Summary
This is the summary of UniProt entry ERN1_HUMAN (O75460).
| Description: | Serine/threonine-protein kinase/endoribonuclease IRE1 Serine/threonine-protein kinase Endoribonuclease EC=2.7.11.1 EC=3.1.26.- |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
View Pfam proteome data. |
| Length: | 977 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| sig_p | n/a | 1 | 21 |
| low_complexity | n/a | 6 | 18 |
| disorder | n/a | 67 | 70 |
| Pfam B | Pfam-B_78284 | 211 | 286 |
| disorder | n/a | 318 | 320 |
| disorder | n/a | 326 | 329 |
| Pfam B | Pfam-B_31513 | 338 | 570 |
| disorder | n/a | 373 | 378 |
| disorder | n/a | 381 | 392 |
| disorder | n/a | 402 | 406 |
| disorder | n/a | 410 | 437 |
| transmembrane | n/a | 444 | 466 |
| coiled_coil | n/a | 469 | 489 |
| low_complexity | n/a | 469 | 496 |
| disorder | n/a | 471 | 486 |
| disorder | n/a | 490 | 540 |
| low_complexity | n/a | 513 | 530 |
| low_complexity | n/a | 536 | 552 |
| disorder | n/a | 542 | 559 |
| Pfam A | Pkinase | 571 | 832 |
| Pfam A | Ribonuc_2-5A | 837 | 963 |
| low_complexity | n/a | 957 | 971 |
| disorder | n/a | 963 | 964 |
| disorder | n/a | 968 | 969 |
| disorder | n/a | 971 | 977 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession O75460. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MPARRLLLLL TLLLPGLGIF GSTSTVTLPE TLLFVSTLDG SLHAVSKRTG
50 51
SIKWTLKEDP VLQVPTHVEE PAFLPDPNDG SLYTLGSKNN EGLTKLPFTI
100 101
PELVQASPCR SSDGILYMGK KQDIWYVIDL LTGEKQQTLS SAFADSLCPS
150 151
TSLLYLGRTE YTITMYDTKT RELRWNATYF DYAASLPEDD VDYKMSHFVS
200 201
NGDGLVVTVD SESGDVLWIQ NYASPVVAFY VWQREGLRKV MHINVAVETL
250 251
RYLTFMSGEV GRITKWKYPF PKETEAKSKL TPTLYVGKYS TSLYASPSMV
300 301
HEGVAVVPRG STLPLLEGPQ TDGVTIGDKG ECVITPSTDV KFDPGLKSKN
350 351
KLNYLRNYWL LIGHHETPLS ASTKMLERFP NNLPKHRENV IPADSEKKSF
400 401
EEVINLVDQT SENAPTTVSR DVEEKPAHAP ARPEAPVDSM LKDMATIILS
450 451
TFLLIGWVAF IITYPLSMHQ QQQLQHQQFQ KELEKIQLLQ QQQQQLPFHP
500 501
PGDTAQDGEL LDTSGPYSES SGTSSPSTSP RASNHSLCSG SSASKAGSSP
550 551
SLEQDDGDEE TSVVIVGKIS FCPKDVLGHG AEGTIVYRGM FDNRDVAVKR
600 601
ILPECFSFAD REVQLLRESD EHPNVIRYFC TEKDRQFQYI AIELCAATLQ
650 651
EYVEQKDFAH LGLEPITLLQ QTTSGLAHLH SLNIVHRDLK PHNILISMPN
700 701
AHGKIKAMIS DFGLCKKLAV GRHSFSRRSG VPGTEGWIAP EMLSEDCKEN
750 751
PTYTVDIFSA GCVFYYVISE GSHPFGKSLQ RQANILLGAC SLDCLHPEKH
800 801
EDVIARELIE KMIAMDPQKR PSAKHVLKHP FFWSLEKQLQ FFQDVSDRIE
850 851
KESLDGPIVK QLERGGRAVV KMDWRENITV PLQTDLRKFR TYKGGSVRDL
900 901
LRAMRNKKHH YRELPAEVRE TLGSLPDDFV CYFTSRFPHL LAHTYRAMEL
950 951
CSHERLFQPY YFHEPPEPQP PVTPDAL
977
Show the unformatted sequence. |
| Checksums: |
CRC64:A2DF808CCE015536
MD5:0efc251039fdec3701d49161200b4f51
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| Pkinase | 571 - 832 | 3P23 | A | 571 - 832 | Jmol AstexViewer SPICE |
| B | 571 - 832 | Jmol AstexViewer SPICE | |||
| C | 571 - 832 | Jmol AstexViewer SPICE | |||
| D | 571 - 832 | Jmol AstexViewer SPICE | |||
| Ribonuc_2-5A | 837 - 963 | 3P23 | A | 837 - 963 | Jmol AstexViewer SPICE |
| B | 837 - 963 | Jmol AstexViewer SPICE | |||
| C | 837 - 963 | Jmol AstexViewer SPICE | |||
| D | 837 - 963 | Jmol AstexViewer SPICE |
