Summary: Tetratricopeptide repeat
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Tetratricopeptide repeat Provide feedback
This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by PF00515.
Das AK, Cohen PW, Barford D; , EMBO J 1998;17:1192-1199.: The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions. PUBMED:9482716 EPMC:9482716
Internal database links
|Similarity to PfamA using HHSearch:||MIT TPR_1 Coatomer_E TPR_3 TPR_4 TPR_21 SHNi-TPR NARP1 Apc5 Apc3 TPR_6 TPR_7 TPR_8 TPR_9 TPR_10 TPR_11 TPR_11 TPR_12 TPR_12 TPR_14 TPR_15 TPR_17 TPR_16 TPR_16 TPR_19 TPR_19 Fis1_TPR_C|
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR013105
The tetratrico peptide repeat (TPR) is a structural motif present in a wide range of proteins [PUBMED:7667876, PUBMED:9482716, PUBMED:1882418]. It mediates protein-protein interactions and the assembly of multiprotein complexes [PUBMED:14659697]. The TPR motif consists of 3-16 tandem-repeats of 34 amino acids residues, although individual TPR motifs can be dispersed in the protein sequence. Sequence alignment of the TPR domains reveals a consensus sequence defined by a pattern of small and large amino acids. TPR motifs have been identified in various different organisms, ranging from bacteria to humans. Proteins containing TPRs are involved in a variety of biological processes, such as cell cycle regulation, transcriptional control, mitochondrial and peroxisomal protein transport, neurogenesis and protein folding.
This repeat includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by INTERPRO.
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This example describes an architecture with one
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We make a range of alignments for each Pfam-A family:
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Curation and family details
|Seed source:||Context matches from Pfam 14.0|
|Number in seed:||369|
|Number in full:||18395|
|Average length of the domain:||32.50 aa|
|Average identity of full alignment:||19 %|
|Average coverage of the sequence by the domain:||6.62 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||12|
|Download:||download the raw HMM for this family|
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There is 1 interaction for this family. More...
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the TPR_2 domain has been found. There are 24 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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