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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: LRC4B_MOUSE (P0C192)

Summary

This is the summary of UniProt entry LRC4B_MOUSE (P0C192).

Description: Leucine-rich repeat-containing protein 4B
Source organism: Mus musculus (Mouse) (NCBI taxonomy ID 10090)
View Pfam proteome data.
Length: 709 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
sig_p n/a 1 50
low_complexity n/a 26 31
low_complexity n/a 38 66
disorder n/a 43 45
Pfam A LRRNT 58 87
Pfam A LRR_5 101 228
Pfam A LRR_1 232 254
Pfam A LRR_8 255 314
low_complexity n/a 278 294
Pfam A I-set 366 455
disorder n/a 380 381
disorder n/a 436 437
disorder n/a 439 441
low_complexity n/a 441 452
disorder n/a 449 479
low_complexity n/a 462 482
disorder n/a 488 557
low_complexity n/a 528 547
disorder n/a 562 563
Pfam B Pfam-B_8195 568 619
transmembrane n/a 575 595
low_complexity n/a 596 607
disorder n/a 606 616
low_complexity n/a 624 644
low_complexity n/a 673 686
disorder n/a 681 684
disorder n/a 691 692
disorder n/a 694 699
disorder n/a 701 703
disorder n/a 705 709

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P0C192. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAQAHIRGSP CPLLPPGRMS WPHGALLLLW LFSPPLRAGG GGVAVTSAAG
50
51
GGSPPATSCP AACSCSNQAS RVICTRRELA EVPASIPVNT RYLNLQENSI
100
101
QVIRTDTFKH LRHLEILQLS KNLVRKIEVG AFNGLPSLNT LELFDNRLTT
150
151
VPTQAFEYLS KLRELWLRNN PIESIPSYAF NRVPSLRRLD LGELKRLEYI
200
201
SEAAFEGLVN LRYLNLGMCN LKDIPNLTAL VRLEELELSG NRLDLIRPGS
250
251
FQGLTSLRKL WLMHAQVATI ERNAFDDLKS LEELNLSHNN LMSLPHDLFT
300
301
PLHRLERVHL NHNPWHCNCD VLWLSWWLKE TVPSNTTCCA RCHAPAGLKG
350
351
RYIGELDQSH FTCYAPVIVE PPTDLNVTEG MAAELKCRTG TSMTSVNWLT
400
401
PNGTLMTHGS YRVRISVLHD GTLNFTNVTV QDTGQYTCMV TNSAGNTTAS
450
451
ATLNVSAVDP VAAGGPGGGG PGGGGGAGGA GGYTYFTTVT VETLETQPGE
500
501
EAQQPRGTEK EPPGPTTDGA WGGGRPDAAA PASASTTAPA PRSSRPTEKA
550
551
FTVPITDVTE NALKDLDDVM KTTKIIIGCF VAITFMAAVM LVAFYKLRKQ
600
601
HQLHKHHGPT RTVEIINVED ELPAASAVSV AAAAAVAGGA GVGGDSHLAL
650
651
PALERDHLNH HHYVAAAFKA HYGGNPGGGC GAKGPGLNSI HEPLLFKSGS
700
701
KENVQETQI                                             
709
 

Show the unformatted sequence.

Checksums:
CRC64:0C39148F9A8E3586
MD5:b3a86a3198a569fd974400d9bb5b0f60

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
I-set 366 - 454 3ZYO A 366 - 454 Jmol AstexViewer SPICE
LRR_1 232 - 254 3ZYN A 232 - 254 Jmol AstexViewer SPICE
B 232 - 254 Jmol AstexViewer SPICE
3ZYO A 232 - 254 Jmol AstexViewer SPICE
LRR_5 101 - 228 3ZYN A 101 - 228 Jmol AstexViewer SPICE
B 101 - 228 Jmol AstexViewer SPICE
3ZYO A 101 - 228 Jmol AstexViewer SPICE
LRR_8 255 - 314 3ZYN A 255 - 314 Jmol AstexViewer SPICE
B 255 - 314 Jmol AstexViewer SPICE
3ZYO A 255 - 314 Jmol AstexViewer SPICE
LRRNT 58 - 87 3ZYN A 58 - 87 Jmol AstexViewer SPICE
B 58 - 87 Jmol AstexViewer SPICE
3ZYO A 58 - 87 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.