Summary
This is the summary of UniProt entry TGFB1_HUMAN (P01137).
| Description: | Transforming growth factor beta-1 |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
View Pfam proteome data. |
| Length: | 390 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| sig_p | n/a | 1 | 29 |
| low_complexity | n/a | 6 | 21 |
| Pfam A | TGFb_propeptide | 9 | 261 |
| disorder | n/a | 60 | 61 |
| disorder | n/a | 64 | 66 |
| disorder | n/a | 88 | 100 |
| low_complexity | n/a | 89 | 101 |
| low_complexity | n/a | 149 | 162 |
| Pfam A | TGF_beta | 290 | 390 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession P01137. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MPPSGLRLLL LLLPLLWLLV LTPGRPAAGL STCKTIDMEL VKRKRIEAIR
50 51
GQILSKLRLA SPPSQGEVPP GPLPEAVLAL YNSTRDRVAG ESAEPEPEPE
100 101
ADYYAKEVTR VLMVETHNEI YDKFKQSTHS IYMFFNTSEL REAVPEPVLL
150 151
SRAELRLLRL KLKVEQHVEL YQKYSNNSWR YLSNRLLAPS DSPEWLSFDV
200 201
TGVVRQWLSR GGEIEGFRLS AHCSCDSRDN TLQVDINGFT TGRRGDLATI
250 251
HGMNRPFLLL MATPLERAQH LQSSRHRRAL DTNYCFSSTE KNCCVRQLYI
300 301
DFRKDLGWKW IHEPKGYHAN FCLGPCPYIW SLDTQYSKVL ALYNQHNPGA
350 351
SAAPCCVPQA LEPLPIVYYV GRKPKVEQLS NMIVRSCKCS
390
Show the unformatted sequence. |
| Checksums: |
CRC64:75391614250288FE
MD5:d71fdec53480702b3083cce071822edb
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| TGF_beta | 290 - 390 | 1KLA | A | 12 - 112 | Jmol AstexViewer SPICE |
| B | 12 - 112 | Jmol AstexViewer SPICE | |||
| 1KLC | A | 12 - 112 | Jmol AstexViewer SPICE | ||
| B | 12 - 112 | Jmol AstexViewer SPICE | |||
| 1KLD | A | 12 - 112 | Jmol AstexViewer SPICE | ||
| B | 12 - 112 | Jmol AstexViewer SPICE | |||
| 3KFD | A | 12 - 112 | Jmol AstexViewer SPICE | ||
| B | 12 - 112 | Jmol AstexViewer SPICE | |||
| C | 12 - 112 | Jmol AstexViewer SPICE | |||
| D | 12 - 112 | Jmol AstexViewer SPICE |
