Summary: Replication terminator protein
Replication terminator protein Provide feedback
The bacterial replication terminator protein (RTP) plays a role in the termination of DNA replication by impeding replication fork movement. Two RTP dimers bind to the two inverted repeat regions at the termination site.
Pai KS, Bussiere DE, Wang F, Hutchison CA 3rd, White SW, Bastia D; , EMBO J 1996;15:3164-3173.: The structure and function of the replication terminator protein of Bacillus subtilis: identification of the 'winged helix' DNA-binding domain. PUBMED:8670817 EPMC:8670817
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR003432The bacterial replication terminator protein (RTP) plays a role in the termination of DNA replication by impeding replication fork movement. Two RTP dimers bind to the two inverted repeat regions at the termination site.
|Molecular function||DNA binding (GO:0003677)|
|Biological process||DNA replication termination (GO:0006274)|
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Curation and family details
|Seed source:||Pfam-B_12997 (release 5.2)|
|Author:||Mian N, Bateman A|
|Number in seed:||3|
|Number in full:||54|
|Average length of the domain:||119.40 aa|
|Average identity of full alignment:||66 %|
|Average coverage of the sequence by the domain:||98.83 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||11|
|Download:||download the raw HMM for this family|
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There is 1 interaction for this family. More...
We determine these interactions using iPfam, which considers the interactions between residues in three-dimensional protein structures and maps those interactions back to Pfam families. You can find more information about the iPfam algorithm in the journal article that accompanies the website.
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the RTP domain has been found. There are 17 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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