# STOCKHOLM 1.0
#=GF ID   Requiem_N
#=GF AC   PF14051.1
#=GF DE   N-terminal domain of DPF2/REQ.
#=GF AU   Weichenberger CX
#=GF SE   Joint Center of Structural Genomics (JCSG)
#=GF GA   22.00 22.00;
#=GF TC   22.10 22.10;
#=GF NC   21.20 21.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   20400511
#=GF RT   Double PHD fingers protein DPF2 recognizes acetylated histones 
#=GF RT   and suppresses the function of estrogen-related receptor alpha 
#=GF RT   through histone deacetylase 1.
#=GF RA   Matsuyama R, Takada I, Yokoyama A, Fujiyma-Nakamura S, Tsuji N,
#=GF RA   Kitagawa H, Fujiki R, Kim M, Kouzu-Fujita M, Yano T, Kato S;
#=GF RL   J Biol Chem. 2010;285:18166-76.
#=GF RN   [2]
#=GF RM   20460684
#=GF RT   Requiem protein links RelB/p52 and the Brm-type SWI/SNF complex 
#=GF RT   in a noncanonical NF-kappaB pathway.
#=GF RA   Tando T, Ishizaka A, Watanabe H, Ito T, Iida S, Haraguchi T,
#=GF RA   Mizutani T, Izumi T, Isobe T, Akiyama T, Inoue J, Iba H;
#=GF RL   J Biol Chem. 2010;285:21951-60.
#=GF DR   INTERPRO; IPR025750;
#=GF CC   This putative domain has been detected on the human DPF2 protein
#=GF CC   and was subsequently targeted for structure determination by the
#=GF CC   Joint Center for Structural Genomics (JCSG). Possibly, the
#=GF CC   C-terminus extends by 30 amino acids and forms a separate
#=GF CC   domain. DPF2 interacts with estrogen related receptor alpha
#=GF CC   (Err-alpha), an orphan receptor which acts as a regulator in
#=GF CC   energy metabolism [1].  It was also identified as an adaptor
#=GF CC   molecule that links nuclear factor kappa-light-chain-enhancer of
#=GF CC   activated B cells (NF-kappa-B) dimer RelB/p52 and
#=GF CC   switch/sucrose-nonfermentable (SWI/SNF) chromatin remodeling
#=GF CC   factor [2].
#=GF SQ   13
#=GS C3Y0H4_BRAFL/2-75   AC C3Y0H4.1
#=GS Q4SC22_TETNG/1-74   AC Q4SC22.1
#=GS A5PF46_DANRE/12-85  AC A5PF46.1
#=GS D1LWY4_SACKO/16-89  AC D1LWY4.1
#=GS Q6DJ77_XENTR/17-90  AC Q6DJ77.1
#=GS B7PW53_IXOSC/1-74   AC B7PW53.1
#=GS Q16SM0_AEDAE/24-97  AC Q16SM0.1
#=GS B3N0A7_DROAN/23-96  AC B3N0A7.1
#=GS Q16QH5_AEDAE/24-97  AC Q16QH5.1
#=GS B4J9F4_DROGR/20-93  AC B4J9F4.1
#=GS D3PK65_9MAXI/19-92  AC D3PK65.1
#=GS A8QFY3_BRUMA/2-76   AC A8QFY3.1
#=GS YP99_CAEEL/2-78     AC Q09477.2
C3Y0H4_BRAFL/2-75              VGNQFYKEALENASHFNARVVMER..KLRLPFLDTLTGVAQTNC.SLWMTPSQRRPGIAPGQIYTFPAKRWRKKRRA
Q4SC22_TETNG/1-74              LGDQFYQEAIEHCRSYNARLCAER..SVRMPFLDSQTGVAQNNC.YIWMEKRQRQPGQAAGQMYTYPARCWRKKRRL
A5PF46_DANRE/12-85             LGEQYYRDALEQCHNYNARLCAER..SVRMPFLDSQTGVAQSNC.YFWMEKRHRGPGVAPGQLYTYPARRWRKKRRA
D1LWY4_SACKO/16-89             DWDQYYKDTLDNASHYNTRLTIER..KLRLPFLDSHTGVAQNNC.YIWMQKRHRGPGEAYGQFYTYPSRRWRKKRGR
Q6DJ77_XENTR/17-90             LSEQYYREVMDSTSNYNVRLCSER..RQRLPFLDSQTGVAQNHS.NLWVPYTYRRPGKCHGQLYSYPARRWKKKCSL
B7PW53_IXOSC/1-74              LADPAYKDAMESSSSANTRLVVER..RLRLPFLDAQTGVAQSDC.ALWMPRWQRMPGHGDGQLYSYPARRWRKKRRQ
Q16SM0_AEDAE/24-97             MRDSTYRETLEVSASFNTRLCLER..RMRLPFFDSQTGVAQNHS.TLYMKHCRRMPGHREGQLYTYPSSRWRKSKRQ
B3N0A7_DROAN/23-96             LKDVSYRETIEYSANFNTRLCIER..RLRLPFLDPQTGVAQNHS.QLFLDKRQRMPGFRQGQIYTYPAARWRKSRRQ
Q16QH5_AEDAE/24-97             FNDSAYKEAIENSETFNTRLCIER..RLRMPFLDPQTGVAQYHS.SLFFRARQRIPGLKEGQIYSYPSARWRKSRRQ
B4J9F4_DROGR/20-93             LNDTAYKEILENSENFNTRLCIER..RLRMPFLDPQTGVAQTHC.ALFMKRKQRMPGFRHGQIYTYPSARWRKPKRQ
D3PK65_9MAXI/19-92             FDDPSYKEYLENATAFNRKLNEER..RMRIPYIDGQTGVAQRHY.NSYRSSRERMPGRREGQILTYPQKPWRKKKFQ
A8QFY3_BRUMA/2-76              ISESLYIEMMKNCSKWNSRVETER..KGRYTVLDPQTGIAQHPSHHAIYELSNRYPPSNPSQYCTYGSRRWKKRKSA
YP99_CAEEL/2-78                ISENGYMDLMRNCIKWNSRQMEDRKKRLRFPYYEHQTATAQRESRFTTRNVDHMYPSNDPNTVVQFATERWKKSKSQ
#=GC seq_cons                  lsDshY+EslEsussaNoRLshER..RlRhPFLDsQTGVAQscs.tlahppcpRhPGpstGQlYTYPu+RWRK++Rp
//