Summary: Bacterial transcriptional repressor
Bacterial transcriptional repressor Provide feedback
This family of bacterial transcriptional repressors is characterised by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity . Another target protein is BetI, an osmoprotectant which controls the choline-glycine betaine pathway in E.coli .
Ramos JL, Martinez-Bueno M, Molina-Henares AJ, Teran W, Watanabe K, Zhang X, Gallegos MT, Brennan R, Tobes R;, Microbiol Mol Biol Rev. 2005;69:326-356. : The TetR family of transcriptional repressors. PUBMED:15944459 EPMC:15944459
Kunin CM, Hua TH, Van Arsdale White L, Villarejo M;, J Infect Dis. 1992;166:1311-1315.: Growth of Escherichia coli in human urine: role of salt tolerance and accumulation of glycine betaine. PUBMED:1431248 EPMC:1431248
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This tab holds annotation information from the InterPro database.
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- the number of sequences which exhibit this architecture
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This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
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We make a range of alignments for each Pfam-A family:
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Curation and family details
|Number in seed:||258|
|Number in full:||2956|
|Average length of the domain:||109.00 aa|
|Average identity of full alignment:||18 %|
|Average coverage of the sequence by the domain:||54.34 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||1|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the TetR_C_6 domain has been found. There are 20 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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