Summary: Parkin co-regulated protein
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Parkin co-regulated protein Provide feedback
This family of proteins is transcribed anti-sense along the DNA to the Parkin gene product and the two appear to be transcribed under the same promoter. The protein has predicted alpha-helical and beta-sheet domains which suggest its function is in the ubiquitin/proteasome system . Mutations in parkin are the genetic cause of early-onset and autosomal recessive juvenile parkinsonism.
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR019399
This family of proteins is transcribed anti-sense along the DNA to the Parkin gene product and the two appear to be transcribed under the same promoter. The protein has predicted alpha-helical and beta-sheet domains which suggest its function is in the ubiquitin/proteasome system [PUBMED:12547187]. Mutations in parkin are the genetic cause of early-onset and autosomal recessive juvenile parkinsonism.
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We make a range of alignments for each Pfam-A family:
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Curation and family details
|Seed source:||KOGs (KOG3961)|
|Author:||KOGs, Finn RD, Coggill PC|
|Number in seed:||21|
|Number in full:||338|
|Average length of the domain:||152.70 aa|
|Average identity of full alignment:||38 %|
|Average coverage of the sequence by the domain:||43.48 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||4|
|Download:||download the raw HMM for this family|
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