Summary

SRC8_HUMAN

This is the summary of UniProt entry SRC8_HUMAN (Q14247).

Description:

Src substrate cortactin

Source organism:

Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.

Length:

550 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source	Domain	Start	End

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q14247. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:

1

MWKASAGHAV SIAQDDAGAD DWETDPDFVN DVSEKEQRWG AKTVQGSGHQ

50

51

EHINIHKLRE NVFQEHQTLK EKELETGPKA SHGYGGKFGV EQDRMDKSAV

100

101

GHEYQSKLSK HCSQVDSVRG FGGKFGVQMD RVDQSAVGFE YQGKTEKHAS

150

151

QKDYSSGFGG KYGVQADRVD KSAVGFDYQG KTEKHESQRD YSKGFGGKYG

200

201

IDKDKVDKSA VGFEYQGKTE KHESQKDYVK GFGGKFGVQT DRQDKCALGW

250

251

DHQEKLQLHE SQKDYKTGFG GKFGVQSERQ DSAAVGFDYK EKLAKHESQQ

300

301

DYSKGFGGKY GVQKDRMDKN ASTFEDVTQV SSAYQKTVPV EAVTSKTSNI

350

351

RANFENLAKE KEQEDRRKAE AERAQRMAKE RQEQEEARRK LEEQARAKTQ

400

401

TPPVSPAPQP TEERLPSSPV YEDAASFKAE LSYRGPVSGT EPEPVYSMEA

450

451

ADYREASSQQ GLAYATEAVY ESAEAPGHYP AEDSTYDEYE NDLGITAVAL

500

501

YDYQAAGDDE ISFDPDDIIT NIEMIDDGWW RGVCKGRYGL FPANYVELRQ

550

551

550

Show the unformatted sequence.

Checksums:

CRC64:7799326C2B4383BB

MD5:6bd552cda63a423412aac6b7301b9ff3

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family	UniProt residues	PDB ID	PDB chain ID	PDB residues	View
SH3_1	498 - 543	1x69	A	21 - 66	Jmol AstexViewer SPICE
		2d1x	A	9 - 54	Jmol AstexViewer SPICE
			B	9 - 54	Jmol AstexViewer SPICE
			C	9 - 54	Jmol AstexViewer SPICE
			D	9 - 54	Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.