Summary
This is the summary of UniProt entry T2FA_HUMAN (P35269).
| Description: | General transcription factor IIF subunit 1 |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
View Pfam proteome data. |
| Length: | 517 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| disorder | n/a | 1 | 2 |
| Pfam A | TFIIF_alpha | 2 | 517 |
| disorder | n/a | 13 | 16 |
| disorder | n/a | 53 | 59 |
| disorder | n/a | 62 | 63 |
| disorder | n/a | 67 | 74 |
| disorder | n/a | 111 | 113 |
| disorder | n/a | 155 | 162 |
| low_complexity | n/a | 157 | 165 |
| disorder | n/a | 168 | 169 |
| disorder | n/a | 175 | 485 |
| low_complexity | n/a | 178 | 201 |
| low_complexity | n/a | 233 | 268 |
| low_complexity | n/a | 303 | 336 |
| low_complexity | n/a | 340 | 359 |
| low_complexity | n/a | 365 | 391 |
| disorder | n/a | 488 | 501 |
| disorder | n/a | 503 | 517 |
Show or hide domain scores.
Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
Note: it can take a few seconds for this image to be generated and loaded.
Show sources update panel.
Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession P35269. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MAALGPSSQN VTEYVVRVPK NTTKKYNIMA FNAADKVNFA TWNQARLERD
50 51
LSNKKIYQEE EMPESGAGSE FNRKLREEAR RKKYGIVLKE FRPEDQPWLL
100 101
RVNGKSGRKF KGIKKGGVTE NTSYYIFTQC PDGAFEAFPV HNWYNFTPLA
150 151
RHRTLTAEEA EEEWERRNKV LNHFSIMQQR RLKDQDQDED EEEKEKRGRR
200 201
KASELRIHDL EDDLEMSSDA SDASGEEGGR VPKAKKKAPL AKGGRKKKKK
250 251
KGSDDEAFED SDDGDFEGQE VDYMSDGSSS SQEEPESKAK APQQEEGPKG
300 301
VDEQSDSSEE SEEEKPPEED KEEEEEKKAP TPQEKKRRKD SSEESDSSEE
350 351
SDIDSEASSA LFMAKKKTPP KRERKPSGGS SRGNSRPGTP SAEGGSTSST
400 401
LRAAASKLEQ GKRVSEMPAA KRLRLDTGPQ SLSGKSTPQP PSGKTTPNSG
450 451
DVQVTEDAVR RYLTRKPMTT KDLLKKFQTK KTGLSSEQTV NVLAQILKRL
500 501
NPERKMINDK MHFSLKE
517
Show the unformatted sequence. |
| Checksums: |
CRC64:1032B04A36BDC24F
MD5:bf794a737f3693f404bfc60fa7242e5f
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| TFIIF_alpha | 449 - 517 | 1I27 | A | 449 - 517 | Jmol AstexViewer SPICE |
| 451 - 517 | 1J2X | A | 451 - 517 | Jmol AstexViewer SPICE | |
| 1NHA | A | 451 - 517 | Jmol AstexViewer SPICE | ||
| 1ONV | A | 451 - 517 | Jmol AstexViewer SPICE | ||
| 2K7L | A | 451 - 517 | Jmol AstexViewer SPICE | ||
| 5 - 153 | 1F3U | B | 5 - 153 | Jmol AstexViewer SPICE | |
| 5 - 168 | 1F3U | F | 5 - 168 | Jmol AstexViewer SPICE | |
| 7 - 153 | 1F3U | H | 7 - 153 | Jmol AstexViewer SPICE | |
| 7 - 168 | 1F3U | D | 7 - 168 | Jmol AstexViewer SPICE |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.
