Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
9  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TLR4_HUMAN (O00206)

Summary

This is the summary of UniProt entry TLR4_HUMAN (O00206).

Description: Toll-like receptor 4
Source organism: Homo sapiens (Human)
Length: 839 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
sig_p n/a 1 23
Pfam A LRR_8 55 114
Pfam A LRR_8 90 138
low_complexity n/a 116 128
Pfam A LRR_4 150 199
low_complexity n/a 203 213
low_complexity n/a 292 303
Pfam A LRR_6 372 395
Pfam A LRR_8 399 458
Pfam A LRR_8 422 483
Pfam A LRR_8 447 508
Pfam A LRR_8 484 532
Pfam A LRR_8 496 556
transmembrane n/a 633 652
low_complexity n/a 636 651
Pfam A TIR 676 814

Show or hide domain scores.

Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

Note: it can take a few seconds for this image to be generated and loaded.

Loading feature alignment...

Show sources update panel.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O00206. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MMSASRLAGT LIPAMAFLSC VRPESWEPCV EVVPNITYQC MELNFYKIPD
50
51
NLPFSTKNLD LSFNPLRHLG SYSFFSFPEL QVLDLSRCEI QTIEDGAYQS
100
101
LSHLSTLILT GNPIQSLALG AFSGLSSLQK LVAVETNLAS LENFPIGHLK
150
151
TLKELNVAHN LIQSFKLPEY FSNLTNLEHL DLSSNKIQSI YCTDLRVLHQ
200
201
MPLLNLSLDL SLNPMNFIQP GAFKEIRLHK LTLRNNFDSL NVMKTCIQGL
250
251
AGLEVHRLVL GEFRNEGNLE KFDKSALEGL CNLTIEEFRL AYLDYYLDDI
300
301
IDLFNCLTNV SSFSLVSVTI ERVKDFSYNF GWQHLELVNC KFGQFPTLKL
350
351
KSLKRLTFTS NKGGNAFSEV DLPSLEFLDL SRNGLSFKGC CSQSDFGTTS
400
401
LKYLDLSFNG VITMSSNFLG LEQLEHLDFQ HSNLKQMSEF SVFLSLRNLI
450
451
YLDISHTHTR VAFNGIFNGL SSLEVLKMAG NSFQENFLPD IFTELRNLTF
500
501
LDLSQCQLEQ LSPTAFNSLS SLQVLNMSHN NFFSLDTFPY KCLNSLQVLD
550
551
YSLNHIMTSK KQELQHFPSS LAFLNLTQND FACTCEHQSF LQWIKDQRQL
600
601
LVEVERMECA TPSDKQGMPV LSLNITCQMN KTIIGVSVLS VLVVSVVAVL
650
651
VYKFYFHLML LAGCIKYGRG ENIYDAFVIY SSQDEDWVRN ELVKNLEEGV
700
701
PPFQLCLHYR DFIPGVAIAA NIIHEGFHKS RKVIVVVSQH FIQSRWCIFE
750
751
YEIAQTWQFL SSRAGIIFIV LQKVEKTLLR QQVELYRLLS RNTYLEWEDS
800
801
VLGRHIFWRR LRKALLDGKS WNPEGTVGTG CNWQEATSI            
839
 

Show the unformatted sequence.

Checksums:
CRC64:92C48F55821133E8
MD5:70505bff44a5752121f6174e6eeabca2

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
LRR_4 150 - 199 2Z62 A 150 - 199 Jmol AstexViewer SPICE
2Z63 A 150 - 199 Jmol AstexViewer SPICE
2Z65 A 150 - 199 Jmol AstexViewer SPICE
B 150 - 199 Jmol AstexViewer SPICE
3FXI A 150 - 199 Jmol AstexViewer SPICE
B 150 - 199 Jmol AstexViewer SPICE
3UL7 A 150 - 199 Jmol AstexViewer SPICE
3UL8 A 150 - 199 Jmol AstexViewer SPICE
3UL9 A 150 - 199 Jmol AstexViewer SPICE
3ULA A 150 - 199 Jmol AstexViewer SPICE
C 150 - 199 Jmol AstexViewer SPICE
LRR_6 372 - 395 2Z63 A 372 - 395 Jmol AstexViewer SPICE
3FXI A 372 - 395 Jmol AstexViewer SPICE
B 372 - 395 Jmol AstexViewer SPICE
380 - 395 2Z66 A 82 - 395 Jmol AstexViewer SPICE
B 82 - 395 Jmol AstexViewer SPICE
C 82 - 395 Jmol AstexViewer SPICE
D 82 - 395 Jmol AstexViewer SPICE
LRR_8 399 - 458 2Z63 A 399 - 458 Jmol AstexViewer SPICE
2Z66 A 399 - 458 Jmol AstexViewer SPICE
B 399 - 458 Jmol AstexViewer SPICE
C 399 - 458 Jmol AstexViewer SPICE
D 399 - 458 Jmol AstexViewer SPICE
3FXI A 399 - 458 Jmol AstexViewer SPICE
B 399 - 458 Jmol AstexViewer SPICE
422 - 483 2Z63 A 422 - 483 Jmol AstexViewer SPICE
2Z66 A 422 - 483 Jmol AstexViewer SPICE
B 422 - 483 Jmol AstexViewer SPICE
C 422 - 483 Jmol AstexViewer SPICE
D 422 - 483 Jmol AstexViewer SPICE
3FXI A 422 - 483 Jmol AstexViewer SPICE
B 422 - 483 Jmol AstexViewer SPICE
447 - 508 2Z63 A 447 - 508 Jmol AstexViewer SPICE
2Z66 A 447 - 508 Jmol AstexViewer SPICE
B 447 - 508 Jmol AstexViewer SPICE
C 447 - 508 Jmol AstexViewer SPICE
D 447 - 508 Jmol AstexViewer SPICE
3FXI A 447 - 508 Jmol AstexViewer SPICE
B 447 - 508 Jmol AstexViewer SPICE
484 - 527 2Z63 A 484 - 527 Jmol AstexViewer SPICE
484 - 532 2Z66 A 484 - 532 Jmol AstexViewer SPICE
B 484 - 532 Jmol AstexViewer SPICE
C 484 - 532 Jmol AstexViewer SPICE
D 484 - 532 Jmol AstexViewer SPICE
3FXI A 484 - 532 Jmol AstexViewer SPICE
B 484 - 532 Jmol AstexViewer SPICE
496 - 527 2Z63 A 496 - 527 Jmol AstexViewer SPICE
496 - 556 2Z66 A 496 - 556 Jmol AstexViewer SPICE
B 496 - 556 Jmol AstexViewer SPICE
C 496 - 556 Jmol AstexViewer SPICE
D 496 - 556 Jmol AstexViewer SPICE
3FXI A 496 - 556 Jmol AstexViewer SPICE
B 496 - 556 Jmol AstexViewer SPICE
55 - 114 2Z62 A 55 - 114 Jmol AstexViewer SPICE
2Z63 A 55 - 114 Jmol AstexViewer SPICE
2Z65 A 55 - 114 Jmol AstexViewer SPICE
B 55 - 114 Jmol AstexViewer SPICE
3FXI A 55 - 114 Jmol AstexViewer SPICE
B 55 - 114 Jmol AstexViewer SPICE
3UL7 A 55 - 114 Jmol AstexViewer SPICE
3UL8 A 55 - 114 Jmol AstexViewer SPICE
3UL9 A 55 - 114 Jmol AstexViewer SPICE
3ULA A 55 - 114 Jmol AstexViewer SPICE
C 55 - 114 Jmol AstexViewer SPICE
90 - 138 2Z62 A 90 - 138 Jmol AstexViewer SPICE
2Z63 A 90 - 138 Jmol AstexViewer SPICE
2Z65 A 90 - 138 Jmol AstexViewer SPICE
B 90 - 138 Jmol AstexViewer SPICE
3FXI A 90 - 138 Jmol AstexViewer SPICE
B 90 - 138 Jmol AstexViewer SPICE
3UL7 A 90 - 138 Jmol AstexViewer SPICE
3UL8 A 90 - 138 Jmol AstexViewer SPICE
3UL9 A 90 - 138 Jmol AstexViewer SPICE
3ULA A 90 - 138 Jmol AstexViewer SPICE
C 90 - 138 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.