# STOCKHOLM 1.0
#=GF ID   Methyltrans_Mon
#=GF AC   PF14314.1
#=GF DE   Virus-capping methyltransferase
#=GF AU   Karlin D, Coggill P
#=GF SE   Pfam-B_840
#=GF GA   20.20 20.20;
#=GF TC   20.30 20.40;
#=GF NC   20.10 20.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   17218273
#=GF RT   Unconventional mechanism of mRNA capping by the RNA-dependent
#=GF RT   RNA polymerase of vesicular stomatitis virus.
#=GF RA   Ogino T, Banerjee AK;
#=GF RL   Mol Cell. 2007;25:85-97.
#=GF CC   This is the methyltransferase region of the Mononegavirales
#=GF CC   single-stranded RNA viral RNA polymerase enzymes. This region is
#=GF CC   involved in the mRNA-capping of the virion particles.
#=GF SQ   10
#=GS L_BEFVB/1375-2064       AC Q9E784.1
#=GS L_RABVN/1361-2051       AC Q9IPJ5.1
#=GS L_MOKV/1361-2051        AC P0C568.1
#=GS Q91DS4_SVCV/1331-2000   AC Q91DS4.1
#=GS L_CHAV/1333-1997        AC P13179.2
#=GS L_ISFV/1333-1998        AC Q5K2K3.1
#=GS A4UIJ9_9RHAB/1343-2013  AC A4UIJ9.1
#=GS Q8B545_9RHAB/1343-2013  AC Q8B545.1
#=GS Q4VKV2_9RHAB/1338-2009  AC Q4VKV2.1
#=GS Q8B6R7_9RHAB/1360-2030  AC Q8B6R7.1
L_BEFVB/1375-2064                  IKDNDDEWDNLTVEDKSYEIGKTIGWLVGDSLLSHKRNYEFKSLFPVSIRYKLEGLPFLEGILDGFKICGSLNLTHRRNYMILKKPKLALQGTVFFLIDRSSFISEFTNFISHPKIYKAIKSLPHKIPTSYPMNLSDLGSILRSFLKQLYYRRKELIIKKSS....WVFSDMRTNE..VICSFGLSHLTYRILIQEGLNKDMKLRLQQCQDLYINIMTESKEEL..DKSSAKREIVECLRELKFVSSEIRHAVKFRYITGEKGEVQLIKEMEERRTWG.DEYTGKANLLDVWYLTSQSSENKNLVKGIKIPYHSNPTISGLRINQIATGAHYKLRTLINMTRITYRDFICGGDGSGGMTSCLLRLKPLSRGVFNSLLILDDKPLHGTRPSPPTAIMELGED.SLRCVNCYDVWKEPSDLSKQETWKYFVKLKKQNSMMIDLIVLDMEIINDEVIEDIYQNTKNHLIYLLEEGGCLIIKTYLTYLLKENTN.ILDMLGHLFTSVQLINTNLSSMKTSEIYVLFKNYKNRL..TPCLQFDRNIILDNWSFFYINKPIREEFERARELLNEDLGMGMPKELEPNPLIELSQMLQNSGVDGVAMSAISQEENLSFFSTKELAVICLIIISESHLVTTKKHKNDCNCLQKKPYSDQEIKSWMSGIIGIGLYLSLLDNKTNSFEILDYLINSDFKSIHVNFNKER....ELCW
L_RABVN/1361-2051                  IRLRPGDFESLSGREKSRHIGSAQGLLYSILVATHDSGYNDGTIFPVNIYGKVSPRDYLRGLARGVLIGSSICFLTRMTNININRPLELISGVISYILLRLDNHPSLYVMLREPSLRGEIFSIPQKIPAAYPTTMKEGNRSILCYLQHVLRYEREVITASPENDWLWIFSDFRSAKMTYLTLITYQSHLLLQRVERNLSKGMRANLQQLSSLMRQVLGGHGEDTLESDDDIQRLLKDSLRRTRWVDQEVRHAAKT..MTGDYSPNKKVSRK.....AGCSEWVCSAQQVAVSTSANPAPVSELDIRALS.KRFQNPLISGLRVVQWATGAHYKLKPILDDLKVFPSLCLVVGDGSGGISRAVLNMFPDAKLVFNSLLEVNDLMASGTHPLPPSAIMSGGDDIVSRVIDFDSIWEKPSDLRNLTTWGYFQSVQKQVNMSFDLIICDAEVTDIASINQITLLMSDFALSI.DGPLYLVFKTYGTMLVNPDYK.AIQHLSRAFPSVTGFVTQATSSFSSELYLRFSKRGKFFRDAEYLTSSTL..REMSLVLFNCSSPKSEMQRARSLNYQDLVRGFPEEIISNPYNEMIITLIDNDVESFLVHKMVDDLELQRGTLSKVAIIIAIVIVFSNRVFNISKPLA.DP.LFYPPSDPKILRHFNICCSTLMYLSTALGDVPSFTRLHDLYNRPI.TYYFRKQVIR.GNIYLSW
L_MOKV/1361-2051                   VGLKAGDLTALSSSERSYHIGTAQGLLYSILVAVHDPGYNDNSLFPVNIYGKVSARGYLRGLARGILIGSSICFLTRMTNININRPLELISGVISYILLKLDNHPSLYIMLKEPELRAEIFSIPQKVPAAYPTTMEEGNRSVLCYLQQVLRYERDSMSFPPGNDILWIFSDFRSIKMTYLTLITFQAYLWLQRVERNLSKQVRVRLRQLNSLMRQVLGGHGEDTIDSDDEILSLLKESLRRTRWVDQEVRHAAKS..MTPDLNPVPKISRR.....MGSSEWICSAQQIAISTSLNPASASDIDLRSLS.RQYQNPLISGLRVVQWATGAHYKIKPILNDLDVCPCLSLVIGDGSGGISRVVLSMFPDSKLVFNSLLEVNDLMASGTHPLPPSALMRGGDDITSRVIDFESIWEKPSDLRNPLTWKYFHSIQSKLRSQFDLIVCDAEVTDIESVNKITLLLSDFSMSI.KGPLYLIFKTYGTMLVNPDYK.AIHHLSRAFPNVTGFVTQMTSSFSSEIYLRFSKTGYFFRDHELLTASTV..REMSLVLFNCSNPKSEMLRARTLNYQDLIRGFPPEIISNPYNEMIITLIDSEVESFLVHKVVDDLELKRGAPSKMAIIIAVAILFSNSVLNVSKSLN.EP.KFFPPSDPKLLRHFNICSSTLLFLSTALGDLSNFTRLHELYNSPV.TYYFGKQTIK.GRRYLSW
Q91DS4_SVCV/1331-2000              IKLREVDWDPLTRYEKSYHIGRCQGFLYGDLTYQKTGRSEESSIFPLSIQYKVEGSGFMRGFCDGIIRASAVQALHRR.VSSIVSTADVIYGGAQYLTNQVGDSPPFQNLCRSGPLREELERIPHKMTSSYPTSNSDMGYLIRNYLKRSLKQLSRGRYETKEGP.IWVFSDVRTKK..FLGPFSLSTDALNCLYKNKLSKRDKNAVRNLSQLSSRMRSGD...L..SDEEIGKVEARFS....FTPAEMRHACKF..TIGKTQVPIVMSE......WG.QEAYGNITMYPVFYSTTKTE....KPDWTF.SRLQNPTISGLRISQQATGAHYKLRSLLKGMKIHYQDAIGCGDGSGGLSSCLLRENKHCRVIFNSLLELTGNTLRGSTPDPPSAI.NGIPQIRDRCVNLNNVWEHPSDLSHPDTWKYFGELKAQFNMDVDLIVMDMEVQDIGISRRIEQNLRDHVHSLLSRHGTVIYKTYMTIMSENEKS.VLDIVGVLFEDVQLCQTQYSSSQTSEVYCVMRRLRQKV.DSQHVDWQSLVRQGINSKVYCNLPLDKEFERALNLYQIDTLVGVPRGLIPNLAVELETLLEIGGLSRGILGKLVLNIEEGKLGF.TMALIVSCILIS.ESAICTTRLSN....KREVPSSGACQRMAVCLIGAAILLSVHHRSIENHKGAIRMLRHSV.PIRISSKLRKDGKLQSRW
L_CHAV/1333-1997                   LKPVEGDWDTIPPVEKSYHVGRILGFLYGDLKSQNSSRADDSSIFPLSIQMRLRGRGFLRGILDGLVRASACQVIHRRSVALLSKPANAIYGGLIYLIDKISASTSFTTLCRDGPIREELSSIPHKIPTSYPTSNSDMGLHIRNYLKFQCKTVELGKYQSDIKD.LWLFSDVMTSN..IAGPFALSTKILKCLYKPALSQKDRNNIRKISNFSKMMRSQLS..W..DPTSSEFITSQIL....VCNEEIRHACKF..GIPKLSLKFDDPV......WG.PEDYGLIWSIPVDYSSQSVP....KNLKPC.PRIQNPSISGFRLGQLPTGAHYKLRSILRKKNIHYRDALCGGDGSGGMTAAVLRYNLKARAIFNSILDFDGSTMKGASPDPPSALETVVNG.RTRCVNAESCWENPSDLSEQRTWDYFKFLKTHHGLKIDLIVLDMEVRDFAISASIEKCVRHNVSSILEEDGVLIYKTYGSTIAAESSN.AVVNIGVLFESVELIQTEYSSTSTSEVYMYCRKIKKFV.DAPHPDWISL..DYYWSKLLCFRSYKEEFFRSYEVSRKESLKGIPNSFIPDPLVNLETLLQIAGVPSGISHQLAIDIKESQLTQITAAMVLCGMIA..NYTLDVTKKRD....SYNPPSDGRLIRMSAALVGISFWISVKYYDKELNFELEQILSRSF.PIRW....ML.SHNYLFW
L_ISFV/1333-1998                   LKPLKGDWEILTPAEKSYHVGRTLGFLFGDLTGQSSIRADDSSLFPLSIQKRLRGRGFLRGVLDGLVRASACQVIHRRSLTQLKRPANAVYGGLIFLIDKISASSTFINLCRDGPIREELSSIPHKIPTSYPTSNADLGLHIRNYFKFQCKSVELGKYQSDLED.LWLFSDLLSSG..FAGPYALSSKVLKSLYKPSLSRRDRNNIRKLGALSRLLRSHEN..W..SELHKEFLTSQLL....LCQEEVRHACKF..GIPKNVSAKSSMV......WG.KEAVSYVLDIPVEFTSQKQT....KHLNAC.PRIQDPTISGLRLGQLPTGAHYKIRTILNAYNIKCRDVLCGGDGSGGMTAACLRYYSNSRAIFNSILEFDGSSMKGSSPDPPSALETVDQG.MVRCVNATTCWENPSDLSQERTWDYFLHLKKSFNMKIDLIILDMEVRDFQISKLIEGNLRLKISKLLEKNGTLIYKTYGTIICSETSN.VLTTLGPLFHSVYIVQTGYSSSFTSEVYVLFSKQKSFV.DSPYVDWGSL..QYNWEKLACFRNPRQEFKRALRIRSSRSLMGIPSSFLPDPLVNLETLLQISGVPSGVSHQLVTDVKSSGASGLSSAIGLLGLISH..FTLDVTKLYV.Q..EYRPPSDNRLIKMASAITGISYWISIAYHDQQLNQALTSVIKKSF.PIRWGLINHR.....LHW
A4UIJ9_9RHAB/1343-2013             IYPLEGNWKNLAPAEQSYQVGRCIGFLYGDLAYRKSTHAEDSSLFPLSIQGRIRGRGFLKGLLDGLMRASCCQVIHRRSLAHLKRPANAVYGGLIYLIDKLSVSPPFLSLTRSGPIRDELETIPHKIPTSYPTSNRDMGVIVRNYFKYQCRLIEKGKYRSHYSQ.LWLFSDVLSID..FIGPFSISTTLLQILYKPFLSGKDKNELRELANLSSLLRSGEG..W..EDIHVKFFTKDIL....LCPEEIRHACKF..GIAKDNNKDMSYPP.....WG.RESRGTITTIPVYYTTTPYP....KMLEMP.PRIQNPLLSGIRLGQLPTGAHYKIRSILHGMGIHYRDFLSCGDGSGGMTAALLRENVHSRGIFNSLLELSGSVMRGASPEPPSALETLGGD.KSRCVNGETCWEYPSDLCDPRTWDYFLRLKAGLGLQIDLIVMDMEVRDSSTSLKIETNVRNYVHRILDEQGVLIYKTYGTYICESEKN.AVTILGPMFKTVDLVQTEFSSSQTSEVYMVCKGLKKLI.DEPNPDWSSI..NESWKNLYAFQSSEQEFARAKKVSTYFTLTGIPSQFIPDPFVNIETMLQIFGVPTGVSHAAALKSSDRPADLLTISLFYMAIISY....YNINHIRV.GPIPPNPPSDGIAQNVGIAITGISFWLSLMEKDIPLYQQCLAVIQQSF.PIRWEAVSVK.GGYKQKW
Q8B545_9RHAB/1343-2013             LKPAEGNWESLSPVEQSYQVARCIGFLYGELTHKKSRQADDSSLFPLSIQLKVRGRGFLRGLLDGLMRSSCCQVIHRRSVSTLKRPANAVYGGLIYLIDKLSASSPFLSLVRTGPIRQELEQVPHKMSTSYPTNIRDLGSIVRNYFKYQCRPVERGNYKTYYNQ.IWLFSDVLSTE..FIGPMAISSSLLKLLYKPSLTKKDKEELRELAALSSNLRSGED..W..DDLHIKFFSNDLL....FCPQEIRHACKF..GIQKENEGIALYPN.....WG.IEYIGNVTDIPVFYRAQNVQ....KDIRIP.PRIQNPLMSGLRLGQLPTGAHYKMRTIISRFKXPYHDFLACGDGSGGMTAALLRLNRASRGIFNSLLDLSDTMLRGSSPEPPSALETLGGE.RSRCVNGDSCWEHPSDLSDENTWKYFLHVKKGCGMSINLITMDMEVKDPTMSYKIELLVRQYVPVLLESDGCLIYKTYGTYIATQKDN.SLTLIGSLFHSVQLVQTDLSSSNTSELYLVCRRLKDYI.DTPFVDWIEL..YDYWENQYAFKDIKDEFHRARSLKPETTLVGIPPQFIPDPGVNLETLFQIAGVPTGVAHGITHHIIQSKNKLISNAIGSMCVISH....FVMNTIRT.TDSMPGPPSDGDVNKMCSALIGTCFWLSWMESDLNLYKTCLRSITKSM.PVRWFRALKN.GKWFQKW
Q4VKV2_9RHAB/1338-2009             LEFQYGNWEAISDAEKTYHVGRAIGFVFSDYAFSSSAQLEESSLFPLSIRNSLTPELFYEGLIDGLIRGCSIQITHRRNVALLKKPRETLVGSVFFAITKITLNTPFLSLVRVGAIHDYIIRNSHRTPPSYPLSKWDLGGILRHYLKTRFLHLLRTGYSSRYTS.VWIFADLAGIE..VGGLLCLSSHLLEYSVSPNKTKLGAERLRKFKEIEINMRQKTQ..VDLSCLDLRRVY........LCKSEVRHSVKS..IDKKTVQSEAPLYK.....FE.EEEVGYVVAWDVSYLSAPALSPKEELTV...PRLQCPLISGLRTIQLATGAHYKVRSILNHFNIQFDDFLCGGDGSGGLTAMCLRWNRFSRGIFNSLLDLSGYDLRGSRPSEPSAIAALGAD.AARCVNRQTCWQHPSDLTDKSTWNYFVDLKAEFGLTIKLMIFDMENRDEQSFL.IEDQIIDYLPRLLSRSGSLIFKTYCHRLISQQNPLLLKRLGRHFKRSCLVQTEFTSNFSSEVYVVLMDYVPGNSLAGIVDYTEM..TRFLGKRFVFSNPVDEFKRALGIKRKAMEKGIPSELLPDPEVELATVLEICGLESGRAASVA.EICCSKSISPKVKYLFVRSITF.CSFFNLTSGFS.E..RPHVPSDSKLLRFFSFFIGLEYWWSWVSEELPRFERMNQFLREDL.FITHESKKGK.DFWVRKV
Q8B6R7_9RHAB/1360-2030             IELKEGNWDILNNQTRSRHVGHIMGFIFTDMLLSHSKHVEDSSIFPIGIRNKLVPNDFFEGLFLGIQRSCALQLIHRRNLLELKKPRVAQWGLGFYAIESICDNQGFINFLRDGPLYDTIMCSPHKIPSSYPLNNKDLGSIARSYLKNMLVNWFNKKLILNFNQNVWLFADLQSHD..ITGSIAISIQALKLVMSTKQTPRFKETVRKIQEIYVNVKNDK...W..DLINVPELIKNIT....TCPQELRHAVKT..NMEKVLVSDRKLQ......WG.SEWFGGIYIHPVLYDSLDK...VYDPIHVP.RR.AHPLISALRTHQFATGAHYKIRSIIENLKITWSYAICGGDGSGGISSYLCRSNPNGKVLFNSLLIMDGINFKGSHPSPPAALVALRGG.KNQCINLEDVWKYPSDLSQENTWAYFRQKGRQVGARWDLIVLDMEVISEEIIEAIENHVAKWGLQLLEPRGSIIFKTYIERLINKN.S.IIDLIGPQFLDVLVCQTEISSSYTSEVYVVFKHLEVANIPKLYPDKQDL..SARLSHCFCFSNHDGELRRARHIQLENLMVGVPPEIISDITVDLGTLLTILGMESGYAVSIAKSWNRYQGKH.HINYLLSIALLCSESNFQTTHGLH.K..GLNIPSNSALLNMLVCLTSLWIWISLKTNSLSLYSRTYEMMNQPI.VVNFGRFLKK.DKIYQTW
#=GC seq_cons                      l+.p-G-W-sLossEKSYHVGRslGFLYGDLshp+Ssps-DSSLFPLSIptKlcGRGFLRGLlDGllRuSulQllHRRolspLK+PtsAlaGulhYLI-KlossssFhsLlRcGPIR-ElpoIPHKIPoSYPToppDhGtllRsYLKpph+plccupYposhss.lWlFSDltSpc..alGshulSoplLchLhcssLSK+s+spLRcLusLppplRoscs..h..s-hclcplhpchL....hCspElRHAsKF..shsKpssspthh.......WG.pEhhGslpplPV.Yoossss....chhphs.PRlQNPLISGLRlsQlATGAHYKlRoILsshcIpacDsLssGDGSGGhTuslLRhNspSRuIFNSLL-lsGpsh+GopPsPPSAL.slGs-.psRCVNt-osWEcPSDLScppTWcYFhcLKpphuhpIDLIVhDMEVpD.phsppIEppl+calhpLL-csGsLIaKTYGThlsspsps.slshLGshFcoVpLlQTphSSShTSEVYllh++h+phl.DssalDasoL..pchhpplasFps.+pEFcRA+plpppchlhGlPsplIPDPhV-LpTlLpIuGVsSGluHplsp-lppupush.phAlllsslIsa.p.shslo+hhs.p..phpPPSDucll+hhsslsGlshWLSltppDlshapphppllscsh.sI+atptht+.uphhhpW
//