Summary
This is the summary of UniProt entry LDHA_HUMAN (P00338) (via secondary accession B7Z5E3).
| Description: | L-lactate dehydrogenase A chain EC=1.1.1.27 |
| Source organism: |
Homo sapiens (Human) |
| Length: | 332 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| Pfam A | Ldh_1_N | 21 | 160 |
| low_complexity | n/a | 25 | 36 |
| Pfam A | Ldh_1_C | 163 | 331 |
Show or hide domain scores.
Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
Note: it can take a few seconds for this image to be generated and loaded.
Show sources update panel.
Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession P00338. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MATLKDQLIY NLLKEEQTPQ NKITVVGVGA VGMACAISIL MKDLADELAL
50 51
VDVIEDKLKG EMMDLQHGSL FLRTPKIVSG KDYNVTANSK LVIITAGARQ
100 101
QEGESRLNLV QRNVNIFKFI IPNVVKYSPN CKLLIVSNPV DILTYVAWKI
150 151
SGFPKNRVIG SGCNLDSARF RYLMGERLGV HPLSCHGWVL GEHGDSSVPV
200 201
WSGMNVAGVS LKTLHPDLGT DKDKEQWKEV HKQVVESAYE VIKLKGYTSW
250 251
AIGLSVADLA ESIMKNLRRV HPVSTMIKGL YGIKDDVFLS VPCILGQNGI
300 301
SDLVKVTLTS EEEARLKKSA DTLWGIQKEL QF
332
Show the unformatted sequence. |
| Checksums: |
CRC64:401E8604CEB7F908
MD5:f107329c51dc2f245e37b0c38e359526
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| Ldh_1_C | 163 - 331 | 1I10 | A | 162 - 330 | Jmol AstexViewer SPICE |
| B | 162 - 330 | Jmol AstexViewer SPICE | |||
| C | 162 - 330 | Jmol AstexViewer SPICE | |||
| D | 162 - 330 | Jmol AstexViewer SPICE | |||
| E | 162 - 330 | Jmol AstexViewer SPICE | |||
| F | 162 - 330 | Jmol AstexViewer SPICE | |||
| G | 162 - 330 | Jmol AstexViewer SPICE | |||
| H | 162 - 330 | Jmol AstexViewer SPICE | |||
| 4AJP | A | 162 - 330 | Jmol AstexViewer SPICE | ||
| B | 162 - 330 | Jmol AstexViewer SPICE | |||
| C | 162 - 330 | Jmol AstexViewer SPICE | |||
| D | 162 - 330 | Jmol AstexViewer SPICE | |||
| Ldh_1_N | 21 - 160 | 1I10 | A | 20 - 159 | Jmol AstexViewer SPICE |
| B | 20 - 159 | Jmol AstexViewer SPICE | |||
| C | 20 - 159 | Jmol AstexViewer SPICE | |||
| D | 20 - 159 | Jmol AstexViewer SPICE | |||
| E | 20 - 159 | Jmol AstexViewer SPICE | |||
| F | 20 - 159 | Jmol AstexViewer SPICE | |||
| G | 20 - 159 | Jmol AstexViewer SPICE | |||
| H | 20 - 159 | Jmol AstexViewer SPICE | |||
| 4AJP | A | 20 - 159 | Jmol AstexViewer SPICE | ||
| B | 20 - 159 | Jmol AstexViewer SPICE | |||
| C | 20 - 159 | Jmol AstexViewer SPICE | |||
| D | 20 - 159 | Jmol AstexViewer SPICE |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.
