Summary
This is the summary of UniProt entry FLT3_HUMAN (P36888).
| Description: | Receptor-type tyrosine-protein kinase FLT3 EC=2.7.10.1 |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
View Pfam proteome data. |
| Length: | 993 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| disorder | n/a | 49 | 53 |
| low_complexity | n/a | 75 | 88 |
| Pfam A | ig | 265 | 332 |
| transmembrane | n/a | 542 | 563 |
| Pfam A | Pkinase_Tyr | 610 | 943 |
| transmembrane | n/a | 673 | 691 |
| disorder | n/a | 736 | 744 |
| disorder | n/a | 747 | 748 |
| disorder | n/a | 766 | 768 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession P36888. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MPALARDGGQ LPLLVVFSAM IFGTITNQDL PVIKCVLINH KNNDSSVGKS
50 51
SSYPMVSESP EDLGCALRPQ SSGTVYEAAA VEVDVSASIT LQVLVDAPGN
100 101
ISCLWVFKHS SLNCQPHFDL QNRGVVSMVI LKMTETQAGE YLLFIQSEAT
150 151
NYTILFTVSI RNTLLYTLRR PYFRKMENQD ALVCISESVP EPIVEWVLCD
200 201
SQGESCKEES PAVVKKEEKV LHELFGTDIR CCARNELGRE CTRLFTIDLN
250 251
QTPQTTLPQL FLKVGEPLWI RCKAVHVNHG FGLTWELENK ALEEGNYFEM
300 301
STYSTNRTMI RILFAFVSSV ARNDTGYYTC SSSKHPSQSA LVTIVEKGFI
350 351
NATNSSEDYE IDQYEEFCFS VRFKAYPQIR CTWTFSRKSF PCEQKGLDNG
400 401
YSISKFCNHK HQPGEYIFHA ENDDAQFTKM FTLNIRRKPQ VLAEASASQA
450 451
SCFSDGYPLP SWTWKKCSDK SPNCTEEITE GVWNRKANRK VFGQWVSSST
500 501
LNMSEAIKGF LVKCCAYNSL GTSCETILLN SPGPFPFIQD NISFYATIGV
550 551
CLLFIVVLTL LICHKYKKQF RYESQLQMVQ VTGSSDNEYF YVDFREYEYD
600 601
LKWEFPRENL EFGKVLGSGA FGKVMNATAY GISKTGVSIQ VAVKMLKEKA
650 651
DSSEREALMS ELKMMTQLGS HENIVNLLGA CTLSGPIYLI FEYCCYGDLL
700 701
NYLRSKREKF HRTWTEIFKE HNFSFYPTFQ SHPNSSMPGS REVQIHPDSD
750 751
QISGLHGNSF HSEDEIEYEN QKRLEEEEDL NVLTFEDLLC FAYQVAKGME
800 801
FLEFKSCVHR DLAARNVLVT HGKVVKICDF GLARDIMSDS NYVVRGNARL
850 851
PVKWMAPESL FEGIYTIKSD VWSYGILLWE IFSLGVNPYP GIPVDANFYK
900 901
LIQNGFKMDQ PFYATEEIYI IMQSCWAFDS RKRPSFPNLT SFLGCQLADA
950 951
EEAMYQNVDG RVSECPHTYQ NRRPFSREMD LGLLSPQAQV EDS
993
Show the unformatted sequence. |
| Checksums: |
CRC64:6C1995718F352ECE
MD5:5d3aedc2cdcf7b145380ccd8e677b1fa
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| ig | 265 - 332 | 3QS7 | E | 265 - 332 | Jmol AstexViewer SPICE |
| F | 265 - 332 | Jmol AstexViewer SPICE | |||
| G | 265 - 332 | Jmol AstexViewer SPICE | |||
| H | 265 - 332 | Jmol AstexViewer SPICE | |||
| 3QS9 | E | 265 - 332 | Jmol AstexViewer SPICE | ||
| F | 265 - 332 | Jmol AstexViewer SPICE | |||
| G | 265 - 332 | Jmol AstexViewer SPICE | |||
| H | 265 - 332 | Jmol AstexViewer SPICE | |||
| Pkinase_Tyr | 610 - 943 | 1RJB | A | 610 - 943 | Jmol AstexViewer SPICE |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.
