# STOCKHOLM 1.0
#=GF ID   Helicase_C_4
#=GF AC   PF13871.1
#=GF DE   Helicase_C-like
#=GF AU   Coggill P
#=GF SE   Jackhmmer:Q9Y2G9
#=GF GA   27.00 27.00;
#=GF TC   27.20 27.30;
#=GF NC   26.70 26.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   20230814
#=GF RT   A strawberry notch homolog, let-765/nsh-1, positively regulates
#=GF RT   lin-3/egf expression to promote RAS-dependent vulval induction
#=GF RT   in C. elegans.
#=GF RA   Simms CL, Baillie DL;
#=GF RL   Dev Biol. 2010;341:472-485.
#=GF CC   Strawberry notch proteins carry DExD/H-box groups and Helicase_C
#=GF CC   domains. These proteins promote the expression of diverse
#=GF CC   targets, potentially through interactions with transcriptional
#=GF CC   activator or repressor complexes [1].
#=GF SQ   47
#=GS B6A585_RHILW/923-1182   AC B6A585.1
#=GS Q11N09_MESSB/356-615    AC Q11N09.1
#=GS A1B289_PARDP/904-1161   AC A1B289.1
#=GS Q1GPR5_SPHAL/858-1117   AC Q1GPR5.1
#=GS Q2GBE8_NOVAD/917-1177   AC Q2GBE8.1
#=GS Q11N69_MESSB/955-1214   AC Q11N69.1
#=GS Q6N7K8_RHOPA/909-1168   AC Q6N7K8.1
#=GS A3T2E9_9RHOB/927-1182   AC A3T2E9.1
#=GS Q0FXP2_9RHIZ/971-1226   AC Q0FXP2.1
#=GS A3IS38_9CHRO/937-1195   AC A3IS38.1
#=GS E0U7A6_CYAP2/1001-1259  AC E0U7A6.1
#=GS B2JBN7_NOSP7/891-1146   AC B2JBN7.1
#=GS A4XE03_NOVAD/893-1148   AC A4XE03.1
#=GS A5VGF7_SPHWW/879-1134   AC A5VGF7.1
#=GS A3W9H2_9SPHN/883-1138   AC A3W9H2.1
#=GS Q1NC34_9SPHN/135-390    AC Q1NC34.1
#=GS A3SRZ6_9RHOB/887-1142   AC A3SRZ6.1
#=GS B9NY20_9RHOB/773-1028   AC B9NY20.1
#=GS A4JVA5_BURVG/1077-1328  AC A4JVA5.1
#=GS A7FC92_YERP3/1426-1680  AC A7FC92.1
#=GS C5B554_METEA/774-1025   AC C5B554.1
#=GS B3RSN6_TRIAD/493-782    AC B3RSN6.1
#=GS C1E7J3_MICSR/536-820    AC C1E7J3.1
#=GS A8IU58_CHLRE/592-875    AC A8IU58.1
#=GS A8JG19_CHLRE/430-719    AC A8JG19.1
#=GS C1FF16_MICSR/633-917    AC C1FF16.1
#=GS Q01BW6_OSTTA/658-940    AC Q01BW6.1
#=GS C5YFM0_SORBI/789-1077   AC C5YFM0.1
#=GS Q0WQ12_ARATH/111-403    AC Q0WQ12.1
#=GS B4G3M5_DROPE/685-964    AC B4G3M5.1
#=GS B4J2E0_DROGR/867-1145   AC B4J2E0.1
#=GS C4QG33_SCHMA/459-745    AC C4QG33.2
#=GS A8ND67_BRUMA/1214-1478  AC A8ND67.1
#=GS A8XLN5_CAEBR/1305-1583  AC A8XLN5.2
#=GS B3S549_TRIAD/641-917    AC B3S549.1
#=GS A0JLU6_MOUSE/22-298     AC A0JLU6.1
#=GS B7PH49_IXOSC/637-914    AC B7PH49.1
#=GS B0W0M2_CULQU/840-1117   AC B0W0M2.1
#=GS SBNO2_BOVIN/739-1017    AC A0JND4.1
#=GS A9V749_MONBE/530-833    AC A9V749.1
#=GS C5L687_PERM5/467-782    AC C5L687.1
#=GS E8RVW0_ASTEC/875-1131   AC E8RVW0.1
#=GS B4RER6_PHEZH/875-1131   AC B4RER6.1
#=GS B0T9F1_CAUSK/878-1134   AC B0T9F1.1
#=GS B4RIT6_PHEZH/173-429    AC B4RIT6.1
#=GS B7L395_METC4/917-1176   AC B7L395.1
#=GS C6KV63_9BACT/480-734    AC C6KV63.1
B6A585_RHILW/923-1182              TALDQIVQHFG..TS.QVAEITGRSRRI...VSR.K..DN....T.SI..ARYAV.QGR....PGSANLDEARAFMDDEKGVLVFSDAGGT.....GRSYHADLAARN.Q..RLRLHNLLEAGWRADVAIQGLGRSHRTNQKQPPRFRMIATNVKAERRFLSTIARRLDTLGAITRGQRQTGGQGMF..................R.SEDNLESQYARD.ALRQFYG...LLHAGG....I.....................EGC....SL.............D...KFESI.TGLT...L....................TS.EEG.......GLK.D.....EL.....P..PIQTFLNRMLALTIAMQNVLFEAFEQLLAARVEGAIAAGI..YDKGLET
Q11N09_MESSB/356-615               TALDQIIHHFG..TE.AVAEITGRSRRI...IRL.P..DGGGIER.FAVQN.......R....PGSSNLDEVRAFMEDAKQILIFSDAGGT.....GRSYHADLTARN.Q..RRRIHDLLEAGWKADAAIQGLGRTQRTNQKQPPLYRLITTNVKAERRFLSTIARRLDTLGAITRGQRQTGGQNLF..................R.PEDNLESRYARD.ALRQLYR...VIVDGKL.........................EGC....SL................ETFQST.TGLSLV.......................T.EEG.......GLR.D.....EL.....P..PISTFLNRLLALRISMQDLIFDAFEALLARRVEGAIAAGI..YDVGVET
A1B289_PARDP/904-1161              GALDQLVQRFG..TD.LVAEVTGRSRRI...VRK.G..DGP.SAR.LAVENRAPS...........ANLAETSAFMDDQKRVLVFSDAGGT.....GRSYHADLLARN.Q..RLRVHYLLEPGWKADAAIQGLGRTNRTNQAQPPLFRPIATDVKAEKRFLSTIARRLDTLGAITRGQRQTGGQGLF..................R.PEDNLESAYARD.ALRQLYL...LIVRGK....V.....................EGC....SL...............ERF.E.TATGLKLM.......................D.ANG.......IK..D.....EL.....P..PITTFLNRLLALTIELQGILFSAFEQLLQARINGAIASGT..YDMGLET
Q1GPR5_SPHAL/858-1117              GALDQIVQHFG..TD.MVAEVTGRSRRV...VPR.HNEDGS..VR.FAVENRPAS...........AALHETDAFQNDAKCILVFSEAGGT.....GRSYHADLGAAN.Q..RRRVHYLLEAGWKADAAIQGFGRTNRTNQKQPPLFRPVSTDVKAQKRFISTIARRLDSLGAITRGQRQTGGQNMF..................R.PEDNFESWYARD.ALRQLYI...LLARGK....V.....................EGC....SL...............ARF..EAATGLSLL.......................D.SDG.......GLK.D.....EL.....P..GINTFLNRMLALTVAMQNLLFEAFEGLLVARIDQARASGS..YEIGLET
Q2GBE8_NOVAD/917-1177              AALDQILHHFG..TD.VVAEVTGRARRI...VAR.R..DG....S.GQ..VRFAV.ETR....PASANLAETQAFMDDAKRILVFSDAGGT.....GRSYHADLGVRN.R..RLRVHYLLEAGWKADNAIQGFGRTNRTNQAQPPRFRPVTTDVKAQKRFISTIARRLDSLGAITRGQRQTGGQNMF..................R.PEDNLESHYARD.ALRQLYA...LIAAGK....V.....................EGC....SL...............QQF.EQA.TGLS...I...........I........DA.EGG.......GLR.D.....EL.....P..PITTFLNRMLALTIALQDILFTAFEDLLTRRIEGAMASGT..YEIGLET
Q11N69_MESSB/955-1214              SALDQILHHFG..TD.IVAEVTGRSRRI...VKK.T..GR.......DGVDRLAV.ENR....PGSANLAETQSFMDDDKSVLIFSDAGGT.....GRSYHADLGARN.Q..RLRKHYLLEAGWRADNAIQGLGRTHRTNQAQPPLFRPMAANVKAGKRFLSTIARRLDTLGAITRGQRQTGGAGLF..................R.AEDNLESPYARA.ALRQFYY...LLHQGK....V.....................DGC....SL.............T...TFETV.TGLS...L....................TT.DEG.......GLR.D.....EL.....P..PITTWLNRLLALRIETQNLLFEVFEQLMTAKIEGAIAAGT..YDRGLET
Q6N7K8_RHOPA/909-1168              GALDQIVQRFG..TE.QVAEVTGRSRRV...VAR.I..G.......ADGERRLCV.ENR....AGSANLAETAAFQDDDKRVLVFSDAGGT.....GRSYHADLGARN.R..RLRIHYLLEAGWKADTAIQGLGRTNRTHQVQPPIFRPISTDVKAEKRFLSTIARRLDTLGAITKGQRQTGGQGLF..................R.AEDNLESAYAKA.ALRQLYT...LLLLGK....VP.....................GC....TL................QRFEDA.TALK...L....................TD.RDG.......TLR.E.....EL.....P..PITQFLNRMLALTIDLQGTIFDVFEGLLRAKIEGAVAAGV..YDRGVET
A3T2E9_9RHOB/927-1182              GALDQILWHFS..GD.VVAEVTGRKRRI...VRT.S..EG....C.LKVENRPAS...........SNLGETQAFMDDTKRILVFSDAGGT.....GRSYHADLGAKN.Q..RLRVHYLLEPGWKADNAIQGLGRTNRTNQAQPPLFRPVATNVKGEKRFLSTIARRLDTLGAITKGQRETGGQNMF..................R.AEDNLESPYARA.ALRQFFY...KLRAGKI.DAC............................SY................ARFQEM.TGLT...L....................DD.ADG.......CMK.E.....VL.....P..PIQQFLNRCLALKISMQDAIFDAFGEFLAAIIEDARQAGT..LDVGLET
Q0FXP2_9RHIZ/971-1226              GALDQLIWRFG..TD.AVAEVTGRSRRV...VRT.T..DG....Q.LKVEKRPAS...........SNIAETQSFMDDDKRILIFSDAGGT.....GRSYHADLGAKN.Q..RIRVHYLLEPGWRADNAIQGLGRTHRTNQAQPPLFRPVATNVKGEKRFLSTIARRLDTLGAITRGQRQTGGQGMF..................R.AEDNLESPYARA.AHRRFFA...AVHAGRI.EA........................C....SL................ERFETM....TSLEL...........T.........G.DDG.......TLR.D.....DL.....P..PIQRFLNRCLALTIEMQNAVFEAFTGILSDIVEAAIAGGT..YDIGLET
A3IS38_9CHRO/937-1195              SALDQIINHFG..YE.AVAEVTGRSKRI...IRV.T..KEG.SDR.MMVDKRSSS...........ANLAESQLFMDDEKQILVFSQAGGT.....GRSYHANRSCQN.Q..RPRVHYLLEGGWQADVAIQGLGRTNRSNQAQPPLYRVICTDIKGEKRFTSTIARRLASLGALTKGERKTGNQGLF..................R.EEDNLESVYAKQ.ALRTLYF...SLYKGLV.E........................GM....T...............LAEF.E....RISGLNL...........L.........T.KEG.......DFK.A.....EL.....P..PMKTFLNRVLAMRLEDQEILFTTLEMCISSAIEKAKEAGI..YEMGVET
E0U7A6_CYAP2/1001-1259             GALDQIIQHFG..YE.NVAEVTGRSKRI...VKE.T..KGE.RER.LVLQKRSGS...........ANLAETGAFMDDKKRILVFSEAGGT.....GRSYHADLKARN.Q..RLRVHYLLEAGWKADSAIQGLGRSNRTNQAQPPLFRPVTTNVKGEKRFLSTIARRLDSLGALTRGQRQTGGQGLF..................R.EEDNLESPYAKA.ALRQLYL...ALYAGKL.DCC...........................................CLKDF.....EAYTGLSL....................TT.PEG.......NLK.E.....DL.....P..PISQFLNRVLALRIELQNALFEEFEVRLESKIEEALATGS..YEAGVET
B2JBN7_NOSP7/891-1146              GALEQLLWHFG..NK.QVAEVTGRSKRV...LKD.D..SG....R.LFVDSRGS...........GANIAETNAFMQGDKQILIFSDAGGT.....GRSYHADLNVIN.R..RRRSHYLLEAGWKADSAIQGLGRSHRTNQASAPIFRPVTTNVRGERRFISTIARRLDSLGALTRGQRQTGGNGIF..................E.AKDNLESQYAEY.ALYELFK...QIFQGRF.YEVP..................L.........G.................TFEQM.TGLS...L....................TS.HEG.......GMRID......L.....P..PLRQFLNRLLALTIRMQNVIFERFELLLSQQIETAIANGI..FEVGVET
A4XE03_NOVAD/893-1148              TALDALLEHYG..VS.AVAEVTGRSKRL...VRD.G..SG....Q.QRLESRSPR...........TNLAETTAFMTGAKRILVFSDAGGT.....GRSYHASLDAKN.Q..QRRVHFLLEPGWRADRAIQGLGRTHRTHQACPPLFRPVTTDCKGEARFTSTIARRLDALGALTRGQRQTGGQGMF..................D.AADNLESAYAKH.ALHDWYG...LLATGKL.KS..............................T.............SLKEF.....QAMSGLEL...........T.........D.QDG.......VLR.E.....DL.....P..PIQRWLNRILAMKIAVQNAIFDEFLTLVETRVSAAKEAGT..FDIGVET
A5VGF7_SPHWW/879-1134              SALDGLLNHFG..HD.YVAEITGRTKRL...IQA.S..DG....R.QKLETRSTR...........TSQAEAAAFMGGLKRILIFSDAGGT.....GRSYHASLDAVN.Q..EQRAHLLLEPGWRADRAIQGLGRTHRTHQACTPLFRPVTTDCKGELRFTSTIARRLDTLGALTRGQRQTGGQNLF..................D.PADNLESSYACA.ALTSWFH...LLHLGKL.KS..............................T.............TLAEFEE..RTGLE...L....................TD.KDG.......VLK.D.....EL.....P..PIQRWLNRLLALPIGLQNRIFEEFLALVETRVQAAREAGR..LDVGVET
A3W9H2_9SPHN/883-1138              TALDAIIEHFG..TE.AVAEVTGRTRRL...VLG.R..DG....Q.QRLERRSAS...........ANVAEAQCFMDGTKRILIFSDAGGT.....GRSYHADLDAQN.Q..QRRVHFLLEPGWRADNAIQGLGRTNRTNQASAPLFRPVTTDVKGERRFISTIARRLDALGALTRGQRQTGGQNLF..................D.PADNLESDYAKD.ALSRWFH...LLYDGKL.EAV...........................................GFGDFV.....ELTGLKL....................EN.PDG.......GLS.D.....NL.....P..TIQRWLNRILALPIALQNAIFEEYLGLVEARIEAAREAGT..LDLGLET
Q1NC34_9SPHN/135-390               SALDHIIGHFG..TE.AVAEVTGRSRRI...VVD.A..DG....R.QRIERRSAR...........TNLAETDIFMRGEKRILIFSDAGGT.....GRSYHASLDAPN.Q..SRRIHYLLEPGWRADAAIQGLGRTHRTHQACPPLFRPVSTDCRGERRFISTIARRLDSLGALTRGQRQTGGQGLF..................D.PRDNLESDFARE.SLDQWFR...LLFQAKL.QSVH................................................FDQFQALTGLNL...........A.........G.EGG.......GL.TE.....TL.....P..TIQRWLNRILALRIDLQNAIFDEYLGLIEARVEKAREAGT..LDLGVET
A3SRZ6_9RHOB/887-1142              SALDQILWAFG..DD.AVAEVTGRSIRP...LKA.V..DG....H.LFIEKRVAS...........SNSSETQAFMDGEKDILIFSDAGGT.....GRSYHAAQTAKN.Q..KRRRHYLLEPGWRADAAIQGLGRTHRSAQVSAPFFRVCTSDVHGEKRFTSTIAKRLDQLGALTKGQRETGSQGMF..................R.EEDNLESPIARA.ALRGYFA...DLAAGRA.EAMS..................Y..........................ESFTDW.TALRL..............I.........D.KDG.......VL.LE.....EL.....P..PIQRFLNRVLALPIHMQNALFAEFMRRIADQSERARAAGT..QDLGVET
B9NY20_9RHOB/773-1028              SALDQIIWAFG..PE.IVTEVTGRNQRP...VKD.D..AG....N.LRIERRGAS...........ANSAETKAFMSGDKVVLIFSDAGGT.....GRSYHAAQSAKN.Q..ARRRHYLLEPGWRADAAIQGLGRTHRAAQVSAPFLRVCTSDVHGEKRFTSTIARRLDTLGALTKGQRETASQGMF..................R.ASDNLESSIARG.CLRSLYG...DLVRGES.PAMS......................Y.....................DEFTN.....WTGLKL....................ST.PEG.......VM.LE.....EL.....P..PIQRFLNRVLALPIVMQNAIFAEFMEKIELATERALAAGT..LDVGLET
A4JVA5_BURVG/1077-1328             APIDYLREALEARGY.TLGEISGRNLRS...RTL.P..NG....K.VTIEAMPGR..TD....KTRVN.RVVREFNNGDLDAIVLTGAGST.....GISLQASPAVGADV..RPRVMIKGEMQQDITAERQMDGRHNRTGQIERPRYKVPVTGLPADDRQAMMFNTKNRSLTASTVANRDS.KE.II..................R.EVPDLLNVVGDM.VAEELLQ...ENFDLAD..RL..................................................DI..AM.........................KD.DSD.......SYQKP.....PL.....Y..YIKVLTGRICLLRVEEQRSLYADLQARFHEKVDKLKAEGR..NPLEVQC
A7FC92_YERP3/1426-1680             MPIDEFKHSLQS.QGFRVAEVSGRKVSLIPVVIN.N..QS....M.WRVSFHEKA.D..........AVSNVAGFQNGKYDAIVITRSGST.....GISLHSSNRFAD.SDIRQRYFIVQQKAANISEFLQWMGRVNRKDQVIPPIIVNIESGLPAEARQTMMHNSKLRKLSANTTSNREN....EN..................LEGDEDLLNSVGDKIALEYLTE...NP.......................................................DIADALDIALPKAG........................ESP.......SSSAS.....EN.....P..YINKLMGRLMMIPVNQQETVLKLLSERFIERIEQLEQEGINPFKVDVYD
C5B554_METEA/774-1025              SPIDEVRDRVEA.AG.RYLHEQGEIPAP..WIMD.E..ISA..RG.MKVERGGYV.PMA....ARDRN.TVIAGFNGGRIDGLVVTRAGST.....GLSLHASEKVAD.R..RPRLMIEHQIPANVVERVQFWGRVNRRGQVVEPGFATLSTGLPMQARPLAMQNKKVADLSANVSGSADNATA.MD..................V...PDILDDIGNE.IARTLLE...ERPS......................................................LAERMCIAMK.V.........................DPE.......AAE.A.....EL.....Y..FVNKILQRLVLLPSDEQDALFAEMLDLYGDRVRELEAVGR..HPHGSRE
B3RSN6_TRIAD/493-782               CSLDELIQQLGG.TN.CVAEMTGRRGRI...VCI.N.GSS....T.PVYQLRDTD.SSSD.HGLESLNVREKNLFMQGKKLIAVLSDAAST.....GISLHSDTRVAN.N..RRRIHITMELPWSAEKAVQQLGRSHRSNQSSAPIYKLMTTNVGGEKRFVAAVAQRLLSLGALTRGDRRAATG.AD..................F.SEFNFNTSYGRS.ALKLMYS...YIQRGVL...CPNITFS.......SILQASTLDDS....SY.............TISQFYIDMKHCLLDMGL...........T.AS........LE........ARVPE.....KD.....A.TDVQRFLNRILGLTIERQNLIFSYFCQCLTTSIERAKKEGK..YNEGVTD
C1E7J3_MICSR/536-820               NFLDELIDQLGG.PR.RVAEMTGRRGRI...VRV.S..RN....N.FK...KVEQ........VDGVNLREKTAFQRGAKLVAIISDAAST.....GISLHARRDEPN.Q..RRRVHVTIELPWSADKAIQQLGRTHRSNQSSGPIYLMTSTNLGGERRFAAAVARRLQSLGALTRGDRRAATG.VD..................L.SEGNLDSPLGRR.ALKKMYD...ALVLDGT..PLP..................PGAVS....PG............SGVVALHAELRALVCSLGVQVGL...LAEGL.SE.....E...NV.......AALIETGGGTKD.....Q.GDVRRFLNRILGLSVRGQNLLFGYFTEVFEAEVKAAKAEGK..YSEGVSD
A8IU58_CHLRE/592-875               NPLDDLIQRLGG.PG.AVAEMTGRNKRM...EAQ.E..GG....G.WKYVPRNH..GCS....MDAVNLREKEQFQAGTKLVAIISDAAST.....GISLQADRSKPN.T..RQRVHITLELAWSADKTAQ............PPLYVLVSSDVAGEHRFASAVAARLMQLGALTHGDRNAVSA.VD.................VL.SGSNFHTTYGPR.ALSKLYRVFKGVLPHSG.DLSPL...............AGITPDR....SS.............CPPSFIAEAVHELEAVGL...........L.RE.....DG.EGGLA..VTGAMMKD.....KAEGAGNM.GGVNRLLNRLLGVRVDMQRRIFQYFTALLDFEVQEAKRAGT..YESGIVR
A8JG19_CHLRE/430-719               NPLDQLLELLGG.PE.AVAEMTGRKVAQ...VRD.E.ETG....R.VVCVQRRDD.E.A....QKMVNMAEKEDFMSGRKLVAVISDAAST.....GISLQADRRVAN.Q..RRRFHVTLELPWSADKA.............SAPEYCLLVTKCGGEYRFAGAVAKRLTSLGALLRGDRRALGASSD..................L.KPYDVDNRYGEA.AVQRVLE...CVASGVH.T.VAGSKPGELPSELLPPDVAATPPGS....AA.............RQRAFLAHMQRCLRSMGL...........L.AA.....TS.LPGG....HVAYSVER..KDQA.....T..GVPKFLNRLLGLPLRDQELLFGYFLGIMDSLVKQARSAGD..YDEAIVN
C1FF16_MICSR/633-917               NPLDHLVDLCGG.PS.KVAEMTGRERRL...VRCLE..TG....N.VEAKLRRSQLDTT....QKLLNMAERESFQSGEKLIAIISEAAST.....GVSLQADKRVKN.Q..RRRCHMTLELPWSADKAIQQFGRSHRSNQSSAPLYQILVTPCGGERRFASAAAKRLQSLGALLKGDRRALGAGVD..................L.RAFDIDTKEGSA.ALNRLYD...DAREKNS.GPMP..................NVNVP....GG.............DFKRFARFARRCLVSVGM...........G.HA.....NR.AKG......NAWELP.....KK.....FEGKVPLFLNRLMGLSVDQQKLLFAYFTETHEAEVAEAKARGT..FDEGVVS
Q01BW6_OSTTA/658-940               NPLDNLITLCGG.PA.HVAEMTGRKLHQ...VRD.Q..DG....K.VRTKKRRDD.DIT...NAKLLNITEKMKFQNGEKLIAIISDAAST.....GISLQADKRVEN.Q..RRRCHMTLELPWSADKAIQQFGRSHRSNQSSAPLYRILMTPCGGERRFASSAAKRLLSLGALLKGDRNALGAGEG..................L.QAFDIDNQYGSK.AMKRVIT...DILDRS..DPMP..................TVKFE....GA.............ELAAAINIIKEEFRNVGI...........A.DY.....DD.YGN......FTMAKQ.....YD.....TKLKTSLFLNRLLGMPVNAQKVVFDYFTQTFEGIVKEYKQNGT..YDRGVID
C5YFM0_SORBI/789-1077              NPLDDIIDQLGG.PD.NVAEITGRRGML...IRT.L..DG....KGVIYQARNAK.EVS....MEMINMHEKQQFMDGKKLIAIISEAGSA.....GVSLHADRRAKN.Q..RRRVHITLELPWSADRAIQQFGRTHRSNQTSAPQYRLLFTNLGGEKRFASIVAKRLESLGALTQGDRRAGPS.....................L.SAFNYDSNYGKK.ALTMMYR...GIMEQDS.FPV...................VPPGCS.DDET.............SIQQFINEAKAALVSVGI...........I.RDAFIYNGK.DPGK....LSGRIVD.....SD.....M.HDVARFLNRLLGLPPNIQNRLFDLFTSILDIVLHNARIEGQ..LDSGIVD
Q0WQ12_ARATH/111-403               NPLDDIVDQLGG.PE.KVAEMTGRRGML...VRA.S..NG....KGVTYQARNTK.DIT....MEMVNMHEKQLFMDGKKLVAIISEAGSA.....GVSLQADRRAVN.Q..KRRVHLTLELPWSADRAIQQFGRTHRSNQTSAPEYRLLFTNLGGERRFASIVAKRLETLGALTQGDRRAGPSGPS..................L.SAYNYDSNFGKK.SLMVMYR...GIMEQEK.LPV...................LPPGCSIDEPE.............TVKEFLTKARAALVAVGI...........V.RD.....SVLANGKDVGRFSGRIID.....SD.....M.HDVGRFLNRLLGLPPDIQNRLFELFTSILDVLVHNARIEGS..FDSGIVD
B4G3M5_DROPE/685-964               NTMDKLKARLGG.HK.AVAEITTRRGGI...VSI.K..Q.....V.YQYMPRCSS.VAH....RDQVNFMEHQSFMADSKKVAIISETTAM.....GISLHSDQTVDN.Q..RQRVHIILELPSSLDLAIQQLGRTHRSNQVNTPEYVFVVADLVGERRMATTVAARLKALGALIKDNTLSPDD.SD..................L.GQININNIHGPS.SLYHVIQ...QMAGQRSIDPSE..................IPDTY....KG.............D...FLADCQVALGDVGV...........L.NV.....ET.GEND....VEINSVA.....KD.....S.SNVDRFINRLRGCCVEIQNVIFKFFIDNMYGGIAQMKRSGR..FNIGILD
B4J2E0_DROGR/867-1145              NTLDKIISKLG..TN.VVAEMTGRRGRV...IKT.E..DN....R.YRYEQRCEA.ETS....MDLVNYMEKQRFMEDTKHVAIISEAASS.....GISLQSDRRLST.Q..RRRLHITLELPWSADRAIQQFGRTHRSNQANAPEYVFLISDLGGESRFAATVAKRLESLGALTQGDRRATDA.RD..................L.SKFNIDNNIGRC.ALENVLQ...QITGEKPLEKIH..................IPESY....KG.............D...FSFDCCVALSGVGM...........L.SV.....TV.NKGQ.....QIFVIE.....KD.....S.YNIPKFLNRILGCRVEVQNALFKFFLNKMYSLILQMKRSGH..FDLGILD
C4QG33_SCHMA/459-745               SSLDELIDKLGG.PS.RVAEMTGRKGRM...VMG.D..DG....R.VSYESRRES.DVN....LELLNLTEKQRFMNGEKLIAIISEAASS.....GISLQADRRAAN.Q..RRRVHITLELPWSADRAVQQFGRTHRSNQVSAPKYIFLISNLAGEQRFASTVAKRLESLGALTHGDRRATET.RD..................L.SQFNLDTKLGRE.ALELVLR...ACIWGDE.GIVD..................PPNDY....ITDTSLDVTVDRDNLNAQSFFNDVKASLQGVGL.......................STG.......RCR.E.....KD.....S.NQMSKFLNRILGIRVHIQNALFQYFSETLEEVTRRAKRDNR..LDLGILD
A8ND67_BRUMA/1214-1478             NTLDQLIDELGG.PD.YVAEMTGRKGRV...VCR.E..DG....D.VEYELRHAGADVP....LELMNMDEKDKFMKGEKLVA..................SDRRATN.R..RRRVHITLELPWSADKAIQQFGRTHRSNQVSAPEYIFLISELAGEKRFASIVAKRLESLGALTHGDRRATES.RD..................L.SQFNLDTRYGRA.ALDVLLR...TVTGLLDPPLIP..................PPKDY....KP.............G..NFIIDMQCYMEGVGL...........L.S.......L.DNG.......VYTIE.....KE.....S.ATIPKFLNRLLGLPVHAQNALFQYFSDIVAELVAQAKHDGT..YDMGIMD
A8XLN5_CAEBR/1305-1583             NTLDQLIDEMGG.PE.YVAEMTGRRGHM...VTT.E..TG....D.VMYQRRNANAEVS....LELINMEEKEKFMRGEKLIAIISEAASS.....GISLQSDRRAMN.K..RRRVHITLELPWSADKAIQQFGRTHRSNQVSGPEYVFLISELAGEKRFASIVAKRLESLGALTHGDRRATET.RD..................L.SQFNMDNKYGRV.ALDTLLK...TVIGQAGVPLIE..................PPKDY....KA.............G..DFFEDMRLYMEGVGL...........L.A......KN.KNG.......QYTIE.....KE.....A.ATIPKFLNRILGLPVHAQNSLFHYFSEIVAELIAQSKHDGT..YDTGIMD
B3S549_TRIAD/641-917               NTLDELIDSLGG.PK.NVAEMTGRKGRV...VCN.A..DG....T.ISYQSRCES.DIP....LEVLNLIEKKRFMDGEKLIAVISEAASS.....GISLHADKRVAN.R..RRRVHITLELPWSADRAIQQFGRSHRSNQVSAPDYLYLISELAGEQRFASIIARRLESLGALTHGDRRATET.RD..................F.SKYNFDNRYGRT.ALEAVFN...SVTGQQK.AIVP..................APENY....EG.............D...FFNDISEAMADVGL...........L.NK.....QN.RWP.......YYVYE.....KD.....Y.NSIPKFLNRILGIPVVLQNKLFAYFSDTLNKIIQESKKTGR..WESGILD
A0JLU6_MOUSE/22-298                NTLDELIDELGG.PE.NVAEMTGRKGRV...VSN.D..DG....S.ISYESRSEL.DVP....VEILNITEKQRFMDGDKNIAIISEAASS.....GISLQADRRAKN.Q..RRRVHMTLELPWSADRAIQQFGRTHRSNQVTAPEYVFLISELAGEQRFASIVAKRLESLGALTHGDRRATES.RD..................L.SRFNFDNKYGRN.ALEIVMK...SIVNLDS.PMVS..................PPPDY....PG................EFFKDVRQGLIGVGL...........I.NV.....ED.RSG.......ILTLD.....KD.....Y.NNIGKFLNRILGMEVHQQNALFQYFADTLTAVVQNAKKNGR..YDMGILD
B7PH49_IXOSC/637-914               NTLDQLIDELGG.PN.CVAEMTGRRGRV...VST.A..KG....T.VHYEPRSEV.DVP....LKTLNLTEKQRFMDGEKLIAIISEAASL.....GISLHSDRRAKN.Q..ARRVHLTLELPWSADRAVQQFGRTHRSNQVNAPEYVFLISDLAGERRFASIVAKRLESLGALTHGDRRAGES.RD..................L.SRFNIDNRYGNE.ALQTMMS...DLMEVETSPLIP..................PPKDW....EG.............D...FFADCRKALVGVGL...........V.NE.....NE.LTK.......MQILD.....KD.....Y.TNMSQFLNRILGIPVELQNAMFKYFTDTLDAIVSEAKRAGH..YDLGILD
B0W0M2_CULQU/840-1117              NTLDQLIDELGG.PE.NVAEMTGRKGRV...VQN.D..NG....T.IQYESRSEQ.DVP....LETLNITEKQRFMDGEKDVAIISEAASS.....GISLQSDRRVRN.Q..RRRVHITLELPWSADRAVQQFGRTHRSNQVNAPEYMFLISDLAGERRFASTVAKRLESLGALTHGDRRATET.RD..................L.SQFNIDNKYGRS.ALESVMK...TIMGYEQ.PLVP..................PPSDY....KG.............D...FFKDIAGALVGVGL...........IVNS.....EQ.MPG.......VLSLD.....KD.....Y.NNISKFLNRILGMPVELQNRLFKYFTDTLVAIIDQAKKRGR..FDLGILD
SBNO2_BOVIN/739-1017               NTLDELIDQLGG.PE.CVAEMTGRKGRV...VSR.P..DG....T.VAFESRAEQ.GLS....IDHVNLREKERFMSGEKLVAIISEASSS.....GVSLQADRRVQN.Q..RRRVHMTLELPWSADRAIQQFGRTHRSNQVSAPEYIFLISELAGERRFASIVAKRLESLGALTHGDRRATES.RD..................L.SKYNFENKYGAR.ALSCVLT...TILSQTE.SKVP..................LPQGY....PG.............GDAAFFRDMKQGLLSVGI...........G.GR.....ES.RSG.......CLDVE.....KD.....C..SISKFLNRILGLEVHKQNALFQYFSDTFDHLIAADKREGK..YDMGILD
A9V749_MONBE/530-833               SPLDDLIDQLGG.PS.AVAELTGRKQRQ...VRV.G.HTS....S.FVIEERAAI.NCGPIDPTDGINIVEKNAFLDGRKLIAIISDAASTGLMSLGISLHADVRREN.Q..HRRVHFTFELPWSADKAVQQLGRSHRSNQACGPRYELMSTELAGERRFAAAVARRLRFMGALTRGDRRAASG.QD..................M.GSWDIDTNYGRL.ALREMGG...LLQEKKK.RESA..................YMAMT....VSS..........ILSLERILEHVPEGRLRARVCQLFPTDDALFQ.GL.....KA.NAR.......RLHSS.....QA.....F.KSVSAFLNGVLGLPVEGQNIMFGALMVLHRRTIERAKEEGK..YSEGIHE
C5L687_PERM5/467-782               NPLDELIDLMGG.PT.KVAELTGRSKRQ...EVD.K..DG....K.VRLVPRQIS..YS....GDNINVLEQQAFQRGEKLVAVISEAASA.....GISLHADARAESGS..RQRVMITLELPWSAEKMVQQLGRVHRTNQLSPPSYVLLVTTLLGELRFVSAVARRLVRLGALTRGDRNMAIG.IERITNIESPSITSPSTSSPF.GAFDYNLPAVRL.ALRRILF...LMIAGPD.YKGEDGTW.........PSEEDL........PEEVWRS...PGPWTSPQDFLKIIAGVMESAGL...........T.SS.....SQ.ARAL....DSSAASE.....TV.....S..AFNLFLNRCLIQPVEIQNALLKWFTYHYHSEYESLKKEDD.LLTHGGRN
E8RVW0_ASTEC/875-1131              GALDAILHHFG..PE.KVAEVTGRSRRV...VMK.N...G....K.QVLERRGAT...........ANKAETDAFNNGEKLILCFTAAGGT.....GRSYHADRRFAN.T..RRRCQYLAEPGWRADVAIQGIGRTHRTNQLHAPIFRPVTTDIKGEKRFLSTIARRLDSLGALSKGERRSTSNGMF..................K.AEDSLENAFARR.ALVSFFQ...AMDMGQI.ECM...........................................SLAEFEDK..TALQ...L....................RD.GEG.......VIKSA.....ED.....L.PPISTFLNRLLAQRIDDQNALFEAFESRLRGIIEKADAAGT..IDNGVED
B4RER6_PHEZH/875-1131              GVLDALLEALG..TG.AVAEITGRARRV...VLR.E...G....R.RMVERRGPS...........AAKAETDAFMDGRKRVLVFSDAGGT.....GRSYHAAVEAVN.R..ARRVHYLVEPGWRADAAIQGLGRTHRTHQVCAPLFRPVTTDIHGEKRFLSTIARRLDSLGALTRGERRVAGAGLF..................R.AEDNLESPWARR.ALLVLYG...ALARGEL.ASM...........................................TLAAF..EAKTGLKLL.......................D.AEG.......LLKGA.....DA.....L.PPITTFLNRLLALRIADQNALFADFERILAGVLDRAAAGGE..LDHGVED
B0T9F1_CAUSK/878-1134              GVLDAVLEALG..TD.LVAEITGRARRV...VTR.E...G....R.RMVERRGAA...........AAKAETDAFMAGRKRVLVFSDAGGT.....GRSYHADLAVAN.Q..QRRVHYLVEPGWRADAAIQGLGRSHRTNQASAPLFRPVTTDIHGEKRFLSTIARRLDSLGALTRGERRTAGNGLF..................R.PEDNLESPWAHR.ALQAFYV...ALHLGNV.PAM............................SR...............EAF..ETKTGLTLL.......................D.HDG.......NLKAS.....DD.....M.PAMNTFLNRLLALRIEDQNSLFSAFDEILASILERAAASGA..LDKGVED
B4RIT6_PHEZH/173-429               GVLDALLDAFG..PD.QVAEITGRSRRV...VAR....DG....R.RVVERRSAS...........AARAETDAFMSGRKRILVFSDAGGT.....GRSYHADLNCGN.T..ERRRHYLVEPGWRADVAIQGLGRSHRTNQASAPLFCPVTTDIHGEKRFTSTISRRLDSLGALTKGERRTAGQGLF..................R.AEDNLESAWARR.ALQAFYV...ALHWGDV.AAMD............................................RETF.EAKTGLHLL.......................D.AEG.......GLKAP.....ED.....L.PPMNTFLNRMLALRIEDQNALFEAFESLLAGILERAAAAGA..LDRGLED
B7L395_METC4/917-1176              SALDQILHHFG..AG.AVAEVTGRSRRI...VRQ.T..GTDGVDR.LVLQNRPA...........GANLSETQAFQDDAKRILVFSDAGGT.....GRSYHADRGAKN.R..RLRVHYLLEAGWKADAAVQGLGRTNRTNQQQPPLFRPVTTDVKGEKRFLSTIARRLDTLGAITRGQRQTGGQGLF..................R.PEDNLEGHYAAT.ALRQLYW...AIVRGE....I.....................EGC....PR................ETFEAM.TGLSLV.......................N.DAG.......CL.LD.....EL.....P..PIGRFLNRVLALRIAMQNRLFAAFEERLALVIEGAISAGV..YDVGVEV
C6KV63_9BACT/480-734               GALDQIIQRFG..TD.KVAEVTGRSRRI...VRK.G..D.....R.LCVENRPPS...........ANLAETQAFMDDEKRILVFSDAGGT.....GRSYHADRGAKN.Q..RLRVHYLLEAGWKADTAIQGLGRSNRTNQAQPPLFRPIATDVKAEKRFLSTIARRLDTLGAITRGQRQTGGQGLF..................R.AEDNLEGDQARA.ALRQFYC...WLAQGA.........................IQGC....SL.............T...QFEEM.TGLT...L....................TF.DGG.......NM.KE.....DL.....P..PITTFLNRLLALPIAMQNTLFAAFEEILNARIEAAIAAGV..HDVGLET
#=GC seq_cons                      ssLDpllpchG..sc.tVAElTGRptRl...Vpp.p..sG....p.hthcpRsss...........sNlsEppsFMsGcKtlhlhS-AGuT.....GhShHADhpstN.Q..RRRVHhhLEhsWpADpAIQthGRTHRoNQsssPhac.lsTcltGE+RFhSolA+RL-oLGALT+GpRpsusp.h...................h.up.Nl-osYu+p.ALcphap...tlhtsp....h.............................h................tFhpch.puLp.l.l....................ps.psG.......shp.-.....c......s..sIspFLNRlLuLslchQNsLFphFpphlpshlcpA+tsGp..aDhGlps
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