# STOCKHOLM 1.0 #=GF ID DUF4346 #=GF AC PF14251.1 #=GF DE Domain of unknown function (DUF4346) #=GF AU Eberhardt R #=GF SE Jackhmmer:B0BZ08 #=GF GA 25.00 25.00; #=GF TC 25.10 25.20; #=GF NC 24.20 24.90; #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq #=GF TP Family #=GF WK Domain_of_unknown_function #=GF RN [1] #=GF RM 10426953 #=GF RT Identifying two ancient enzymes in Archaea using predicted #=GF RT secondary structure alignment. #=GF RA Xu H, Aurora R, Rose GD, White RH; #=GF RL Nat Struct Biol. 1999;6:750-754. #=GF DR INTERPRO; IPR025595; #=GF CC This family of proteins is found in bacteria, archaea and #=GF CC eukaryotes. Proteins in this family are typically between 127 #=GF CC and 502 amino acids in length. There are two conserved sequence #=GF CC motifs: LDP and DHA. Many members of this family have been #=GF CC annotated as dihydropteroate synthases, however no experimental #=GF CC evidence can be found for this and Swiss:Q57571 has been shown #=GF CC not to possess dihydropteroate synthase activity [1]. #=GF SQ 36 #=GS Q7NMB3_GLOVI/22-140 AC Q7NMB3.1 #=GS C1EAD1_MICSR/65-184 AC C1EAD1.1 #=GS C1MHU3_MICPC/58-178 AC C1MHU3.1 #=GS Q2JKV6_SYNJB/13-131 AC Q2JKV6.1 #=GS P74560_SYNY3/9-127 AC P74560.1 #=GS A0YZC0_LYNSP/16-134 AC A0YZC0.1 #=GS B5VWN6_SPIMA/16-134 AC B5VWN6.1 #=GS B1XPX6_SYNP2/9-127 AC B1XPX6.1 #=GS Q5N567_SYNP6/12-130 AC Q5N567.1 #=GS B1X460_PAUCH/9-127 AC B1X460.1 #=GS Q46HR9_PROMT/15-133 AC Q46HR9.1 #=GS Q7VE90_PROMA/13-131 AC Q7VE90.1 #=GS A9BCW0_PROM4/15-134 AC A9BCW0.1 #=GS A2BU64_PROM5/11-128 AC A2BU64.1 #=GS B9NZI0_PROMR/11-128 AC B9NZI0.1 #=GS Q05VZ2_9SYNE/15-133 AC Q05VZ2.1 #=GS A3Z9R9_9SYNE/13-131 AC A3Z9R9.1 #=GS A5GNX0_SYNPW/6-124 AC A5GNX0.1 #=GS Q7V8Z8_PROMM/7-124 AC Q7V8Z8.1 #=GS Q0I731_SYNS3/14-132 AC Q0I731.1 #=GS A5GQP0_SYNR3/10-128 AC A5GQP0.1 #=GS Q063S0_9SYNE/15-134 AC Q063S0.1 #=GS Q3AH59_SYNSC/16-135 AC Q3AH59.1 #=GS A3YX28_9SYNE/22-140 AC A3YX28.1 #=GS Q8DLX5_THEEB/7-124 AC Q8DLX5.1 #=GS B0BZ08_ACAM1/9-127 AC B0BZ08.1 #=GS B8HUS6_CYAP4/19-137 AC B8HUS6.1 #=GS B4WKR7_9SYNE/20-139 AC B4WKR7.1 #=GS E0UBS1_CYAP2/9-127 AC E0UBS1.1 #=GS YC91L_NOSS1/9-127 AC Q8YPT9.1 #=GS Q11AC0_TRIEI/9-127 AC Q11AC0.1 #=GS B4VNF6_9CYAN/9-127 AC B4VNF6.1 #=GS A8YLF1_MICAE/9-127 AC A8YLF1.1 #=GS B7K4T3_CYAP8/9-127 AC B7K4T3.1 #=GS B1WZ03_CYAA5/23-141 AC B1WZ03.1 #=GS D3EQU3_UCYNA/5-122 AC D3EQU3.1 Q7NMB3_GLOVI/22-140 EEVDRNLSSRHIDLDAAGYFLIAVDRQEGLLVARHFGLTVDARGLAIDPQTGKPLPARG.PVS.T.PLLSTYTARTAKEMCVKLFES.DAPPPVGMFNHAAYLGRELQRAEYALIHGTEYVQD C1EAD1_MICSR/65-184 REIDDELSNRWIDLDPAGYYLISVDHNRGVIRAAHFLNVIDKEGRACDPMTGEVIPCDG.SYK.P.AVHKTFSGRTAKELSVKILESEEGQGTVTMLVHANYLGREFQRAEACLVSGDKYVQD C1MHU3_MICPC/58-178 TSVDTELSNRWIDLDPAGYFLVKVDHATRTIEAAHFENAIDDAGRACDPVTGEVIPCDG.SYR.KPAASATFAGRTAKEISVKILETEEGEGLCTMLVHANYLGREFQRAEACLREGTEYVQD Q2JKV6_SYNJB/13-131 RSIDDHLSRRPLDLDPAGYFVIYLDREQNLICAKYYSTVINERGLATDPETGAVIPAKG.SVN.R.SPERVYVGRTAKELCVQIFEK.EQEKVVSQLSHAAYLGREFQKAEAALISGEEYIQD P74560_SYNY3/9-127 KSIDNQLSRRHIDLDPAGYWLVMVEREAGVLKVEHYSNDINDQGLAVDPETGEVIACQG.GRK.R.LPSLTLTGRTAKELCVKIFEE.LESCPVTMLNHAAYLGRELMRAELALTGGGEYIQD A0YZC0_LYNSP/16-134 KAIDDQLSQRFIHLDPAGYFIIYVDQEAGLICAEHYTNNINGQGLAVDPETGEPFPCTG.SLK.R.QPTAVFKGRTAKELGIKITEE.ADCCPLSTFDHALYLGREFVRAEIALTTEQEYVQD B5VWN6_SPIMA/16-134 IALDDKLSQRFIQLDPGGYFIIYIDRDKGLICAEHYSNDINEQGLAVDPDTGEPFPCKG.ELK.R.TPIGIYRGRTAKELGIKITEE.ASTCPLTCFDHALYLGREFVRAEMALVNGQDYIQD B1XPX6_SYNP2/9-127 AKLDNELSNRFIDLDPDGYFIIYLDREQGLICAKHYTNTINDKGLATDPETGEVLACKG.SLE.R.THVTVYAGRTAKELGIEITEK.ADPCPISKLDHALYLGREFVKAEIALLSGTEYIQD Q5N567_SYNP6/12-130 KALDHQLSNRFIKLDPEGYFVIYLDREAGLICADHYSNAINDKGLATDPETGEVLACKG.NLK.R.VPTATFRGRTAKELGKLITED.TQPCPLSYLDHALYLGREFQRAEACLLSGQDYVQD B1X460_PAUCH/9-127 ITLDMRLSQRFISLDPKGYFLIKIDINRGELVAEHYSNTLDQKGVAIDPETGEELTCWN.LSS.Q.KPVNIYRARTAKELGIRLTEG.KGPHPITCLDHALYLGRELQKAEQALIASQLYIQD Q46HR9_PROMT/15-133 KLLDAKLSKRQIELDPKGYFLIKIEPKTNELILEHYLNDIDQKGRAIDPKSGEPIGCKT.KSR.N.QPNNIYRGKSAKQLGIQISEG.HGPFPISHLDHAIYIGRELQRAEQCLITGKQYIQD Q7VE90_PROMA/13-131 NNLDEKYSQRFIELDPSGYFLIKVSHETNELIVEHFSNNIDETGLATDPETGEPLKCND.NKE.R.SPIKVFKGKSAKEIGIQITEG.HVPKPLTKLDHALYLGRELQKAEFCLTNGKPYVQD A9BCW0_PROM4/15-134 ANIDEKHSRRFIALDPKGYFIIKLDQDTKEIIVEHYKNDIDKLGRAIDPDTGKPIKCEK.GEK.R.CPNKVYKGQTAKELGIKLSEVEKETILISRLDHALYLGRELQKAEYCLIHGIAYVQD A2BU64_PROM5/11-128 IEIDNNLSNRYIELDPNGYFIIKIDIEKKHIILEHYLNTINEEGYALDPKTNEPIKCDS.REI.K.TCNETFTGISAKEIGIAITEK..RNDLISRFDHALYLGRELQKAEECLYKQLTYVQD B9NZI0_PROMR/11-128 TMIDNNLSNRYIDLDPNGYFIIKVDLEEKKIILEHFLNNINDEGYALDPETNEPIKCDS.QNK.R.VSNEVFKGISAKQLGIMITEE..RNDLITKFDHALYLGRELQKAEECLHKRLPYIQD Q05VZ2_9SYNE/15-133 KALDDQLSQRFIALDPAGYFLIKLDRETAELVVEHYRNDVDERGLATDPETGEVLSCRG.SGP.R.TAAAVYRARTAKEMGIQLTEG.DGPHPLSCLDHALYLGRELQRAELALLTGIDYVQD A3Z9R9_9SYNE/13-131 QALDDQLSQRFIALDPAGYFLIRVDAAAAELVVEHYRNDVDAKGRATDPETGEVLACRG.GGP.R.EAARIYRAKTAKALGIQLTEA.EGPLPISQLDHALYLGRELQKAEQAMLQGTPYIQD A5GNX0_SYNPW/6-124 PSLDDQLSQRFIALDPSGYFLIRVDSRAGELVAEHFRNDVDDKGRATDPETGEVLSCRG.GSQ.R.AATVCYRGRTAKELGIALTEG.EGPHPVSRLDHALYLGRELQKAEACLLQGKPYVQD Q7V8Z8_PROMM/7-124 SSIDDQLSQRFIALDPSGYFLIQVDASAAELVVEHYLNDVDELGRATDPVTGEVLACRG.GI..R.SPATVYRGRTAKQLGIQLTEG.QGPYPLSKLDHALYLGRELQRAESCLLSGTPYVQD Q0I731_SYNS3/14-132 VQLDDQLSQRFIALDPLGYFLIRVDAAAAELVVEHYGNTIDERGLARDPDSGKVIACRQ.GGP.R.KPSAVLRGRTAKEVGIALSEG.EENYFLSRLDHALYLGRELQKAEQCLKDGSPYVQD A5GQP0_SYNR3/10-128 RELDDAHSNRTIELDPSGYFLIRVDAAAGELVVQHFGNAINDQGLATDPDTGEVLSCRG.GGP.R.AASAEYRGRSAKELGMALTES.AEPLPLSRLDHALYLGRELQKAELCLEQGLDYVQD Q063S0_9SYNE/15-134 AELDDRLSQRFIALDPKGYFLIKVDHASAELVLEHYGNTIDDKGLAHDPETGEVLSCKGGNGQ.R.KPSRVYRGLTAKQIGIQLTES.DGPHPLSSLDHAFYLGRELQKAEVCLIEGTSYVQD Q3AH59_SYNSC/16-135 DALDQRLSQRFIALDPSGYFLIKLDRDAAELVLEHYGNTIDDKGLARDSETGEVLRCDG.GNAPR.RPSAVYRGSTAKQLGIQLTEG.DAPHPVSCLDHALYLGRELQKAEQCLRNGSTYVQD A3YX28_9SYNE/22-140 RALDERLSQRSIDLDPAGYVLISLDRERGELVAELYGNGINARGLATDPDTGEVLSCRG.GAP.R.LPLTVFRGRTAKELGIQLTEG.AGPAPISRLDHALYLGRELQKAEAALRSGDSYIQD Q8DLX5_THEEB/7-124 TALDNKLSQRFIHLDPAGYFIIYIDPEQQLIWMKHYPNDINEKGLAVDPDTGEPIPTKG.KVT.R.EPDLVLSGRTAKELCIELFEK..DRQLVTMFDHAAYLGRELMRAQFCLDEGIEYIQD B0BZ08_ACAM1/9-127 AAINNQLSQRFIALDPGGYFLIYLDRQAPAICADHYANDIDDKGLAVDPDTGEPLSCRG.KVE.R.KPDAKFRAKTAKELCIAIFEE.PQTCLVTKLDHAAYLGREFIRAEIALAQDQEYIQD B8HUS6_CYAP4/19-137 AHLNHKLSQRFIALDPGGYFLIYLDRAAQLICAKHFTNVINEKGLALDPETGKPLPTRG.KVE.R.TPTALFTGRTAKELCIKIFEE.PETCLVTRFDHAAYLGREFMRAEFCLDSGEEYIQD B4WKR7_9SYNE/20-139 AALDDKLSKRYIDLDPAGYFLIYLDRAAALICAKHFTNTINEKGLACDPETGKPLSVRG.NTS.R.QETTIFTGRTAKELCMKIFEDKDNPCPLTYLDHAAYLGREFVRAEIALINGTDYVQD E0UBS1_CYAP2/9-127 TTIDNQLSNRHIDLDPGGYFIIYLDRESGLICAKHFTNIINEQGLAVDPETGKVIPAKG.KVA.R.TAETLYTARTAKELCVKIFEE.TQPSPVTMFDHAAYLGREFVRAELALINGQEYVQD YC91L_NOSS1/9-127 AAIDNKLSQRHIDLDPNGYFIIYIDKTAGLIYAKHFTNIIDERGLAVDPETGKVIPARG.KVE.R.TYTTVFAGRTAKELCVKIFEE.TQPCPVTMLDHAAYLGREFVRAEVALVAGQEYVQD Q11AC0_TRIEI/9-127 NTIDKKLSKRHIDLDPGGYFIIFIDKKAGLIFAKHFTNIIDSRGLAIDPETGKPIPAKG.KVE.R.QENAIFTAKTAKEMCVKIFEE.TRPCHITMLDHAAYLGREFVRAEIALLSGKEYIQD B4VNF6_9CYAN/9-127 RTINDKLSKREIELDPGGYFIIYLDRDARLICAKHFTNVIDDRGLAVDPETGKPIPARG.KVE.R.THTTLFTGRTAKELCVVIFEQ.TQPCPVTMLDHAAYLGREFMRAEFALISGQEYVQD A8YLF1_MICAE/9-127 TAIDHQLSKRPIALDPAGYFIIYLDREAGLICAKHYSNIINEKGLAVDPETGKVIGVRQ.KLD.R.NPETIYTARTAKELAVKVIEE.TQPCPITMFDHAAYLGREFTRAEYALITGEEYIQD B7K4T3_CYAP8/9-127 TSLDNELSKRYIALDPGGYFIIYVDREAGLICAKHFTNIINEKGLAVDPATGKVIPCDG.SLK.R.TSETVYKGRTAKELCVKLLEE.IQPCPVTMLDHAAYLGREFLRAEIALINGSEYIQD B1WZ03_CYAA5/23-141 KQLDDQLSKRPIDLDPGGYFIIYLDRENELICAKHFTNIINEKGLAVDPETGEVIAARG.KTN.R.TAETLFTGRSAKELCVKVIED.NENCPITMLDHAAYLGREFMKAEIALIQGTEYIQD D3EQU3_UCYNA/5-122 EQLDKKLSKRYINLDPGGYFIIYIDSSQDLICAKYFTNIINDKGLAVDPESREVISVKN.KVT.R.NADQIFTARSAKELCIKIIEN..NNCPITRLDHAAYLGREFTKAELALTQGRKYIQD #=GC seq_cons pslDcpLSpRaIsLDPuGYFlIhlD+csuhIsAcHasNsIs-+GLAsDPETGEslsC+G.psp.R.sssslapGRTAKELulplhEp.ppssPlopLDHAhYLGREhp+AEhsLlsGpcYlQD //