Summary
This is the summary of UniProt entry HDAC6_HUMAN (Q9UBN7).
| Description: | Histone deacetylase 6 EC=3.5.1.98 |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
View Pfam proteome data. |
| Length: | 1215 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| disorder | n/a | 1 | 38 |
| low_complexity | n/a | 2 | 28 |
| disorder | n/a | 40 | 44 |
| disorder | n/a | 46 | 47 |
| disorder | n/a | 50 | 51 |
| low_complexity | n/a | 51 | 58 |
| disorder | n/a | 53 | 56 |
| Pfam A | Hist_deacetyl | 95 | 403 |
| disorder | n/a | 445 | 464 |
| low_complexity | n/a | 451 | 467 |
| Pfam A | Hist_deacetyl | 489 | 799 |
| disorder | n/a | 556 | 557 |
| low_complexity | n/a | 798 | 813 |
| disorder | n/a | 810 | 812 |
| disorder | n/a | 837 | 838 |
| disorder | n/a | 842 | 1086 |
| low_complexity | n/a | 1072 | 1083 |
| disorder | n/a | 1088 | 1092 |
| Pfam A | zf-UBP | 1133 | 1195 |
| disorder | n/a | 1212 | 1215 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession Q9UBN7. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MTSTGQDSTT TRQRRSRQNP QSPPQDSSVT SKRNIKKGAV PRSIPNLAEV
50 51
KKKGKMKKLG QAMEEDLIVG LQGMDLNLEA EALAGTGLVL DEQLNEFHCL
100 101
WDDSFPEGPE RLHAIKEQLI QEGLLDRCVS FQARFAEKEE LMLVHSLEYI
150 151
DLMETTQYMN EGELRVLADT YDSVYLHPNS YSCACLASGS VLRLVDAVLG
200 201
AEIRNGMAII RPPGHHAQHS LMDGYCMFNH VAVAARYAQQ KHRIRRVLIV
250 251
DWDVHHGQGT QFTFDQDPSV LYFSIHRYEQ GRFWPHLKAS NWSTTGFGQG
300 301
QGYTINVPWN QVGMRDADYI AAFLHVLLPV ALEFQPQLVL VAAGFDALQG
350 351
DPKGEMAATP AGFAQLTHLL MGLAGGKLIL SLEGGYNLRA LAEGVSASLH
400 401
TLLGDPCPML ESPGAPCRSA QASVSCALEA LEPFWEVLVR STETVERDNM
450 451
EEDNVEESEE EGPWEPPVLP ILTWPVLQSR TGLVYDQNMM NHCNLWDSHH
500 501
PEVPQRILRI MCRLEELGLA GRCLTLTPRP ATEAELLTCH SAEYVGHLRA
550 551
TEKMKTRELH RESSNFDSIY ICPSTFACAQ LATGAACRLV EAVLSGEVLN
600 601
GAAVVRPPGH HAEQDAACGF CFFNSVAVAA RHAQTISGHA LRILIVDWDV
650 651
HHGNGTQHMF EDDPSVLYVS LHRYDHGTFF PMGDEGASSQ IGRAAGTGFT
700 701
VNVAWNGPRM GDADYLAAWH RLVLPIAYEF NPELVLVSAG FDAARGDPLG
750 751
GCQVSPEGYA HLTHLLMGLA SGRIILILEG GYNLTSISES MAACTRSLLG
800 801
DPPPLLTLPR PPLSGALASI TETIQVHRRY WRSLRVMKVE DREGPSSSKL
850 851
VTKKAPQPAK PRLAERMTTR EKKVLEAGMG KVTSASFGEE STPGQTNSET
900 901
AVVALTQDQP SEAATGGATL AQTISEAAIG GAMLGQTTSE EAVGGATPDQ
950 951
TTSEETVGGA ILDQTTSEDA VGGATLGQTT SEEAVGGATL AQTTSEAAME
1000 1001
GATLDQTTSE EAPGGTELIQ TPLASSTDHQ TPPTSPVQGT TPQISPSTLI
1050 1051
GSLRTLELGS ESQGASESQA PGEENLLGEA AGGQDMADSM LMQGSRGLTD
1100 1101
QAIFYAVTPL PWCPHLVAVC PIPAAGLDVT QPCGDCGTIQ ENWVCLSCYQ
1150 1151
VYCGRYINGH MLQHHGNSGH PLVLSYIDLS AWCYYCQAYV HHQALLDVKN
1200 1201
IAHQNKFGED MPHPH
1215
Show the unformatted sequence. |
| Checksums: |
CRC64:6F17731268A33114
MD5:2134affc7c11f07e50105fa98770aecb
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| zf-UBP | 1133 - 1195 | 3C5K | A | 25 - 87 | Jmol AstexViewer SPICE |
| 3GV4 | A | 25 - 87 | Jmol AstexViewer SPICE | ||
| 3PHD | A | 25 - 87 | Jmol AstexViewer SPICE | ||
| B | 25 - 87 | Jmol AstexViewer SPICE | |||
| C | 25 - 87 | Jmol AstexViewer SPICE | |||
| D | 25 - 87 | Jmol AstexViewer SPICE |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.
