Summary
This is the summary of UniProt entry NALP1_HUMAN (Q9C000).
| Description: | NACHT, LRR and PYD domains-containing protein 1 |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
View Pfam proteome data. |
| Length: | 1473 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| Pfam A | PYRIN | 7 | 88 |
| low_complexity | n/a | 13 | 28 |
| disorder | n/a | 33 | 49 |
| disorder | n/a | 83 | 86 |
| disorder | n/a | 90 | 122 |
| disorder | n/a | 131 | 143 |
| disorder | n/a | 158 | 212 |
| disorder | n/a | 217 | 257 |
| low_complexity | n/a | 220 | 231 |
| disorder | n/a | 295 | 299 |
| Pfam A | NACHT | 328 | 497 |
| transmembrane | n/a | 513 | 531 |
| low_complexity | n/a | 535 | 552 |
| low_complexity | n/a | 555 | 568 |
| low_complexity | n/a | 705 | 720 |
| Pfam A | LRR_6 | 807 | 830 |
| Pfam A | LRR_6 | 864 | 887 |
| Pfam A | LRR_6 | 921 | 944 |
| disorder | n/a | 967 | 971 |
| disorder | n/a | 985 | 986 |
| disorder | n/a | 992 | 1017 |
| low_complexity | n/a | 1039 | 1062 |
| disorder | n/a | 1067 | 1079 |
| disorder | n/a | 1084 | 1085 |
| Pfam A | FIIND | 1099 | 1355 |
| Pfam A | CARD | 1379 | 1462 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession Q9C000. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MAGGAWGRLA CYLEFLKKEE LKEFQLLLAN KAHSRSSSGE TPAQPEKTSG
50 51
MEVASYLVAQ YGEQRAWDLA LHTWEQMGLR SLCAQAQEGA GHSPSFPYSP
100 101
SEPHLGSPSQ PTSTAVLMPW IHELPAGCTQ GSERRVLRQL PDTSGRRWRE
150 151
ISASLLYQAL PSSPDHESPS QESPNAPTST AVLGSWGSPP QPSLAPREQE
200 201
APGTQWPLDE TSGIYYTEIR EREREKSEKG RPPWAAVVGT PPQAHTSLQP
250 251
HHHPWEPSVR ESLCSTWPWK NEDFNQKFTQ LLLLQRPHPR SQDPLVKRSW
300 301
PDYVEENRGH LIEIRDLFGP GLDTQEPRIV ILQGAAGIGK STLARQVKEA
350 351
WGRGQLYGDR FQHVFYFSCR ELAQSKVVSL AELIGKDGTA TPAPIRQILS
400 401
RPERLLFILD GVDEPGWVLQ EPSSELCLHW SQPQPADALL GSLLGKTILP
450 451
EASFLITART TALQNLIPSL EQARWVEVLG FSESSRKEYF YRYFTDERQA
500 501
IRAFRLVKSN KELWALCLVP WVSWLACTCL MQQMKRKEKL TLTSKTTTTL
550 551
CLHYLAQALQ AQPLGPQLRD LCSLAAEGIW QKKTLFSPDD LRKHGLDGAI
600 601
ISTFLKMGIL QEHPIPLSYS FIHLCFQEFF AAMSYVLEDE KGRGKHSNCI
650 651
IDLEKTLEAY GIHGLFGAST TRFLLGLLSD EGEREMENIF HCRLSQGRNL
700 701
MQWVPSLQLL LQPHSLESLH CLYETRNKTF LTQVMAHFEE MGMCVETDME
750 751
LLVCTFCIKF SRHVKKLQLI EGRQHRSTWS PTMVVLFRWV PVTDAYWQIL
800 801
FSVLKVTRNL KELDLSGNSL SHSAVKSLCK TLRRPRCLLE TLRLAGCGLT
850 851
AEDCKDLAFG LRANQTLTEL DLSFNVLTDA GAKHLCQRLR QPSCKLQRLQ
900 901
LVSCGLTSDC CQDLASVLSA SPSLKELDLQ QNNLDDVGVR LLCEGLRHPA
950 951
CKLIRLGLDQ TTLSDEMRQE LRALEQEKPQ LLIFSRRKPS VMTPTEGLDT
1000 1001
GEMSNSTSSL KRQRLGSERA ASHVAQANLK LLDVSKIFPI AEIAEESSPE
1050 1051
VVPVELLCVP SPASQGDLHT KPLGTDDDFW GPTGPVATEV VDKEKNLYRV
1100 1101
HFPVAGSYRW PNTGLCFVMR EAVTVEIEFC VWDQFLGEIN PQHSWMVAGP
1150 1151
LLDIKAEPGA VEAVHLPHFV ALQGGHVDTS LFQMAHFKEE GMLLEKPARV
1200 1201
ELHHIVLENP SFSPLGVLLK MIHNALRFIP VTSVVLLYHR VHPEEVTFHL
1250 1251
YLIPSDCSIR KAIDDLEMKF QFVRIHKPPP LTPLYMGCRY TVSGSGSGML
1300 1301
EILPKELELC YRSPGEDQLF SEFYVGHLGS GIRLQVKDKK DETLVWEALV
1350 1351
KPGDLMPATT LIPPARIAVP SPLDAPQLLH FVDQYREQLI ARVTSVEVVL
1400 1401
DKLHGQVLSQ EQYERVLAEN TRPSQMRKLF SLSQSWDRKC KDGLYQALKE
1450 1451
THPHLIMELW EKGSKKGLLP LSS
1473
Show the unformatted sequence. |
| Checksums: |
CRC64:438F0DCE45C2562D
MD5:173f33f1d4c3e5545dc5c2e5ed80f0a0
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| CARD | 1379 - 1462 | 3KAT | A | 1379 - 1462 | Jmol AstexViewer SPICE |
| PYRIN | 7 - 88 | 1PN5 | A | 65 - 146 | Jmol AstexViewer SPICE |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.
