Summary: Vacuolar sorting protein 39 domain 1
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Vacuolar sorting protein 39 domain 1 Provide feedback
This domain is found on the vacuolar sorting protein Vps39 which is a component of the C-Vps complex . Vps39 is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole . In Saccharomyces cerevisiae, Vps39 has been shown to stimulate nucleotide exchange . The precise function of this domain has not been characterised.
Wurmser AE, Sato TK, Emr SD; , J Cell Biol. 2000;151:551-562.: New component of the vacuolar class C-Vps complex couples nucleotide exchange on the Ypt7 GTPase to SNARE-dependent docking and fusion. PUBMED:11062257 EPMC:11062257
Nakamura N, Hirata A, Ohsumi Y, Wada Y; , J Biol Chem. 1997;272:11344-11349.: Vam2/Vps41p and Vam6/Vps39p are components of a protein complex on the vacuolar membranes and involved in the vacuolar assembly in the yeast Saccharomyces cerevisiae. PUBMED:9111041 EPMC:9111041
Raymond CK, Howald-Stevenson I, Vater CA, Stevens TH; , Mol Biol Cell. 1992;3:1389-1402.: Morphological classification of the yeast vacuolar protein sorting mutants: evidence for a prevacuolar compartment in class E vps mutants. PUBMED:1493335 EPMC:1493335
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR019452
This entry represents a domain found in the vacuolar sorting protein Vps39 and transforming growth factor beta receptor-associated protein Trap1. Vps39, a component of the C-Vps complex, is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole [PUBMED:9111041, PUBMED:1493335]. In Saccharomyces cerevisiae (Baker's yeast), Vps39 has been shown to stimulate nucleotide exchange [PUBMED:11062257]. Trap1 plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling [PUBMED:9545258, PUBMED:11278302]. The precise function of this domain has not been characterised.
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Curation and family details
|Author:||Mistry J, Wood V|
|Number in seed:||23|
|Number in full:||369|
|Average length of the domain:||105.10 aa|
|Average identity of full alignment:||34 %|
|Average coverage of the sequence by the domain:||11.14 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||4|
|Download:||download the raw HMM for this family|
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