# STOCKHOLM 1.0
#=GF ID   PEPcase_2
#=GF AC   PF14010.1
#=GF DE   Phosphoenolpyruvate carboxylase
#=GF AU   Coggill P
#=GF SE   manual
#=GF GA   25.00 25.00;
#=GF TC   25.00 25.00;
#=GF NC   24.90 24.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   15262949
#=GF RT   The phosphoenolpyruvate carboxylase from Methanothermobacter
#=GF RT   thermautotrophicus has a novel structure.
#=GF RA   Patel HM, Kraszewski JL, Mukhopadhyay B;
#=GF RL   J Bacteriol. 2004;186:5129-5137.
#=GF CC   This family of phosphoenolpyruvate carboxylases is based on
#=GF CC   seqeunces not picked up by the model for PEPcase, PF00311. Most
#=GF CC   of the family members are from Archaea.
#=GF SQ   27
#=GS B1I2W1_DESAP/7-489   AC B1I2W1.1
#=GS CAPPA_PYRAB/2-469    AC Q9V2Q9.1
#=GS F0LK16_THEBM/2-476   AC F0LK16.1
#=GS C6A2T7_THESM/11-485  AC C6A2T7.1
#=GS CAPPA_METHJ/3-484    AC Q2FLH1.2
#=GS CAPPA_METTH/3-483    AC O27026.2
#=GS B5YCF7_DICT6/5-497   AC B5YCF7.1
#=GS Q1PXR4_9BACT/4-490   AC Q1PXR4.1
#=GS D3S0D1_FERPA/2-476   AC D3S0D1.1
#=GS CAPPA_ARCFU/2-471    AC O28786.1
#=GS CAPPA_HALSA/4-492    AC Q9HN43.1
#=GS CAPPA_CALMQ/4-512    AC A8MBK0.1
#=GS CAPPA_PICTO/6-508    AC Q6L0F3.1
#=GS CAPPA_SULTO/4-511    AC Q96YS2.1
#=GS CAPPA_SULAC/4-511    AC Q4JCJ1.2
#=GS D2PDY7_SULID/4-511   AC D2PDY7.1
#=GS CAPPA_METS5/4-509    AC A4YES9.1
#=GS C6HVN3_9BACT/19-520  AC C6HVN3.1
#=GS A3EQI3_9BACT/19-520  AC A3EQI3.1
#=GS A8A9C2_IGNH4/3-488   AC A8A9C2.1
#=GS CAPPA_PYRAE/3-460    AC Q8ZT64.1
#=GS B1YBY2_THENV/2-461   AC B1YBY2.1
#=GS CAPPA_PYRCJ/3-459    AC A3MVZ5.1
#=GS CAPPA_PYRAR/4-460    AC A4WJM7.1
#=GS B1V5L0_CLOPF/3-537   AC B1V5L0.1
#=GS CAPPA_METMA/7-526    AC Q8PS70.1
#=GS CAPPA_METKA/9-532    AC Q8TYV1.1
B1I2W1_DESAP/7-489              ISRTMSTQHPDNVTVPFF.A.NSQDMSGEDEIQEAYYVIS.....HLQCQEQMWDCEGKEVDNFVVRKLLTQYEHFFAHNRLGRDVFLTLRVPNPTVEHTEGKVLIETLQSIPRSFDAARLVY...GE.EIPPIFEVILPMTTSHKCLNRVYYFYKDFVAGRQTLPFYPG..DISIAEWVGDFKPEEINVIPLFEDRHHMLEAAAILRRYL....ENK..PFTYQRVFLARSDPALNYGMISAVLLNKVALQRLAALEKETGVEIYPILGVGSAPFRGNLKPHTVERV.LAEYPDVQTFTIQSAFKYDYPVTTVLEGIRKINA.ASRGQAGEVDAER...CIRIIDSVSRAYASKVRVLAPVVNYVASAIPPRRKRKLHIGL.FGYARKT.SGV..............................SLPRAIGFCAACYSIGLPPELLGYAGL...DK...EDA......RYLQTVYHQLDQDLEDALPFFNED........VFKLVPELRHLLR.TELFPFRAD.............EEHRKITSRIIKAVREDRREG.................LTHLILEAGYLRGFLG
CAPPA_PYRAB/2-469               IPRIMSTQHPDNYSIPFF.A.NSPVLGGEDEITEAFYAFN.....VLGADEQMWDFEGKEVDEFVVKKLLERYPSFFRKVILGKDVRLTPRVPNPTVEKAEAKLLLETLQGITRAADYARVFY...GE.DIAPIFEVILPMTTSLAEIERVHELYRKVVNLADER.IYD....TTVKEWIGEFYPKEIGIIPLFETKVALLKSAKIIGEYL....ERR..EPEYQRVFLARSDPAMNYGLISAVTYVKNALQEIWELEEETSIPIYPIVGVGGPPFRGGMRPDNVDNV.LSEYPSVQTYTVQSSFKFDYPTKEVVKAVEKVKS.TKRKEPYSLE......VPDFITLYEVEYQRQVKILAPHIRRLATRIPDRRKRKLHIGL.FGYSRNV.GGL..............................SLPRAIKFTASLYSIGVPPELLGLNAL...TD...RQL......DVVSEYYVNIYEDLEFAMRFFSF.........RVAEKAGLKELVERIKEFKPEIE.............EEYVAEAEIVFRG..........................EGDIIKLAQMRGFLG
F0LK16_THEBM/2-476              IPKTMSTQHPDNVYIPFF.A.REPQLGGEDEIIEAFYAFS.....VLGIEEQMWDFEGKEVDEFVVKKLLERYPHFFRKHKLGEDFRLTPRVPNPSVEKAEAKLLLETLESISRSADYSKIFY...GK.EIAPIFEVILPMTTSANEINRVYDLYKRYIVGKQYKRVYD....VKLYEWIGKFFPEEINVIPLFETKDAILNSAEILREYL....HGK..DFEYQRVFLARSDPAMNYGLISAVVYDKYALFKLQELEEEESVSIYPIIGVGSAPFRGHLVPENVENV.LEEYRGAQTFTIQSSFKYDNPPREVIKAVEKIKS.SKRKEAEPINGQ....ILLILRKYEIEYSKQIKALAKLVREVAKFVPSRRKRKLHIGL.FGYARDV.NGF..............................ALPRAIKFTASLYSLGVPPEVLGLNAL...SE...KDV......EVISNVYNGIYKDLSLAFRYFNPK........SAEKFKFLRDILKMSQLFEFERN.............EEHCEITNKILDGEIN.......................EELIIKAASIRGFLG
C6A2T7_THESM/11-485             IPRTMSTQHPDNVYIPFF.A.HESSLGGEDEVLEAFYAFS.....VLGVQEQMWDFEGKEVDEFVIKKLLEKYGQFFKKKKLGRDIRITPRVPNPSVEKAEAKLLLETLESIPRSADYAKLFY...GE.EIAPIFEVILPMTTSSKEIERVYELYKRYIIGKQYKRVYD....IKIYEWIGEFYPEEINVIPLFETKEAILNSHEILKEYL....TGK..NFEYQRVFLARSDPAMNYGLISAVIYDKYALFNIQELEEELSVPIYPIIGVGSAPFRGHFIPENVENT.IKEYPNVQTFTVQSSFKYDNDPKEVIRAIEKVNE.RKRKKSASVDEG....VFKILEKYEKEYTAELKLLAPYIREIAKFVPSRRKRKLHIGL.FGYSRKI.NGE..............................VLPRAIKFTASLYSLGVPPELLGLSTL...SE...KDI......EELAEYYYGLYRDLEFALKFFNPK........TSQKFKFLNKIVKLQKEMGIEAE.............ERHQTLTSQIISGKFE.......................ESVIVQAADIRGFLG
CAPPA_METHJ/3-484               IPRTMSTQHPDNVHTPFF.T.ENIELTGEDEVKEAYYVYS.....HLGCTEQMWDCEGKEVDNYVVKKLLSRYGDYFKEHHLGRDLFLTLRVPNPEIERTEAKILLETLGSIPRSYDVAHHFY...ND.TYAPIFEIILPMTTSFASIDNIYQYYCDFVIGQQYKRLGGR..DLTIAEWIGPFHPDKIRVIPLFEDKDGMLAADTILRRYF....QDK..DLDYQRVFLARSDPAVNYGQIGAVLLNKIALWRLHLLSEDTGIPVYPIIGAGSAPFRGNLRPDTVRRV.TDEYAGAYTFTIQSAFKYDTNLEEAVSAIRYLEE.REITPAREIDDTY...AISLIERYAAGYQKQIRSLAPLINRVAAYIPSRRKRKLHVGL.FGYSRNM.GGV..............................SLPRAITVTAALYSIGIPPEVLGLSAL...TE...NDR......EFVLENYRYVTEDLSDACRYLNPD........SSFLPDEIKKI..LPDWIEIDPH.............SEHRVLSGQIEKAVTACQIDS.................VQDMIIRAGAIRKFLG
CAPPA_METTH/3-483               VPRCMSTQHPDNVNPPFF.A.EEPELGGEDEIREAYYVFS.....HLGCDEQMWDCEGKEVDNYVVKKLLTKYQAFFRDHVLGEDLRLTLRVPNPTVERAEAKILLETLESIPRSYDTASLFY...GM.DAAPVFEVILPMTSSSSCLNRIHSYYLDFVKGKERLQLAD...GVTVKEWIGEFRPDEINVIPLFEDHEGMLNAAKITGEYL....DGK..DIQEQRVFLARSDPAMNYGMISATLLNRIALSDFRDLEEESGVKLYPIIGMGSAPFRGNLRPDNVEDV.TWEYRGAYTFTVQSSFKYDHEPSDVIRGIKKLRS.VKPGRAAEIERES...VLEIISAYCREYRRQVMDLVDIINRVARYVPGRRKRKLHIGL.FGYSRSM.GNV..............................SLPRAITFTAALYSLGVPPELLGFNAL...SS...GDL......EFIEEVYPGLGRDLHDAARYANPE........SPFLSPEVKSSF..EEYLEPEYD.............EGHMKTTEEIIRALRINRTAN.................LQELILEAASQRKFLG
B5YCF7_DICT6/5-497              IPRTMSTQHPDNANVPFF.S.NNPVLQGDDEIKEAYYAFS.....YLGVDEVMWDVEGKETDEFVIRKLVSDYPEFFKQKVIGKDIFITLRVPNPNYEKAEGKLLIETLESIPRSYDTAYVFY...QDESVVPIFEVIVPMA.DTETCNRVYYYYKNVVAGKEDKPFCDTNPQLKLKDWIGEFRPKKINVIPLFEDIDNIINVDKNLKEFL....KDKLDEVEYQRVFLARSDPAMNYSSLSVIIAIKLALEKLYELQESLKLPIYPILGCGTAPFRGNFSPNTYRYV.INNYPSVATFTIQSAFKYDFPVKEVQRAIENINL.TPVKSPNSISSKDR..VESIMYKVSSEYKKQLAEIAPLVNNIAVFVPKRRARKIHVGL.FGYSRQTDEGI..............................TLPRVISFCAVLYSLGLPPDILGLSAL...TD...EDI......KYVESVFPRFKEEMSEILSMWNEDVL...DLLPVSIRSEIKQT...VKRFDFEIN.............QEHLSFSKDLVKRIKENKFDT................KITDLIVASAKVRNFLG
Q1PXR4_9BACT/4-490              IPRTMSTQHPDNVIMPFF.T.EGAPFHGEDEIKEAYYVFS.....HLRCDEQMWDCEGKEVDEFVIKKLLTRYENFFKNKRIGKDLFITLRAPNPAYEMSEAKILLETLESAPRSYDTARIFY...GDGAVPPIFEVIIPMTTNADIINRVYHYYHDFVVGKQYKKCFSG..DITIREWIGEFMPETIEVIPLVEDVQYMLSADAIVQDYL....KDK..NFPYQRVFLGRSDPALNYGFLPAVLVVKIALQRLNLLQEKLKIPIYPILGVGSNLFRGNMTPFNVKEC.LNEYPSVQTFTIQSAFKYDYDEEVVRKAVETINN.QERKPPVVIDEET...ALDITKRLSSAYREQIKELAPLIGDIARFVPRRRMRKLHIGL.FGYSRNV.EGI..............................TLPRVISFCAALYSIGLPPELLGLHAL...TG...KDL......SFLKTAYPGFFEDISIAASYYNEDVK...KLISPKIAKDIEKALGVTNYVEN................LLHSEYTTQIINALLSKKEET.................VSENIISAGKVRGFLG
D3S0D1_FERPA/2-476              VPRVMSTQHPDNANVPFF.A.RGEYLNGEDEVKEAYYVFS.....HFGCDEQMWDFEGKEVDDFVVRKLLSNYPDFFKKKPLGKCFRLTPRIPNPSVEKEEAKLLSEILEMIPRSYDYVKSF.....DIDHEPIFEVILPMTRTHEEVLRIYYFYKDFVAGKGKLSLRD...GTKISEWLGEFKPEEIKVIPLLEDKNSLLNAEKIVSKIV....EET..GSENIRVFLARSDPALNYGFVSATIYVKYALMRL....EDVNAEVYPILGVGSCPFRGGLSPKNLQ.P.VDEFPSVETFTVQSAFKYDYEFSEVRKAVERIKE.KRRGKAEVIDEE....HLKVAEKLTEAYRMRIPLIANFVNSFSKNIPRRRMRKLHIGL.FGYSRG..EGV..............................KLPRAITFCAALYSIGFPPELLGIAEL...SD...KDY......EVVTEVFRGFENMMREALKYFNPNSL...KVLNSKLEKDVERA...KELFEIEVD.............EEHEKVTNEIINTLGKGLD...................LKERVAEAGILRGFLG
CAPPA_ARCFU/2-471               VPRVMSTQHPDNARIPFF.A.ASEVLNGEDEVREAYYVFS.....HFKCDEQMWDFEGKEADAHIVRKLLSSYYDFFSSRPLGKDFRLTMRVPNPEIEKGEAKLLAETLEMIPRSYDYVRSL.....GIEHPPIFEVILPMTRSAEEVMKVHAFYRDFVAGKGRFELLG....EKVSDWLGDFLPEEIKVIPLFEDRDSLMRAAEISERYA....EWA..ELDELRVFLARSDPAMNYGFVAATIYVKKALYDL....SQLGISTYPILGVGSCPFRGGFSPKNLS.V.LDEFPSVYTFTVQSAFKYDYEFGDVRRAIKRAKE.AARRKSDYVDEE....HLQVAEKLKDGYRRRIAKIAEIVNRISSRIPRRRMRKLHVGL.FGYSRG..EEI..............................KLPRAITFCASLYSIGLPSEIIGIAEM...SD...KDY......EAVCEVFKNFDGMMESAMSLFNPES.....LKIVDLSMDFERA...KELFGYEPD.............ERHLEKTNEIIKQIDGD.....................IKNLVVEAGILRGFLG
CAPPA_HALSA/4-492               VPRLMSTQHPDNATLPFF.T.AGDVIEGEDEIQEAYYVYS.....HLGCDEQMWDFEGKEGDEYAVKKLLSRYDEFFADHQLGTDVRLTVRGPNPDVEGSEAKILLEILESIPRSFDAARRFAGEYGLETTAPIFEVIVPMVTDADQLNAVHEYYERFVTGKADEAVWD...GRTVEEWVGEFDPASITVIPLIEEREAMLAADDIVREYA....TAH..DQDAVRVFLARSDPALNYGCLAADLINKVALQRLYEMSEATGVDVHPILGAGSAPFRGNLTPERAAAT.ADAYSEVETFTVQSAFKYDYPVETVRDGVATLRD.ADLGAPPFPIDEAR..ALAVIDRTADAYADQVDAIAGTVNRLSSYVPDRRARKLHVGL.FGYAREV.GEN..............................ALPRAIGYTASLYAVGCPPTLLGAHAL...TD...DDA......AFVREAFPAYFDHLADAARYFNPR.......CTDVLDLDDDTLAAAVERVDVTPN.............SEHRAATDDAIDALQRGDDDA.................LRSAIRRGARERQFLG
CAPPA_CALMQ/4-512               IPRTMCTQHPDYANVPQW.V.VNDFIKGDDEVYEAYMNYS.....IYDCQETMWDFEGKDVDIYVVRKLLENYGGFFINKVLGEDIYLTYRLPNPNVEASDRKIFAEALETIPMAYDLARVFY...GK.PVKAIFEVIFPLTSSSRDLIMTLRYYERIVAGKCSVELDD...GLKVSDVIGEVEPKTIEVIPLVEDMESLVRIDSIIEGYV....KVA..KPQYLRVFIARSDPAMNYGLIPAVLLAKIALSRVYAIGNSLGLSIYPIIGVGPTPFRGNFNPRNVNNT.LKEYPGVYTFTVQSAFRYDYPVDNAKDAINLINN.SKPTEPVILSSDEEELALTIIRQYTDRYQAEVEGLANAVNYIAQLLPPRRTRRLHIGL.FGYGRGF.RGV..............................TLPRAIAFVGALYSIGIPPEILGLSTLLKLNE...RQW......GVLEGNYVNLWSDLSDAAQYICMECIEQLPSMKSELRVSKETIAMVLEDIKAIDE.LGVKVSSPGFEQRKHALLTKLFLESVNNSYIND.................AKAYLLDMAKVRRAIG
CAPPA_PICTO/6-508               IPKTMSTQHPDNAKMPAWAS.EKSMIRNDDEVEEAYQCYT......IGIKEVMWDAEGKDVDTHVLRKLISKNHEFFEKNVLGSDIFLTYRVPNPAIEGTERKVLTETLESIPVNYDVFNTVY...KR.DIPPIFEVILPFTTSSKDLLNIAKYYEKAVAARDEIELYD...NVMVKNILGETKPKKINIIPLIEDKDSMFNIDGIVKNFA....RAV..SAKKMRVFIARSDPAMNYGMIPAVLMSKYAASRLCKMNDD..IENYPIVGVGSSTFRGRFSPENIEKS.LYEYSNYYTFTLQSAFKYDYPQDSVKNSINIINR.HE.RSFDYLEDYEEEIIKNAVNKYVINYQKIIEKLAPAINNITMYLPKRRSRKLHIGL.FGYSRST.GNV..............................TLPRAISFVGAMYSMGLPPEIIGISSLLNMKD...DEL......DIIEKTYINLRSDIMESSSYLNYEVF...DALKDVYKIDQETINMIKADVKYIENNYGIKSD.LGYERERHNYLSSLMNLAFKNHDFEN.................TRKYILDMALIRKFIG
CAPPA_SULTO/4-511               IPRTMSTQHPDNARVPEW.S.RSEVISGESEVIEAYLAYE.....HYEVDEVMWDAEGKDVDTHVVRKLLTQYPEFFKEKILGRDIFLTYRIPNPKIEGAEKKVFAETMESIPITYDLAEKFF...NTKPTPPVFEVILPFTTDYKELIAILKYYEVAIVNKENVKLVD...DIYVKDLIGEINPKSIEIIPLIEDRDSMFKIDQIVGEYI....KAM..KPPYMRVFLARSDPAMNYGLISAVLSVKYALNRLGKIEKKYGIKIFPLIGVGSLPFRGHFNPMNFEKV.IDEYRGVYTFTVQSAFKYDYEDNEVINAIRKINE.REISEFELLDEEEEKILHRIANVYTSSYQPIIESLADVINKIALFLPRRRARKLHIGL.FGYSRST.GKV..............................TLPRAITFTGALYSIGIPPELIGISSLSTLTE...KEW......NVLEKNYKYIKHDLQAAARFVSYESI...DLMKETWNVNEEIIKKIMEDLSYAENTLNIKIGDSNSVGRKHALISSLALIALKEGNIDE.................AKSYLLEMAKIRKSLG
CAPPA_SULAC/4-511               IPRTMSTQHPDNAKVPEW.N.QGEAISGENEIIEAYLAFS.....RYGVEEVMWDAEGKDVDTHVVRKLLSQYPEFFRHRILGKDIFLTYRVPNPKIEGAERKVFAETLNTIPITYDLAEKFY...GENPNPPVFEVILPFTTSYEELIAVIKFYEKVIVNSDNTKLVD...DTYVKDIIGETNPKKIEVIPLIEDRDSMLRIDTIVGKYI....EIE..RPPYLRVFLARSDPAMNYGLLSAVLSVKYALSRLSKMEKIYGVKIFPLLGVGSLPFRGHFSPYNVENT.LNEYRGIYTFTVQSAFKYDYEDDLVISAIKKVNG.TNVTEKIELSEEDEEIISNVTRKYTQGYQNKIEALADVINKVALLLPRRRARKLHIGL.FGYSRST.GKV..............................TLPRAISFVGSLYTIGIPPEIIGLSSLSKMTD...QEL......NAIFNNYKYLKNDLQFAARFVNFEAL...QLLKDIWNIDAEVVKAIKEDIDYAENSLGIRIGESDYMSKKHVLLSTLALLSIKEGKLDE.................AKTYIKEMAIVRRAIG
D2PDY7_SULID/4-511              IPRTMSTQHPDNAKVPEW.A.KSEVIEGEDEVKEAFLAYS.....MYGVHEVMWDAEGKDVDTHVVRKLLSNYPDYFREHILGKDVFLTYRLPNPKVEGADRKVFAETMESIPITYDLAEKFY...GNGITVPVFEVILPMTTSNLEIISVARYYEKAVANEDELELYD...GVKVKDLVGEIYPKVIEVIPLVEERDSLQNIDNIVEGYY....KVI..KPKYMRVFLARSDPAMNYGMITAVLSVKIALSELYKLSESLNFEIYPIIGVGSLPFRGHLSPENYEKV.LEEYKGVYTYTIQSAFKYDYDYDKVKSAISSINN.SRIGPAKILEKYEEDVLRKITILYTERYQPIIESLANAINDVSVLLPRRRARKLHIGL.FGYSRSA.GKV..............................SLPRAISFVGSLYSIGIPPELIGISSLSNLDE...KEW......DIFKQNYVNFKHDLQTAARFFNWESF...ELIKDIWKISEDTIAKIKEDIDYAESVIGIKLGGIDYDSRKHILMSSLFLLSFKEKILQE.................SKKYLYEMALIRRSLG
CAPPA_METS5/4-509               IPRTMSTQHPDNATVPEW.A.KGDVIEGEAEVIEAYYAFS.....RLNVHEVMWDAEGKDVDTHVVRKLFSSFDEYFKNNILGEDIFLTYRLPNPKIEGAERKVFAETMESIPITFDVAERFY...GR.KVVPVFEVILPFTTNASDIISVARYYERAVAMEENIELQD...GVYVRDLVGEIYPKRIEVIPLIEDKDSLLNTRNIIEGYY....RAI..KPSYMRLFIARSDPAMNYGMLTAVLLAKYALSEAGKLAEELGIPIFPIIGVGSLPFRGHLSPENYQRV.MEEYEGVYTFTIQSAFKYDYSEEQVKGAISHINR.EEVKEPRILGEEEKKVTRDIIETYTLSYQPVIESLANLINTVALHLPRRRARKLHISL.FGYARST.GKV..............................MLPRAITFVGSLYSVGLPPEVIGISSLGKLNE...MQW......NILEENYKFLKNDLQKASEFINPEGL...STLVSYGYLDAEISKKLEEDIKYLES.MGVKIGPRSYETKKHALLSQLLMLSLKEKKYNE.................VKQYAREMAVIRKSIG
C6HVN3_9BACT/19-520             IPTTMATQHPDNAAPPYWKGNQDPFISTLDEIEECYRSYI.....DIGCQEYMWDWEGKYVDEGVVEKLFSTYYDYFKDNQIGKDIFLTFRLPNIWYEKEYR..IARAYIGILTFEDLARDL.....HLKTPPVFEVILPMTDEGQKMLYLQQTFRKIAKLKN..........QVFDEEGTVKDSSYLQVIPLVEGVSELTASRKILHDYVDLHDREYSTKPLYLRPFIARSDPALNAGIVPATIAAKVALSEYYKFEEETGIPVFPIMGVGSLPFRGGLSPWNVPHF.IEEYPGVRTVTVQSAFRYDYPQEDVREAITLLNRSLPGAVPLAYTPEEVKAGERLAEIFSDHYRKTIEEVADVINRVSSRIPPRRERKLHIGL.FGYSRGI.GQK..............................QLPRAIGFTASLYSLGIPPELIGTGRGIAQAI...REGL....GDHLSLFYRRLKDDMQDAGNFLNKE.......NLEFLAAEDQAWRTVKEDIDLIEDFFKITLGPVTIEHYLHRNFVSSIYFLMQEEKD...................FSEYLLNAATLRRSLG
A3EQI3_9BACT/19-520             IPTTMATQHPDNARAPYWKTNNDPFISTLDEIEECYRTYT.....DLGCQEYMWDWEGKYVDEGVVDKLFSLYHPYFSENQLGKDVFLTFRLPNIWYEKEYR..IARAYIGILTFEELSRDL.....GLNSPPVFEVILPMTDEAQKMIYLKTTFRKIAKLKS..........QVFDETTEASDPSYLQVIPLIEGVPQLAASHNILMEYADLHQKEYGSKPSYLRPFIARSDPALNAGFIPATIAAKVALSEYYKFGQESGIAIFPIMGVGSLPFRGGLNPFTVSQF.LDEYPGVRTVTLQSAFRYDYPLDSVKEAIHSLNRALPFTKPLTYTEEEIAMGERLAQLFSTIYQETVEEIADAINQISSHIPPRRERKLHIGL.FGYSRGI.GQK..............................RLPRAISFTGALYSLGVPPELIAIGRGIEAAI...KENL....EDALFMFCRHLKEDLRHAGHYLNRE.......NLRFFASGNPAWERILEDIIIAEKYFKLELGPVTTEHYLHRNIVSSIYFLTQEEKD...................ISPYLFDAALLRRSLG
A8A9C2_IGNH4/3-488              VPKLMATQHPD..........STVVLMPQDEVEEAIQDVLPLDQGGRGCDEKMVDYEGKATPYNQMRDIIEEVRK..YDVVPGEDFLITPRVPNPKLEDKDRHLLAITAAVTANMY.SQMYF.......NTDAIKYIILPMSTSTLELAEVQRRILKVER.............LVSEEFSLRIE.EWIKLIPLFETAESHMHIDEIVEGLRIAFIKEIGMFENEFRIFMGKSDSGIHSGHIASSIGVRMGLLKLWNWQKDTMFKVYPIIGMGKPPLRGHMAEWVIEDW.VEAWRGYYTATVQSALRFNTDRKDYVHTITVVTK.NSGKQPPLELLGYAKEMVNVAWRASEVYLSRLERLADMISFMAKFVTRTRARLD......SYKRRA.KTG.............................KEMPRAIRFCASLYSMGLGPTLIGAGVIEELASGTAEKL......EHLLKFVPLLPKDFAFDYAFTDLE........VFKRYVDEKTFEIIKKDVDVVKEYFANV.....EPPKSPPEGYFEKLRELRGALDEAEV.............SRAKAIVMELAEMRGFLG
CAPPA_PYRAE/3-460               IPCLMCTQHPD..........STVKITAGEEVDEAVVAFL.....AYGCDEVMVDYEGKATPYSQPRDVASKALA..LGLPLGERFFITPRVPNPRLEDFERSMLSLEAAVLANSY.SQRAA.......GVQAVKWVVLPMTEDVETMAFVYKALDMKAR..............DLAELNAVKRDSSIELIPLVEDAMRQIKIESFIKALFR.TAAQSGRILEHMRIFLGISDSAVRHGHMASALAMVKALGQISEINRDGEFKISPIVGMGSPPFRGGLNNPHLAVPEAAQYAGYKTATIQSAVRYDVSYAEYQKVREAILS...VYTPRRLHVEE.....AWITKASELYREAIRPYIGKIAELANAIPSTRDRVSWR....EYGRVI.EGVE............................WRVPRAIVYTATWYFAGVPPTLLDARFIAWAYK..NDLL......DDVLRALPATVEEWKFESRFYSRE........RAEKTLGGEIVKDIDNAFDILGI............KPEPDRTYITLLNSADT.......................QPHAIALGRIRGFLG
B1YBY2_THENV/2-461              IPRLMCTQHPD..........ATVKVTASEEVDEAIVAYT.....AYGCDEVMIDYEGKTTPYAQPKDITVKAHD..SGLPLGEKFYLTPRMPNPRLEEFERSMLTLEAAILANYF.SAKLT.......GRQAIRWVVLPMVADVETLGLVYRMLIHKTE.............AYTRETGVKL..EPPELIPLIEDAVAQLKADELIGGLL....KQMSQPPRYLRLFLGKSDSAVKHGHIASALAIVATLSKVKAVERELGVKIYPILGMGSPPFRGAINNPTLSHLEVIQYAGYYTATIQSAVRYDTSYDEYTRVRESILN.ACCLPSRDIDTPE...VEGLITKASSTYRSLIVKYAERVVQVARLVPGTRDRVSWA....VYGRNI.TAEDR..........................VVNMPRAIVYTSTWYAMGLPPIFLDAPTVVELAK..SDQL......DVVLRALPTLKREWEYDAQFFDPQ........TAAKYTSEELVKTVQEAMDYLGI............NARASGTYLSLLRMNRN.......................ESNILAMGKFRKFLG
CAPPA_PYRCJ/3-459               IPRLMCTQHPD..........TTVKITAAEEVDEAIVAFT.....AYGCDEVMVDYEGKATPYSQPKEVVMKAAK..SELPLGEKFVITVRLPNPRLEEFDRAMLALEAAVVANYF.SVKYM.......GVRAVKWVVLPMVEDVETMSLVRRMLKRKVE.............DYKAEAKVDV..GNIEVIPLFEDAFVQLKAKALLGEVF......KGEEVREVRLFLGKSDSAVKHGHLASALAIAYTLSRLGDVESELGLRIRPILGMGSPPFRGGLNNPRLAPMEVVQYAGYYTATIQSAVRYDVALEEFLKVREAILN..GCCAPRQRAPDE...VLHIVQEASARYRALVMKYADKVIEVARLVPSTRDRVSWT....AYGRTL.TGGER..........................VVNMPRAIVYTSAWYATGLPPTLLDAPYLLELAK..SDKL......DLVLKVLPTYLKELEYDLEFFDRA........TAEKYLDGEIVKAVVELADYLGL............EARPNPAYATLLRMPRN.......................EANIIALGKYRKFLG
CAPPA_PYRAR/4-460               IPRLMCTQHPD..........TTVKITTAEEVDEAIVAYT.....AYGCDEVMVDYEGKMTPYGQPKEIVMKAIR..GDVPLGDEFYITVRLPNPKLEEFDRAMLSLEAALVANYF.SRRYA.......DAQAVRWVVLPMVEDFDTVILVRRMLRRKAE.............IYKSETGVDV..GEVEVIPLIEDAFVQVKAKVIVGEVF......KSEEAREVRVFLGKSDSAVRHGHLASALAIIYAMSKLKEFEAESGIRVRPILGMGSPPFRGALNNPRLAHLEVVQYAGYYTATIQSAVRYDTSLDEYVKVRESILN..ACCGTRGLVGEE...VLPLIQEASAKYRSQAMKHVDKIAEVARLVPSTRDRVSWK....EYGRSL.LDGDR..........................VVHMPRAIVYTSAWYAMGFPPTLIDAPLLLELAK..SDKL......DAVFKLLPTYKMELEYDYEFFDPQ........TARNYLSEELVYAAVELADYLGV............EARPTPTYTALLKMPRS.......................EPNIIALSKYRKFLG
B1V5L0_CLOPF/3-537              IPCSMMTQHPDN.........VETYISIQQEPAEAIKGLTPQDKGGLGIEEVMIDFEGKLTPYHQTSQIALGLIS..NGIIPGKDVRVTPRIPNANKESVFRQLMSIMSIIETNVQ.SKELT.......GTPAISEVVVPMIETGKEISEFQDRVNSVVD.............MGNKNYKTKLDLNSVRIIPLVEDVPALANIDRILDEHYE.IEKSKGHVLKDLRIMIARSDTAMSYGLISGVLSVLMAVDGAYKWGEKHGVTISPILGCGSLPFRGHFSEENIDEI.LATYSGIKTFTFQSALRYDHGEEATKHAVNELKAKIEESKPRNFSEEDKDLMKEFIGICSKHYLQTFLKVIDTVSFVSDFIPKNRDRLTKAKTGLEYNREV.ANLDNVADLVKDEVL.....KQEILSIDNSKEYAVPRAISFTGAMYTLGMPPELMGMGRALNEIK...TKYGQ.EGIDKLLEIYPILRKDLAFAARFANGG........VSKKIIDEEARQEYKEDMKYVNEILNLGL...DYDFLNENEFYHTLLKTTKPIIMHLMGLEENVMRNSTEELKILNEWIVRMGKVRGSIG
CAPPA_METMA/7-526               YPKVMCTQHPDS.........ASKYISTQEEPGEAIEAAV.....VFGCDEYMPDYEGKATPYHQNVQIVSRFIEE.TDLIPGKDIFITPRAPSAAQENRFRQLMVMMSIAEANHG.ALEYS.......DVQAINEFVHPMTGTVGEILDAQQHMVDVGE.............LAKKEFGVAM..EVPRIIPLIEDAPALLHAKELAENTLLSWEKRFGAAPEKFRVFLGKSDSALSFGHVASTLSCKYAISGISELDLELDTSTGIIFGAGTLPFRGHLSLKNAENF.FREYRGIGTITLQSAVRYSHDKGEAEALVRLAEE.RLPESPEIYSGEEKEEIVNLIGIFGARYNRIIREMSCTINQLAGLLPQQRDRLMHKGT.GGYSRNV.PDISGLVCLCRKDVG......KELSASMPAEDLNLPRAIKFTGALYSIGLPPEFIGTGTALEEAR...EKLGEEACERLLKKYFPSLASDLSFASGYLDLN........VASRFLPEACLKEIRKDIEVLRDTFSL........KVQPEPSYRILLEMMQPDLLQAGTKGNCM...DEEVSQLVCSTLTKMGKIRKALG
CAPPA_METKA/9-532               IARTLATQHPD..........ATKFVRVQEEPEEAVECLV.....ELGAEEYMVDFEGKLTPYLQPIQVLMELYD..AGVRVGEERFVIVRVPSATKENVLRQVQALLGVMEANSELLKEDP.......DARGIFEVVHPMTSSPEELVETVDRISYARR.............FASRELDVPLKAGNLRIIPLIEEVPELLDIRNILTGYVE.GMREIGMDVSYLRVFIGRSDPALSYGHLPAVLACKLAIFEVYELSDELGVPMAPILGGGCLPFRGHIRPGMEEEF.VEEYAGTATYTVQSGFRYDHDREKAVASIRRINE.LAANDPLQLSGDDIEYLVLATAIFMKHYLSVFFRCIGTLNIVADMIPNTRDRLARKGP.VGYARDI.PEPDRVGAQCKDLGDVGRELYRELRRMRVEKLPELPRAIKFTGACYTVGMPPELIGTGRGLAEIE...ERLGEDALDAVISRLYPMLREDLQFAVEYTFLE........TAGSVLPSSGVAMVNTDLEYCVEYLDL........EPPSDFEYQNLVHTLEPYLRYVVSEGGV.....EEVNPFVRDLLLEMGRMRGSLG
#=GC seq_cons                   IPRsMuTQHPDNs.hP.a.s.psshlsu-DElpEAahsao.....thGs-EhMWDaEGK-sDpaVl+KLlopY.caFpcphLGcDlaLThRlPNPplEpsEtKlLsEshtsIspsaDhuchh.....t.sssPIFEVILPMTsssccl.plhchYcchlt.pt...h.s....htlcEhlG-h.PcpIcVIPLlEDtsuhlpscpIlpcYh....ctt..c.pahRVFLARSDPAhNYGhluAsLhsKhALpclhclpc-hulplaPIlGsGSsPFRGphsPtslpps.lpEYsGlhTaTlQSAF+YDashccVhculcplpp.tphppst.lsp-c...hhplhpphoppYppplcplAshlNplAphlPpRRpRKLHlGL.FGYuRsh.ssl..............................sLPRAIsFsuuLYSlGlPPELlGhusL...sc...cch......-hlpcsa.tltcDLphAscahN.-........ssthhhstctlhtlp-th-hhtp.............pcHp.hsppllpshppt.....................hcshllchuplRtFLG
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