Summary
This is the summary of UniProt entry KPCT_HUMAN (Q04759).
| Description: | Protein kinase C theta type EC=2.7.11.13 |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
View Pfam proteome data. |
| Length: | 706 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| Pfam B | Pfam-B_1893 | 1 | 99 |
| Pfam B | Pfam-B_34337 | 101 | 139 |
| Pfam A | C1_1 | 160 | 212 |
| Pfam A | C1_1 | 232 | 284 |
| disorder | n/a | 331 | 338 |
| disorder | n/a | 343 | 345 |
| Pfam A | Pkinase | 380 | 634 |
| low_complexity | n/a | 411 | 422 |
| low_complexity | n/a | 504 | 515 |
| Pfam A | Pkinase_C | 654 | 700 |
Show or hide domain scores.
Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
Note: it can take a few seconds for this image to be generated and loaded.
Show sources update panel.
Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession Q04759. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MSPFLRIGLS NFDCGSCQSC QGEAVNPYCA VLVKEYVESE NGQMYIQKKP
50 51
TMYPPWDSTF DAHINKGRVM QIIVKGKNVD LISETTVELY SLAERCRKNN
100 101
GKTEIWLELK PQGRMLMNAR YFLEMSDTKD MNEFETEGFF ALHQRRGAIK
150 151
QAKVHHVKCH EFTATFFPQP TFCSVCHEFV WGLNKQGYQC RQCNAAIHKK
200 201
CIDKVIAKCT GSAINSRETM FHKERFKIDM PHRFKVYNYK SPTFCEHCGT
250 251
LLWGLARQGL KCDACGMNVH HRCQTKVANL CGINQKLMAE ALAMIESTQQ
300 301
ARCLRDTEQI FREGPVEIGL PCSIKNEARP PCLPTPGKRE PQGISWESPL
350 351
DEVDKMCHLP EPELNKERPS LQIKLKIEDF ILHKMLGKGS FGKVFLAEFK
400 401
KTNQFFAIKA LKKDVVLMDD DVECTMVEKR VLSLAWEHPF LTHMFCTFQT
450 451
KENLFFVMEY LNGGDLMYHI QSCHKFDLSR ATFYAAEIIL GLQFLHSKGI
500 501
VYRDLKLDNI LLDKDGHIKI ADFGMCKENM LGDAKTNTFC GTPDYIAPEI
550 551
LLGQKYNHSV DWWSFGVLLY EMLIGQSPFH GQDEEELFHS IRMDNPFYPR
600 601
WLEKEAKDLL VKLFVREPEK RLGVRGDIRQ HPLFREINWE ELERKEIDPP
650 651
FRPKVKSPFD CSNFDKEFLN EKPRLSFADR ALINSMDQNM FRNFSFMNPG
700 701
MERLIS
706
Show the unformatted sequence. |
| Checksums: |
CRC64:B3C53AB892D5210A
MD5:bffe28f8aa424873f7864a842f842f72
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| C1_1 | 160 - 212 | 2ENN | A | 160 - 212 | Jmol AstexViewer SPICE |
| 232 - 284 | 2ENZ | A | 232 - 284 | Jmol AstexViewer SPICE | |
| Pkinase | 380 - 634 | 1XJD | A | 380 - 634 | Jmol AstexViewer SPICE |
| 2JED | A | 380 - 634 | Jmol AstexViewer SPICE | ||
| B | 380 - 634 | Jmol AstexViewer SPICE | |||
| Pkinase_C | 654 - 700 | 2JED | A | 654 - 700 | Jmol AstexViewer SPICE |
| B | 654 - 700 | Jmol AstexViewer SPICE | |||
| 688 - 696 | 1XJD | A | 688 - 696 | Jmol AstexViewer SPICE |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.
