Summary
This is the summary of UniProt entry BRAF_HUMAN (P15056).
| Description: | Serine/threonine-protein kinase B-raf EC=2.7.11.1 |
| Source organism: |
Homo sapiens (Human) |
| Length: | 766 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| disorder | n/a | 2 | 7 |
| low_complexity | n/a | 6 | 11 |
| disorder | n/a | 9 | 38 |
| low_complexity | n/a | 27 | 39 |
| disorder | n/a | 64 | 67 |
| coiled_coil | n/a | 82 | 102 |
| low_complexity | n/a | 92 | 103 |
| disorder | n/a | 96 | 97 |
| disorder | n/a | 103 | 105 |
| low_complexity | n/a | 110 | 137 |
| disorder | n/a | 111 | 116 |
| disorder | n/a | 122 | 123 |
| disorder | n/a | 141 | 149 |
| Pfam A | RBD | 155 | 227 |
| Pfam A | C1_1 | 235 | 282 |
| disorder | n/a | 305 | 377 |
| low_complexity | n/a | 314 | 328 |
| low_complexity | n/a | 333 | 343 |
| disorder | n/a | 380 | 456 |
| low_complexity | n/a | 428 | 432 |
| Pfam A | Pkinase_Tyr | 457 | 714 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession P15056. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MAALSGGGGG GAEPGQALFN GDMEPEAGAG AGAAASSAAD PAIPEEVWNI
50 51
KQMIKLTQEH IEALLDKFGG EHNPPSIYLE AYEEYTSKLD ALQQREQQLL
100 101
ESLGNGTDFS VSSSASMDTV TSSSSSSLSV LPSSLSVFQN PTDVARSNPK
150 151
SPQKPIVRVF LPNKQRTVVP ARCGVTVRDS LKKALMMRGL IPECCAVYRI
200 201
QDGEKKPIGW DTDISWLTGE ELHVEVLENV PLTTHNFVRK TFFTLAFCDF
250 251
CRKLLFQGFR CQTCGYKFHQ RCSTEVPLMC VNYDQLDLLF VSKFFEHHPI
300 301
PQEEASLAET ALTSGSSPSA PASDSIGPQI LTSPSPSKSI PIPQPFRPAD
350 351
EDHRNQFGQR DRSSSAPNVH INTIEPVNID DLIRDQGFRG DGGSTTGLSA
400 401
TPPASLPGSL TNVKALQKSP GPQRERKSSS SSEDRNRMKT LGRRDSSDDW
450 451
EIPDGQITVG QRIGSGSFGT VYKGKWHGDV AVKMLNVTAP TPQQLQAFKN
500 501
EVGVLRKTRH VNILLFMGYS TKPQLAIVTQ WCEGSSLYHH LHIIETKFEM
550 551
IKLIDIARQT AQGMDYLHAK SIIHRDLKSN NIFLHEDLTV KIGDFGLATV
600 601
KSRWSGSHQF EQLSGSILWM APEVIRMQDK NPYSFQSDVY AFGIVLYELM
650 651
TGQLPYSNIN NRDQIIFMVG RGYLSPDLSK VRSNCPKAMK RLMAECLKKK
700 701
RDERPLFPQI LASIELLARS LPKIHRSASE PSLNRAGFQT EDFSLYACAS
750 751
PKTPIQAGGY GAFPVH
766
Show the unformatted sequence. |
| Checksums: |
CRC64:0798C2AAB487E813
MD5:74c9b69323bd112084c1b5b385e7e6c5
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.
