# STOCKHOLM 1.0 #=GF ID HRXXH #=GF AC PF13933.1 #=GF DE Putative peptidase family #=GF AU Bateman A #=GF SE Jackhmmer:Q5A0Y5 #=GF GA 21.40 21.40; #=GF TC 21.40 21.40; #=GF NC 21.30 21.10; #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq #=GF TP Domain #=GF RN [1] #=GF RM 9273358 #=GF RT Molecular cloning and expression of a recombinant Aspergillus #=GF RT fumigatus protein Asp f II with significant immunoglobulin E #=GF RT reactivity in allergic bronchopulmonary aspergillosis. #=GF RA Banerjee B, Kurup VP, Phadnis S, Greenberger PA, Fink JN; #=GF RL J Lab Clin Med. 1996;127:253-262. #=GF CC This family of putative peptidases are closely related to the #=GF CC M35 family Pfam:PF02102. In this family the metal binding HEXXH #=GF CC motif is replaced with HRXXH. The exact function of these #=GF CC proteins is unknown. Members of this family are found to be #=GF CC fungal allergens. #=GF SQ 28 #=GS A7ET73_SCLS1/7-254 AC A7ET73.1 #=GS Q0PV92_BEABA/6-253 AC Q0PV92.1 #=GS C7ZGH1_NECH7/3-249 AC C7ZGH1.1 #=GS Q6QUX8_VERDA/7-253 AC Q6QUX8.1 #=GS Q2GQB8_CHAGB/5-265 AC Q2GQB8.1 #=GS B2AFK4_PODAN/177-421 AC B2AFK4.1 #=GS Q0UZ18_PHANO/4-251 AC Q0UZ18.1 #=GS B2VUC4_PYRTR/5-254 AC B2VUC4.1 #=GS C5GRH5_AJEDR/4-248 AC C5GRH5.1 #=GS C4JGA4_UNCRE/6-241 AC C4JGA4.1 #=GS Q8J0P2_COCPO/6-241 AC Q8J0P2.1 #=GS B8MYQ2_ASPFN/4-243 AC B8MYQ2.1 #=GS B0Y6E9_ASPFC/7-249 AC B0Y6E9.1 #=GS A1CHQ9_ASPCL/5-238 AC A1CHQ9.1 #=GS B6HBQ3_PENCW/3-246 AC B6HBQ3.1 #=GS ANG1_EMENI/3-233 AC Q00746.1 #=GS A3LZN3_PICST/4-241 AC A3LZN3.1 #=GS A5DNU0_PICGU/4-243 AC A5DNU0.2 #=GS Q6BVW4_DEBHA/6-248 AC Q6BVW4.2 #=GS C4R4T0_PICPG/4-248 AC C4R4T0.1 #=GS PRA1_CANAL/4-241 AC P87020.2 #=GS C5MDK1_CANTT/4-240 AC C5MDK1.1 #=GS Q4P9V4_USTMA/7-269 AC Q4P9V4.1 #=GS C5DDE7_LACTC/11-261 AC C5DDE7.1 #=GS C5DFQ2_LACTC/11-260 AC C5DFQ2.1 #=GS ZPS1_YEAST/7-248 AC Q12512.1 #=GS Q6CQ42_KLULA/8-279 AC Q6CQ42.1 #=GS Q6CV33_KLULA/6-251 AC Q6CV33.1 A7ET73_SCLS1/7-254 LIVSINAFGALAYPLTATN....AA.APVSELVVSSGDAQSYNWQSGY.....................VSQFT.IHSSCNATERHELSEGLRQAVEMAEHAKNHILVHGNKSEIFQKYFGK.........GPTSTPMGWFDKIA...........................SGNRAGVIFRCDDPDRNCETQDA.WAGHWRGENATAETVICPLSYQ..TRLPLTALCARGFNVATGRPANFWAADLMHRLYHVPLIG.EEIVDHH....ADGYHGVQDLAAGINYTLAGHNSATLTYFATEAYAYDIAVPGEGCVGK Q0PV92_BEABA/6-253 FLLALAAPGLMASPLAAEK....ATPTELVTTPTSTPKAEAYNWSDGW.....................EQSFP.IHSSCNSTLRAQLQTGLDDAVQLAQHARNHILRFGSKSEFVQKYFGN.........GSLAEPIGWYDRVV...........................AADKAAMTFRCDDPDKNCASKPT.WGGHWRGSNATEETVICPLSFQ..IRRPLSSVCNLGYTVAGSPLNTIWAVDLLHRMFHVPTIN.VNTVDHF....ADDYNGILALAKK.DPSKSAKDSNVLQYFAIDVWAYDVAAPGVGCTGK C7ZGH1_NECH7/3-249 VAALLFGAAIASPIVPRE.....EAATQTAEAPKATESAGAYDWAEGW.....................KKAYP.IHQSCNSTLHRQLANGLDEAVQLATHAKEHILRFGHKSEFVQKYFGN.........ASTSQPIGWYERII...........................NADKTGMLFRCDDPDRNCATQDE.WAGHWRGDNATTETVICPLSFE..IRRNLDQVCNRGYTVAASKLNTFWATDLMHRILHVPTVS.EEVVDHF....ASAYTEVTALAKK.NPEESVIDSNTLQFFAIDVYAYDIAAPGVGCTGE Q6QUX8_VERDA/7-253 AALLLFPLVAASPVARAAE....TSVTVTVDTAPAGPTSSTYNWAEGW.....................KANFP.IHQSCNITLRTQLEAALAETMTIAAHARDHLL.HNPKSELATKFFGN.........QSVAGPIGWYSKVV...........................STDKSEMLFRCDDPDRNCATQDG.WAGHWRGSNATQETVICDLSYE..IRRPLAALCGGGYTVAESKLNTYWATDLLHRAFHLPGIS.DGIIDHY....AEDYAEALKLAAT.EPELSIIDSDTLQYFAIEAYAYDIAIPGVGCPGE Q2GQB8_CHAGB/5-265 ILSALYVLAAGTSALPASSAAQDTATTIPSSTASASSTPTPYDFTAGA.....................VPSFP.IHSSCNSTLRRQLERALDETVELAAHARDHILRFGSDSPFVQKYFGTGNGTDGAALASTAMPLGWFSRVA...........................SADRGNMTFRCDDPDENCATQDE.WAGHWRGANATQETVICAPSFA..KRRWLSSVCGLGHTVVGSPLNTFWATDLLHRVLHVPRIS.EGIVEHF....AEDYEGVLELAKS.DPAKSAIDSDTLQYFAIDVYAFDVAAPGVGCTGD B2AFK4_PODAN/177-421 TLLSLLTAAAAVSASPL..........GRQEITTTTTTIISNTGSSST.....................TPAFP.IHSSCNSTLSHQLTRAFDETVTLASVARDHLLEHGQSSPFVKKYFGP........NSTTIAPLGVFSRVA...........................SAARGKMLFRCDDPDRNCATQEG.WAGHWRGSNATQETVICDLSFAPGKRRWLDQVCGLGYTVKEGATNLFWATDLLHRTFHVPQVS.ENAVHHY....ADGWDEVLGMAEG.GDERSGFDSDALIYFAVDVYAYEVAEPGRGCGGY Q0UZ18_PHANO/4-251 YSSLVLLGASAAVANPIF.....PRQAAASSAPVAAVAPASTAWDAGA.....................VNEYP.IHASCNATQKAYIKKGLQETETIARHARDHILRWGNSSAIYKKYFGD.........AATGEPAGWFAKIA...........................DGDKAGVVFRCDDPDQNCATQKG.WAGHWRGANASSETVICDVSYE..TRRSLEGLCGFGWTVATGATNFYWAGDLLHRLLHIPKVG.EGVVEHY...SVGKYPGVLELAKE.NSTYAVRDSDTLQYFALEAYAQDIAVPGVGCAGK B2VUC4_PYRTR/5-254 LSALMLFGASAAIAGPIV.....PRQNGLTTAAPVAATPVATTWNAGA.....................VQNFP.IHASCNATQRTMLQKGLNEAITIVSHARDHILRWGNSSEIYTKYFGN.........APTGEPIGWYTKLA...........................DGDKADILFRCDNIDGNCG.QSG.WAGHWRGSNASQETVICDLSYE..IRKPLEAMCMHGYNVANGPTNYFWASDLVHRLLHVPSVG.EGVVEHYIGESGEKYPGVMNLAKN.NATFAVRDSDALQYFALEAYAHDIAVPGIGCSGT C5GRH5_AJEDR/4-248 PIPVVFASVYAGAVLAV..........PHADWNPAPPCHACAGWLQCNH..................SPRNDYP.IHNSCNATERRMIRRGLQDAMTLAARARDHVLWYGKDSALYRKYFGD.........GPTSEVIGNLERVV...........................SGKKWKTLFRCDDPDGNCKHFPK.YGGHWRGENATDETVICALSYH..TRLYLDYFCTRGYTVSGSPRNTYWGTDMLHRLFHMPAIG.ESYVDHF....ASSYEDVMHLAKY.NSTYATRDSNTLQYFAADVYGHEVAVPHFGCPGK C4JGA4_UNCRE/6-241 LPLLVIASPLLAAPLAG...............RELQPGNDLPPCDQGA.....................VQKYP.IPKSCNATERRLIPPGLDDAMTLSKRAKEHGLCFGNTSALDRKCFGN.........APSGEVIGNLYRIV...........................NADKGNTLFRCDDPDGNCQ.IPT.YGGHWRGSNATGETVICPLSYK..TRLFLEYFCTGGYTVSGSPLKTYFGTDLLHRLYHMPAIG.EGHVEHF....SNTYEDVLQLGAH.NSSFAVRDSDTLQYFAADVYGFDIAIPGVGCAGE Q8J0P2_COCPO/6-241 VSLLAVVSPLLAAPLAG...............RNSYPGNDLPAWDHGA.....................VTQYP.IHDSCNVTERRLIERGLQDAITLANHAKKHVLRFSNSSSIYRKYFGN.........APSGEVIGNLDRIV...........................NADRAKTLFRCDNPDGNCK.LPK.WGGHWRGSNATGETVICPLSYT..TRLFLEHFCTRGYTVAGSPLNTYFGTDLLHRLYHLPAIG.EGHIEHF....SDSYEDVLELGAH.NSSFAVRDSNALQYFAADVYGFDIAVPGIGCAGT B8MYQ2_ASPFN/4-243 LISFLLLSTVTAIPAPI...........SLTTRDQATPHAPSPWDAGA.....................TTQYP.IHQSCNATQRRQIEAGLNETIALVDHAKAHILRWGNESTIYRKYFGN.........RPSFEAIGAYDIVS...........................NGDKGSVLFRCDNPDGNCE.NEG.WAGHWRGENATAETVICDLSYS..TRRSLTSMCALGYTISGSETNTFWAADLLHRLFHMPPIG.QNWVEHF....ADGYGEVLELAAG.NESTSTRDSETLQYFALEAYAYDIAAPGVGCAGE B0Y6E9_ASPFC/7-249 LAVLLPLAAPLVATLPT........SPVPIAARATPHEPVFFSWDAGA.....................VTSFP.IHSSCNATQRRQIEAGLNEAVELARHAKAHILRWGNESEIYRKYFGN.........RPTMEAVGAYDVIV...........................NGDKANVLFRCDNPDGNCA.LEG.WGGHWRGANATSETVICDRSYT..TRRWLVSMCSQGYTVAGSETNTFWASDLMHRLYHVPAVG.QGWVDHF....ADGYDEVIALAKS.NGTESTHDSEALQYFALEAYAFDIAAPGVGCAGE A1CHQ9_ASPCL/5-238 LRLLCLLPVVLALPTAH.............VQRESPDKPALSPWNAGA.....................TTSFA.IHSSCNATQRRQIEAGLNEAVALADHAKAHLLRWGNSSDIYRKYFGD.........RPSMEAIGAYDVII...........................SGDKRDMLFRCDNPDGNC......WGGHWRGNNATGETVICDRSYT..TRRSLLTMCAQGYTVSASDTNTFWAADLMHRLYHMPAVG.QGRIEHF....ADGHEEVLTLAKG.EGDEPTHDSETLQYFALEAYAFDVAVPGVGCPGE B6HBQ3_PENCW/3-246 FFSLILSSAAIAAALPT.......RETSEGNQSQPFSQNGLAPWDAGA.....................VTQFP.IHSSCNATQRRQIELGLNETITLAQHAQDHILRWRNESAIYRKYFGD.........RPSMEAIGAFDVVV...........................NGDKKDILFRCDNPDGNCD.LEG.YAGHWRGENGTDETVICDLSYE..TRRSLSTMCGLGYTVSESETNTFWAADLLHRLYHVSAIG.QGWIDHF....ADGYEEVVDLAKT.NATLTTRDSETLQYFALEAYAYDISVPGVGCPGV ANG1_EMENI/3-233 LLALTLALCASIAALPT....................QQTPLPLEDPI.....................KSPFP.IHHSCNATEQRQLATALQETVTLAEHAKDHILRWGNESAIYRKYFGD.........RPSLTAIGAYDIIV...........................NGNPDNILFRCDNPDGNCA.LEG.WGGHWRGENASDETVICELSYT..TRRSLSTMCSQGYTISEWETNTFWAGDLLHRLYHMPAIG.QGLVEHY....ADGYEGVLELAEG.NRTEAVHDSETLQYFALEVYAYDVAVPGIGCVGG A3LZN3_PICST/4-241 SSVLLFTSTALAAPASP..............DSFSQVRVPAYDWSSGW.....................VKDFP.IHSSCNETQYNQLRSALEETEELAAHARDHTLRFGNNSDFFRLYFGN........ETASAEVIGWFDSIV...........................SEDKSALTFRCDNPDGNCD.LEG.YAGHWRGENGSDETVICDLSFS..SRLSLTKLCSAGFTVGRYKNTNYWSADLLHRIWHTDAFG.KGAIGHY....ADTYEDVLELAKT.NGSRAVRNSASLILYALDIYAHDISVPGVGCNGI A5DNU0_PICGU/4-243 SGLLFSVAIAAAAPAFV...........LEENLNSSTTEISFSWDATW.....................NQDFE.IHKSCNSTQRNQLVQAFTETKLLAQHAKEHTLRFGNSSKFYRKYFGD.........APSGEVVGLYENVI...........................SANKTGVLFRCDNIDGNCD.LDG.YAGHWRGSNGTDETVICDLSYT..SRLFLSQVCSRGYTVAGSKNTVFWAGDLLHRIWHTDKIG.QGVVGHY....ADTYNECLDLAKN.NATYAIRNSASLRYYAMDVYAYDIAVPGKGCTGK Q6BVW4_DEBHA/6-248 ILLLVFTTGCLAAPASS........SEDITVTKYVDSSSTAYDWSEDW.....................VKNFP.VHKSCNDSQFNQLSNALEETQILAAHARDHTARFGNSSRFYQKYFGN.........APSGEVVGWFENIV...........................SSDKSKTLFRCDDIDDNCK.LDG.WAGHWRGENATNENVICDLSYT..SRLYLAQMCSQGYTVSNSKNSVFWAGDLLHRIWHTDSIG.QGVVGHY....ADTYDECLELARK.NATEAVRNSATLRYYALDVYAYDIAVPGKGCTGD C4R4T0_PICPG/4-248 INLTITSLLALASRTTAE......DVTVTQLVSSPTSASEAGDWSANW.....................VKGFP.IHSSCNQTKFNQLSLGLEEAQIMAAHARDHTLRYGNESEFFTQYFGN.........ASTAEVIGWFSVVV...........................DADKSNLLFRCDDIDGNCK.FDG.WAGHWRGENGSDETVICDLSFQ..TRKFLAQMCSNGYNVANYPNNLYWASDLLHRLYHTTTIG.QLTVDHY....ADTYEECLELAIE.SPDEAVRNTASLRFYALDVYAYDIAVPGEGCSGE PRA1_CANAL/4-241 LLFCLFFAFSVAAPVTV..............TRFVDASPTGYDWRADW.....................VKGFP.IDSSCNATQYNQLSTGLQEAQLLAEHARDHTLRFGSKSPFFRKYFGN........DTASAEVVGHFENVV...........................GADKSSILFLCDDLDDKCK.NDG.WAGYWRGSNHSDQTIICDLSFV..TRRYLSQLCSGGYTVSKSKTNIFWAGDLLHRFWHLKSIG.QLVIEHY....ADTYEEVLELAQE.NSTYAVRNSNSLIYYALDVYAYDVTIPGEGCNGD C5MDK1_CANTT/4-240 SILALL.STAAAAPVTV..............TRVVDASPTGYDWQADW.....................VKTFP.IANSCNSTQFNQLAVGLQEAQTLAEHARDHTLRYGYKSPFYRKYFGN........ESSIAEVAGVFQTIV...........................SADKSDILFHCEDLDDKCS.NDG.WAGYWRGTNGSDETVICDLSFT..SRRYLSQLCAYGYTVSQSATNTFWASDLLHRFFHLDSIG.NQIIGHY....VDSYEESLEFSSS.NATYAVRNSDSLIYYALDVYAYDIAVPGEGCSGD Q4P9V4_USTMA/7-269 FVALTSLAVSAVSAAPFSS....LL.........ATRALESFQPEGQI.....................DSVWR.IHESCNGTQRAQISSGIDDMKKLAHNSINHILNY.PKDEFFIKYFGQ........DADPAPVVGYYVELVYVSVGDSRSVHVVDDDFMLTIDLLVCIQGNKGDALLRCDNPDDNCR.LPE.WNGHWRGNNATAETVICELSYV..TRRPLEKLCSAGFQLGTDNPSLYFGADLMHRAFHVPEFV.HEKIHHY....ADSYADVLELAEH.NSTAAVQNQHSLQYFALDVYSRKLT..KWGCIGD C5DDE7_LACTC/11-261 NGLVLLTSIVCIGTLIAGFV..LAIIAERDAVNIKNTRKTFTTVATGEW...................ANAQFPRLHKSCNATDVDFLTRTMNETMEVASYAKEQLLVKGANDTIYKRWFGD.........GELYDVLGVVDGIA...........................NMTKTDVLLRCDDVDGLCAANPNYYAGHHR.EKADAETVICDYFYE..SRAWLSDICANG.TLKDFPPPRYAGIDMIHRYFHVSFINLDEYIGEY....TEEVEDVLDLAKS.NSTFAVRNVDNYLYYLADVYSSDK.ISG.GCLGL C5DFQ2_LACTC/11-260 GIALSATFIVVAILVISMV...FGILADRKFNEKSGQTPNNPTVAATAW...................DDPVLPELYKTCNGTHLETLKSAFEETWNVTSFARSRLLAYGTNDRIYQRWFGD.........GSLYTVLGTIEALA...........................EVPKKDVLFRCDDVDGLCAANPSYYAGHHR.LNATQETVICDYFYT..AKKPVSEICSNG.TLAEVAPSKYMGIDMVHRYFHVPTVNLDGYIGEH....TEEVDEILSMASK.NSSFAVRNVDSYLYYLADVYSSAI.VPG.GCLGD ZPS1_YEAST/7-248 KSIIFATIASLALSAPV.............TYDTNSTAELQSPSSQEILG.................WSHATFPTIYQTCNETNARMLNAAFKDTAEITAYGKDRLLNYGVDDVYYKRWFGN.........GSIFTVMGVFEQLM...........................EASKGAMLMRCDDIDGLCAANPNYYAGHHR.QSAPAETVICDYFYT..SKKPLSTICFEG.TIVDVGPKHYAGIDMLHRYLHVPTMSMDGYVGEY....AETLEEVVDYTQN.NATYAVRNTDNYLYYLADVYSASV.IPG.GCLGN Q6CQ42_KLULA/8-279 SNILLTLYLALIAQASIVVKRADSSSTSSASSTSSSPATISKPASANLTTENQALAPFQDGVFEFFGWTNPTFPQYHNSCNITNQRMINGALIDTLEVSSFARDRLLANGTSDEIYKRWFGD.........APLFTVAGVIENTI...........................QGVKDDLLFRCDDPQGGCAANPTSWWGYHV.LNTTGETNFCDLFYS..GKKPLTHICFEG.TIVEVGPTLYAGIDLFHRYFHLDQMSSEGYIGEY....TEELDDILALAQN.NATYAVRNVDNYLYYLADVYAEAV.IPG.GCLGD Q6CV33_KLULA/6-251 SNIVGCISIISSIAGAT........PLKNHDFHSNSSLELIEFGESGESG.................WGSPVFPYFHQSCNATNQRMLSSGLKDTLEVTAVARDKLLANGT.DKFFKRWFGN.........SSVFTVIGTLEYVI...........................ESGKSDVLYRCDDPSGDCAVHSTDWPGYHV.TNTTGETNICDLFYQ..TKKPLSTICFEG.DIVELGPKHYSGIDLFHRFLHLDNLNGNGFISEW....TETLPEVLYLAEN.NATFAARNTDNYLYYLADVYAATV.NPG.GCLGE #=GC seq_cons hhlllhsusshAussss.............tspsssssssshsWsuuh.....................sssFP.IHpSCNuTppcQLpsGLpEshpLAsHA+-HlLRaGspSpha+KYFGs.........usou-slGha-pll...........................suDKushLFRCDDPDGNCs..ss.WAGHWRGpNATsETVICDLSYp..oR+.LsplCutGYTVusussNsaWAsDLLHRlaHlPslG.pGhl-Ha....A-sY--VLcLAcs.NuohAlRsS-oLpYFAlDVYAaDlAlPGhGCsGc //