Summary
This is the summary of UniProt entry SHPS1_HUMAN (P78324).
| Description: | Tyrosine-protein phosphatase non-receptor type substrate 1 |
| Source organism: |
Homo sapiens (Human) |
| Length: | 504 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| disorder | n/a | 1 | 4 |
| sig_p | n/a | 1 | 30 |
| low_complexity | n/a | 3 | 21 |
| Pfam A | V-set | 33 | 144 |
| disorder | n/a | 90 | 92 |
| disorder | n/a | 135 | 140 |
| disorder | n/a | 145 | 158 |
| Pfam A | C1-set | 156 | 241 |
| disorder | n/a | 166 | 168 |
| disorder | n/a | 242 | 264 |
| Pfam A | C1-set | 259 | 343 |
| disorder | n/a | 294 | 303 |
| disorder | n/a | 328 | 329 |
| disorder | n/a | 331 | 335 |
| disorder | n/a | 340 | 366 |
| transmembrane | n/a | 372 | 394 |
| Pfam B | Pfam-B_18965 | 374 | 502 |
| low_complexity | n/a | 378 | 394 |
| disorder | n/a | 402 | 504 |
Show or hide domain scores.
Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
Note: it can take a few seconds for this image to be generated and loaded.
Show sources update panel.
Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession P78324. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MEPAGPAPGR LGPLLCLLLA ASCAWSGVAG EEELQVIQPD KSVLVAAGET
50 51
ATLRCTATSL IPVGPIQWFR GAGPGRELIY NQKEGHFPRV TTVSDLTKRN
100 101
NMDFSIRIGN ITPADAGTYY CVKFRKGSPD DVEFKSGAGT ELSVRAKPSA
150 151
PVVSGPAARA TPQHTVSFTC ESHGFSPRDI TLKWFKNGNE LSDFQTNVDP
200 201
VGESVSYSIH STAKVVLTRE DVHSQVICEV AHVTLQGDPL RGTANLSETI
250 251
RVPPTLEVTQ QPVRAENQVN VTCQVRKFYP QRLQLTWLEN GNVSRTETAS
300 301
TVTENKDGTY NWMSWLLVNV SAHRDDVKLT CQVEHDGQPA VSKSHDLKVS
350 351
AHPKEQGSNT AAENTGSNER NIYIVVGVVC TLLVALLMAA LYLVRIRQKK
400 401
AQGSTSSTRL HEPEKNAREI TQDTNDITYA DLNLPKGKKP APQAAEPNNH
450 451
TEYASIQTSP QPASEDTLTY ADLDMVHLNR TPKQPAPKPE PSFSEYASVQ
500 501
VPRK
504
Show the unformatted sequence. |
| Checksums: |
CRC64:18D2FD04F6182AD0
MD5:b4747fa2d011c89573345678201fe041
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| C1-set | 156 - 241 | 2WNG | A | 125 - 210 | Jmol AstexViewer SPICE |
| 259 - 343 | 2WNG | A | 228 - 312 | Jmol AstexViewer SPICE | |
| V-set | 33 - 144 | 2JJS | A | 3 - 113 | Jmol AstexViewer SPICE |
| B | 3 - 113 | Jmol AstexViewer SPICE | |||
| 2JJT | A | 3 - 113 | Jmol AstexViewer SPICE | ||
| B | 3 - 113 | Jmol AstexViewer SPICE | |||
| 2UV3 | A | 3 - 113 | Jmol AstexViewer SPICE | ||
| B | 3 - 113 | Jmol AstexViewer SPICE | |||
| 2WNG | A | 3 - 113 | Jmol AstexViewer SPICE |
