# STOCKHOLM 1.0
#=GF ID   CSTF2_hinge
#=GF AC   PF14327.1
#=GF DE   Hinge domain of cleavage stimulation factor subunit 2
#=GF AU   Coggill P
#=GF SE   Jackhmmer:Q8VYM7
#=GF GA   27.00 27.00;
#=GF TC   27.40 27.20;
#=GF NC   26.90 26.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   19887456
#=GF RT   The hinge domain of the cleavage stimulation factor protein
#=GF RT   CstF-64 is essential for CstF-77 interaction, nuclear
#=GF RT   localization, and polyadenylation.
#=GF RA   Hockert JA, Yeh HJ, MacDonald CC;
#=GF RL   J Biol Chem. 2010;285:695-704.
#=GF DR   INTERPRO; IPR025742;
#=GF CC   The hinge domain of cleavage stimulation factor subunit 2
#=GF CC   proteins, CSTF2, is necessary for binding to the subunit CstF-77
#=GF CC   within the polyadenylation complex and subsequent nuclear
#=GF CC   localisation. This suggests that nuclear import of a pre-formed
#=GF CC   CSTF complex is an essential step in polyadenylation. Accurate
#=GF CC   and efficient polyadenylation is essential for transcriptional
#=GF CC   termination, nuclear export, translation, and stability of
#=GF CC   eukaryotic mRNAs. CSTF2 is an important regulatory subunit of
#=GF CC   the polyadenylation complex.
#=GF SQ   52
#=GS Q750E6_ASHGO/166-251  AC Q750E6.2
#=GS A6ZUG7_YEAS7/173-257  AC A6ZUG7.1
#=GS Q6CJ87_KLULA/220-303  AC Q6CJ87.1
#=GS C5DGC5_LACTC/168-251  AC C5DGC5.1
#=GS A7TLA6_VANPO/167-251  AC A7TLA6.1
#=GS C5DZU2_ZYGRC/180-264  AC C5DZU2.1
#=GS Q6FVB7_CANGA/179-263  AC Q6FVB7.1
#=GS C5MIR7_CANTT/207-288  AC C5MIR7.1
#=GS B9WMR3_CANDC/170-251  AC B9WMR3.1
#=GS Q5A422_CANAL/178-259  AC Q5A422.1
#=GS C4R2R8_PICPG/218-301  AC C4R2R8.1
#=GS A5E6V1_LODEL/194-275  AC A5E6V1.1
#=GS C4XVP2_CLAL4/184-266  AC C4XVP2.1
#=GS A3LYA2_PICST/188-270  AC A3LYA2.2
#=GS A5DCN3_PICGU/166-250  AC A5DCN3.2
#=GS Q6BU11_DEBHA/188-270  AC Q6BU11.2
#=GS Q6C6J0_YARLI/168-252  AC Q6C6J0.1
#=GS B6K5P6_SCHJY/168-251  AC B6K5P6.1
#=GS CTF1_SCHPO/200-283    AC O43040.1
#=GS A6SSI6_BOTFB/126-209  AC A6SSI6.1
#=GS B2ABD7_PODAN/137-220  AC B2ABD7.1
#=GS C7YHM4_NECH7/121-204  AC C7YHM4.1
#=GS B2VU88_PYRTR/867-950  AC B2VU88.1
#=GS A1CSX0_ASPCL/118-201  AC A1CSX0.1
#=GS B6H860_PENCW/121-204  AC B6H860.1
#=GS Q4PAI2_USTMA/198-281  AC Q4PAI2.1
#=GS Q55NS5_CRYNB/187-270  AC Q55NS5.1
#=GS B6JXU9_SCHJY/124-207  AC B6JXU9.1
#=GS B9W6X3_CANDC/97-180   AC B9W6X3.1
#=GS Q6BU04_DEBHA/99-182   AC Q6BU04.1
#=GS C4V881_NOSCE/82-165   AC C4V881.1
#=GS Q8SRE5_ENCCU/82-166   AC Q8SRE5.1
#=GS A7ATY8_BABBO/108-192  AC A7ATY8.1
#=GS B6AGT9_CRYMR/147-231  AC B6AGT9.1
#=GS Q5CNN1_CRYHO/117-201  AC Q5CNN1.1
#=GS Q01FM4_OSTTA/130-214  AC Q01FM4.1
#=GS A9NXV2_PICSI/22-106   AC A9NXV2.1
#=GS B4FMY5_MAIZE/157-235  AC B4FMY5.1
#=GS B9GT48_POPTR/165-249  AC B9GT48.1
#=GS Q8LKG6_ARATH/148-232  AC Q8LKG6.1
#=GS Q54V94_DICDI/163-247  AC Q54V94.1
#=GS Q7QA65_ANOGA/108-192  AC Q7QA65.3
#=GS C1BRW6_9MAXI/108-192  AC C1BRW6.1
#=GS B3RWE9_TRIAD/108-192  AC B3RWE9.1
#=GS A8NNE9_BRUMA/130-214  AC A8NNE9.1
#=GS A8WVC9_CAEBR/110-194  AC A8WVC9.2
#=GS Q1HDZ6_BOMMO/110-194  AC Q1HDZ6.2
#=GS B7P1L7_IXOSC/111-195  AC B7P1L7.1
#=GS A1A4I6_BOVIN/109-193  AC A1A4I6.1
#=GS B3LW79_DROAN/108-192  AC B3LW79.1
#=GS B0WZY9_CULQU/107-191  AC B0WZY9.1
#=GS Q7QGW8_ANOGA/106-190  AC Q7QGW8.1
Q750E6_ASHGO/166-251             QHLPPLHP...GSLVATEPISANLTNIPPLQLLEMISNLKM.LSNQDPAKIAKLEQFLRNNSVVTMVTVAQALLEMGFINYEVVTKVISE
A6ZUG7_YEAS7/173-257             KHLPSFQD...GSIIAPDKISQNLSKIPPLQLIEIISNLKI.LSNQENIQKSQLESFLDTNSDITI.SVTQALLEMGFIDYSVVTKVLKS
Q6CJ87_KLULA/220-303             KHLPAYQP...GSMTAPDVVSQNLSKIPTLQMIEILSNLKI.LANQHNK.KPQLEQFLKTNIDLTV.AVTQAMLEMGLINYHVISNVLGQ
C5DGC5_LACTC/168-251             KHLPGLQP...NSMTSPDAISANLGKIAPLQLLEMISNLKI.LASQDAN.RDQLTKFLASNPDISV.AVTQALLEMGFVNYSVVTKVIAE
A7TLA6_VANPO/167-251             QHLPQLKP...ESLTVSDPVSFNLSKIPPLQLIEIISNLKI.LSNQDGNRRGQLENFLKTNLDISI.AVTQALLEMGFINYNVVTQVMRK
C5DZU2_ZYGRC/180-264             QHLPQLQP...NILSTPDPVSSNLSKIPPLQLIEIISNLKI.LANQDSMKRSQLEAFLKTNLNISI.SVTQALLEMGFINYNAVTQVLKR
Q6FVB7_CANGA/179-263             QNLPKLEK...EALESSDPISANLSKIPPAQMIEVISNLKM.LANQHNTKRSQLETFLKSNNDILM.TMSQAMLEMGFIDYEVVTQVMKD
C5MIR7_CANTT/207-288             QSLPFNPE...FRLETPDNINVTLSKIYPPELIQMIANMKN.VAQTDP...MRVQDFFHQNPQFTL.PVAQALFLMGLIDNDVIAESQKS
B9WMR3_CANDC/170-251             KFLPPASN...FRLETTDNINVSLSKIPPPSLIELISQMKA.LSQRDP...TTLRDFFQNQPEVAL.CTAQALLLMGFIDSDVIEESSRS
Q5A422_CANAL/178-259             KFLPFAPN...FKLETANNINVLLSKIPPPQFIELLSQMKS.LSQTDP...TMVRNFFQSQPEISL.SVAQALLLMGFIDNGVIEESSKS
C4R2R8_PICPG/218-301             DLLELNTA...LPFRTDSVISENCSKLTPPVFVQLIANLKNALNKNAS..LEDTKNLLQKSPDSVT.NIAQALLLMGLIDESVIQYITTK
A5E6V1_LODEL/194-275             RNLPHTAS...LPFAKNSKVDENLSIVTPPQMVELIANMKN.LVMTDP...QRALLILQGSSSYAL.CAAQALLLMGFIDIDVISESQKA
C4XVP2_CLAL4/184-266             KMLPHVAQ...LPFATPDKINQTLSQIPPTQLIELIANLKNILSGPGA...SRAPDVFQISPALAT.TAAQALLLMGLIDEEVIQEAMKA
A3LYA2_PICST/188-270             KILPQPAQ...LPFGVPDKINDTLSKIPPAQLVELIASLKNMLSGPDA...SRAYEVFSLSPYLAT.AAAQALLLMGFIDEEVISDSMKS
A5DCN3_PICGU/166-250             STLPPFPNGV.SPFEIPDKINDTLSKIPPAQLIELISNLKNILTGPNA...ARAADVFQLSPHLAS.SAAQALLLMGFIDSDVIAESMKS
Q6BU11_DEBHA/188-270             QGLPPPSN...LPFAVPDKINETLSQIPPAQLIELISNLKSILSGPNA...NRAVDVFQLSPQLAT.AAAQALLLMGFIDADVISESMKS
Q6C6J0_YARLI/168-252             PNPSTPIPTPAPTLTTPDATSTVLSALQPNQLLDLIAHLKT.LITKNP...AEAAQILQVSEPITY.AAVQAMLLMGLIDAKVVQQVVGG
B6K5P6_SCHJY/168-251             IPGPAVVSAP.ATISKTSPIAKTLSAFPAKELLDIVEQLKT.VVHVAP...DEAKNLLKATPALSY.AVFQILLLLNMVDARVLQQVLQN
CTF1_SCHPO/200-283               YTSGTSISNP.TSIPLAPSVVQVLSTFSAQELLNMLSKLQT.VVHIAP...EEARRLLIANPALPY.AAFQAMLLMNLVDANVLQQVVVA
A6SSI6_BOTFB/126-209             PPLPIGIDLP.QGLTCPDAISRTLNTLPPSQLLDVLSQMKT.LASTDP...QKATELLHQAPQLSY.AVFQALLLMGLVQPEALSSVIES
B2ABD7_PODAN/137-220             PPLPQGKDLP.PGVSCTDAISQTLRTLPPAQLLDIIQQMKT.LATNDP...ARCAELLNQAPQLGY.AVFQALLIMGLVSPDAINSVLDT
C7YHM4_NECH7/121-204             PPLPAGKELP.HGVTCTDAISRTLETLPPPQLLDILSQMKT.LATNEP...QRAAELLQQAPQLAY.AVFQALLLMGLVSPEAIQSVVEP
B2VU88_PYRTR/867-950             GPLPPGVELP.PNLTCPDAISRTLSTLPPDQLLDILSQMKG.LVMTDP...AKATELLRQAPQLAY.AIFQSLLLLQLVDPAILTSLVET
A1CSX0_ASPCL/118-201             PPLPPGVDVP.PHLDCPNAISQTLSSLPPNQLLDVLSQMKS.LVMTDP...ARATELLRQAPQLAY.AIFQALLLMNLVDYSTLGAVVEQ
B6H860_PENCW/121-204             PPLPPGVELP.PQIDCPNAISHTLASLPPNQLLDVLTQMKS.LAVADP...ARAAELLRQAPQLAY.AVFQALLLMNLVEYQLLGSIVEQ
Q4PAI2_USTMA/198-281             ANLPAGVPLP.AGVGSTDAITQTLATLPPNQLLDIMSQMKS.LVATSP...DQARALLTGHPQLAY.ALFQAMLMMNVVDPDILQRILAA
Q55NS5_CRYNB/187-270             RMAPQGIDLL.PGQKAVDTISKTLAGIAPGQMGDVMTSMKS.LIQTNP...DQARQLLSQQPQLAY.ALFQAMLLLNLVDPSVLSSIQPL
B6JXU9_SCHJY/124-207             PPLPAGKYPP.PKMLVPEAISRVLSSYSAAELDSVLMSTKT.LCQENP...DQMCQLFDLCPQYSY.AIFQAMLMKNYTEPSLLPTILAA
B9W6X3_CANDC/97-180              PPLPLGIQIH.PNQNASQVISTILSNIDPNSALQILKEIKI.MSIDNP...KSTKVLLERFPQLSL.ALVELGLLSNTTNQELIELTLNK
Q6BU04_DEBHA/99-182              PALPLGIQLF.NNQTIPQAISNALSGLDQRSAYQLMKEAKQ.MSEDNP...TLMKKLLDQFPQLAH.ALVETSLLLNFTTPEIVKLCVNS
C4V881_NOSCE/82-165              KDTPVEIKEETTSLDI.NNIINVLNNMDADNLKEVILYLKN.LAISQP...TFFKELLAKNNQLVY.ALLYSFKLLKLVDESLITDFIKQ
Q8SRE5_ENCCU/82-166              NDMPAKAREPESQVPEIDNLINVLDNMDKDNLKEVLFYLRK.LALDQP...SYLRELLNKNPNLVY.AIIHAMLKLKLADPGVVDEILKE
A7ATY8_BABBO/108-192             VPAPQNEPFTVVEPYMAAEIASIMHTLTSSQLTHALAAFKL.FHDKSP...INAKRLLINNPQLVY.ALLHAQYILGNVDEQIMKLCGPD
B6AGT9_CRYMR/147-231             SVISLAQSPNTSLDGLSAEIIQIVQSMTIGQLYYLLGHMQK.LIIQNP...DTARCILLENPQFCY.ALLHAQYIVGMVNEPFVPLTPEQ
Q5CNN1_CRYHO/117-201             TSMPSIPNNNANFDNISSEIIQLVQGMTVSQLYYLIGHMQK.LVVQNP...ETARSILLDNPQFCY.ALLHSQFILGMVNEPFVPLNQEQ
Q01FM4_OSTTA/130-214             MRHAFEGVVTSTTGAAMDLLTKRVADLTPTQLYEIMSQVKQ.MTESDP...AQARTLLVNNPQLSL.ALFQAQLVLGMVKPPAGGATAPP
A9NXV2_PICSI/22-106              INGQSNPSGNSANAAGNRSFTSHIAGMSKPQLYDLMSQMKL.LIEQNE...QQARQILVANPAMTK.TLFQAQIMLGMLRPPQVMPNIQQ
B4FMY5_MAIZE/157-235             NGLPVQYG......LGNDPLTHYLARMSRHQLHEVMVELKF.LATQNK...EQSKTLLQGIPQLPK.ALFQAQIMLGMVTPQMMHMAKSQ
B9GT48_POPTR/165-249             VMQSNQNGLQSQPALASDPLTLHLAKMSRNQLNEIMSELKG.MATQNR...EAAHQLLLGKPQLSK.ALFQAQIMLGMVTPQVLQLPNIR
Q8LKG6_ARATH/148-232             PQVGSQFTQSNLQVPASDPLALHLAKMSRSQLTEIISSIKL.MATQNK...EHARQLLVSRPQLLK.AVFLAQVMLGIVSPQVLQSPNIV
Q54V94_DICDI/163-247             QQNQQQQQQQLSPQQTKNAIQNIIESTNPAQLFEMLSNMKS.FVQHQP...DQAISILINYPQMGL.ALLHAQVVLGMISQNAATQILLS
Q7QA65_ANOGA/108-192             NRAESPYGEHCSPQHAPEVITKHVSSLPPERLHELMLQMKQ.LVQTNP...FEARHMLVQNPQLAY.ALLQVQVLTKAIDPAAAYSFLYK
C1BRW6_9MAXI/108-192             EIVESPYGDPVHPDRAPETIANLVSSLPPEHMYSIIKEMRT.CVLHNP...DQAKRILQQNPQLAY.ALLQITVVMRAIDPEMATTVLHP
B3RWE9_TRIAD/108-192             LAEPSMYGDAVPMEEVPEVIKKSVQSLPPEQMFELMVQMKE.SIHKYP...DETRRMLLQNPQLAY.ALLQALVVMKVVDPAEATKLLHP
A8NNE9_BRUMA/130-214             QAQESPYGPETEAEKAPEAISRSVASLPPEQMFELMKQMKQ.CVHNNP...NEAKNLLMNNPQLAY.ALLQAQVVMRIIDPQVAIAMLHR
A8WVC9_CAEBR/110-194             IVEENPYGPECDAGKAPERISQTVASLAPEKMFELMKQLQE.ALKNNP...AELNSILVENPQLSY.AVLQAAVVMRIVDPQTALGLLHR
Q1HDZ6_BOMMO/110-194             PQVENPYGDPVEPEKAPEAISKAVATLPPEQMXELMKQMKL.CIQNNP...NEARNMLLQNPQLAY.ALLQAQVIMRIVDPATAVTMLHP
B7P1L7_IXOSC/111-195             PPVESPYGAEVEPERAPEAISKAVASLPPEQMFELMKQMKL.CIQNNP...GEARNMLLQNPQLAY.ALLQAQVIMKVVEPQVALSILHR
A1A4I6_BOVIN/109-193             PVIESPYGETISPEDAPESISKAVASLPPEQMFELMKQMKL.CVQNSP...QEARNMLLQNPQLAY.ALLQAQVVMRIVDPEIALKILHR
B3LW79_DROAN/108-192             PQVENPYGEPCEPEDAPELITKTVASLPPEQMYELMKQMKL.CIVSNP...SEARQMLMLNPQLAY.ALLQAMVVMRIVDPQQALGMLFK
B0WZY9_CULQU/107-191             PQVDNPYGDPCDPSDAPEIITKTVVSLPPEQMYELMKQMKT.CFQNNP...VEARTMLMQNPQLAY.ALLQAQVVMRIVDPATAVTFLHK
Q7QGW8_ANOGA/106-190             PQVENPYGAECDPKETPDLIAKTVTGLQPDQMYELMRQAKA.CIQNDP...LEARNMLLENPQLTY.ALLQSAVVMRIVDSHTALSFLHG
#=GC seq_cons                    ..lPsshs...sshpss-sIopsLuslsPsQLh-llsphKp.LsppsP...spAcplLtpsPQLuh.AlhQAhllMshl-spllppslpp
//