Summary
This is the summary of UniProt entry DICER_HUMAN (Q9UPY3).
| Description: | Endoribonuclease Dicer EC=3.1.26.- |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
View Pfam proteome data. |
| Length: | 1922 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| Pfam A | DEAD | 45 | 213 |
| low_complexity | n/a | 217 | 231 |
| disorder | n/a | 411 | 430 |
| low_complexity | n/a | 413 | 431 |
| Pfam A | Helicase_C | 469 | 556 |
| disorder | n/a | 484 | 486 |
| disorder | n/a | 489 | 496 |
| coiled_coil | n/a | 491 | 511 |
| disorder | n/a | 597 | 598 |
| low_complexity | n/a | 600 | 615 |
| disorder | n/a | 601 | 602 |
| Pfam A | Dicer_dimer | 630 | 722 |
| disorder | n/a | 723 | 744 |
| low_complexity | n/a | 723 | 733 |
| disorder | n/a | 788 | 789 |
| Pfam B | Pfam-B_11197 | 825 | 881 |
| Pfam A | PAZ | 891 | 1065 |
| Pfam B | Pfam-B_10082 | 1068 | 1107 |
| low_complexity | n/a | 1099 | 1115 |
| disorder | n/a | 1133 | 1144 |
| disorder | n/a | 1218 | 1225 |
| disorder | n/a | 1234 | 1239 |
| disorder | n/a | 1253 | 1259 |
| disorder | n/a | 1269 | 1273 |
| disorder | n/a | 1281 | 1286 |
| Pfam A | Ribonuclease_3 | 1313 | 1575 |
| disorder | n/a | 1392 | 1394 |
| disorder | n/a | 1411 | 1417 |
| low_complexity | n/a | 1414 | 1425 |
| disorder | n/a | 1419 | 1430 |
| low_complexity | n/a | 1494 | 1507 |
| low_complexity | n/a | 1618 | 1633 |
| Pfam A | Ribonuclease_3 | 1702 | 1824 |
| disorder | n/a | 1784 | 1803 |
| low_complexity | n/a | 1786 | 1803 |
| disorder | n/a | 1858 | 1862 |
| disorder | n/a | 1865 | 1866 |
| disorder | n/a | 1868 | 1872 |
| low_complexity | n/a | 1882 | 1894 |
| low_complexity | n/a | 1900 | 1914 |
| disorder | n/a | 1910 | 1922 |
Show or hide domain scores.
Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
Note: it can take a few seconds for this image to be generated and loaded.
Show sources update panel.
Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession Q9UPY3. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MKSPALQPLS MAGLQLMTPA SSPMGPFFGL PWQQEAIHDN IYTPRKYQVE
50 51
LLEAALDHNT IVCLNTGSGK TFIAVLLTKE LSYQIRGDFS RNGKRTVFLV
100 101
NSANQVAQQV SAVRTHSDLK VGEYSNLEVN ASWTKERWNQ EFTKHQVLIM
150 151
TCYVALNVLK NGYLSLSDIN LLVFDECHLA ILDHPYREIM KLCENCPSCP
200 201
RILGLTASIL NGKCDPEELE EKIQKLEKIL KSNAETATDL VVLDRYTSQP
250 251
CEIVVDCGPF TDRSGLYERL LMELEEALNF INDCNISVHS KERDSTLISK
300 301
QILSDCRAVL VVLGPWCADK VAGMMVRELQ KYIKHEQEEL HRKFLLFTDT
350 351
FLRKIHALCE EHFSPASLDL KFVTPKVIKL LEILRKYKPY ERQQFESVEW
400 401
YNNRNQDNYV SWSDSEDDDE DEEIEEKEKP ETNFPSPFTN ILCGIIFVER
450 451
RYTAVVLNRL IKEAGKQDPE LAYISSNFIT GHGIGKNQPR NKQMEAEFRK
500 501
QEEVLRKFRA HETNLLIATS IVEEGVDIPK CNLVVRFDLP TEYRSYVQSK
550 551
GRARAPISNY IMLADTDKIK SFEEDLKTYK AIEKILRNKC SKSVDTGETD
600 601
IDPVMDDDDV FPPYVLRPDD GGPRVTINTA IGHINRYCAR LPSDPFTHLA
650 651
PKCRTRELPD GTFYSTLYLP INSPLRASIV GPPMSCVRLA ERVVALICCE
700 701
KLHKIGELDD HLMPVGKETV KYEEELDLHD EEETSVPGRP GSTKRRQCYP
750 751
KAIPECLRDS YPRPDQPCYL YVIGMVLTTP LPDELNFRRR KLYPPEDTTR
800 801
CFGILTAKPI PQIPHFPVYT RSGEVTISIE LKKSGFMLSL QMLELITRLH
850 851
QYIFSHILRL EKPALEFKPT DADSAYCVLP LNVVNDSSTL DIDFKFMEDI
900 901
EKSEARIGIP STKYTKETPF VFKLEDYQDA VIIPRYRNFD QPHRFYVADV
950 951
YTDLTPLSKF PSPEYETFAE YYKTKYNLDL TNLNQPLLDV DHTSSRLNLL
1000 1001
TPRHLNQKGK ALPLSSAEKR KAKWESLQNK QILVPELCAI HPIPASLWRK
1050 1051
AVCLPSILYR LHCLLTAEEL RAQTASDAGV GVRSLPADFR YPNLDFGWKK
1100 1101
SIDSKSFISI SNSSSAENDN YCKHSTIVPE NAAHQGANRT SSLENHDQMS
1150 1151
VNCRTLLSES PGKLHVEVSA DLTAINGLSY NQNLANGSYD LANRDFCQGN
1200 1201
QLNYYKQEIP VQPTTSYSIQ NLYSYENQPQ PSDECTLLSN KYLDGNANKS
1250 1251
TSDGSPVMAV MPGTTDTIQV LKGRMDSEQS PSIGYSSRTL GPNPGLILQA
1300 1301
LTLSNASDGF NLERLEMLGD SFLKHAITTY LFCTYPDAHE GRLSYMRSKK
1350 1351
VSNCNLYRLG KKKGLPSRMV VSIFDPPVNW LPPGYVVNQD KSNTDKWEKD
1400 1401
EMTKDCMLAN GKLDEDYEEE DEEEESLMWR APKEEADYED DFLEYDQEHI
1450 1451
RFIDNMLMGS GAFVKKISLS PFSTTDSAYE WKMPKKSSLG SMPFSSDFED
1500 1501
FDYSSWDAMC YLDPSKAVEE DDFVVGFWNP SEENCGVDTG KQSISYDLHT
1550 1551
EQCIADKSIA DCVEALLGCY LTSCGERAAQ LFLCSLGLKV LPVIKRTDRE
1600 1601
KALCPTRENF NSQQKNLSVS CAAASVASSR SSVLKDSEYG CLKIPPRCMF
1650 1651
DHPDADKTLN HLISGFENFE KKINYRFKNK AYLLQAFTHA SYHYNTITDC
1700 1701
YQRLEFLGDA ILDYLITKHL YEDPRQHSPG VLTDLRSALV NNTIFASLAV
1750 1751
KYDYHKYFKA VSPELFHVID DFVQFQLEKN EMQGMDSELR RSEEDEEKEE
1800 1801
DIEVPKAMGD IFESLAGAIY MDSGMSLETV WQVYYPMMRP LIEKFSANVP
1850 1851
RSPVRELLEM EPETAKFSPA ERTYDGKVRV TVEVVGKGKF KGVGRSYRIA
1900 1901
KSAAARRALR SLKANQPQVP NS
1922
Show the unformatted sequence. |
| Checksums: |
CRC64:9452B96A601D4551
MD5:9323f9b553167e2e5e663988e11d487d
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| Ribonuclease_3 | 1702 - 1824 | 2EB1 | A | 44 - 166 | Jmol AstexViewer SPICE |
| B | 44 - 166 | Jmol AstexViewer SPICE | |||
| C | 44 - 166 | Jmol AstexViewer SPICE |
