Summary
This is the summary of UniProt entry CTCF_HUMAN (P49711).
| Description: | Transcriptional repressor CTCF |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
View Pfam proteome data. |
| Length: | 727 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| disorder | n/a | 1 | 13 |
| disorder | n/a | 19 | 58 |
| disorder | n/a | 69 | 70 |
| disorder | n/a | 72 | 89 |
| disorder | n/a | 93 | 96 |
| low_complexity | n/a | 116 | 131 |
| disorder | n/a | 128 | 155 |
| disorder | n/a | 174 | 214 |
| low_complexity | n/a | 202 | 211 |
| disorder | n/a | 223 | 228 |
| disorder | n/a | 237 | 258 |
| low_complexity | n/a | 250 | 264 |
| Pfam A | zf-H2C2_2 | 280 | 305 |
| disorder | n/a | 282 | 287 |
| Pfam A | zf-H2C2_2 | 308 | 333 |
| disorder | n/a | 310 | 312 |
| Pfam A | zf-H2C2_2 | 336 | 362 |
| Pfam A | zf-H2C2_2 | 365 | 389 |
| Pfam A | zf-H2C2_2 | 393 | 418 |
| Pfam A | zf-C2H2 | 437 | 460 |
| Pfam A | zf-H2C2_2 | 481 | 506 |
| Pfam A | zf-H2C2_2 | 507 | 534 |
| disorder | n/a | 515 | 516 |
| Pfam A | zf-C2H2_4 | 555 | 578 |
| disorder | n/a | 568 | 727 |
| low_complexity | n/a | 592 | 606 |
| low_complexity | n/a | 613 | 648 |
| Pfam B | Pfam-B_18810 | 671 | 725 |
| low_complexity | n/a | 691 | 708 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession P49711. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MEGDAVEAIV EESETFIKGK ERKTYQRRRE GGQEEDACHL PQNQTDGGEV
50 51
VQDVNSSVQM VMMEQLDPTL LQMKTEVMEG TVAPEAEAAV DDTQIITLQV
100 101
VNMEEQPINI GELQLVQVPV PVTVPVATTS VEELQGAYEN EVSKEGLAES
150 151
EPMICHTLPL PEGFQVVKVG ANGEVETLEQ GELPPQEDPS WQKDPDYQPP
200 201
AKKTKKTKKS KLRYTEEGKD VDVSVYDFEE EQQEGLLSEV NAEKVVGNMK
250 251
PPKPTKIKKK GVKKTFQCEL CSYTCPRRSN LDRHMKSHTD ERPHKCHLCG
300 301
RAFRTVTLLR NHLNTHTGTR PHKCPDCDMA FVTSGELVRH RRYKHTHEKP
350 351
FKCSMCDYAS VEVSKLKRHI RSHTGERPFQ CSLCSYASRD TYKLKRHMRT
400 401
HSGEKPYECY ICHARFTQSG TMKMHILQKH TENVAKFHCP HCDTVIARKS
450 451
DLGVHLRKQH SYIEQGKKCR YCDAVFHERY ALIQHQKSHK NEKRFKCDQC
500 501
DYACRQERHM IMHKRTHTGE KPYACSHCDK TFRQKQLLDM HFKRYHDPNF
550 551
VPAAFVCSKC GKTFTRRNTM ARHADNCAGP DGVEGENGGE TKKSKRGRKR
600 601
KMRSKKEDSS DSENAEPDLD DNEDEEEPAV EIEPEPEPQP VTPAPPPAKK
650 651
RRGRPPGRTN QPKQNQPTAI IQVEDQNTGA IENIIVEVKK EPDAEPAEGE
700 701
EEEAQPAATD APNGDLTPEM ILSMMDR
727
Show the unformatted sequence. |
| Checksums: |
CRC64:2110538B65DC5706
MD5:4967edda2288d17f59286e856827cbc7
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| zf-C2H2 | 437 - 460 | 2CT1 | A | 46 - 69 | Jmol AstexViewer SPICE |
| zf-C2H2_4 | 555 - 578 | 1X6H | A | 48 - 71 | Jmol AstexViewer SPICE |
| zf-H2C2_2 | 399 - 418 | 2CT1 | A | 8 - 27 | Jmol AstexViewer SPICE |
| 515 - 534 | 1X6H | A | 8 - 27 | Jmol AstexViewer SPICE |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.
