Summary
This is the summary of UniProt entry KEAP1_HUMAN (Q14145).
| Description: | Kelch-like ECH-associated protein 1 |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
View Pfam proteome data. |
| Length: | 624 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| disorder | n/a | 1 | 2 |
| disorder | n/a | 49 | 52 |
| Pfam A | BTB | 67 | 179 |
| Pfam A | BACK | 184 | 286 |
| Pfam A | Kelch_1 | 317 | 359 |
| Pfam A | Kelch_1 | 361 | 410 |
| disorder | n/a | 387 | 391 |
| Pfam A | Kelch_1 | 412 | 457 |
| Pfam A | Kelch_1 | 459 | 504 |
| Pfam A | Kelch_1 | 506 | 551 |
| Pfam A | Kelch_1 | 553 | 598 |
| disorder | n/a | 594 | 596 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession Q14145. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MQPDPRPSGA GACCRFLPLQ SQCPEGAGDA VMYASTECKA EVTPSQHGNR
50 51
TFSYTLEDHT KQAFGIMNEL RLSQQLCDVT LQVKYQDAPA AQFMAHKVVL
100 101
ASSSPVFKAM FTNGLREQGM EVVSIEGIHP KVMERLIEFA YTASISMGEK
150 151
CVLHVMNGAV MYQIDSVVRA CSDFLVQQLD PSNAIGIANF AEQIGCVELH
200 201
QRAREYIYMH FGEVAKQEEF FNLSHCQLVT LISRDDLNVR CESEVFHACI
250 251
NWVKYDCEQR RFYVQALLRA VRCHSLTPNF LQMQLQKCEI LQSDSRCKDY
300 301
LVKIFEELTL HKPTQVMPCR APKVGRLIYT AGGYFRQSLS YLEAYNPSDG
350 351
TWLRLADLQV PRSGLAGCVV GGLLYAVGGR NNSPDGNTDS SALDCYNPMT
400 401
NQWSPCAPMS VPRNRIGVGV IDGHIYAVGG SHGCIHHNSV ERYEPERDEW
450 451
HLVAPMLTRR IGVGVAVLNR LLYAVGGFDG TNRLNSAECY YPERNEWRMI
500 501
TAMNTIRSGA GVCVLHNCIY AAGGYDGQDQ LNSVERYDVE TETWTFVAPM
550 551
KHRRSALGIT VHQGRIYVLG GYDGHTFLDS VECYDPDTDT WSEVTRMTSG
600 601
RSGVGVAVTM EPCRKQIDQQ NCTC
624
Show the unformatted sequence. |
| Checksums: |
CRC64:CE180F3897BB8C97
MD5:14772e4250adfb2be962807b2c503860
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| Kelch_1 | 322 - 359 | 1U6D | X | 322 - 359 | Jmol AstexViewer SPICE |
| 1ZGK | A | 322 - 359 | Jmol AstexViewer SPICE | ||
| 325 - 359 | 2FLU | X | 325 - 359 | Jmol AstexViewer SPICE | |
| 361 - 410 | 1U6D | X | 361 - 410 | Jmol AstexViewer SPICE | |
| 1ZGK | A | 361 - 410 | Jmol AstexViewer SPICE | ||
| 2FLU | X | 361 - 410 | Jmol AstexViewer SPICE | ||
| 412 - 457 | 1U6D | X | 412 - 457 | Jmol AstexViewer SPICE | |
| 1ZGK | A | 412 - 457 | Jmol AstexViewer SPICE | ||
| 2FLU | X | 412 - 457 | Jmol AstexViewer SPICE | ||
| 459 - 504 | 1U6D | X | 459 - 504 | Jmol AstexViewer SPICE | |
| 1ZGK | A | 459 - 504 | Jmol AstexViewer SPICE | ||
| 2FLU | X | 459 - 504 | Jmol AstexViewer SPICE | ||
| 506 - 551 | 1U6D | X | 506 - 551 | Jmol AstexViewer SPICE | |
| 1ZGK | A | 506 - 551 | Jmol AstexViewer SPICE | ||
| 2FLU | X | 506 - 551 | Jmol AstexViewer SPICE | ||
| 553 - 598 | 1U6D | X | 553 - 598 | Jmol AstexViewer SPICE | |
| 1ZGK | A | 553 - 598 | Jmol AstexViewer SPICE | ||
| 2FLU | X | 553 - 598 | Jmol AstexViewer SPICE |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.
