Summary
This is the summary of UniProt entry DPYL2_HUMAN (Q16555).
| Description: | Dihydropyrimidinase-related protein 2 |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
View Pfam proteome data. |
| Length: | 572 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| Pfam A | Amidohydro_1 | 64 | 413 |
| disorder | n/a | 226 | 228 |
| disorder | n/a | 302 | 304 |
| low_complexity | n/a | 303 | 315 |
| disorder | n/a | 347 | 352 |
| disorder | n/a | 510 | 538 |
| disorder | n/a | 542 | 547 |
| disorder | n/a | 550 | 572 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession Q16555. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MSYQGKKNIP RITSDRLLIK GGKIVNDDQS FYADIYMEDG LIKQIGENLI
50 51
VPGGVKTIEA HSRMVIPGGI DVHTRFQMPD QGMTSADDFF QGTKAALAGG
100 101
TTMIIDHVVP EPGTSLLAAF DQWREWADSK SCCDYSLHVD ISEWHKGIQE
150 151
EMEALVKDHG VNSFLVYMAF KDRFQLTDCQ IYEVLSVIRD IGAIAQVHAE
200 201
NGDIIAEEQQ RILDLGITGP EGHVLSRPEE VEAEAVNRAI TIANQTNCPL
250 251
YITKVMSKSS AEVIAQARKK GTVVYGEPIT ASLGTDGSHY WSKNWAKAAA
300 301
FVTSPPLSPD PTTPDFLNSL LSCGDLQVTG SAHCTFNTAQ KAVGKDNFTL
350 351
IPEGTNGTEE RMSVIWDKAV VTGKMDENQF VAVTSTNAAK VFNLYPRKGR
400 401
IAVGSDADLV IWDPDSVKTI SAKTHNSSLE YNIFEGMECR GSPLVVISQG
450 451
KIVLEDGTLH VTEGSGRYIP RKPFPDFVYK RIKARSRLAE LRGVPRGLYD
500 501
GPVCEVSVTP KTVTPASSAK TSPAKQQAPP VRNLHQSGFS LSGAQIDDNI
550 551
PRRTTQRIVA PPGGRANITS LG
572
Show the unformatted sequence. |
| Checksums: |
CRC64:5CDB6CF7F5C308AD
MD5:f92ef21bb3b348908fd608756b9a1990
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| Amidohydro_1 | 64 - 413 | 2GSE | A | 64 - 413 | Jmol AstexViewer SPICE |
| B | 64 - 413 | Jmol AstexViewer SPICE | |||
| C | 64 - 413 | Jmol AstexViewer SPICE | |||
| D | 64 - 413 | Jmol AstexViewer SPICE | |||
| 2VM8 | A | 64 - 413 | Jmol AstexViewer SPICE | ||
| B | 64 - 413 | Jmol AstexViewer SPICE | |||
| C | 64 - 413 | Jmol AstexViewer SPICE | |||
| D | 64 - 413 | Jmol AstexViewer SPICE |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.
