Summary
This is the summary of UniProt entry TLR4_HUMAN (O00206).
| Description: | Toll-like receptor 4 |
| Source organism: |
Homo sapiens (Human) |
| Length: | 839 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| sig_p | n/a | 1 | 23 |
| Pfam A | LRR_8 | 55 | 114 |
| Pfam A | LRR_8 | 90 | 138 |
| low_complexity | n/a | 116 | 128 |
| Pfam A | LRR_4 | 150 | 199 |
| low_complexity | n/a | 203 | 213 |
| low_complexity | n/a | 292 | 303 |
| Pfam A | LRR_6 | 372 | 395 |
| Pfam A | LRR_8 | 399 | 458 |
| Pfam A | LRR_8 | 422 | 483 |
| Pfam A | LRR_8 | 447 | 508 |
| Pfam A | LRR_8 | 484 | 532 |
| Pfam A | LRR_8 | 496 | 556 |
| transmembrane | n/a | 633 | 652 |
| low_complexity | n/a | 636 | 651 |
| Pfam A | TIR | 676 | 814 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession O00206. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MMSASRLAGT LIPAMAFLSC VRPESWEPCV EVVPNITYQC MELNFYKIPD
50 51
NLPFSTKNLD LSFNPLRHLG SYSFFSFPEL QVLDLSRCEI QTIEDGAYQS
100 101
LSHLSTLILT GNPIQSLALG AFSGLSSLQK LVAVETNLAS LENFPIGHLK
150 151
TLKELNVAHN LIQSFKLPEY FSNLTNLEHL DLSSNKIQSI YCTDLRVLHQ
200 201
MPLLNLSLDL SLNPMNFIQP GAFKEIRLHK LTLRNNFDSL NVMKTCIQGL
250 251
AGLEVHRLVL GEFRNEGNLE KFDKSALEGL CNLTIEEFRL AYLDYYLDDI
300 301
IDLFNCLTNV SSFSLVSVTI ERVKDFSYNF GWQHLELVNC KFGQFPTLKL
350 351
KSLKRLTFTS NKGGNAFSEV DLPSLEFLDL SRNGLSFKGC CSQSDFGTTS
400 401
LKYLDLSFNG VITMSSNFLG LEQLEHLDFQ HSNLKQMSEF SVFLSLRNLI
450 451
YLDISHTHTR VAFNGIFNGL SSLEVLKMAG NSFQENFLPD IFTELRNLTF
500 501
LDLSQCQLEQ LSPTAFNSLS SLQVLNMSHN NFFSLDTFPY KCLNSLQVLD
550 551
YSLNHIMTSK KQELQHFPSS LAFLNLTQND FACTCEHQSF LQWIKDQRQL
600 601
LVEVERMECA TPSDKQGMPV LSLNITCQMN KTIIGVSVLS VLVVSVVAVL
650 651
VYKFYFHLML LAGCIKYGRG ENIYDAFVIY SSQDEDWVRN ELVKNLEEGV
700 701
PPFQLCLHYR DFIPGVAIAA NIIHEGFHKS RKVIVVVSQH FIQSRWCIFE
750 751
YEIAQTWQFL SSRAGIIFIV LQKVEKTLLR QQVELYRLLS RNTYLEWEDS
800 801
VLGRHIFWRR LRKALLDGKS WNPEGTVGTG CNWQEATSI
839
Show the unformatted sequence. |
| Checksums: |
CRC64:92C48F55821133E8
MD5:70505bff44a5752121f6174e6eeabca2
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.
