Summary
This is the summary of UniProt entry MKNK1_HUMAN (Q9BUB5).
| Description: | MAP kinase-interacting serine/threonine-protein kinase 1 EC=2.7.11.1 |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
View Pfam proteome data. |
| Length: | 465 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| Pfam B | Pfam-B_34638 | 1 | 29 |
| disorder | n/a | 3 | 38 |
| low_complexity | n/a | 23 | 35 |
| Pfam A | Pkinase | 50 | 374 |
| disorder | n/a | 184 | 205 |
| disorder | n/a | 375 | 377 |
| disorder | n/a | 379 | 389 |
| Pfam B | Pfam-B_141 | 381 | 429 |
| disorder | n/a | 412 | 428 |
| low_complexity | n/a | 416 | 428 |
| Pfam B | Pfam-B_31545 | 431 | 463 |
| disorder | n/a | 431 | 432 |
| disorder | n/a | 443 | 465 |
| low_complexity | n/a | 443 | 456 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession Q9BUB5. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MVSSQKLEKP IEMGSSEPLP IADGDRRRKK KRRGRATDSL PGKFEDMYKL
50 51
TSELLGEGAY AKVQGAVSLQ NGKEYAVKII EKQAGHSRSR VFREVETLYQ
100 101
CQGNKNILEL IEFFEDDTRF YLVFEKLQGG SILAHIQKQK HFNEREASRV
150 151
VRDVAAALDF LHTKDKVSLC HLGWSAMAPS GLTAAPTSLG SSDPPTSASQ
200 201
VAGTTGIAHR DLKPENILCE SPEKVSPVKI CDFDLGSGMK LNNSCTPITT
250 251
PELTTPCGSA EYMAPEVVEV FTDQATFYDK RCDLWSLGVV LYIMLSGYPP
300 301
FVGHCGADCG WDRGEVCRVC QNKLFESIQE GKYEFPDKDW AHISSEAKDL
350 351
ISKLLVRDAK QRLSAAQVLQ HPWVQGQAPE KGLPTPQVLQ RNSSTMDLTL
400 401
FAAEAIALNR QLSQHEENEL AEEPEALADG LCSMKLSPPC KSRLARRRAL
450 451
AQAGRGEDRS PPTAL
465
Show the unformatted sequence. |
| Checksums: |
CRC64:CAE225C35DCB2B43
MD5:c9be1bd12301019f6ee750057c8bf2d3
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| Pkinase | 50 - 374 | 2HW6 | A | 50 - 333 | Jmol AstexViewer SPICE |
| B | 50 - 333 | Jmol AstexViewer SPICE |
