Summary
This is the summary of UniProt entry TIE2_HUMAN (Q02763).
| Description: | Angiopoietin-1 receptor EC=2.7.10.1 |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
View Pfam proteome data. |
| Length: | 1124 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| sig_p | n/a | 1 | 22 |
| low_complexity | n/a | 3 | 18 |
| Pfam A | Ig_Tie2_1 | 23 | 118 |
| Pfam A | fn3 | 445 | 530 |
| low_complexity | n/a | 520 | 535 |
| disorder | n/a | 527 | 539 |
| low_complexity | n/a | 542 | 553 |
| Pfam A | fn3 | 544 | 626 |
| disorder | n/a | 578 | 579 |
| disorder | n/a | 587 | 589 |
| Pfam A | fn3 | 640 | 724 |
| transmembrane | n/a | 746 | 770 |
| Pfam A | Pkinase_Tyr | 824 | 1092 |
| low_complexity | n/a | 931 | 942 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession Q02763. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MDSLASLVLC GVSLLLSGTV EGAMDLILIN SLPLVSDAET SLTCIASGWR
50 51
PHEPITIGRD FEALMNQHQD PLEVTQDVTR EWAKKVVWKR EKASKINGAY
100 101
FCEGRVRGEA IRIRTMKMRQ QASFLPATLT MTVDKGDNVN ISFKKVLIKE
150 151
EDAVIYKNGS FIHSVPRHEV PDILEVHLPH AQPQDAGVYS ARYIGGNLFT
200 201
SAFTRLIVRR CEAQKWGPEC NHLCTACMNN GVCHEDTGEC ICPPGFMGRT
250 251
CEKACELHTF GRTCKERCSG QEGCKSYVFC LPDPYGCSCA TGWKGLQCNE
300 301
ACHPGFYGPD CKLRCSCNNG EMCDRFQGCL CSPGWQGLQC EREGIQRMTP
350 351
KIVDLPDHIE VNSGKFNPIC KASGWPLPTN EEMTLVKPDG TVLHPKDFNH
400 401
TDHFSVAIFT IHRILPPDSG VWVCSVNTVA GMVEKPFNIS VKVLPKPLNA
450 451
PNVIDTGHNF AVINISSEPY FGDGPIKSKK LLYKPVNHYE AWQHIQVTNE
500 501
IVTLNYLEPR TEYELCVQLV RRGEGGEGHP GPVRRFTTAS IGLPPPRGLN
550 551
LLPKSQTTLN LTWQPIFPSS EDDFYVEVER RSVQKSDQQN IKVPGNLTSV
600 601
LLNNLHPREQ YVVRARVNTK AQGEWSEDLT AWTLSDILPP QPENIKISNI
650 651
THSSAVISWT ILDGYSISSI TIRYKVQGKN EDQHVDVKIK NATITQYQLK
700 701
GLEPETAYQV DIFAENNIGS SNPAFSHELV TLPESQAPAD LGGGKMLLIA
750 751
ILGSAGMTCL TVLLAFLIIL QLKRANVQRR MAQAFQNVRE EPAVQFNSGT
800 801
LALNRKVKNN PDPTIYPVLD WNDIKFQDVI GEGNFGQVLK ARIKKDGLRM
850 851
DAAIKRMKEY ASKDDHRDFA GELEVLCKLG HHPNIINLLG ACEHRGYLYL
900 901
AIEYAPHGNL LDFLRKSRVL ETDPAFAIAN STASTLSSQQ LLHFAADVAR
950 951
GMDYLSQKQF IHRDLAARNI LVGENYVAKI ADFGLSRGQE VYVKKTMGRL
1000 1001
PVRWMAIESL NYSVYTTNSD VWSYGVLLWE IVSLGGTPYC GMTCAELYEK
1050 1051
LPQGYRLEKP LNCDDEVYDL MRQCWREKPY ERPSFAQILV SLNRMLEERK
1100 1101
TYVNTTLYEK FTYAGIDCSA EEAA
1124
Show the unformatted sequence. |
| Checksums: |
CRC64:E739DEC3E4FEB124
MD5:1409a6a3e2e73fd8d0d60e56f0585b8f
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| Ig_Tie2_1 | 23 - 118 | 2GY5 | A | 23 - 118 | Jmol AstexViewer SPICE |
| 2GY7 | B | 23 - 118 | Jmol AstexViewer SPICE | ||
| Pkinase_Tyr | 824 - 1092 | 1FVR | A | 824 - 1092 | Jmol AstexViewer SPICE |
| B | 824 - 1092 | Jmol AstexViewer SPICE | |||
| 2WQB | A | 824 - 1092 | Jmol AstexViewer SPICE | ||
| 3L8P | A | 824 - 1092 | Jmol AstexViewer SPICE | ||
| 836 - 1092 | 2OO8 | X | 836 - 1092 | Jmol AstexViewer SPICE | |
| 2P4I | B | 836 - 1092 | Jmol AstexViewer SPICE | ||
| 837 - 1092 | 2OSC | A | 837 - 1092 | Jmol AstexViewer SPICE | |
| 838 - 1092 | 2P4I | A | 838 - 1092 | Jmol AstexViewer SPICE | |
| 917 - 935 | 3BEA | A | 679 - 697 | Jmol AstexViewer SPICE |
