Summary
This is the summary of UniProt entry MK01_HUMAN (P28482).
| Description: | Mitogen-activated protein kinase 1 EC=2.7.11.24 |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
View Pfam proteome data. |
| Length: | 360 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| sig_p | n/a | 1 | 16 |
| low_complexity | n/a | 2 | 10 |
| Pfam A | Pkinase | 25 | 313 |
| low_complexity | n/a | 332 | 346 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession P28482. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MAAAAAAGAG PEMVRGQVFD VGPRYTNLSY IGEGAYGMVC SAYDNVNKVR
50 51
VAIKKISPFE HQTYCQRTLR EIKILLRFRH ENIIGINDII RAPTIEQMKD
100 101
VYIVQDLMET DLYKLLKTQH LSNDHICYFL YQILRGLKYI HSANVLHRDL
150 151
KPSNLLLNTT CDLKICDFGL ARVADPDHDH TGFLTEYVAT RWYRAPEIML
200 201
NSKGYTKSID IWSVGCILAE MLSNRPIFPG KHYLDQLNHI LGILGSPSQE
250 251
DLNCIINLKA RNYLLSLPHK NKVPWNRLFP NADSKALDLL DKMLTFNPHK
300 301
RIEVEQALAH PYLEQYYDPS DEPIAEAPFK FDMELDDLPK EKLKELIFEE
350 351
TARFQPGYRS
360
Show the unformatted sequence. |
| Checksums: |
CRC64:E85D0B2A5D2D724E
MD5:ccb174681d880da0eae8c0c11a73434c
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| Pkinase | 25 - 313 | 1PME | A | 25 - 313 | Jmol AstexViewer SPICE |
| 1TVO | A | 25 - 313 | Jmol AstexViewer SPICE | ||
| 1WZY | A | 25 - 313 | Jmol AstexViewer SPICE | ||
| 2E14 | A | 25 - 313 | Jmol AstexViewer SPICE | ||
| 2OJG | A | 23 - 311 | Jmol AstexViewer SPICE | ||
| 2OJI | A | 23 - 311 | Jmol AstexViewer SPICE | ||
| 2OJJ | A | 23 - 311 | Jmol AstexViewer SPICE | ||
| 2Y9Q | A | 25 - 313 | Jmol AstexViewer SPICE | ||
| 3I5Z | A | 23 - 311 | Jmol AstexViewer SPICE | ||
| 3I60 | A | 23 - 311 | Jmol AstexViewer SPICE | ||
| 3SA0 | A | 25 - 313 | Jmol AstexViewer SPICE |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.
