# STOCKHOLM 1.0
#=GF ID   Prok-E2_A
#=GF AC   PF14457.1
#=GF DE   Prokaryotic E2 family A
#=GF AU   Iyer LM, Burroughs AM, Aravind L
#=GF SE   Manual
#=GF GA   25.00 25.00;
#=GF TC   27.40 26.70;
#=GF NC   22.90 22.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   16859499
#=GF RT   The prokaryotic antecedents of the ubiquitin-signaling system
#=GF RT   and the early evolution of ubiquitin-like beta-grasp domains. 
#=GF RA   Iyer LM, Burroughs AM, Aravind L; 
#=GF RL   Genome Biol. 2006;7:R60.
#=GF RN   [2]
#=GF RM   18276160
#=GF RT   Anatomy of the E2 ligase fold: implications for enzymology and
#=GF RT   evolution of ubiquitin/Ub-like protein conjugation.
#=GF RA   Burroughs AM, Jaffee M, Iyer LM, Aravind L;
#=GF RL   J Struct Biol. 2008;162:205-218.
#=GF CC   A member of the E2/UBC superfamily of proteins found in several
#=GF CC   bacteria. The active site residues are very similar to the
#=GF CC   eukaryotic E2 proteins [1,2]. Members of this family are usually
#=GF CC   fused to E1 and JAB domains C-terminal to the E2 domain. The
#=GF CC   protein is usually in the gene neighborhood of a gene encoding a
#=GF CC   distinct metallobetalactamase family protein [1].
#=GF SQ   12
#=GS A1VVG1_POLNA/24-184  AC A1VVG1.1
#=GS Q8PFM8_XANAC/22-182  AC Q8PFM8.1
#=GS A1U033_MARAV/19-179  AC A1U033.1
#=GS A3U023_9RHOB/20-179  AC A3U023.1
#=GS Q5HY19_GLUOX/8-170   AC Q5HY19.1
#=GS Q4ZFT1_CLOPF/15-178  AC Q4ZFT1.1
#=GS Q3SNL9_NITWN/14-180  AC Q3SNL9.1
#=GS A9BTW4_DELAS/5-166   AC A9BTW4.1
#=GS Q21PA7_SACD2/14-175  AC Q21PA7.1
#=GS A1U5J0_MARAV/18-180  AC A1U5J0.1
#=GS A0L5E1_MAGSM/13-169  AC A0L5E1.1
#=GS Q3J4T6_RHOS4/6-183   AC Q3J4T6.1
A1VVG1_POLNA/24-184             RAKTLFDVVSRQRDYAVVQLLQHCDDGTPKLECIVVEVECDGVPPKNGVGINYRERL..ALCVSDDPKQLIEVLAMRKDFPVL........MHQNQGILDAP......ASLCLYFESV.....AAVMRTWTP.....QSFLRRIQWWLEKSARGELHPTDQPVEHLFFATRYE.LVLPWNLSTLRKSA
Q8PFM8_XANAC/22-182             DGRMQALLRACNAHADINVVELRRIEDPFIAEIIVADVGDGAVSPGNDAGIHRIERM.ALLYRTGARFPFE.ARPLRKTFPKA........LHQYATGNEGP......PSLCIMEGDW.....ELAEHRFTP.....EALLETLLAWLEKTADGTIHEADRGLEPVFYSLGQC.LMLPPDFAEALSDP
A1U033_MARAV/19-179             NLPEPLSDLADACNDNSDFDIVEFRRISKDSYALVVDAGDGTFDAENPVGIRRIERL.AFVLNPNLGFPWE.VRALRSDFPVT........MHQNHVEPNSP......RSLCLYVEPW.....SSVERTWSP.....QSFLARALWWLRETACENLHQANQPLEQLFFEPADQ.FVLPEDYFERLTDT
A3U023_9RHOB/20-179             LTSSAAASFARFVDRHAAELAAIVALRRGGAGELVELAFRTGRPQQSVVPIRRTERI...GVRFAGGDSMPFVYVLRSDFPDT........AHQNLTAEGSP......RAICIDDRGW.....AEARLTWTP.....AELVQRILAWFRRAAEGALHDARQPVDPLMFGTGYNI.IMSRALIDNANTQ
Q5HY19_GLUOX/8-170              RSRLARSVIEYVCDSVEHPYATIQEFQSDGLSDIVDLELEIDLAQDRAVPIRHREPV.RIVFASPDDLIAPRVLSLREDFPSG.......QVHTNLDREVDG......LCLCIWEEGW.....HDLSRNLTG.....QALVERIRWWFAGMADGSLHADDQILEPLVATTSDT.IVFPLGTFVGPWFI
Q4ZFT1_CLOPF/15-178             NDDFTMFYKGLLECKNVKNITIYKLNINSVIIRLELKINLPSRRSLMEFDIKEFEPIKLLCSTNEIKYKAPLVFSDRNDFPVEK......LPHTLAMGLNY.......SYICLHRGNI.....DDWYIDHSV.....EDFVNRIRFWFSDAACNNLIKPGDDFEPMINYTETG.NIVYSYNKLTKFIE
Q3SNL9_NITWN/14-180             AERFLAAALRHPECRGGRLISVDAGGSRIELDLNVEMPLAFKVDGASPNGVRVVETV.NVRLWPSYPWSSP.SFYLRMDFPRD.......LPHVQPGPVTEP......PRPCLIDGNQ.....REYFFQFGLVELGIFNLVHQLVLWLQRAAEGTLIHHGRGWEPTLRCDLND.VIALNAEACRAVVD
A9BTW4_DELAS/5-166              IADALHQLQRHRGLIRVGEPRTTGASTEIEVDVAVQLPNRSRRNGISETGVRTVETC.VLVFGSDWPLSAP.EPFLRADFPLN.......LPHINPHRQGEL......VSPCLFEGSL.....NELLHRFGL.....DAVVDQLIDWLHKAAAGTLLDLEQGWEPTRRDSCPS.TVVFSAEKVAAAAP
Q21PA7_SACD2/14-175             IHDVIRWLDETRSVAGIQTVTSSDDGVVVATNWRVDLPIRFESEGETESGIRSIEAV.SWVFPWEYPLRAP.QPKLREDFPLT.......LPHINPVVEGED......ISPCIAEVDL.....TDLLHSSGI.....EAVFGAMTHWLNNAASGELLCPVQGWEPVRRDNASG.LISADTYAIREELN
A1U5J0_MARAV/18-180             HIQMLVAAILQHQRSEDHQVTERENELVLDVSWRVQLSSRDVEVGQSGTGIKRLEPV.RFLIPFAFPLRPP.DITLRSDFPREF......VPHIYPGSPGDP......VCPCIAEVGI.....TDLMFQEGI.....SGVLRSLQAWLDRAAQGTLMDPSQGWEPILFQNIAG.SFLDDKGSFLRGVR
A0L5E1_MAGSM/13-169             ALEQVADIVAASNGTVELVQIDPPTSEGDTLLLRVSIDTSDYTFQKGGLKFRKREGF.HIRVSSRFPIEPPIAKFTHQRFMG........QAHVQWG...........NQICLYLATD.....VEWSASDGM.....FGFIKRLDQWLGDAAQDQLDPDDAPLHPPAVYHSSD.TKFSVEIDTPELAD
Q3J4T6_RHOS4/6-183              DEEIPDVLHPVTSLLRIGVGPVTALEGWKEWRRGFFSLPLVARVTISPGQSFPAESR...WHLVVSSGSYPA...DIFILPDKVAGPNLTFPHQAAVYSRDGKEPWLNGEPCLTDPTAAFGDRHGSRPEPIAL...ADRLIWKVERFSRWCELAAAGRLHNPGDHFELPPLSG.HTNPMTIGFHETEG
#=GC seq_cons                   ttchhtshhtptsstsht.htspttptshthphhVths.psshsstssssI+phEsl..hhhssshshphP.shhLRpDFPhp........sH.p.sh.sps......ss.Clh-ssh.....s-hhhphsh.....pullpplhhWLpcuApGsLhpsspshEPhhhsstss.hlhs.shthtttss
//