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12  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: FAK1_HUMAN (Q05397)

Summary

This is the summary of UniProt entry FAK1_HUMAN (Q05397).

Description: Focal adhesion kinase 1 EC=2.7.10.2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 1052 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
disorder n/a 8 10
disorder n/a 12 28
Pfam A FERM_M 134 258
coiled_coil n/a 217 237
disorder n/a 361 364
disorder n/a 369 379
disorder n/a 381 389
disorder n/a 394 395
disorder n/a 400 405
disorder n/a 409 413
Pfam A Pkinase_Tyr 422 676
disorder n/a 634 640
disorder n/a 672 749
coiled_coil n/a 677 697
low_complexity n/a 686 698
low_complexity n/a 712 726
disorder n/a 753 756
disorder n/a 758 762
disorder n/a 764 790
disorder n/a 793 801
disorder n/a 805 832
coiled_coil n/a 809 829
disorder n/a 836 923
low_complexity n/a 863 883
Pfam A Focal_AT 914 1052
disorder n/a 1049 1052

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q05397. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAAAYLDPNL NHTPNSSTKT HLGTGMERSP GAMERVLKVF HYFESNSEPT
50
51
TWASIIRHGD ATDVRGIIQK IVDSHKVKHV ACYGFRLSHL RSEEVHWLHV
100
101
DMGVSSVREK YELAHPPEEW KYELRIRYLP KGFLNQFTED KPTLNFFYQQ
150
151
VKSDYMLEIA DQVDQEIALK LGCLEIRRSY WEMRGNALEK KSNYEVLEKD
200
201
VGLKRFFPKS LLDSVKAKTL RKLIQQTFRQ FANLNREESI LKFFEILSPV
250
251
YRFDKECFKC ALGSSWIISV ELAIGPEEGI SYLTDKGCNP THLADFTQVQ
300
301
TIQYSNSEDK DRKGMLQLKI AGAPEPLTVT APSLTIAENM ADLIDGYCRL
350
351
VNGTSQSFII RPQKEGERAL PSIPKLANSE KQGMRTHAVS VSETDDYAEI
400
401
IDEEDTYTMP STRDYEIQRE RIELGRCIGE GQFGDVHQGI YMSPENPALA
450
451
VAIKTCKNCT SDSVREKFLQ EALTMRQFDH PHIVKLIGVI TENPVWIIME
500
501
LCTLGELRSF LQVRKYSLDL ASLILYAYQL STALAYLESK RFVHRDIAAR
550
551
NVLVSSNDCV KLGDFGLSRY MEDSTYYKAS KGKLPIKWMA PESINFRRFT
600
601
SASDVWMFGV CMWEILMHGV KPFQGVKNND VIGRIENGER LPMPPNCPPT
650
651
LYSLMTKCWA YDPSRRPRFT ELKAQLSTIL EEEKAQQEER MRMESRRQAT
700
701
VSWDSGGSDE APPKPSRPGY PSPRSSEGFY PSPQHMVQTN HYQVSGYPGS
750
751
HGITAMAGSI YPGQASLLDQ TDSWNHRPQE IAMWQPNVED STVLDLRGIG
800
801
QVLPTHLMEE RLIRQQQEME EDQRWLEKEE RFLKPDVRLS RGSIDREDGS
850
851
LQGPIGNQHI YQPVGKPDPA APPKKPPRPG APGHLGSLAS LSSPADSYNE
900
901
GVKLQPQEIS PPPTANLDRS NDKVYENVTG LVKAVIEMSS KIQPAPPEEY
950
951
VPMVKEVGLA LRTLLATVDE TIPLLPASTH REIEMAQKLL NSDLGELINK
1000
1001
MKLAQQYVMT SLQQEYKKQM LTAAHALAVD AKNLLDVIDQ ARLKMLGQTR
1050
1051
PH                                                    
1052
 

Show the unformatted sequence.

Checksums:
CRC64:D8A4C15138AB0243
MD5:90e48a696fe33eb2470b05009cc5d288

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Focal_AT 914 - 1047 1K05 B 914 - 1047 Jmol AstexViewer SPICE
1OW6 B 914 - 1047 Jmol AstexViewer SPICE
C 914 - 1047 Jmol AstexViewer SPICE
1OW7 B 914 - 1047 Jmol AstexViewer SPICE
C 914 - 1047 Jmol AstexViewer SPICE
1OW8 B 914 - 1047 Jmol AstexViewer SPICE
C 914 - 1047 Jmol AstexViewer SPICE
3B71 B 914 - 1047 Jmol AstexViewer SPICE
C 914 - 1047 Jmol AstexViewer SPICE
3S9O B 914 - 1047 Jmol AstexViewer SPICE
914 - 1048 1K05 C 914 - 1048 Jmol AstexViewer SPICE
3S9O C 914 - 1048 Jmol AstexViewer SPICE
914 - 1049 1K04 A 914 - 1049 Jmol AstexViewer SPICE
3S9O A 914 - 1049 Jmol AstexViewer SPICE
916 - 1049 1OW6 A 916 - 1049 Jmol AstexViewer SPICE
1OW7 A 916 - 1049 Jmol AstexViewer SPICE
1OW8 A 916 - 1049 Jmol AstexViewer SPICE
3B71 A 916 - 1049 Jmol AstexViewer SPICE
916 - 1050 1K05 A 916 - 1050 Jmol AstexViewer SPICE
Pkinase_Tyr 422 - 676 1MP8 A 422 - 676 Jmol AstexViewer SPICE
2ETM A 422 - 676 Jmol AstexViewer SPICE
B 422 - 676 Jmol AstexViewer SPICE
2IJM A 422 - 676 Jmol AstexViewer SPICE
B 422 - 676 Jmol AstexViewer SPICE
3BZ3 A 422 - 676 Jmol AstexViewer SPICE
3PXK A 422 - 676 Jmol AstexViewer SPICE
B 422 - 676 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.