Summary: Taurine catabolism dioxygenase TauD, TfdA family
Taurine catabolism dioxygenase TauD, TfdA family Provide feedback
This family consists of taurine catabolism dioxygenases of the TauD, TfdA family. TauD from E. coli P37610 is a alpha-ketoglutarate-dependent taurine dioxygenase . This enzyme catalyses the oxygenolytic release of sulfite from taurine . TfdA from Burkholderia sp. Q45423 is a 2,4-dichlorophenoxyacetic acid/alpha-ketoglutarate dioxygenase . TfdA from Alcaligenes eutrophus JMP134 P10088 is a 2,4-dichlorophenoxyacetate monooxygenase . Also included are gamma-Butyrobetaine hydroxylase enzymes EC:22.214.171.124 .
Eichhorn E, van der Ploeg JR, Kertesz MA, Leisinger T; , J Biol Chem 1997;272:23031-23036.: Characterization of alpha-ketoglutarate-dependent taurine dioxygenase from Escherichia coli. PUBMED:9287300 EPMC:9287300
Suwa Y, Wright AD, Fukimori F, Nummy KA, Hausinger RP, Holben WE, Forney LJ; , Appl Environ Microbiol 1996;62:2464-2469.: Characterization of a chromosomally encoded 2,4-dichlorophenoxyacetic acid/alpha-ketoglutarate dioxygenase from Burkholderia sp. strain RASC. PUBMED:8779585 EPMC:8779585
Streber WR, Timmis KN, Zenk MH; , J Bacteriol 1987;169:2950-2955.: Analysis, cloning, and high-level expression of 2,4-dichlorophenoxyacetate monooxygenase gene tfdA of Alcaligenes eutrophus JMP134. PUBMED:3036764 EPMC:3036764
Ruetschi U, Nordin I, Odelhog B, Jornvall H, Lindstedt S; , Eur J Biochem 1993;213:1075-1080.: gamma-Butyrobetaine hydroxylase. Structural characterization of the Pseudomonas enzyme. PUBMED:8504802 EPMC:8504802
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR003819This family consists of TauD/TfdA taurine catabolism dioxygenases. The Escherichia coli tauD gene is required for the utilization of taurine (2-aminoethanesulphonic acid) as a sulphur source and is expressed only under conditions of sulphate starvation. TauD is an alpha-ketoglutarate-dependent dioxygenase catalyzing the oxygenolytic release of sulphite from taurine [PUBMED:9287300]. The 2,4-dichlorophenoxyacetic acid/alpha-ketoglutarate dioxygenase from Burkholderia sp. (strain RASC) also belongs to this family [PUBMED:8779585]. TfdA from Ralstonia eutropha (Alcaligenes eutrophus) is a 2,4-D monooxygenase [PUBMED:3036764].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Molecular function||oxidoreductase activity (GO:0016491)|
|Biological process||oxidation-reduction process (GO:0055114)|
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Curation and family details
|Author:||Bashton M, Bateman A, Mifsud W|
|Number in seed:||123|
|Number in full:||5659|
|Average length of the domain:||240.80 aa|
|Average identity of full alignment:||19 %|
|Average coverage of the sequence by the domain:||77.33 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||11|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the TauD domain has been found. There are 78 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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