Summary
This is the summary of UniProt entry XRCC5_HUMAN (P13010).
| Description: | X-ray repair cross-complementing protein 5 EC=3.6.4.- |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
View Pfam proteome data. |
| Length: | 732 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| Pfam A | Ku_N | 9 | 244 |
| disorder | n/a | 70 | 71 |
| disorder | n/a | 178 | 182 |
| Pfam A | Ku | 251 | 454 |
| low_complexity | n/a | 366 | 376 |
| Pfam A | Ku_C | 473 | 571 |
| disorder | n/a | 474 | 478 |
| disorder | n/a | 507 | 513 |
| disorder | n/a | 550 | 569 |
| Pfam A | Ku_PK_bind | 590 | 709 |
| disorder | n/a | 702 | 704 |
| disorder | n/a | 715 | 717 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession P13010. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MVRSGNKAAV VLCMDVGFTM SNSIPGIESP FEQAKKVITM FVQRQVFAEN
50 51
KDEIALVLFG TDGTDNPLSG GDQYQNITVH RHLMLPDFDL LEDIESKIQP
100 101
GSQQADFLDA LIVSMDVIQH ETIGKKFEKR HIEIFTDLSS RFSKSQLDII
150 151
IHSLKKCDIS LQFFLPFSLG KEDGSGDRGD GPFRLGGHGP SFPLKGITEQ
200 201
QKEGLEIVKM VMISLEGEDG LDEIYSFSES LRKLCVFKKI ERHSIHWPCR
250 251
LTIGSNLSIR IAAYKSILQE RVKKTWTVVD AKTLKKEDIQ KETVYCLNDD
300 301
DETEVLKEDI IQGFRYGSDI VPFSKVDEEQ MKYKSEGKCF SVLGFCKSSQ
350 351
VQRRFFMGNQ VLKVFAARDD EAAAVALSSL IHALDDLDMV AIVRYAYDKR
400 401
ANPQVGVAFP HIKHNYECLV YVQLPFMEDL RQYMFSSLKN SKKYAPTEAQ
450 451
LNAVDALIDS MSLAKKDEKT DTLEDLFPTT KIPNPRFQRL FQCLLHRALH
500 501
PREPLPPIQQ HIWNMLNPPA EVTTKSQIPL SKIKTLFPLI EAKKKDQVTA
550 551
QEIFQDNHED GPTAKKLKTE QGGAHFSVSS LAEGSVTSVG SVNPAENFRV
600 601
LVKQKKASFE EASNQLINHI EQFLDTNETP YFMKSIDCIR AFREEAIKFS
650 651
EEQRFNNFLK ALQEKVEIKQ LNHFWEIVVQ DGITLITKEE ASGSSVTAEE
700 701
AKKFLAPKDK PSGDTAAVFE EGGDVDDLLD MI
732
Show the unformatted sequence. |
| Checksums: |
CRC64:2363CA84834E74A3
MD5:80abc9cd1d17278c7193551bd701a75e
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| Ku | 251 - 454 | 1JEQ | B | 251 - 454 | Jmol AstexViewer SPICE |
| 1JEY | B | 251 - 454 | Jmol AstexViewer SPICE | ||
| Ku_C | 473 - 542 | 1JEQ | B | 473 - 542 | Jmol AstexViewer SPICE |
| 473 - 545 | 1JEY | B | 473 - 545 | Jmol AstexViewer SPICE | |
| 560 - 571 | 3RZ9 | B | 560 - 571 | Jmol AstexViewer SPICE | |
| 566 - 571 | 1RW2 | A | 8 - 13 | Jmol AstexViewer SPICE | |
| Ku_N | 9 - 244 | 1JEQ | B | 9 - 244 | Jmol AstexViewer SPICE |
| 1JEY | B | 9 - 244 | Jmol AstexViewer SPICE | ||
| Ku_PK_bind | 590 - 709 | 1RW2 | A | 32 - 151 | Jmol AstexViewer SPICE |
| 592 - 708 | 1Q2Z | A | 3 - 119 | Jmol AstexViewer SPICE |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.
