHPVD......KLRYSVFSWQRV Q5Z153_NOCFA/60-119 APFLRILKGSPTDEEIAALVCVFAAA..GNGGQDSGPARPL........DMWGRPTL.....MHRGTSPFSPYAF C1B1A7_RHOOB/58-118 DTFLTVVKGSPSDEEIAALVAVLSAV..AAAGSGDPDSGIPP.......ESWGAPTR.....MHRSIAPFSPYAF C0ZWV3_RHOE4/46-105 ASVIKIVKGSPTDVEIAALVSVLAA...AAGSGQAPESNVPA.......ETWGDPTQ.....FHRTRAPFSPYAY E3J1Z9_FRASU/11-70 RPLLKLVRGDATPEEIAAIVAVLAAH..AAANAGPAPRPAR........SVWADRGY.....AMRVGTAPGPSGW D3D5U4_9ACTO/11-68 RAHLRLVRGDASPEEIAALVAVLAAR..GGSGPPVVRAR..........STWADPAL.....AMRGRLTAGPGAW A8L9X1_FRASN/11-68 RAHLRLVRGDATPEEIAALVAVLAAR..SAPAAPPARVR..........STWADPAF.....RLRGGVAAGPGGW Q0RRE7_FRAAA/11-68 RPRLRLIRGNATPEEIAAVVALLAAR..AVPVEGPSPVR..........SAWADPAQ.....ALRAPLATGAGSW Q2JF59_FRASC/11-68 QPRLQLIRGEATPEEIAAVVALLTAR..AVPSSAPATRR..........SSWASPTL.....ALRGSLTTGPGAW C6WKE1_ACTMD/4-66 RGHLRVVRGNPTEEELAALVAVLTAV..AARRAVDGGARGDRE.....ASRWADRSR.....LVRQPLSRGPGAW D1A206_THECD/6-66 RPFLQVIRGDATAEEVAALVAVLSAR..AAAAARSAAAPARR.......SGWADRSR.....MMRRPLPHGPGAW #=GC seq_cons pshl+Vl+GsPosEElAALsAVLsuh..uusssssssss..........stWuc.sc......htt..hsuPsuW //