Summary
This is the summary of UniProt entry BMPR2_HUMAN (Q13873).
| Description: | Bone morphogenetic protein receptor type-2 EC=2.7.11.30 |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
View Pfam proteome data. |
| Length: | 1038 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| sig_p | n/a | 1 | 26 |
| Pfam A | Activin_recp | 33 | 131 |
| low_complexity | n/a | 132 | 142 |
| disorder | n/a | 134 | 142 |
| transmembrane | n/a | 151 | 172 |
| low_complexity | n/a | 151 | 168 |
| low_complexity | n/a | 198 | 208 |
| Pfam A | Pkinase | 203 | 501 |
| disorder | n/a | 447 | 450 |
| disorder | n/a | 452 | 453 |
| disorder | n/a | 515 | 540 |
| disorder | n/a | 542 | 551 |
| low_complexity | n/a | 545 | 558 |
| disorder | n/a | 557 | 699 |
| Pfam B | Pfam-B_16241 | 581 | 638 |
| low_complexity | n/a | 603 | 628 |
| low_complexity | n/a | 694 | 710 |
| disorder | n/a | 719 | 720 |
| disorder | n/a | 724 | 726 |
| disorder | n/a | 728 | 730 |
| disorder | n/a | 743 | 978 |
| low_complexity | n/a | 901 | 908 |
| disorder | n/a | 995 | 997 |
| disorder | n/a | 1000 | 1007 |
| disorder | n/a | 1009 | 1017 |
| disorder | n/a | 1020 | 1021 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession Q13873. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MTSSLQRPWR VPWLPWTILL VSTAAASQNQ ERLCAFKDPY QQDLGIGESR
50 51
ISHENGTILC SKGSTCYGLW EKSKGDINLV KQGCWSHIGD PQECHYEECV
100 101
VTTTPPSIQN GTYRFCCCST DLCNVNFTEN FPPPDTTPLS PPHSFNRDET
150 151
IIIALASVSV LAVLIVALCF GYRMLTGDRK QGLHSMNMME AAASEPSLDL
200 201
DNLKLLELIG RGRYGAVYKG SLDERPVAVK VFSFANRQNF INEKNIYRVP
250 251
LMEHDNIARF IVGDERVTAD GRMEYLLVME YYPNGSLCKY LSLHTSDWVS
300 301
SCRLAHSVTR GLAYLHTELP RGDHYKPAIS HRDLNSRNVL VKNDGTCVIS
350 351
DFGLSMRLTG NRLVRPGEED NAAISEVGTI RYMAPEVLEG AVNLRDCESA
400 401
LKQVDMYALG LIYWEIFMRC TDLFPGESVP EYQMAFQTEV GNHPTFEDMQ
450 451
VLVSREKQRP KFPEAWKENS LAVRSLKETI EDCWDQDAEA RLTAQCAEER
500 501
MAELMMIWER NKSVSPTVNP MSTAMQNERN LSHNRRVPKI GPYPDYSSSS
550 551
YIEDSIHHTD SIVKNISSEH SMSSTPLTIG EKNRNSINYE RQQAQARIPS
600 601
PETSVTSLST NTTTTNTTGL TPSTGMTTIS EMPYPDETNL HTTNVAQSIG
650 651
PTPVCLQLTE EDLETNKLDP KEVDKNLKES SDENLMEHSL KQFSGPDPLS
700 701
STSSSLLYPL IKLAVEATGQ QDFTQTANGQ ACLIPDVLPT QIYPLPKQQN
750 751
LPKRPTSLPL NTKNSTKEPR LKFGSKHKSN LKQVETGVAK MNTINAAEPH
800 801
VVTVTMNGVA GRNHSVNSHA ATTQYANGTV LSGQTTNIVT HRAQEMLQNQ
850 851
FIGEDTRLNI NSSPDEHEPL LRREQQAGHD EGVLDRLVDR RERPLEGGRT
900 901
NSNNNNSNPC SEQDVLAQGV PSTAADPGPS KPRRAQRPNS LDLSATNVLD
950 951
GSSIQIGEST QDGKSGSGEK IKKRVKTPYS LKRWRPSTWV ISTESLDCEV
1000 1001
NNNGSNRAVH SKSSTAVYLA EGGTATTMVS KDIGMNCL
1038
Show the unformatted sequence. |
| Checksums: |
CRC64:1389923CE574B913
MD5:d25d18a139bb22d3f55d7753ff980cad
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| Activin_recp | 33 - 131 | 2HLQ | A | 33 - 131 | Jmol AstexViewer SPICE |
| Pkinase | 203 - 501 | 3G2F | A | 203 - 501 | Jmol AstexViewer SPICE |
| B | 203 - 501 | Jmol AstexViewer SPICE |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.
